WO2025094125A1

WO2025094125A1 - An agrochemical combination

Info

Publication number: WO2025094125A1
Application number: PCT/IB2024/060801
Authority: WO
Inventors: Srinivasan RENGAN; Randall CHEN
Original assignee: UPL Europe Supply Chain GmbH; UPL Mauritius Ltd
Current assignee: UPL Europe Supply Chain GmbH; UPL Mauritius Ltd
Priority date: 2023-11-01
Filing date: 2024-11-01
Publication date: 2025-05-08
Anticipated expiration: 2026-05-01
Also published as: AR134207A1

Abstract

The present invention relates to a herbicidal combination comprising a first herbicide comprising pyroxasulfone, a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof, and a third herbicide selected from phenyl ether herbicides. Furthermore, the present invention relates to a method for controlling weeds by applying an effective amount of the herbicidal combination thereof.

Description

TITLE: AN AGROCHEMICAL COMBINATION

FIELD OF THE DISCLOSURE:

The present disclosure relates to a herbicidal combination comprising a first herbicide and a second herbicide. More particularly, the herbicidal combination also comprises a third herbicide. Furthermore, the present disclosure relates to a method for controlling weeds by applying an effective amount of the herbicidal combination thereof.

BACKGROUND OF THE DISCLOSURE:

Herbicides are chemical substances, which are used to control unwanted plants/weeds. The mode of action for herbicides is a biochemical or a physical mechanism, which disrupts or alters one or more of the metabolic processes of the unwanted plants/weed, thereby controlling their growth. Therefore, when and how any herbicide should be applied may be determined by the mode of action of the herbicide.

Furthermore, there are certain species or groups of unwanted plants/weeds, which are susceptible to certain herbicides and not susceptible to certain herbicides. This may be because either the herbicides use different biochemical pathways, or the herbicides have slightly different enzymes. In situations, when one herbicide is ineffective, additional herbicide(s) with different modes of action may provide better results.

Herbicidal combinations comprising two or more herbicides have some disadvantages. They have none or insufficient herbicidal activity against specific unwanted plants/weeds, the spectrum of unwanted plants/weeds which can be controlled with the herbicides is not broad enough, the selectivity and compatibility of the herbicides with crops is too low, thereby causing unwanted damage and/or reduced yield of the crops, the initial herbicidal activity is not acceptable or not strong enough, and/or the herbicidal activity does not last long enough. For these reasons, there is a constant need to develop herbicidal combinations which overcome the aforementioned disadvantages. There also exists a need for an environmentally safe herbicidal combination that can selectively control unwanted plants/weeds, while leaving other plants and crops relatively unharmed.

OBJECTIVES OF THE DISCLOSURE:

It is a primary objective of the present disclosure to provide a herbicidal combination comprising two or more herbicides.

It is another objective of the present disclosure to provide a herbicidal combination comprising two or more herbicides for controlling or preventing unwanted plants/weeds in crops.

It is another objective of the present disclosure to provide a synergistic herbicidal combination comprising two or more herbicides for controlling weeds in crops.

It is yet another objective of the present disclosure to provide a herbicidal combination possessing enhanced efficacy over the individual herbicides.

It is another objective of the present disclosure to provide a herbicidal combination achieving increased yield in the crops to which they are applied, by reducing the number of weeds in the crops.

SUMMARY OF THE DISCLOSURE:

In one aspect, the present disclosure provides a herbicidal combination comprising a first herbicide, a second herbicide and a third herbicide.

In another aspect, the present disclosure provides a herbicidal combination comprising: a first herbicide selected from isoxazoline herbicides; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; and a third herbicide selected from phenyl ether herbicides.

In another aspect, the present disclosure provides use of the herbicidal combination comprising a first herbicide, a second herbicide and a third herbicide for controlling or preventing unwanted plants/weeds in crops.

In yet another aspect, the present disclosure provides a method for efficient control, suppression or eradication of weeds by applying an effective amount of the herbicidal combination comprising a first herbicide, a second herbicide and a third herbicide.

Additional features and advantages of the present disclosure will be apparent from the detailed description that follows, which illustrates by way of example, the most preferred features of the present disclosure which are not to be construed as limiting the scope of the disclosure described herein.

DETAILED DESCRIPTION OF THE DISCLOSURE:

The present disclosure now will be described hereinafter with reference to the accompanying examples, in which embodiments of the disclosure are shown. This description is not intended to be a detailed catalogue of all the different ways in which the disclosure may be implemented, or all the features that may be added to the instant disclosure. For example, features illustrated with respect to one embodiment may be incorporated into other embodiments, and features illustrated with respect to a particular embodiment may be deleted from that embodiment. Thus, the disclosure contemplates that in some embodiments of the disclosure, any feature or combination of features set forth herein can be excluded or omitted. In addition, numerous variations and additions to the various embodiments suggested herein will be apparent to those skilled in the art in light of the instant disclosure, which do not depart from the instant disclosure. Hence, the following descriptions are intended to illustrate some particular embodiments of the disclosure, and not to exhaustively specify all permutations, combinations and variations thereof.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the disclosure, suitable methods and materials are described herein.

