SG10202001468UA - Hydrophilic antibody-drug conjugates - Google Patents

Hydrophilic antibody-drug conjugates

Info

Publication number
SG10202001468UA
SG10202001468UA SG10202001468UA SG10202001468UA SG10202001468UA SG 10202001468U A SG10202001468U A SG 10202001468UA SG 10202001468U A SG10202001468U A SG 10202001468UA SG 10202001468U A SG10202001468U A SG 10202001468UA SG 10202001468U A SG10202001468U A SG 10202001468UA
Authority
SG
Singapore
Prior art keywords
drug conjugates
hydrophilic
antibody
hydrophilic antibody
conjugates
Prior art date
Application number
SG10202001468UA
Inventor
Svetlana Doronina
Robert Lyon
Peter Senter
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of SG10202001468UA publication Critical patent/SG10202001468UA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6861—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from kidney or bladder cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6881—Cluster-antibody conjugates, i.e. the modifying agent consists of a plurality of antibodies covalently linked to each other or of different antigen-binding fragments covalently linked to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG10202001468UA 2014-02-17 2015-02-17 Hydrophilic antibody-drug conjugates SG10202001468UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461940759P 2014-02-17 2014-02-17
US201461947368P 2014-03-03 2014-03-03

Publications (1)

Publication Number Publication Date
SG10202001468UA true SG10202001468UA (en) 2020-04-29

Family

ID=53800705

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202001468UA SG10202001468UA (en) 2014-02-17 2015-02-17 Hydrophilic antibody-drug conjugates
SG11201605886RA SG11201605886RA (en) 2014-02-17 2015-02-17 Hydrophilic antibody-drug conjugates

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201605886RA SG11201605886RA (en) 2014-02-17 2015-02-17 Hydrophilic antibody-drug conjugates

Country Status (14)

