SG11202004426SA - Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof - Google Patents

Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof

Info

Publication number
SG11202004426SA
SG11202004426SA SG11202004426SA SG11202004426SA SG11202004426SA SG 11202004426S A SG11202004426S A SG 11202004426SA SG 11202004426S A SG11202004426S A SG 11202004426SA SG 11202004426S A SG11202004426S A SG 11202004426SA SG 11202004426S A SG11202004426S A SG 11202004426SA
Authority
SG
Singapore
Prior art keywords
ilt3
transcript
immunoglobulin
antibodies specific
antibodies
Prior art date
Application number
SG11202004426SA
Inventor
Michael Meehl
Philip Brandish
Laurence Fayadat-Dilman
Veronica Juan
Carl Mieczkowski
Latika Singh
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of SG11202004426SA publication Critical patent/SG11202004426SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11202004426SA 2017-11-17 2018-11-15 Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof SG11202004426SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762587604P 2017-11-17 2017-11-17
PCT/US2018/061165 WO2019099597A2 (en) 2017-11-17 2018-11-15 Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof

Publications (1)

Publication Number Publication Date
SG11202004426SA true SG11202004426SA (en) 2020-06-29

Family

ID=64572590

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202004426SA SG11202004426SA (en) 2017-11-17 2018-11-15 Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof

Country Status (26)

Country Link
US (6) US11111297B2 (en)
EP (1) EP3710479A2 (en)
JP (1) JP7194481B2 (en)
KR (1) KR102478433B1 (en)
CN (2) CN111712518B (en)
AR (1) AR113696A1 (en)
AU (1) AU2018367524B2 (en)
BR (1) BR112020009759A8 (en)
CA (1) CA3082409A1 (en)
CL (1) CL2020001240A1 (en)
CO (1) CO2020006405A2 (en)
CR (1) CR20200204A (en)
DO (1) DOP2020000074A (en)
EA (1) EA202091228A1 (en)
EC (1) ECSP20032082A (en)
GE (2) GEP20237565B (en)
IL (1) IL274574A (en)
JO (1) JOP20200131A1 (en)
MA (1) MA50900A (en)
MX (2) MX2020005128A (en)
NI (1) NI202000036A (en)
PE (1) PE20210475A1 (en)
PH (1) PH12020550890A1 (en)
SG (1) SG11202004426SA (en)
TW (1) TWI816715B (en)
WO (1) WO2019099597A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122017025062B8 (en) 2007-06-18 2021-07-27 Merck Sharp & Dohme monoclonal antibody or antibody fragment to human programmed death receptor pd-1, polynucleotide and composition comprising said antibody or fragment
CN111712518B (en) * 2017-11-17 2025-03-25 默沙东有限责任公司 Antibodies specific for immunoglobulin-like transcript 3 (ILT3) and uses thereof
PH12022551462A1 (en) 2019-12-19 2023-11-13 Ngm Biopharmaceuticals Inc Ilt3-binding agents and methods of use thereof
MY209480A (en) 2020-05-01 2025-07-11 Ngm Biopharmaceuticals Inc Ilt-binding agents and methods of use thereof
WO2022197900A1 (en) * 2021-03-19 2022-09-22 Merck Sharp & Dohme Llc Methods for treating cancer with anti-ilt3 antibodies
EP4376885A4 (en) * 2021-07-28 2025-07-02 Merck Sharp & Dohme Llc Method for treating acute myelogenous leukemia with anti-ILT3 antibodies
CN116082502A (en) * 2021-11-08 2023-05-09 复旦大学 Regulator for combining Galectin8 with LILRB4 and application thereof
WO2023140875A1 (en) * 2022-01-19 2023-07-27 Ngm Biopharmaceuticals, Inc. Uses of ilt3-binding agents
EP4499683A1 (en) 2022-03-29 2025-02-05 NGM Biopharmaceuticals, Inc. Ilt3 and cd3 binding agents and methods of use thereof
AU2023258644A1 (en) 2022-04-25 2024-12-05 Biond Biologics Ltd. Anti-ilt3 antibodies and use thereof
WO2023235699A1 (en) 2022-05-31 2023-12-07 Jounce Therapeutics, Inc. Antibodies to lilrb4 and uses thereof
CN115925941B (en) * 2022-06-08 2026-04-03 北京科诺信诚科技有限公司 Nanobodies targeting human LILRB4 and their applications
WO2024235317A1 (en) 2023-05-18 2024-11-21 南京维立志博生物科技有限公司 Antibody binding lilrb4 and cd3, and use thereof
WO2025062392A1 (en) 2023-09-20 2025-03-27 Biond Biologics Ltd. Anti-ilt3 blockade combinations
WO2025141589A1 (en) 2023-12-31 2025-07-03 Biond Biologics Ltd. Treatment of cancer with anti-ilt3 antibodies