“About” or “approximately” as used herein is inclusive of the stated value and means within an acceptable range of deviation for the particular value as determined by one of ordinary skill in the art, considering the measurement in question and the error associated with measurement of the particular quantity (i.e., the limitations of the measurement system). For example, “about” can mean within one or more standard deviations, or within ±10 or ±5 of the stated value.

The use of the terms “a”, “an”, and “the” and similar referents (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. The terms first, second etc., as used herein are not meant to denote any particular ordering, but simply for convenience to denote a plurality of, for example, layers.

The terms “comprising”, “having”, “including”, and “containing” are to be construed as open-ended terms (i.e., meaning “including, but not limited to”) unless otherwise noted. The use of any and all examples, or exemplary language (e.g., “such as”), is intended merely to better illustrate the disclosure and does not pose a limitation on the scope of the disclosure unless otherwise claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the disclosure as used herein. While the disclosure has been described with reference to an exemplary embodiment, it will be understood by those skilled in the art that various changes may be made, and equivalents may be substituted for elements thereof without departing from the scope of the disclosure. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the disclosure without departing from the essential scope thereof. Therefore, it is intended that the disclosure is not limited to the particular embodiment disclosed as the best mode contemplated for carrying out this disclosure, but that the disclosure will include all embodiments falling within the scope of the appended claims.

The term “control” relates to a weed, includes control of the weed, as well as protecting a plant, a portion of the plant, or a plant seed from attack or invasion by said weed.

As used herein, the term “agrochemical” refers to all active substances which can be used in the agrochemical field, i.e., fungicides, bactericides, insecticides, acaricides, nematicides, molluscicides, rodenticides, repellents, plant growth regulators, herbicides and safeners, and plant nutrients.

Subsequently, the term “herbicide” encompasses both herbicides as well as plant growth regulators, as far as this does not otherwise emerge from the context. The term herbicide as used herein denotes a compound which controls or modifies the growth of undesired weeds/plants.

The term “herbicidally effective amount” indicates the quantity of such a compound or combination of such compounds which is capable of controlling or modifying effect on the growth of harmful plants/undesired vegetation/weeds. Controlling effects include all deviation from natural development, for example: killing, retardation, leaf bum, albinism, dwarfism, etc. As used herein the term “plant” or “crop” refers to whole plants, plant organs (e.g., leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.), plant cells, and plant seeds. This term also encompasses plant crops such as fruits. The term “plant” may further include the propagation material thereof, which may include all the generative parts of the plant such as seeds and vegetative plant material such as cuttings and tubers, which can be used for the multiplication of the plant. This includes seeds, tubers, spores, corms, bulbs, rhizomes, sprouts basal shoots, stolon, and buds and other parts of plants, including seedlings and young plants, which are to be transplanted after germination or after emergence from soil.

As used herein, the term “plant propagation material” is understood to denote generative parts of a plant, such as seeds, vegetative material such as cuttings or tubers, roots, fruits, tubers, bulbs, rhizomes and parts of plants, germinated plants and young plants which are to be transplanted after germination or after emergence from the soil. These young plants may be protected before transplantation by a total or partial treatment by immersion.

As used herein, the term “seed” embraces seeds and plant propagules of all kinds including but not limited to true seeds, seed pieces, suckers, corms, bulbs, fruit, tubers, grains, cuttings, cut shoots and the like. In a preferred embodiment a seed is a true seed.

As used herein, the term “pre-emergence” refers to the time point before seedlings emerge from the ground. When any herbicide is applied at pre-emergence stage, it prevents establishment of the germinated weed seedlings.

As used herein, the term “post-emergence” refers to the time point after seedlings emerge from the ground. When any herbicide is applied at post-emergence stage, it prevents growth of the germinated weed seedlings. As used herein, the term “increased yield” of an agricultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the compositions described herein. According to the present disclosure, it is preferred that the crop yield be increased by at least 0.5%, preferably at least 2%, more preferably at least 5%, upon application of the combinations and compositions described herein.

The term “weed” as used herein refers to the plant whose growth is considered undesirable in a particular situation i.e., growth of a plant at a wrong place and includes pesticide resistant plants. In the broadest sense, the term “weed” refers to plants which grow in locations in which they are not desired. In other words, a “weed” is a plant in which in the context of a crop is undesirable due to competition for water, nutrients, sunlight, soil, etc. The term may also refer to crop plants which are undesirable at a location. As used herein, the terms “undesirable vegetation”, “harmful plants”, “unwanted plants”, “weeds” and “weed species”, as used herein, are synonyms.

