The ability to assess the quality properties of each pharmaceutical tablet, in the production line during manufacturing, is one of the burning desires of pharmaceutical scientists as well as patients. We have therefore developed and...
moreThe ability to assess the quality properties of each pharmaceutical tablet, in the production line during manufacturing, is one of the burning desires of pharmaceutical scientists as well as patients. We have therefore developed and proposed a suit of nondestructive and non-invasive methods based on terahertz timedomain (THz-TD) measurement techniques, allowing us to predict important tablet quality parameters such as porosity, strain, structural parameter, weight and height of training sets of pharmaceutical compacts. A close match was observed between the predicted tablet parameters (i.e. porosity, weight, strain and height) and the experimental data. For the first time, we have introduced and demonstrated a novel structure parameter and an optical strain concept which can offer valuable information on the dissolution rate and mechanical behaviour of pharmaceutical tablets. It is therefore suggested that this preliminary study could be the onset of in-depth future studies geared towards the realisation of a multifunctional terahertz sensor for the screening of each tablet during production.