Zhang et al., 2019 - Google Patents

Redox-responsive and dual-targeting hyaluronic acid–methotrexate prodrug self-assembling nanoparticles for enhancing intracellular drug self-delivery

Zhang et al., 2019

Document ID
2937798245984425459
Author
Zhang Y
Li Y
Tian H
Zhu Q
Wang F
Fan Z
Zhou S
Wang X
Xie L
Hou Z
Publication year
Publication venue
Molecular pharmaceutics

External Links

Snippet

The clinical translation of methotrexate (MTX) is limited because of low aqueous solubility, poor bioavailability, low uptake efficiency, and toxicity concerns. Herein, dual-acting MTX (not only targeting folate receptors but also killing cells via inhibition of intracellular folate …
Continue reading at pubs.acs.org (other versions)

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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
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