Key research themes
1. How does potassium (K+) concentration affect electrophysiological and mechanical functions of heart and ventricle cells?
This research theme investigates the direct modulatory effects of extracellular potassium levels on cardiac electrophysiology and myocardial function, focusing on ventricular action potentials, ion channel behavior, arrhythmia risk, and myocardial contractility. Understanding these mechanisms is critical for managing potassium imbalances in critically ill patients, arrhythmic risk prediction, and optimizing cardiac therapies.
2. What are the clinical implications of potassium imbalances on critically ill patients’ outcomes, and how can potassium supplementation be personalized?
This theme explores the epidemiology, risk, and therapeutic considerations of hypokalemia and hyperkalemia in intensive care units, including their associations with mortality, arrhythmias, and kidney function. It also addresses personalized predictive modeling for potassium supplementation responses to optimize treatment efficacy and safety in critically ill adults.
3. How can vitamin K (K1 and K2) status influence chronic kidney disease, bone health, and cardiovascular complications in transplant and CKD patients?
This theme encapsulates investigations into vitamin K vitamers’ roles in coagulation, vascular calcification prevention, bone metabolism, and organ survival—especially in kidney transplant and chronic kidney disease (CKD) populations—examining vitamin K status assessment challenges, supplementation benefits, and interaction with kidney function.