Country Link
US (4) US10933112B2 (en)
EP (2) EP3107557B1 (en)
JP (5) JP6716461B2 (en)
KR (3) KR102647074B1 (en)
CN (1) CN106029083B (en)
AU (3) AU2015218202B2 (en)
CA (1) CA2937753A1 (en)
EA (1) EA201691650A1 (en)
ES (2) ES2994375T3 (en)
IL (4) IL290116B2 (en)
MX (2) MX385823B (en)
SG (2) SG10202001468UA (en)
WO (1) WO2015123679A1 (en)
ZA (1) ZA201605111B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10202001468UA (en) 2014-02-17 2020-04-29 Seattle Genetics Inc Hydrophilic antibody-drug conjugates
CN107043406B (en) * 2015-11-03 2021-08-17 财团法人工业技术研究院 Compounds, Linker-Drugs, and Ligand-Drug Conjugates
TW202500191A (en) 2016-08-09 2025-01-01 美商思進公司 Drug conjugates with self-stabilizing linkers having improved physiochemical properties
KR102574659B1 (en) 2016-10-11 2023-09-04 비온디스 비.브이. Non-linear self-immolative linkers and conjugates thereof
CN118359705A (en) 2016-10-19 2024-07-19 英温拉公司 Antibody Constructs
MX2019007019A (en) 2016-12-22 2019-08-16 Univ Degli Studi Magna Graecia Catanzaro A monoclonal antibody targeting a unique sialoglycosilated cancer-associated epitope of cd43.
CN110177569A (en) 2017-03-30 2019-08-27 江苏恒瑞医药股份有限公司 The preparation method of antibody drug conjugates
WO2018233571A1 (en) * 2017-06-19 2018-12-27 四川百利药业有限责任公司 Antibody-drug conjugate having acidic self-stabilization junction
WO2019034176A1 (en) * 2017-08-18 2019-02-21 四川百利药业有限责任公司 Camptothecin-antibody conjugate
WO2019034177A1 (en) * 2017-08-18 2019-02-21 四川百利药业有限责任公司 Antibody drug conjugate having two different drugs
KR20250034200A (en) 2017-11-14 2025-03-10 데비오팜 리서치 ＆ 매뉴팩처링 에스아 Ligand-drug-conjugates as substrates for selective cleavage by the exopeptidase activity of cathepsin b
SG11202007540SA (en) 2018-02-20 2020-09-29 Seattle Genetics Inc Hydrophobic auristatin f compounds and conjugates thereof
IL322895A (en) 2018-06-05 2025-10-01 King S College London Btnl3/8 targeting constructs for delivery of payloads to the gastrointestinal system
EP4031186A1 (en) * 2019-09-19 2022-07-27 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
JP7787083B2 (en) 2020-03-12 2025-12-16 テフニーシェ ウニヴェルジテート ミュンヘン Cyclic peptides and their conjugates for addressing alpha-V-beta-6-integrin in vivo - Patent Application 20070122997
US12036286B2 (en) 2021-03-18 2024-07-16 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
WO2022217022A1 (en) 2021-04-10 2022-10-13 Profoundbio Us Co. Folr1 binding agents, conjugates thereof and methods of using the same
US20250066490A1 (en) 2021-04-23 2025-02-27 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
TW202320857A (en) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 Linkers, drug linkers and conjugates thereof and methods of using the same
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
MX2024000612A (en) 2021-07-19 2024-03-14 Zeno Man Inc Immunoconjugates and methods.
MX2024002571A (en) 2021-09-03 2024-03-20 Toray Industries Pharmaceutical composition for treating and/or preventing cancer.
WO2023083381A1 (en) * 2021-11-15 2023-05-19 成都百利多特生物药业有限责任公司 Bispecific antibody-camptothecin drug conjugate and pharmaceutical use thereof
US20250090680A1 (en) 2021-11-19 2025-03-20 Ardeagen Corporation Gpc3 binding agents, conjugates thereof and methods of using the same
CA3245264A1 (en) * 2021-12-03 2025-06-13 Systimmune, Inc. Anti-human trop2 antibody-camptothecin drug conjugate and medical use thereof
WO2023241621A1 (en) * 2022-06-16 2023-12-21 山东博安生物技术股份有限公司 Anti-liv-1-antibody and antibody-drug conjugate
AU2023298568A1 (en) 2022-06-30 2025-01-09 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention
WO2025027529A1 (en) 2023-07-31 2025-02-06 Advesya Anti-il-1rap antibody drug conjugates and methods of use thereof
WO2025058000A1 (en) 2023-09-13 2025-03-20 東レ株式会社 Pharmaceutical composition for treating, preventing and/or diagnosing cancer
US20250115680A1 (en) 2023-09-26 2025-04-10 Profoundbio Us Co. Ptk7 binding agents, conjugates thereof and methods of using the same
TW202530255A (en) 2023-12-15 2025-08-01 法商亞維西亞有限公司 Anti il-1rap binding domains and antibody-drug conjugates thereof
TW202547866A (en) 2024-01-10 2025-12-16 丹麥商珍美寶股份有限公司 Slitrk6 binding agents, conjugates thereof and methods of using the same
US20250381289A1 (en) 2024-02-29 2025-12-18 Genmab A/S Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same
WO2026027771A1 (en) 2024-08-02 2026-02-05 Trimt Gmbh Alpha v beta 6-integrin binding cyclopeptides with non-natural amino acids, and conjugates thereof
WO2026039642A1 (en) 2024-08-16 2026-02-19 Ardeagen Corporation Anti-mesothelin antibody conjugates and methods of use thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3628624A (en) 1967-04-26 1971-12-21 Buero Patent Ag Guidance system for self-propelled trackless carriages
GB2036891B (en) 1978-12-05 1983-05-05 Windsor Smith C Change speed gear
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (en) 1984-08-15 1986-03-07 Res Dev Corp Of Japan Chimera monoclonal antibody and its preparation
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (en) 1984-12-04 1986-06-21 Teijin Ltd Expression of hybrid antibody gene
WO1987002671A1 (en) 1985-11-01 1987-05-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JP4046354B2 (en) 1996-03-18 2008-02-13 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム Immunoglobulin-like domain with increased half-life
AU5159798A (en) * 1996-11-05 1998-05-29 Bristol-Myers Squibb Company Branched peptide linkers
DK2357006T3 (en) * 2002-07-31 2015-12-21 Seattle Genetics Inc Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
NZ583292A (en) * 2003-11-06 2012-03-30 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
US8067546B2 (en) 2005-04-19 2011-11-29 Seattle Genetics, Inc. Humanized anti-CD70 binding agents and uses thereof
EP1917020B1 (en) * 2005-07-07 2016-05-25 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
WO2007086083A1 (en) 2006-01-24 2007-08-02 Tecnoimage Srl Supporting frame for covering elements
US8257706B2 (en) 2006-08-25 2012-09-04 Seattle Genetics, Inc. CD30 binding agents and uses thereof
CN101616911A (en) 2007-02-21 2009-12-30 梅达莱克斯公司 Chemical linkers with single amino acids and conjugates thereof
HUE031533T2 (en) 2007-10-19 2017-07-28 Seattle Genetics Inc Cd19 binding agents and uses thereof
EP2842575B1 (en) * 2008-03-18 2017-09-27 Seattle Genetics, Inc. Auristatin drug linker conjugates
BR112013013781A2 (en) 2010-12-06 2016-09-13 Seattle Genetics Inc humanized antibodies to liv-1 and use them to treat cancer
BR112014019861A2 (en) 2012-02-17 2017-07-04 Seattle Genetics Inc antibody, isolated nucleic acid, method of treating a cancer patient, and pharmaceutical composition of an antibody
WO2013147153A1 (en) 2012-03-29 2013-10-03 株式会社未来創薬研究所 Anti-lamp5 antibody and utilization thereof
US20130309223A1 (en) 2012-05-18 2013-11-21 Seattle Genetics, Inc. CD33 Antibodies And Use Of Same To Treat Cancer
SG10202001468UA (en) * 2014-02-17 2020-04-29 Seattle Genetics Inc Hydrophilic antibody-drug conjugates
EP4031186A1 (en) 2019-09-19 2022-07-27 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
US12036286B2 (en) 2021-03-18 2024-07-16 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
MX2023010819A (en) 2021-03-18 2023-09-28 Seagen Inc Selective drug release from internalized conjugates of biologically active compounds.