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042924B1 (en) 1980-06-30 1984-03-21 International Business Machines Corporation Data transfer apparatus
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
DE3920358A1 (en) 1989-06-22 1991-01-17 Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
ATE207080T1 (en) 1991-11-25 2001-11-15 Enzon Inc MULTIVALENT ANTIGEN-BINDING PROTEINS
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
GB9818110D0 (en) 1998-08-19 1998-10-14 Weston Medical Ltd Needleless injectors and other devices
US6096002A (en) 1998-11-18 2000-08-01 Bioject, Inc. NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method
HK1044159A1 (en) 1998-12-01 2002-10-11 蛋白质设计实验室股份有限公司 Humanized antibodies to gamma-interferon
WO2003000199A2 (en) * 2001-06-25 2003-01-03 The Trustees Of Columbia University In The City Of New York Ilt3 and ilt4-related compositions and methods
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
CA2391438A1 (en) 2002-05-01 2003-11-01 Procyon Biopharma Inc. Psp94 diagnostic reagents and assays
CN101899114A (en) 2002-12-23 2010-12-01 惠氏公司 Anti-PD-1 antibody and uses thereof
WO2006033811A2 (en) * 2004-09-03 2006-03-30 The Trustees Of Columbia University In The City Of New York Ilt3 polypeptides and uses thereof
DK2439273T3 (en) 2005-05-09 2019-06-03 Ono Pharmaceutical Co HUMAN MONOCLONAL ANTIBODIES FOR PROGRAMMED DEATH-1 (PD-1) AND PROCEDURES FOR TREATMENT OF CANCER USING ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNTER APPLICATIONS
EP1907001B1 (en) * 2005-06-17 2015-07-15 Merck Sharp & Dohme Corp. Ilt3 binding molecules and uses therefor
PT1907424E (en) 2005-07-01 2015-10-09 Squibb & Sons Llc Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
NZ616992A (en) * 2005-12-20 2015-07-31 Sbi Biotech Co Ltd Anti-ilt7 antibody
US20090202544A1 (en) 2006-02-02 2009-08-13 The Trustees Of Columbia University In The City Of New York Methods of Treating Diseases by Targeting Silt3
CA2655903A1 (en) * 2006-06-19 2008-08-07 Tolerx, Inc. Ilt3 binding molecules and uses therefor
GB0705775D0 (en) 2007-03-26 2007-05-02 Affitech As Product
BR122017025062B8 (en) 2007-06-18 2021-07-27 Merck Sharp & Dohme monoclonal antibody or antibody fragment to human programmed death receptor pd-1, polynucleotide and composition comprising said antibody or fragment
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP3124497B1 (en) 2007-09-14 2020-04-15 Adimab, LLC Rationally designed, synthetic antibody libraries and uses therefor
CN101970499B (en) 2008-02-11 2014-12-31 治疗科技公司 Monoclonal Antibodies for Cancer Therapy
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme BINDING PROTEINS WITH PD-1
AU2009288730B2 (en) 2008-08-25 2013-06-20 Amplimmune, Inc. Compositions of PD-1 antagonists and methods of use
JP2012500855A (en) 2008-08-25 2012-01-12 アンプリミューン、インコーポレーテッド PD-1 antagonists and methods for treating infectious diseases
EP3255060A1 (en) 2008-12-09 2017-12-13 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
JP5844159B2 (en) 2009-02-09 2016-01-13 ユニヴェルシテ デクス−マルセイユＵｎｉｖｅｒｓｉｔｅ Ｄ’Ａｉｘ−Ｍａｒｓｅｉｌｌｅ PD-1 antibody and PD-L1 antibody and use thereof
CN101830978A (en) * 2009-03-09 2010-09-15 中国科学院微生物研究所 Human immunoglobulin-like receptor mutant and application thereof
WO2011066342A2 (en) 2009-11-24 2011-06-03 Amplimmune, Inc. Simultaneous inhibition of pd-l1/pd-l2
JP2013528357A (en) 2010-03-29 2013-07-11 ザイムワークス，インコーポレイテッド Antibody with enhanced or suppressed effector function
WO2011127543A1 (en) 2010-04-16 2011-10-20 Transbio Ltd Proteins that bind pi16 and uses thereof
ES2692268T5 (en) 2011-03-29 2025-02-26 Roche Glycart Ag Antibody fc variants
WO2013033734A1 (en) * 2011-09-02 2013-03-07 The Trustees Of Columbia University In The City Of New York Diagnosis and Treatment of Cancer Expressing ILT3 or ILT3 Ligand
WO2013043569A1 (en) 2011-09-20 2013-03-28 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
US20150174203A1 (en) 2012-05-30 2015-06-25 Icahn School Of Medicine At Mount Sinai Compositions And Methods For Modulating Pro-Inflammatory Immune Response
WO2014116846A2 (en) 2013-01-23 2014-07-31 Abbvie, Inc. Methods and compositions for modulating an immune response
EP3594240B1 (en) 2013-05-20 2023-12-06 F. Hoffmann-La Roche AG Anti-transferrin receptor antibodies and methods of use
JO3663B1 (en) * 2014-08-19 2020-08-27 Merck Sharp & Dohme Anti-lag3 antibodies and antigen-binding fragments
CA2961950A1 (en) 2014-09-28 2016-03-31 The Regents Of The University Of California Modulation of stimulatory and non-stimulatory myeloid cells
WO2016127427A1 (en) 2015-02-15 2016-08-18 华为技术有限公司 Processing method for electronic device housing, electronic device housing and electronic device
CA2977544C (en) * 2015-03-06 2023-12-19 The Board Of Regents Of The University Of Texas System Anti-lilrb antibodies and their use in detecting and treating cancer
WO2017015227A1 (en) 2015-07-17 2017-01-26 The Trustees Of Columbia University In The City Of New York Methods of treating cd166-expressing cancer
IL300122A (en) * 2015-11-18 2023-03-01 Merck Sharp ַ& Dohme Llc PD1 and/or LAG3 Binders
US11249081B2 (en) 2016-08-31 2022-02-15 Agency For Science, Technology And Research Methods for the identification, targeting and isolation of human dendritic cell (DC) precursors “pre-DC” and their uses thereof
EP3538141A4 (en) 2016-11-10 2020-07-15 Merck Sharp & Dohme Corp. ILT3 LIGAND
WO2018148494A1 (en) 2017-02-09 2018-08-16 Bluefin Biomedicine, Inc. Anti-ilt3 antibodies and antibody drug conjugates
CN111712518B (en) * 2017-11-17 2025-03-25 默沙东有限责任公司 Antibodies specific for immunoglobulin-like transcript 3 (ILT3) and uses thereof
WO2022197900A1 (en) * 2021-03-19 2022-09-22 Merck Sharp & Dohme Llc Methods for treating cancer with anti-ilt3 antibodies
EP4376885A4 (en) * 2021-07-28 2025-07-02 Merck Sharp & Dohme Llc Method for treating acute myelogenous leukemia with anti-ILT3 antibodies
WO2023017525A1 (en) * 2021-08-11 2023-02-16 OncoHost Ltd. Predicting patient response
WO2023159152A2 (en) * 2022-02-17 2023-08-24 Immune-Onc Therapeutics, Inc. Combination therapy of lilrb antagonist and pd-1/pd-l1 axis inhibitor
WO2023235699A1 (en) * 2022-05-31 2023-12-07 Jounce Therapeutics, Inc. Antibodies to lilrb4 and uses thereof
EP4561623A1 (en) * 2022-07-28 2025-06-04 Merck Sharp & Dohme LLC Methods for treating chronic myelomonocytic leukemia with anti-ilt3 antibodies

