WO2025144800A1 - Système de capteur implantable - Google Patents

Système de capteur implantable Download PDF

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Publication number
WO2025144800A1
WO2025144800A1 PCT/US2024/061724 US2024061724W WO2025144800A1 WO 2025144800 A1 WO2025144800 A1 WO 2025144800A1 US 2024061724 W US2024061724 W US 2024061724W WO 2025144800 A1 WO2025144800 A1 WO 2025144800A1
Authority
WO
WIPO (PCT)
Prior art keywords
sensor
lumen
capacitance
pressure
capacitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/061724
Other languages
English (en)
Inventor
J. Freddy HANSEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TC1 LLC
Original Assignee
TC1 LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TC1 LLC filed Critical TC1 LLC
Publication of WO2025144800A1 publication Critical patent/WO2025144800A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031—Implanted circuitry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body

Definitions

  • U.S. Pat. No. 6,111 ,520, U.S. Pat. No. 6,855,115, and U.S. Publication No. 2003/0136417 each of which is incorporated herein by reference, all describe wireless sensors that can be implanted within the body. These sensors can be used to monitor physical conditions within the heart or an abdominal aneurysm.
  • An abdominal aortic aneurysm (AAA) is a dilatation and weakening of the abdominal aorta that can lead to aortic rupture and sudden death.
  • a sensor can be used to monitor pressure within the aneurysm sac to determine whether the intervention is leaking.
  • MEMS Micro- Electro-Mechanical Systems
  • a capacitor can be utilized as an indicator of pressure.
  • Such a sensor includes two parallel plates that are spaced apart from one another and surrounded by a dielectric. The pressure within a lumen of a patient can then deform a portion of the sensor to push one plate towards the second plate resulting in a change in the capacitance of the capacitor. This change in capacitance can then be correlated to the change in pressure of the lumen to determine the pressure change.
  • the fundamental physics of a capacitor causes its capacitance value to change when there is a change in the dielectric value of the medium surrounding the capacitor electrodes (e.g., plates).
  • the embodiments described herein are directed toward an implantable sensor system for determining a change in pressure of a lumen in a body.
  • the implantable medical device includes a first sensor that can be configured to detect variances in a first capacitance of a first capacitor based on changes in pressure in the lumen and environmental changes of the lumen.
  • the implantable medical device can also include a second sensor configured to detect variances in a second capacitance of a second capacitor based on environmental changes of the lumen, and one or more processors.
  • the one or more processors are configured to determine a change in pressure of the lumen based on the variances in the first capacitance and the variances in the second capacitance.
  • the first sensor can include a first capacitor with first and second spaced apart plates
  • the second sensor may include a second capacitor with first and second spaced apart plates.
  • the first plate of the second capacitor can be coupled to the second plate of the second capacitor to move together.
  • a size and shape of each of the first and second spaced apart plates of the first capacitor may be the same as a size and shape of each of the first and second spaced apart plates of the second capacitor.
  • the one or more processors can be further configured to subtract a variance of the first capacitance detected by the first sensor by a variance of the second capacitance detected by the second sensor to determine the change in pressure of the lumen.