Also Published As

Publication number Publication date
US20230132738A1 (en) 2023-05-04
NZ761644A (en) 2023-08-25
JP2020073607A (en) 2020-05-14
SG11201605886RA (en) 2016-09-29
NZ722252A (en) 2023-08-25
US10933112B2 (en) 2021-03-02
MX385823B (en) 2025-03-18
JP2023018157A (en) 2023-02-07
JP6716461B2 (en) 2020-07-01
KR20160120777A (en) 2016-10-18
US20210283210A1 (en) 2021-09-16
CN106029083A (en) 2016-10-12
AU2015218202B2 (en) 2020-10-15
NZ761646A (en) 2023-08-25
JP2022103282A (en) 2022-07-07
EA201691650A1 (en) 2017-04-28
US12257281B2 (en) 2025-03-25
ES2885686T3 (en) 2021-12-15
CN106029083B (en) 2020-02-07
KR20240036143A (en) 2024-03-19
JP2024096335A (en) 2024-07-12
AU2020239744A1 (en) 2020-10-22
EP3107557B1 (en) 2021-06-09
AU2020239744B2 (en) 2022-12-08
KR102647074B1 (en) 2024-03-14
IL309933A (en) 2024-03-01
EP3912641B1 (en) 2024-11-06
IL290116A (en) 2022-03-01
JP7447183B2 (en) 2024-03-11
ES2994375T3 (en) 2025-01-23
IL282434B (en) 2022-03-01
MX2021010550A (en) 2021-10-01
NZ761642A (en) 2023-08-25
EP3912641A1 (en) 2021-11-24
AU2023201373A1 (en) 2023-04-06
IL290116B2 (en) 2024-06-01
US20170216391A1 (en) 2017-08-03
WO2015123679A1 (en) 2015-08-20
JP2017512752A (en) 2017-05-25
IL246829B (en) 2021-05-31
IL282434A (en) 2021-06-30
IL246829A0 (en) 2016-08-31
CA2937753A1 (en) 2015-08-20
ZA201605111B (en) 2020-10-28
EP3107557A1 (en) 2016-12-28
HK1232123A1 (en) 2018-01-05
KR20230066119A (en) 2023-05-12
US20240115648A1 (en) 2024-04-11
MX2016009862A (en) 2016-10-31
AU2015218202A1 (en) 2016-08-04
IL290116B1 (en) 2024-02-01
EP3107557A4 (en) 2017-11-01
US11510959B2 (en) 2022-11-29

Similar Documents

Publication Publication Date Title
IL290116A (en) Hydrophilic antibody-drug conjugates
IL285516B (en) Amatoxin-antibody conjugates
ZA201607385B (en) Anti-ptk7 antibody-drug conjugates
ZA201700306B (en) Her2 antibody-drug conjugates
ZA201704297B (en) Pyrrolobenzodiazepine-antibody conjugates
PL3119885T3 (en) Antibody-fynomer conjugates
GB201513607D0 (en) Pyrrolobenzodiazepine-antibody conjugates
PT3270711T (en) Sugar-dipeptide conjugates
SG10201506686WA (en) Conjugates
GB201518839D0 (en) Conjugates
GB201420910D0 (en) Pyrrolobenzodiazepine-antibody conjugates
GB201513605D0 (en) Pyrrolobenzodiazepine-antibody conjugates
GB201406720D0 (en) Pyrrolobenzodiazepine-antibody conjugates
GB201406717D0 (en) Pyrrolobenzodiazepine-Antibody conjugates
GB201406718D0 (en) Pyrrolobenzodiazepine-antibody conjugates
GB201406719D0 (en) Pyrrolobenzodiaepine-antibody conjugates
GB201406725D0 (en) Site-specific antibody-drug conjugates
GB201406728D0 (en) Site-specific antibody-drug conjugates
GB201406722D0 (en) Site-specific antibody-drug conjugates
GB201406724D0 (en) Site-specific antibody-drug conjugates
GB201406727D0 (en) Site-specific antibody-drug conjugates
GB201406733D0 (en) Site-specific antibody-drug conjugates
GB201406731D0 (en) Site-specific antibody-drug conjugates
GB201406729D0 (en) Site-specific antibody-drug conjugates