Typically, the combinations/compositions of the present disclosure are applied to the targeted weed or to their locus or to the crop/plant. The term “locus” as used herein shall denote the vicinity of a desired crop in which weed control, typically selective weed control is desired. The locus includes the vicinity of desired crop plants wherein the weed infestation has either emerged or is yet to emerge. The term crop shall include a multitude of desired crop plants or an individual crop plant growing at a locus. The said locus could be a weed, an area adjacent to the weed, soil adapted to support growth of the weed, a root of the weed and/or foliage of the weed.

As used herein, the term “phytotoxicity” refers to any adverse effect or reaction on plant growth, physiology, or metabolism caused by any chemical substance, fertilizer, herbicide, heavy metal, etc. According to an embodiment, the present disclosure provides a herbicidal combination for controlling weeds. In another embodiment, the present disclosure provides a herbicidal combination for controlling herbicide -resistant weeds and/or herbicide-tolerant weeds.

In another embodiment, the present disclosure provides a herbicidal combination comprising a first herbicide, a second herbicide and a third herbicide.

In another embodiment, the present disclosure provides a herbicidal combination comprising: a first herbicide selected from isoxazoline herbicides; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; and a third herbicide selected from phenyl ether herbicides.

In another embodiment, the isoxazoline herbicides comprise pyroxasulfone, fenoxasulfone, or combinations thereof. In a preferred embodiment, the isoxazoline herbicide is pyroxasulfone. In a preferred embodiment, the isoxazoline herbicide is fenoxasulfone.

In another embodiment, the present disclosure provides a herbicidal combination comprising: a first herbicide comprising pyroxasulfone; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; and a third herbicide selected from phenyl ether herbicides.

In another embodiment, the carbamate herbicides are selected from the group comprising asulam, barban, 1 -methylpropyl 3 -chlorophenylcarbamate (BCPC), carbasulam, carbetamide, carboxazole, 2-chloroethyl (3-chlorophenyl)carbamate (CEPC), chlorbufam, 2-chloro-l -methylethyl (3-chlorophenyl)carbamate (CPPC), dichlormate, famoxacarb, fenasulam, propham, swep, terbucarb, or combinations thereof. In a preferred embodiment, the carbamate herbicide is asulam. In a preferred embodiment, the carbamate herbicide is carbasulam. In a preferred embodiment, the carbamate herbicide is fenasulam.

In another embodiment, the acetamide herbicides are selected from the group comprising napropamide, napropamide-M, diphenamid, naproanilide, or combinations thereof. In a preferred embodiment, the acetamide herbicide is napropamide. In a preferred embodiment, the acetamide herbicide is napropamide - M.

In another embodiment, the phenyl ether herbicides comprise diflufenican, beflubutamid, beflubutamid-M, flufenican, picolinafen, or combinations thereof. In a preferred embodiment, the phenyl ether herbicide is diflufenican. In a preferred embodiment, the phenyl ether herbicide is flufenican.

As used throughout the disclosure, the isoxazoline herbicide, carbamate herbicide, acetamide herbicide, phenyl ether herbicide, or other active ingredients, include their salts, esters, ethers, polymorphs including solvates and hydrates. A salt includes salts that retain the biological effectiveness and properties of the active ingredient, and which are not biologically or otherwise undesirable, and include derivatives of the disclosed compounds in which the parent compound is modified by making inorganic and organic, non-toxic, acid or base addition salts thereof. The salts can be synthesized from the parent compound by conventional chemical methods.

In another embodiment, the present disclosure provides a herbicidal combination comprising: a first herbicide selected from pyroxasulfone, fenoxasulfone, or combinations thereof; a second herbicide selected from asulam, carbasulam, fenasulam, napropamide, napropamide-M, or combinations thereof; and a third herbicide selected from phenyl ether herbicides.

In another embodiment, the present disclosure provides a herbicidal combination comprising: a first herbicide comprising pyroxasulfone; a second herbicide selected from asulam, napropamide, napropamide-M, or combinations thereof; and a third herbicide selected from phenyl ether herbicides.

In a preferred embodiment, the third herbicide is diflufenican.

In another embodiment, the present disclosure provides a herbicidal combination comprising: a first herbicide comprising pyroxasulfone; a second herbicide selected from asulam, napropamide, or combinations thereof; and a third herbicide comprising diflufenican.

In another embodiment, the present disclosure provides a herbicidal combination consisting of: a first herbicide comprising pyroxasulfone; a second herbicide selected from asulam, napropamide, or combinations thereof; and a third herbicide comprising diflufenican.

In another embodiment, the present disclosure provides a herbicidal combination consisting essentially of: a first herbicide comprising pyroxasulfone; a second herbicide selected from asulam, napropamide, or combinations thereof; and a third herbicide comprising diflufenican.

