Chapters authored
Pediatric Acne By Bilgen Gencler, Ozge Keseroglu, Selda Pelin Kartal and Muzeyyen
Gonul
Acne is a dermatological disorder that can be more commonly seen in adolescents as well as younger patients. The pediatric acne is classified according to the age groups as neonatal acne, infantile acne, mid-childhood acne, and prepubertal acne. The presentation, pathogenesis, differential diagnosis, and treatment of the disease vary in each age group. Early diagnosis is important to prevent the scar formation and determine the underlying abnormalities.
Part of the book: Acne and Acneiform Eruptions
The Use of Topical Retinoids in Acne By Dilek Bayramgurler, Selda Pelin Kartal and Cemile Altunel
Acne vulgaris is the most common skin disease in adolescents and young adults and has serious influence on quality of life of the patients. Acne vulgaris is the most common skin disease in adolescents and young adults and has serious influence on quality of life of the patients. The initial lesions of acne are the microcomedones that can be observed histologically in normal-appearing skin. The first step in the treatment of acne is to understand the pathophysiology of disease and to act on the factors involved in the development of acne. Increased sebum secretion from sebaceous glands, secretion of inflammatory mediators, altered keratinization and follicular plugging, and follicular colonization of Propionibacterium acnes are major four steps of acne pathogenesis. Topical retinoids have multiple effects in the treatment of acne and act on more than one factor implicated in the etiology of acne. They prevent the formation of microcomedones and reduce their number, reduce macrocomedones, promote the normal desquamation of follicular epithelium, exert anti-inflammatory effects, enhance the penetration of other topical acne drugs, and prolong the remission periods of acne by inhibiting the formation of microcomedone formation and preventing the development of new lesions and bacterial resistance. Therefore, topical retinoids have been the first-line treatment for most forms of acne vulgaris either alone or together with other agents.
Part of the book: Acne and Acneiform Eruptions
Cosmetic Procedures in the Treatment of Alopecia By Selda Pelin Kartal, Cemile Altunel and Bilgen Gencler
Alopecia has a significant negative impact on the quality of life. Unfortunately, there is no satisfactory cure for most types of alopecia. Alopecia is divided into cicatricial and noncicatricial types. Androgenetic alopecia, alopecia areata, and telogen effluvium are common forms of noncicatricial alopecias. In order to treat or improve the appearance, various procedures that are being applied for different types of alopecia including mesotherapy, microneedling, platelet‐rich plasma, low‐level light therapy, and stem‐cell therapy with variable outcomes are reviewed in this chapter.
Part of the book: Hair and Scalp Disorders
Comorbidities in Chronic Spontaneous Urticaria By Müzeyyen Gönül, Havva Hilal Ayvaz and Selda Pelin Kartal
Chronic spontaneous urticaria (CSU) is a disease that makes people’s lives miserable with unknown etiology. In recent years, there have been many studies trying to explain the etiology of CSU, and many of them reported that there are some comorbidities or triggering factors related to CSU. However, it has not been clearly known yet that whether these conditions are true comorbidities associated with CSU or they are coincidentally found at the same time. In this chapter, related comorbidities and conditions have been told.
Part of the book: Urticaria and Angioedema
Exosome as a Therapeutic Agent in Cosmetic Dermatology By Gökçe Işıl Kurmuş and Selda Pelin Kartal
Exosomes, nanosized extracellular vesicles, have emerged as crucial mediators of intercellular communication, facilitating the transfer of bioactive molecules such as proteins, lipids, and nucleic acids. In recent years, their potential application in cosmetic dermatology has attracted significant interest due to their ability to influence various biological processes, including skin regeneration, collagen synthesis, and the modulation of inflammation and oxidative stress. Exosomes derived from mesenchymal stem cells and other cell types have effectively promoted skin rejuvenation, reduced wrinkles, improved elasticity, and enhanced wound healing. Their use as a non-invasive, cell-free therapy offers distinct advantages, such as targeted delivery, minimal side effects, and improved bioavailability of therapeutic agents. Additionally, exosome-based formulations have shown promise in addressing photoaging, pigmentation disorders, and hair loss. Despite these advancements, challenges remain regarding the standardization of exosome isolation, characterization, and large-scale clinical validation. This chapter aims to provide a comprehensive overview of the current and potential cosmetic applications of exosomes, emphasizing their role as innovative therapeutic agents capable of transforming cosmetic dermatology.
Part of the book: Cosmetic Industry
Practical Management of Psoriasis in Special Clinical Circumstances By Selda Pelin Kartal and Tuğcan Yüksek
This chapter thoroughly discusses the management strategies for psoriasis within complex clinical scenarios and special patient groups. It examines therapeutic options and safety considerations for systemic and biologic therapies in patients who have coexisting hepatic or renal disease, cardiovascular issues, malignancies, or inflammatory bowel disease, and addresses specific cases such as pregnancy and lactation. Furthermore, the management of psoriasis complicated by psoriatic arthritis, latent tuberculosis, or neurological disorders such as multiple sclerosis is detailed. The chapter emphasizes evidence-based, personalized treatment approaches informed by contemporary clinical trials and real-life patient data.
Part of the book: Psoriasis
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