Junne et al., 2018 - Google Patents

How scalable and suitable are single-use bioreactors?

Junne et al., 2018

Document ID
10715437475314559672
Author
Junne S
Neubauer P
Publication year
Publication venue
Current opinion in biotechnology

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Highlights•Engineering parameters of most common single-use bioreactor designs are provided.•Scale up and down between the μL to the m 3 range is discussed.•Impacts on cultivation performances of cell lines and microbes are described.•Suitability of single-use …
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    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/04—Flat or tray type, drawers
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    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
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    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting
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    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
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    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
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    • C12M27/14—Rotation or movement of the cells support, e.g. rotated hollow fibers
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    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
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    • C12N1/00—Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
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