SG11202104585YA - Pyrazoles as modulators of hemoglobin - Google Patents
Pyrazoles as modulators of hemoglobinInfo
- Publication number
- SG11202104585YA SG11202104585YA SG11202104585YA SG11202104585YA SG11202104585YA SG 11202104585Y A SG11202104585Y A SG 11202104585YA SG 11202104585Y A SG11202104585Y A SG 11202104585YA SG 11202104585Y A SG11202104585Y A SG 11202104585YA SG 11202104585Y A SG11202104585Y A SG 11202104585YA
- Authority
- SG
- Singapore
- Prior art keywords
- pyrazoles
- hemoglobin
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862772815P | 2018-11-29 | 2018-11-29 | |
| US201962915784P | 2019-10-16 | 2019-10-16 | |
| PCT/IB2019/060171 WO2020109994A1 (en) | 2018-11-29 | 2019-11-26 | Pyrazoles as modulators of hemoglobin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202104585YA true SG11202104585YA (en) | 2021-06-29 |
Family
ID=68807213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202104585YA SG11202104585YA (en) | 2018-11-29 | 2019-11-26 | Pyrazoles as modulators of hemoglobin |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US11014908B2 (en) |
| EP (1) | EP3886984A1 (en) |
| JP (1) | JP2022510628A (en) |
| KR (1) | KR20210097161A (en) |
| CN (1) | CN113329789A (en) |
| AU (1) | AU2019387290A1 (en) |
| BR (1) | BR112021009057A2 (en) |
| CA (1) | CA3121139A1 (en) |
| CO (1) | CO2021006924A2 (en) |
| CR (1) | CR20210284A (en) |
| CU (1) | CU20210044A7 (en) |
| DO (1) | DOP2021000103A (en) |
| EC (1) | ECSP21037191A (en) |
| IL (1) | IL283408A (en) |
| MA (1) | MA54283A (en) |
| MX (1) | MX2021006095A (en) |
| PE (1) | PE20211592A1 (en) |
| PH (1) | PH12021551035A1 (en) |
| PY (1) | PY19100637A (en) |
| SG (1) | SG11202104585YA (en) |
| TW (2) | TW202140452A (en) |
| UY (1) | UY38488A (en) |
| WO (1) | WO2020109994A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU20210044A7 (en) * | 2018-11-29 | 2022-01-13 | Pfizer | PYRAZOLE AS HEMOGLOBIN MODULATORS |
| JP7449390B2 (en) | 2020-01-24 | 2024-03-13 | ファイザー・インク | Anti-E-selectin antibodies, compositions and methods of use |
| CN112079774A (en) * | 2020-10-17 | 2020-12-15 | 甘肃天后光学科技有限公司 | Blue light absorber for soft contact lenses, preparation method and application method thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (en) | 1990-01-23 | 1999-01-15 | . | Cyclodextrin derivatives with increased water solubility and uses thereof |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| US20040167188A1 (en) | 2003-02-14 | 2004-08-26 | Zhili Xin | Protein-tyrosine phosphatase inhibitors and uses thereof |
| US7169797B2 (en) | 2003-02-14 | 2007-01-30 | Abbott Laboratories | Protein-tyrosine phosphatase inhibitors and uses thereof |
| EP1760071A4 (en) | 2004-06-23 | 2008-03-05 | Ono Pharmaceutical Co | Compound having s1p receptor binding potency and use thereof |
| TW200606133A (en) | 2004-06-30 | 2006-02-16 | Sankyo Co | Substituted benzene compounds |
| JP2007176799A (en) | 2005-12-27 | 2007-07-12 | Sankyo Co Ltd | Medicine comprising substituted benzene compound |
| US8039442B2 (en) | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
| WO2011015524A2 (en) | 2009-08-03 | 2011-02-10 | Bayer Cropscience Ag | Fungicide heterocycles derivatives |
| CN102206172B (en) | 2010-03-30 | 2015-02-25 | 中国医学科学院医药生物技术研究所 | Substituted diaryl compound and preparation method and antiviral application thereof |
| EP2566858A2 (en) * | 2010-05-04 | 2013-03-13 | Pfizer Inc. | Heterocyclic derivatives as alk inhibitors |
| EP2616442B8 (en) | 2010-09-14 | 2018-10-17 | Exelixis, Inc. | Inhibitors of pi3k-delta and methods of their use and manufacture |
| WO2012129562A2 (en) | 2011-03-24 | 2012-09-27 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
| ES2643403T3 (en) | 2011-12-28 | 2017-11-22 | Global Blood Therapeutics, Inc. | Substituted benzaldehyde compounds and methods for use in increasing tissue oxygenation |
| HK1203412A1 (en) | 2011-12-28 | 2015-10-30 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| JP5791532B2 (en) | 2012-01-31 | 2015-10-07 | 株式会社ソシオネクスト | Container and reel |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| CN105073728A (en) | 2013-03-15 | 2015-11-18 | 全球血液疗法股份有限公司 | Compounds and their use for regulating hemoglobin |
| WO2014150258A1 (en) | 2013-03-15 | 2014-09-25 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| MX379235B (en) | 2013-03-15 | 2025-03-11 | Global Blood Therapeutics Inc | COMPOUNDS AND THEIR USES TO MODULATE HEMOGLOBIN. |