  • the body may include a cavity defined in part by a first wall adjacent to the first sensor, the first wall configured to deform in response to the changes in pressure in the lumen, and a second wall adjacent to the second sensor, the second wall configured to prevent detection of the changes in pressure in the lumen.
  • FIG. 5 is a schematic view showing the imposed wafers of FIG. 4 being laser-cut around their peripheries.
  • FIG. 8 is a schematic view illustrating a second step in the process for manufacturing wafers with capacitor plates formed thereon.
  • FIG. 9 is schematic view illustrating a third step in the process or manufacturing wafers with capacitor plates formed thereon.
  • Embodiments set forth herein describe an implantable sensor system that includes a first sensor and a second sensor.
  • the first and second sensors are designed to be implanted within a lumen of a patient body.
  • the first sensor measures a first capacitance variance within the lumen.
  • the first capacitance variance is based on both pressure-based changes in the lumen and material-based changes in the lumen.
  • the pressure-based changes may be attributable to movement of the wall(s) of the lumen.
  • the material-based changes may be attributable to blood flow and blood consistency.
  • the second sensor measures a second capacitance variance within the lumen.
  • the second capacitance variance is based on the material-based changes in the lumen.
  • the body 1304 manufactured to have additional mechanical supports surrounding the second wall 1324, including in some examples a spacer, preventing movement of the plates of the second capacitor 1318 despite having a similar thickness to the first capacitor 1310.
  • the body 1304 is designed such that the first capacitor 1310 has plates that move relative to one another because of changes in pressure within the lumen 1302, while the second capacitor 1318 has plates that do not move relative to one another because of changes in pressure within the lumen 1302.
  • FIG. 16 illustrates an exemplary system for communicating with a wireless sensor implanted within a body.
  • the system includes a coupling loop 1600, a base unit 1602, a display device 1604 and an input device 1606, such as a keyboard.
  • the non-signal medium may be a storage medium.
  • a storage medium may be, for example, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any suitable combination of the foregoing. More specific examples of a storage medium would include the following: a portable computer diskette, a hard disk, a random access memory (RAM), a dynamic random access memory (DRAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or Flash memory), a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.
  • a server having a first processor, a network interface, and a storage device for storing code may store the program code for carrying out the operations and provide this code through its network interface via a network to a second device having a second processor for execution of the code on the second device.
  • the program instructions may be provided to a processor of a general- purpose computer, special purpose computer, or other programmable data processing device or information handling device to produce a machine, such that the instructions, which execute via a processor of the device implement the functions/acts specified.
  • the program instructions may also be stored in a device readable medium that can direct a device to function in a particular manner, such that the instructions stored in the device readable medium produce an article of manufacture including instructions which implement the function/act specified.
  • the program instructions may also be loaded onto a device to cause a series of operational steps to be performed on the device to produce a device implemented process such that the instructions which execute on the device provide processes for implementing the functions/acts specified.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Vascular Medicine (AREA)
  • Physiology (AREA)
  • Measuring Fluid Pressure (AREA)