In another embodiment, addition of a third herbicide to the first and second herbicide results in improved control of weeds as compared to the control by the combination of first and second herbicide alone. In another embodiment, addition of a second herbicide to the first and third herbicide results in improved control of weeds as compared to the control by the combination of first and third herbicide alone. In another embodiment, addition of a first herbicide to the second and third herbicide results in improved control of weeds as compared to the control by the combination of second and third herbicide alone. In another preferred embodiment, the triple combination comprising first, second and third herbicides provides improved control of weeds as compared to the double combination comprising first and second; or second and third; or first and third herbicides.

According to an embodiment, the present disclosure provides a herbicidal combination comprising a first herbicide, a second herbicide and a third herbicide, wherein the first, second and third herbicides are present in a weight ratio from about 1: 1: 100 to about 100: 100: 1, preferably from about 1: 1:80 to about 80:80: 1, preferably from about 1: 1:70 to about 70:70: 1, preferably from about 1:1:60 to about 60:60: 1, preferably from about 1: 1:50 to about 50:50: 1, preferably from about 1: 1:40 to about 40:40: 1, preferably from about 1: 1:30 to about 30:30: 1, preferably from about 1 : 1 :20 to about 20:20: 1 , and more preferably rom about 1 : 1 : 10 to about 10: 10: 1.

In a preferred embodiment, the first herbicide comprising isooxazoline herbicides; the second herbicides selected from the group comprising carbamate herbicides, acetamide herbicides, or combinations thereof; and the third herbicide comprising phenyl ether herbicides are present in a weight ratio from about 1: 1: 10 to about 10: 10: 1. Unless otherwise indicated, the ratios disclosed throughout the specification are weight ratios.

In another embodiment, the present disclosure provides a herbicidal composition comprising: a first herbicide selected from isoxazoline herbicides; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; a third herbicide selected from phenyl ether herbicides; and at least one agrochemically acceptable excipient.

In another embodiment, the present disclosure provides a herbicidal composition comprising: a first herbicide selected from pyroxasulfone, fenoxasulfone, or combinations thereof; a second herbicide selected from asulam, carbasulam, fenasulam, napropamide, napropamide-M, or combinations thereof; a third herbicide selected from phenyl ether herbicides; and at least one agrochemically acceptable excipient.

In another embodiment, the present disclosure provides a herbicidal composition comprising: a first herbicide comprising pyroxasulfone; a second herbicide selected from asulam, napropamide, or combinations thereof; a third herbicide selected from phenyl ether herbicides; and at least one agrochemically acceptable excipient.

In a preferred embodiment, the phenyl ether herbicide is diflufenican.

In a preferred embodiment, the present disclosure provides a herbicidal composition comprising: a first herbicide comprising pyroxasulfone; a second herbicide selected from asulam, napropamide, or combinations thereof; a third herbicide comprising diflufenican; and at least one agrochemically acceptable excipient.

According to an embodiment of the present disclosure, the agrochemically acceptable excipients are selected from the group comprising emulsifier(s), colorant(s), thickener(s)/binder(s), antifreeze agent(s), antifoaming agent(s), antioxidant(s), solvent(s), preservative(s), glidant(s), anticaking agent(s), pH- regulating agent(s), buffering agent(s), formulation aid(s), disintegrant(s), or combinations thereof.

In another embodiment, the herbicidal composition comprises from about 10% w/w to about 90% w/w, preferably from about 10% w/w to about 70% w/w, preferably from about 10% w/w to about 60% w/w, and more preferably from about 10% w/w to about 50% w/w of the isoxazoline herbicide, based on total weight of the composition.

In another embodiment, the herbicidal composition from about 10% w/w to about 90% w/w, preferably from about 10% w/w to about 70% w/w, preferably from about 10% w/w to about 60% w/w, and more preferably from about 10% w/w to about 50% w/w of the carbamate herbicide, based on total weight of the composition.

In another embodiment, the herbicidal composition comprises from about 10% w/w to about 90% w/w, preferably from about 10% w/w to about 70% w/w, preferably from about 10% w/w to about 60% w/w, and more preferably from about 10% w/w to about 50% w/w of the acetamide herbicide, based on total weight of the composition. In another embodiment, the herbicidal composition comprises from about 10% w/w to about 90% w/w, preferably from about 10% w/w to about 70% w/w, preferably from about 10% w/w to about 60% w/w, and more preferably from about 10% w/w to about 50% w/w of the phenyl ether herbicide, based on total weight of the composition.

In another embodiment, the herbicidal composition comprises from about 10% w/w to about 90% w/w of the agrochemically acceptable excipient, based on total weight of the composition.

In another embodiment, the present disclosure provides use of the herbicidal combination for controlling weeds, the combination comprising: a first herbicide selected from isoxazoline herbicides; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; and a third herbicide selected from phenyl ether herbicides.

In another embodiment, the present disclosure provides use of the stable herbicidal combination for controlling weeds. In an embodiment, the present disclosure provides use of a herbicidal combination, for controlling herbicide-resistant and/or herbicide-tolerant weeds. In an embodiment, the present disclosure provides use of a herbicidal combination, for improving yield of the desired crop.