| US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| WO2014150289A1 (en) | 2013-03-15 | 2014-09-25 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US20140271591A1 (en) * | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compositions and methods for the modulation of hemoglobin (s) |
| US9248199B2 (en) * | 2014-01-29 | 2016-02-02 | Global Blood Therapeutics, Inc. | 1:1 adducts of sickle hemoglobin |
| WO2015193506A1 (en) | 2014-06-20 | 2015-12-23 | Institut Pasteur Korea | Anti-infective compounds |
| WO2016043849A2 (en) | 2014-07-24 | 2016-03-24 | Global Blood Therapeutics, Inc. | Compounds for treating acute respiratory distress syndrome or a negative effect thereof |
| JP6554547B2 (en) | 2014-11-03 | 2019-07-31 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | BACE1 inhibitor |
| HUE061448T2 (en) | 2014-11-16 | 2023-07-28 | Array Biopharma Inc | (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-A]pyrimidin-3-yl)-3-hydroxypyrrolidin- Crystalline form of 1-carboxamide hydrogen sulfate |
| SG11201804647TA (en) | 2015-12-04 | 2018-06-28 | Global Blood Therapeutics Inc | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| EP3472150A1 (en) | 2016-06-17 | 2019-04-24 | Fronthera U.S. Pharmaceuticals LLC | Hemoglobin modifier compounds and uses thereof |
| CA3158951A1 (en) | 2016-08-15 | 2018-02-22 | Purdue Research Foundation | 4-substituted aminoisoquinoline derivatives |
| CU20210044A7 (en) * | 2018-11-29 | 2022-01-13 | Pfizer | PYRAZOLE AS HEMOGLOBIN MODULATORS |
-
2019
- 2019-11-26 CU CU2021000044A patent/CU20210044A7/en unknown
- 2019-11-26 EP EP19816457.6A patent/EP3886984A1/en not_active Withdrawn
- 2019-11-26 CN CN201980090794.6A patent/CN113329789A/en active Pending
- 2019-11-26 WO PCT/IB2019/060171 patent/WO2020109994A1/en not_active Ceased
- 2019-11-26 CR CR20210284A patent/CR20210284A/en unknown
- 2019-11-26 TW TW110125518A patent/TW202140452A/en unknown
- 2019-11-26 MA MA054283A patent/MA54283A/en unknown
- 2019-11-26 KR KR1020217020051A patent/KR20210097161A/en not_active Withdrawn
- 2019-11-26 JP JP2021529740A patent/JP2022510628A/en active Pending
- 2019-11-26 US US16/695,709 patent/US11014908B2/en active Active
- 2019-11-26 PE PE2021000762A patent/PE20211592A1/en unknown
- 2019-11-26 MX MX2021006095A patent/MX2021006095A/en unknown
- 2019-11-26 CA CA3121139A patent/CA3121139A1/en not_active Abandoned
- 2019-11-26 SG SG11202104585YA patent/SG11202104585YA/en unknown
- 2019-11-26 TW TW108142940A patent/TWI736037B/en not_active IP Right Cessation
- 2019-11-26 AU AU2019387290A patent/AU2019387290A1/en not_active Abandoned
- 2019-11-26 BR BR112021009057-6A patent/BR112021009057A2/en not_active Application Discontinuation
- 2019-11-27 UY UY0001038488A patent/UY38488A/en not_active Application Discontinuation
- 2019-11-29 PY PY201919100637A patent/PY19100637A/en unknown
-
2021
- 2021-04-12 US US17/227,819 patent/US11702405B2/en active Active
- 2021-05-05 PH PH12021551035A patent/PH12021551035A1/en unknown
- 2021-05-24 IL IL283408A patent/IL283408A/en unknown
- 2021-05-25 EC ECSENADI202137191A patent/ECSP21037191A/en unknown
- 2021-05-26 CO CONC2021/0006924A patent/CO2021006924A2/en unknown
- 2021-05-26 DO DO2021000103A patent/DOP2021000103A/en unknown
-
2023
- 2023-05-24 US US18/322,844 patent/US12103921B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CO2021006924A2 (en) | 2021-06-10 |
| CN113329789A (en) | 2021-08-31 |
| DOP2021000103A (en) | 2021-07-30 |
| ECSP21037191A (en) | 2021-06-30 |
| WO2020109994A1 (en) | 2020-06-04 |
| BR112021009057A2 (en) | 2021-08-10 |
| US11014908B2 (en) | 2021-05-25 |
| EP3886984A1 (en) | 2021-10-06 |
| JP2022510628A (en) | 2022-01-27 |
| PE20211592A1 (en) | 2021-08-18 |
| TWI736037B (en) | 2021-08-11 |
| TW202140452A (en) | 2021-11-01 |
| US12103921B2 (en) | 2024-10-01 |
| MX2021006095A (en) | 2021-07-06 |
| IL283408A (en) | 2021-07-29 |
| US20230382892A1 (en) | 2023-11-30 |
| TW202033513A (en) | 2020-09-16 |
| AU2019387290A1 (en) | 2021-05-27 |
| PY19100637A (en) | 2021-06-16 |
| UY38488A (en) | 2020-06-30 |
| CR20210284A (en) | 2021-07-09 |
| MA54283A (en) | 2022-03-09 |
| US11702405B2 (en) | 2023-07-18 |
| US20220348555A1 (en) | 2022-11-03 |
| CU20210044A7 (en) | 2022-01-13 |
| US20200172512A1 (en) | 2020-06-04 |
| KR20210097161A (en) | 2021-08-06 |
| CA3121139A1 (en) | 2020-06-04 |
| PH12021551035A1 (en) | 2021-12-06 |
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