Seçkin Engin

Karadeniz Technical University Turkey

Seçkin Engin received his BS in Pharmacy (2013) from Gazi University in Türkiye and a Ph.D. in Pharmacology (2020) from the Health Sciences Institute of Karadeniz Technical University in Türkiye. He currently works as a full-time researcher and lecturer in the Department of Pharmacology at the Faculty of Pharmacy at the Karadeniz Technical University. He has published multiple scientific papers and book chapters as the lead author in peer-reviewed international journals. He is also a journal peer reviewer and a member of the editorial boards of journals. His research interests include smooth muscle pharmacology and urogenital system pharmacology, which are focused on identifying novel drugs or drugs repurposing for cystitis and diabetic urological complications such as erectile dysfunction and diabetic cystopathy.

1books edited

2chapters authored

Latest work with IntechOpen by Seçkin Engin

Despite remarkable advances in pharmaceutical sciences, traditional and de novo drug discovery and development face significant barriers to obtaining marketing approval, including long timeframes, substantial financial investment, and high failure rates. Thus, a lot of effort is being made to bring out novel approaches to deal with the debilitating challenges facing the global pharmaceutical industry. Drug repurposing (or drug repositioning) represents one of the alternative strategies for traditional drug discovery, in which the process aims to seek new uses for already approved or investigational drugs beyond their original indication. Drug repurposing has been largely preferred owing to superior benefits related to reduced drug discovery timelines and costs. To date, a number of drugs have been successfully repurposed by providing effective solutions to various diseases that are especially hard to manage, making the drug repurposing a growing trend. This book's chapters offer comprehensive topics on drug repurposing and repurposed drugs.

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Repurposed Drugs

Edited by Seçkin Engin

Chapters authored

Drug-Related Cystitis: An Overview

By Seçkin Engin

Cystitis is an inflammatory condition of the urinary bladder with infectious or noninfectious aetiologies. Chemical-induced cystitis represents a relatively highly prevalent kind of noninfectious cystitis resulting from therapeutic agents or environmental chemicals. Drug-related cystitis is a type of urotoxicity of drugs, which is a commonly underreported condition leading to impaired quality of patients’ life, discontinuation of medication and non-compliance. Drug-related cystitis can occur in several forms ranging from mild urinary symptoms to gross haematuria, which can be challenging for physicians to treat. Chemotherapeutic drugs, ketamine, tiaprofenic acid and several drugs have been reported to be associated with cystitis until now. Cyclophosphamide (CP) is an alkylating agent that leads to haemorrhagic cystitis with widespread awareness due to its high prevalence in patients under treatment intravenously. However, several currently available drugs have been also reported to induce cystitis, which may be usually ignored. Drug-related cystitis can cause emergency admissions and prolonged hospitalisation, leading to increased medical costs. Some cases of drug-related cystitis are clinically managed with established therapeutic interventions and/or prophylaxis, such as CP-induced haemorrhagic cystitis. On the other hand, standard treatment is currently unavailable for most cases. This chapter will provide current knowledge regarding the drug-related cystitis that should be taken into consideration as a potential adverse effect of drugs by physicians.

Part of the book: Cystitis

Introductory Chapter: Repurposed Drugs – Current State and Future Perspectives

By Seçkin Engin

Part of the book: Repurposed Drugs

Seçkin Engin

Latest work with IntechOpen by Seçkin Engin

Repurposed Drugs

Chapters authored

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