In another embodiment, the present disclosure provides a method for controlling weeds, wherein the method comprises applying an effective amount of a herbicidal combination comprising: a first herbicide selected from isoxazoline herbicides; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; and a third herbicide selected from phenyl ether herbicides. In another embodiment, the present disclosure provides a method for controlling weeds, wherein the method comprises applying an effective amount of a herbicidal combination comprising: a first herbicide selected from pyroxasulfone, fenoxasulfone, or combinations thereof; a second herbicide selected from asulam, carbasulam, fenasulam, napropamide, napropamide-M, or combinations thereof; and a third herbicide selected from phenyl ether herbicides.

In another embodiment, the present disclosure provides a method for controlling weeds, wherein the method comprises applying an effective amount of a herbicidal combination comprising: a first herbicide comprising pyroxasulfone; a second herbicide selected from asulam, napropamide, or combinations thereof; and a third herbicide selected from phenyl ether herbicides.

In another embodiment, the present disclosure provides a method for controlling weeds by application of the synergistic herbicidal combination. In another embodiment, the present disclosure provides a method for controlling herbicideresistant and/or herbicide-tolerant weeds by application of the herbicidal combination.

In another embodiment, the present disclosure provides a method for controlling weeds by application of an effective amount of the herbicidal combination to a plant, or a plant propagation material, or a locus thereof. In an embodiment, the present disclosure provides a method for controlling weeds, wherein the weeds are treated by applying concurrently or subsequently or sequentially the herbicidal combination. According to an embodiment, the herbicidal combination/compo sition is present either in a form of a tank mix or a pre-formulated (pre-mix) composition.

In another embodiment, the herbicidal composition comprises a first herbicide selected from isoxazoline herbicides, wherein the first herbicide is applied at an application rate from about 1 g a.i./ha to about 500 g a.i./ha, preferably from about 10 g a.i./ha to about 400 g a.i./ha, preferably from about 50 g a.i./ha to about 300 g a.i./ha, and more preferably from about 80 g a.i./ha to about 200 g a.i./ha. In a preferred embodiment, the first herbicide is applied at an application rate of about 100 g a.i./ha. In a preferred embodiment, pyroxasulfone is applied at an application rate of about 100 g a.i./ha

In another embodiment, the herbicidal composition comprises a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof, wherein the second herbicide is applied at an application rate from about 1 g a.i./ha to about 1500 g a.i./ha, preferably from about 100 g a.i./ha to about 1400 g a.i./ha, preferably from about 200 g a.i./ha to about 1300 g a.i./ha, and more preferably from about 300 g a.i./ha to about 1350 g a.i./ha. In a preferred embodiment, the second herbicide is applied at an application rate of about 400 g a.i./ha. In a preferred embodiment, the second herbicide is applied at an application rate of about 800 g a.i./ha. In a preferred embodiment, the second herbicide is applied at an application rate of about 1200 g a.i./ha. In a preferred embodiment, the second herbicide is applied at an application rate of about 450 g a.i./ha.

In a preferred embodiment, asulam is applied at an application rate of about 400 g a.i./ha. In a preferred embodiment, asulam is applied at an application rate of about 800 g a.i./ha. In a preferred embodiment, asulam is applied at an application rate of about 1200 g a.i./ha. In a preferred embodiment, napropamide is applied at an application rate of about 450 g a.i./ha. In another embodiment, the herbicidal composition comprises a third herbicide selected from phenyl ether herbicides, wherein the third herbicide is applied at an application rate from about 1 g a.i./ha to about 500 g a.i./ha, preferably from about 10 g a.i./ha to about 400 g a.i./ha, from about 50 g a.i./ha to about 300 g a.i./ha, and more from about 100 g a.i./ha to about 200 g a.i./ha. In a preferred embodiment, the third herbicide is applied at an application rate of about 125 g a.i./ha. In a preferred embodiment, diflufenican is applied at an application rate of about 125 g a.i./ha.

