Bayerl et al., 2021 - Google Patents

Principles of signaling pathway modulation for enhancing human naive pluripotency induction

Bayerl et al., 2021

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Document ID
4583323258365110906
Author
Bayerl J
Ayyash M
Shani T
Manor Y
Gafni O
Massarwa R
Kalma Y
Aguilera-Castrejon A
Zerbib M
Amir H
Sheban D
Geula S
Mor N
Weinberger L
Tassa S
Krupalnik V
Oldak B
Livnat N
Tarazi S
Tawil S
Wildschutz E
Ashouokhi S
Lasman L
Rotter V
Hanna S
Ben-Yosef D
Novershtern N
Viukov S
Hanna J
Publication year
Publication venue
Cell stem cell

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Snippet

Isolating human MEK/ERK signaling-independent pluripotent stem cells (PSCs) with naive pluripotency characteristics while maintaining differentiation competence and (epi) genetic integrity remains challenging. Here, we engineer reporter systems that allow the screening …
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
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    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
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    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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