Abstract

L'invention concerne un dispositif médical implantable pour déterminer un changement de pression d'une lumière dans un corps. Le dispositif médical implantable comprend un premier capteur qui peut être configuré pour détecter des variances dans une première capacité d'un premier condensateur sur la base de changements de pression dans la lumière et de changements dans l'environnement de la lumière. Le dispositif médical implantable peut également comprendre un second capteur configuré pour détecter des variances dans une seconde capacité d'un second condensateur sur la base de changements dans l'environnement de la lumière, et un ou plusieurs processeurs. Lors de l'exécution d'instructions de programme, le ou les processeurs sont configurés pour déterminer un changement de pression de la lumière sur la base des variances dans la première capacité et des variances dans la seconde capacité.
PCT/US2024/061724 2023-12-29 2024-12-23 Système de capteur implantable Pending WO2025144800A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363616480P 2023-12-29 2023-12-29
US63/616,480 2023-12-29

Publications (1)

Publication Number Publication Date
WO2025144800A1 true WO2025144800A1 (fr) 2025-07-03

Family

ID=94383776

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/061724 Pending WO2025144800A1 (fr) 2023-12-29 2024-12-23 Système de capteur implantable

Country Status (1)

Country Link
WO (1) WO2025144800A1 (fr)

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6111520A (en) 1997-04-18 2000-08-29 Georgia Tech Research Corp. System and method for the wireless sensing of physical properties
US6248080B1 (en) * 1997-09-03 2001-06-19 Medtronic, Inc. Intracranial monitoring and therapy delivery control device, system and method
US6278379B1 (en) 1998-04-02 2001-08-21 Georgia Tech Research Corporation System, method, and sensors for sensing physical properties
US20030136417A1 (en) 2002-01-22 2003-07-24 Michael Fonseca Implantable wireless sensor
US6855115B2 (en) 2002-01-22 2005-02-15 Cardiomems, Inc. Implantable wireless sensor for pressure measurement within the heart
US20060287602A1 (en) * 2005-06-21 2006-12-21 Cardiomems, Inc. Implantable wireless sensor for in vivo pressure measurement
US7245117B1 (en) 2004-11-01 2007-07-17 Cardiomems, Inc. Communicating with implanted wireless sensor
US7621036B2 (en) 2005-06-21 2009-11-24 Cardiomems, Inc. Method of manufacturing implantable wireless sensor for in vivo pressure measurement
US9078563B2 (en) 2005-06-21 2015-07-14 St. Jude Medical Luxembourg Holdings II S.à.r.l. Method of manufacturing implantable wireless sensor for in vivo pressure measurement
US11206988B2 (en) * 2015-12-30 2021-12-28 Vectorious Medical Technologies Ltd. Power-efficient pressure-sensor implant
US11284840B1 (en) * 2016-08-26 2022-03-29 W. L. Gore & Associates, Inc. Calibrating passive LC sensor

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6111520A (en) 1997-04-18 2000-08-29 Georgia Tech Research Corp. System and method for the wireless sensing of physical properties
US6248080B1 (en) * 1997-09-03 2001-06-19 Medtronic, Inc. Intracranial monitoring and therapy delivery control device, system and method
US6278379B1 (en) 1998-04-02 2001-08-21 Georgia Tech Research Corporation System, method, and sensors for sensing physical properties
US20030136417A1 (en) 2002-01-22 2003-07-24 Michael Fonseca Implantable wireless sensor
US6855115B2 (en) 2002-01-22 2005-02-15 Cardiomems, Inc. Implantable wireless sensor for pressure measurement within the heart
US7245117B1 (en) 2004-11-01 2007-07-17 Cardiomems, Inc. Communicating with implanted wireless sensor
US9078563B2 (en) 2005-06-21 2015-07-14 St. Jude Medical Luxembourg Holdings II S.à.r.l. Method of manufacturing implantable wireless sensor for in vivo pressure measurement
US7621036B2 (en) 2005-06-21 2009-11-24 Cardiomems, Inc. Method of manufacturing implantable wireless sensor for in vivo pressure measurement
US20060287602A1 (en) * 2005-06-21 2006-12-21 Cardiomems, Inc. Implantable wireless sensor for in vivo pressure measurement
US10143388B2 (en) 2005-06-21 2018-12-04 St, Jude Medical Luxembourg Holdings II S.A.R.L. (“SJM LUX II”) Method of manufacturing implantable wireless sensor for pressure measurement
US11033192B2 (en) 2005-06-21 2021-06-15 St. Jude Medical Luxembourg Holdings Ii S.A.R.L. (“Sjm Lux 11”) Wireless sensor for measuring pressure
US11103146B2 (en) 2005-06-21 2021-08-31 St. Jude Medical Luxembourg Holdings Ii S.A.R.L. (“Sjm Lux 11”) Wireless sensor for measuring pressure
US11103147B2 (en) 2005-06-21 2021-08-31 St. Jude Medical Luxembourg Holdings Ii S.A.R.L. (“Sjm Lux 11”) Method and system for determining a lumen pressure
US11179048B2 (en) 2005-06-21 2021-11-23 St. Jude Medical Luxembourg Holdings Ii S.A.R.L. (“Sjm Lux 11”) System for deploying an implant assembly in a vessel
US11206988B2 (en) * 2015-12-30 2021-12-28 Vectorious Medical Technologies Ltd. Power-efficient pressure-sensor implant
US11284840B1 (en) * 2016-08-26 2022-03-29 W. L. Gore & Associates, Inc. Calibrating passive LC sensor

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