In another embodiment, the composition of the present disclosure is used to control weeds in various agricultural crops. Non-limiting examples of weeds controlled by the composition of the present disclosure include: Brassicaceae weeds: Raphanus raphanistrum, Raphanus sativus, Sinapis arvensis, Capsella bursa-pastoris, Brassica juncea, Brassica campestris, Descurainia pinnata, Rorippa islandica, Rorippa sylvestris, Thlaspi arvense, Myagrum rugosum, Lepidium virginicum, Coronopus didymus, and combinations thereof. Non-limiting examples of weeds controlled by the composition of the present disclosure include: Poaceae weeds: Dinebra retroflexa, Cynodon dactylon, Echinochloa colonum, Echinochloa crusgalli, Setaria viridis, Setaria faberi, Setaria glauca, Setaria ilosa ate, Digitaria ciliaris, Digitaria sanguinalis, Digitaria horizontalis, Digitaria insularis, Eleusine indica, Poa annua, Alospecurus aequalis, Alopecurus myosuroides, Avena fatua, Sorghum halepense, Sorghum vulgare, Agropyron repens, Eolium multiflorum, Eolium perenne, Eolium rigidum, Bromus secalinus, Bromus tectorum, Hordeum jubatum, Aegilops cylindrica, Phalaris arundinacea, Phalaris minor, Apera spicaventi, Panicum dichotomiflorum, Panicum texanum, Panicum maximum, Brachiaria reptains Brachiaria platyphylla, Brachiaria ruziziensis, Brachiaria plantaginea, Brachiaria decumbens, Brachiaria brizantha, Brachiaria humidicola, Brachiaria mutica, Cenchrus echinatus, Cenchrus pauciflorus, Eriochloa villosa, Pennisetum setosum, Chloris gayana, Chloris barbata, Eragrostis ilosa, Rhynchelitrum repens, Dactyloctenium aegyptium, Ischaemum rugosum, Oryza sativa, Paspalum notatum, Paspalum maritimum, Pennisetum clandestinum, Pennisetum setosum, Rottboellia cochinchinensis , or combinations thereof. In another embodiment, the composition of the present disclosure is used to control weeds in various agricultural crops.

In an embodiment, the herbicidal combination is applied to a plant, or a plant propagation material, or a locus thereof, in an effective amount. The selection of the effective amount depends on the density of weed infestation, weather patterns, crop health, etc.

According to an embodiment, the present disclosure provides a method for controlling weeds in crops comprising rice, wheat, barley, rye, oat, sorghum, cotton, soybean, peanut, buckwheat, beet, rapeseed, sunflower, durum wheat, fall wheat, field corn, winter barley, cotton, fall barley, fallow, spring wheat, triticale, winter wheat, sugar cane, tobacco, etc.; vegetables; solanaceous vegetables such as eggplant, tomato, pimento, popper, potato, etc., cucurbit vegetables such as cucumber, pumpkin, zucchini, water melon, melon, squash, etc., cruciferous vegetables such as radish, white turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, leaf mustard, broccoli, cauliflower, etc., asteraceous vegetables such as burdock, crown daisy, artichoke, lettuce, etc., liliaceous vegetables such as green onion, onion, garlic, and asparagus, ammiaceous vegetables such as carrot, parsley, celery, parsnip, etc., chenopodiaceous vegetables such as spinach, Swiss chard, etc., lamiaceous vegetables such as Perilla frutescens, mint, basil, etc. strawberry, sweet potato, Dioscorea japonica, colocasia, etc., flowers, foliage plants, turf grasses, fruits: pome fruits such apple, pear, quince, etc. stone fleshy fruits such as peach, plum, nectarine, Prunus mume, cherry fruit, apricot, prune, etc., citrus fruits such as orange, lemon, rime, grapefruit, etc., nuts such as chestnuts, walnuts, hazelnuts, almond, pistachio, cashew nuts, macadamia nuts, etc. berries such as blueberry, cranberry, blackberry, raspberry, etc., grape, kaki fruit, olive, plum, banana, coffee, date palm, coconuts, etc., trees otter than fruit trees; tea, mulberry, flowering plant, trees such as ash, birch, dogwood, Eucalyptus, Ginkgo biloba, lilac, maple, Quercus, poplar, Judas tree, liquidambar formosana, plane tree, zelkova. Japanese arborvitae, fir wood, hemlock, juniper, Pinus, Picea, and Taxus cuspidate, or combinations thereof.

In a preferred embodiment, the present disclosure provides a method for controlling weeds in crops comprising row crops comprising sunflower, potato, canola, dry bean, field pea, flax, safflower, buckwheat, cotton, maize, soybeans, sugarbeets, or combinations thereof. In a preferred embodiment, the present disclosure provides a method for controlling weeds in crops comprising wheat, lentils, chickpea, or combinations thereof.

According to an embodiment of the present disclosure, the herbicidal combination is usually applied to the unwanted plants/weeds by spraying on the leaves. Here, the application can be carried out using, for example, water as carrier by customary spraying techniques. In an embodiment, the application of the herbicidal combination may be done before, during and/or after, preferably before and/or after, the sowing of the crops. In an embodiment, the application of the herbicidal combination may be done on fallow field. In a preferred embodiment, the application of the herbicidal combination may be done to control the growth of weeds at the pre-emergence stage or the post-emergence stage. In a preferred embodiment, the application of the herbicidal combination may be done to control the growth of weeds close to the sowing stage of the crop.

According to an embodiment of the present disclosure, the herbicidal combination may be applied pre-or post-emergence of weeds, or together with the plant, or plant propagation material, or locus of a plant thereof. It is also possible to apply the herbicidal combination to a plant, or a plant propagation material, or a locus thereof or pre-treating a crop plant with the herbicidal combination.

In another embodiment, the herbicidal combination of the present disclosure may be applied in combination with agrochemically active components such as fertilizers, macronutrients, micronutrients, biologicals, bio stimulants, plant extracts, synergists, or combinations thereof.

