WO2001079539A3 - Method for using transfectable constructions from luciferase and from the promotor of the human period 1 gene for identifying novel active substances that influence the day/night rhythm and sleep - Google Patents

Method for using transfectable constructions from luciferase and from the promotor of the human period 1 gene for identifying novel active substances that influence the day/night rhythm and sleep Download PDF

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Publication number
WO2001079539A3
WO2001079539A3 PCT/EP2001/004383 EP0104383W WO0179539A3 WO 2001079539 A3 WO2001079539 A3 WO 2001079539A3 EP 0104383 W EP0104383 W EP 0104383W WO 0179539 A3 WO0179539 A3 WO 0179539A3
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WIPO (PCT)
Prior art keywords
transfectable
promotor
luciferase
gene
sleep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/004383
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German (de)
French (fr)
Other versions
WO2001079539A9 (en
WO2001079539A2 (en
Inventor
Dirk Motzkus
Erik Maronde
Sabine Loumi
Urs Albrecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IPF Pharmaceuticals GmbH
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IPF Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IPF Pharmaceuticals GmbH filed Critical IPF Pharmaceuticals GmbH
Priority to AU2001268973A priority Critical patent/AU2001268973A1/en
Publication of WO2001079539A2 publication Critical patent/WO2001079539A2/en
Publication of WO2001079539A3 publication Critical patent/WO2001079539A3/en
Anticipated expiration legal-status Critical
Publication of WO2001079539A9 publication Critical patent/WO2001079539A9/en
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2864—Sleep disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to a transfectable construct from the promotor of the human period 1 gene and from luciferase (hPER1-luc).
PCT/EP2001/004383 2000-04-18 2001-04-18 Method for using transfectable constructions from luciferase and from the promotor of the human period 1 gene for identifying novel active substances that influence the day/night rhythm and sleep Ceased WO2001079539A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001268973A AU2001268973A1 (en) 2000-04-18 2001-04-18 Method for using transfectable constructions from luciferase and from the promotor of the human period 1 gene for identifying novel active substances that influence the day/night rhythm and sleep

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10019360.9 2000-04-18
DE10019360 2000-04-18

Publications (3)

Publication Number Publication Date
WO2001079539A2 WO2001079539A2 (en) 2001-10-25
WO2001079539A3 true WO2001079539A3 (en) 2002-05-10
WO2001079539A9 WO2001079539A9 (en) 2003-05-22

Family

ID=7639288

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/004383 Ceased WO2001079539A2 (en) 2000-04-18 2001-04-18 Method for using transfectable constructions from luciferase and from the promotor of the human period 1 gene for identifying novel active substances that influence the day/night rhythm and sleep

Country Status (2)

Country Link
AU (1) AU2001268973A1 (en)
WO (1) WO2001079539A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1248107A3 (en) * 2001-03-22 2002-10-16 IPF Pharmaceuticals GmbH Method and device for time-resolved screening
CN114306607A (en) * 2021-12-31 2022-04-12 中国人民解放军军事科学院军事医学研究院 Primary cilia regulate biological rhythms and their related applications

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003549A1 (en) * 1996-07-18 1998-01-29 The General Hospital Corporation MELATONIN 1a RECEPTOR GENE REGULATORY REGIONS AND USES THEREOF
WO1999012952A1 (en) * 1997-09-09 1999-03-18 Research Development Foundation Mammalian circadian rhythm-like gene

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003549A1 (en) * 1996-07-18 1998-01-29 The General Hospital Corporation MELATONIN 1a RECEPTOR GENE REGULATORY REGIONS AND USES THEREOF
WO1999012952A1 (en) * 1997-09-09 1999-03-18 Research Development Foundation Mammalian circadian rhythm-like gene

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHEN, D, BUCHANAN, GF, DING JM, HANNIBAL, J & GILLETTE MU: "Pituitary adenylyl cyclase-activating peptide: A pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock", PROCEEDINGS OF THE NATIONAL ADCADEMY OF SCIENCE USA, vol. 96, no. 23, 9 November 1999 (1999-11-09), pages 13468 - 13473, XP002181664 *
DATABASE GENBANK *
GEKAKIS N, STAKNIS D, NGUYEN HB, DAVIS FC, WILSBACHERLD, KING DP, TAKAHASHI JS & WEITZ CJ: "Role of the CLOCK Protein in the Mammalian Circadian Mechanism", SCIENCE, vol. 280, 5 June 1998 (1998-06-05), pages 1564 - 1569, XP002181665 *
HANNIBAL J, DING JM, CHEN D, FAHRENKRUG J, LARSEN PJ, GILLETTE MU & MIKKELSEN JD: "Pituitary Adenylate Cyclase-Activating Peptide (PACAP) in the Retinohypothalamic Tract: A Potential Daytime Regulator of the Biological Clock", THE JOURNAL OF NEUROSCIENCE, vol. 17, no. 7, 1 April 1997 (1997-04-01), pages 2637 - 2644, XP002181663 *
MOTZKUS D, MARONDE E, GRUNENBERG U, LEE CC, FORSSMANN W-G & ALBRECHT U: "The human PER1 gene is transcriptionally regulated by multiple signaling pathways", FEBS LETTERS, vol. 486, no. 3, 30 November 2000 (2000-11-30), pages 315 - 319, XP001018855 *
SUN Z S ET AL: "RIGUI, A PUTATIVE MAMMALIAN ORTHOLOG OF THE DROSOPHILA PERIOD GENE", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 90, no. 6, 19 September 1997 (1997-09-19), pages 1003 - 1011, XP002915075, ISSN: 0092-8674 *
TARUSCIO D ET AL: "The human Per1 gene: genomic organization and promoter analysis of the first human orthologue of the Drosophila period gene", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 253, no. 2, 8 August 2000 (2000-08-08), pages 161 - 170, XP004215719, ISSN: 0378-1119 *

Also Published As

Publication number Publication date
WO2001079539A9 (en) 2003-05-22
AU2001268973A1 (en) 2001-10-30
WO2001079539A2 (en) 2001-10-25

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