Also Published As

Publication number Publication date
JP7194481B2 (en) 2022-12-22
BR112020009759A2 (en) 2020-11-03
US20220010010A1 (en) 2022-01-13
AR113696A1 (en) 2020-06-03
BR112020009759A8 (en) 2023-01-31
GEP20237565B (en) 2023-11-10
CR20200204A (en) 2020-06-18
MA50900A (en) 2020-09-23
US20220025042A1 (en) 2022-01-27
JOP20200131A1 (en) 2020-05-28
KR20200083598A (en) 2020-07-08
CN111712518B (en) 2025-03-25
CN120058946A (en) 2025-05-30
US11111297B2 (en) 2021-09-07
US12441792B2 (en) 2025-10-14
IL274574A (en) 2020-06-30
EP3710479A2 (en) 2020-09-23
MX2025000940A (en) 2025-03-07
CN111712518A (en) 2020-09-25
JP2021503280A (en) 2021-02-12
US20220033497A1 (en) 2022-02-03
AU2018367524B2 (en) 2022-09-15
PE20210475A1 (en) 2021-03-08
US20190153093A1 (en) 2019-05-23
NI202000036A (en) 2020-09-24
WO2019099597A3 (en) 2019-06-13
PH12020550890A1 (en) 2021-04-12
CL2020001240A1 (en) 2020-12-18
MX2020005128A (en) 2020-07-27
ECSP20032082A (en) 2020-08-31
US20220010011A1 (en) 2022-01-13
EA202091228A1 (en) 2020-08-12
GEAP202315366A (en) 2023-07-25
KR102478433B1 (en) 2022-12-15
AU2018367524A1 (en) 2020-06-11
TW201922786A (en) 2019-06-16
WO2019099597A2 (en) 2019-05-23
CO2020006405A2 (en) 2020-06-09
US20220025043A1 (en) 2022-01-27
CA3082409A1 (en) 2019-05-23
US12435133B2 (en) 2025-10-07
DOP2020000074A (en) 2020-08-31
TWI816715B (en) 2023-10-01

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