In an embodiment, the macronutrients or a micronutrient is selected from the group comprising nitrogen, phosphorus, potassium, calcium, sulfur, magnesium, iron, zinc, copper, boron, manganese, chlorine, molybdenum, nickel, or combinations thereof.

According to an embodiment, the herbicidal combination is applied from a predosage device, a knapsack sprayer, a spray tank, a spray plane, or an irrigation system, or a drone, or an spot spray system. Typically, the herbicidal combination is made up with water, buffer, and/or further auxiliaries to the desired application concentration and the ready-to-use spray liquor of the herbicidal combination is thus obtained.

In another embodiment, the herbicidal combination may be used for foliar application, application to a ground, or to the soil, or to a plant, or a locus or a plant propagation material, or combinations thereof.

In another embodiment, the herbicidal combination can be used in agricultural lands such as fields, paddy fields, lawns and orchards or in non-agricultural lands, fallow fields, or for the purpose of chemical fallow application.

According to an embodiment, the present disclosure provides a process for preparing a herbicidal combination/composition comprising: a first herbicide selected from isoxazoline herbicides; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; a third herbicide selected from phenyl ether herbicides; and at least one agrochemically acceptable excipient thereof; wherein the process comprises mixing the first, second and third herbicides and at least one agrochemically acceptable excipient homogenously to form the herbicidal combination/composition.

According to an embodiment, the various components of the herbicidal combination may be used individually or already partially or completely mixed with one or more to prepare the herbicidal combination. It is also possible for the components to be separately packaged and used as a component in a kit of parts. In one embodiment, the kits may include one or more of the components that are used to prepare the herbicidal combination. For examples, the kits may include active ingredients and/or at least one agrochemically acceptable excipient. One or more of the components may already be combined together or pre-formulated.

One or more of the components may already be combined together or preformulated. In those embodiments where more than two components are provided in a kit, the components may already be combined and as such are packaged in a single container such as a vial, bottle, can, pouch, bag and/or canister. In other embodiments, two or more components of a kit may be packaged separate from one another, i.e., they are not pre-formulated. As such, a kit may include one or more separate containers such as vials, cans, bottles, pouches, bags and/or canisters, each container containing a separate component of the herbicidal combination.

According to an embodiment, the kit of parts comprises: a first herbicide selected from isoxazoline herbicides; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; a third herbicide selected from phenyl ether herbicides; and optionally further comprises: instructions for use.

In an embodiment, the herbicidal combination comprising a first herbicide selected from isoxazoline herbicides; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; a third herbicide selected from phenyl ether herbicides; may provide synergistic control for weeds at pre-emergent and/or at post-emergent stage.

In another embodiment, the herbicidal combination is synergistic and effective in improving yield of desired crop by controlling weeds. The herbicidal combination also provides increase in crop yield and crop quality.

In view of the above, it will be seen that the several advantages of the disclosure are achieved, and other advantageous results attained. Although the present disclosure has been disclosed in full, it will be understood that numerous additional modifications and variations could be made thereto without departing from the scope of the disclosure.

The present disclosure is more particularly described in the following examples that are intended as illustration only, since numerous modifications and variations within the scope of the present disclosure will be apparent to those skilled in the art. The following examples illustrate the basic methodology and versatility of the present disclosure. It will be understood that the specification and examples are illustrative but not limitative of the present disclosure and that other embodiments within the spirit and scope of the disclosure will suggest themselves to those skilled in the art. Other embodiments can be practiced that are also within the scope of the present disclosure. The following examples illustrate the disclosure, but by no means intend to limit the scope of the claims. EXAMPLES:

Example 1 : Efficacy for control of Lolium rigidum in wheat

The effect of application of pyroxasulfone in combination with asulam, and pyroxasulfone + asulam + diflufenican, was observed on the growth of Lolium rigidum in wheat at 35 days after application (DAA). The percentage (%) control of weeds was evaluated to assess the efficacy of the herbicidal combination and the same has been disclosed in Table 1.

Table 1: Efficacy observed for Lolium rigidum

Therefore, the combination comprising pyroxasulfone, asulam and diflufenican showed significant control of Lolium rigidum in wheat.

Example 2: Efficacy for control of Lolium rigidum in barley

The effect of application of pyroxasulfone in combination with asulam, and pyroxasulfone + asulam + diflufenican, was observed on the growth of Lolium rigidum in barley at 38 DAA. The percentage (%) control of weeds was evaluated to assess the efficacy of the herbicidal combination and the same has been disclosed in Table 2. Table 2: Efficacy observed for Lolium rigidum

Therefore, the combination comprising pyroxasulfone, asulam and diflufenican showed significant control of Lolium rigidum in barley.

