Di Micco et al., 2014 - Google Patents

The yeast model suggests the use of short peptides derived from mt LeuRS for the therapy of diseases due to mutations in several mt tRNAs

Di Micco et al., 2014

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Document ID
17316798328636173519
Author
Di Micco P
d'Orsi M
Morea V
Frontali L
Francisci S
Montanari A
Publication year
Publication venue
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research

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We have previously established a yeast model of mitochondrial (mt) diseases. We showed that defective respiratory phenotypes due to point-mutations in mt tRNA Leu (UUR), tRNA Ile and tRNA Val could be relieved by overexpression of both cognate and non-cognate …
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