Example 3: Efficacy for control of Bromus in barley

The effect of application of pyroxasulfone in combination with asulam, and pyroxasulfone + asulam + diflufenican, was observed on the growth of Bromus in barley at 38 DAA. The percentage (%) control of weeds was evaluated to assess the efficacy of the herbicidal combination and the same has been disclosed in Table 3.

Table 3: Efficacy observed for Bromus

Therefore, the combination comprising pyroxasulfone, asulam and diflufenican showed significant control of Bromus in barley.

Example 4: Efficacy for control of Lolium rigidum in wheat

The effect of application of napropamide in combination with diflufenican, and pyroxasulfone + napropamide + diflufenican, was observed on the growth of Lolium rigidum in wheat at 35 days after application (DAA). The percentage (%) control of weeds was evaluated to assess the efficacy of the herbicidal combination and the same has been disclosed in Table 4.

Table 4: Efficacy observed for Lolium rigidum

Therefore, the combination comprising pyroxasulfone, napropamide and diflufenican showed significant control of Lolium rigidum in wheat.

Example 5: Efficacy for control of Avena fatua in wheat

The effect of application of napropamide in combination with diflufenican, and pyroxasulfone + napropamide + diflufenican, was observed on the growth of Avena fatua in wheat at 35 days after application (DAA). The percentage (%) control of weeds was evaluated to assess the efficacy of the herbicidal combination and the same has been disclosed in Table 5. Table 5: Efficacy observed for Avena fatua

Therefore, the combination comprising pyroxasulfone, napropamide and diflufenican showed significant control of Avena fatua in wheat.

Example 6: Efficacy for control of Lolium rigidum in barley

The effect of application of napropamide in combination with diflufenican, and pyroxasulfone + napropamide + diflufenican, was observed on the growth of Lolium rigidum in barley at 38 DAA. The percentage (%) control of weeds was evaluated to assess the efficacy of the herbicidal combination and the same has been disclosed in Table 6.

Table 6: Efficacy observed for Lolium rigidum

Therefore, the combination comprising pyroxasulfone, napropamide and diflufenican showed significant control of Lolium rigidum in barley.

Example 7 : Efficacy for control of Bromus in barley The effect of application of napropamide in combination with diflufenican, and pyroxasulfone + napropamide + diflufenican, was observed on the growth of Bromus in barley at 38 DAA. The percentage (%) control of weeds was evaluated to assess the efficacy of the herbicidal combination and the same has been disclosed in Table 7. Table 7: Efficacy observed for Bromus

Therefore, the combination comprising pyroxasulfone, napropamide and diflufenican showed significant control of Bromus in barley.

Claims

CLAIMS:

1. A herbicidal combination comprising: a first herbicide comprising pyroxasulfone; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; and a third herbicide selected from phenyl ether herbicides.

2. The combination as claimed in claim 1, wherein the carbamate herbicides are selected from the group comprising asulam, barban, 1 -methylpropyl 3- chl or ophenyl carbamate (BCPC), carbasulam, carbetamide, carboxazole, 2- chloroethyl (3-chlorophenyl)carbamate (CEPC), chlorbufam, 2-chloro-l- methylethyl (3-chlorophenyl)carbamate (CPPC), dichlormate, fam oxacarb, fenasulam, propham, swep, terbucarb, or combinations thereof.

3. The combination as claimed in claim 1, wherein the acetamide herbicides are selected from the group comprising napropamide, napropamide-M, diphenamid, naproanilide, or combinations thereof.

4. The combination as claimed in claim 1, wherein the phenyl ether herbicides are selected from the group comprising diflufenican, beflubutamid, beflubutamid- M, flufenican, picolinafen, or combinations thereof.

5. The combination as claimed in claim 1, wherein the first herbicide, the second herbicide and the third herbicide are present in a weight ratio from about 1 :1 : 10 to about 10: 10: 1.

6. A herbicidal combination comprising: pyroxasulfone; asulam or napropamide; and diflufenican.

7. Use of a herbicidal combination for controlling weeds, the combination comprising: a first herbicide comprising pyroxasulfone; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; and a third herbicide selected from phenyl ether herbicides.

8. A method for controlling weeds, wherein the method comprises applying an effective amount of a herbicidal combination comprising: a first herbicide comprising pyroxasulfone; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; and a third herbicide selected from phenyl ether herbicides.

9. The method as claimed in claim 8, wherein the first herbicide is applied at an application rate from about 80 g a.i./ha to about 200 g a.i./ha.

10. The method as claimed in claim 8, wherein the second herbicide is applied at an application rate from about 300 g a.i./ha to about 1350 g a.i./ha.

11. The method as claimed in claim 8, wherein the third herbicide is applied at an application rate from about 100 g a.i./ha to about 200 g a.i./ha.

12. A herbicidal composition comprising: a first herbicide comprising pyroxasulfone; a second herbicide selected from carbamate herbicides, acetamide herbicides, or combinations thereof; a third herbicide selected from phenyl ether herbicides; and at least one agrochemically acceptable excipient.