RU2004108463A - Офтальмические композиции, содержащие аскомицин - Google Patents
Офтальмические композиции, содержащие аскомицин Download PDFInfo
- Publication number
- RU2004108463A RU2004108463A RU2004108463/15A RU2004108463A RU2004108463A RU 2004108463 A RU2004108463 A RU 2004108463A RU 2004108463/15 A RU2004108463/15 A RU 2004108463/15A RU 2004108463 A RU2004108463 A RU 2004108463A RU 2004108463 A RU2004108463 A RU 2004108463A
- Authority
- RU
- Russia
- Prior art keywords
- composition according
- conditions
- ascomycin
- copolymer
- eye
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 12
- ZDQSOHOQTUFQEM-PKUCKEGBSA-N ascomycin Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C\C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](O)[C@H](OC)C1 ZDQSOHOQTUFQEM-PKUCKEGBSA-N 0.000 claims 5
- ZDQSOHOQTUFQEM-XCXYXIJFSA-N ascomycin Natural products CC[C@H]1C=C(C)C[C@@H](C)C[C@@H](OC)[C@H]2O[C@@](O)([C@@H](C)C[C@H]2OC)C(=O)C(=O)N3CCCC[C@@H]3C(=O)O[C@H]([C@H](C)[C@@H](O)CC1=O)C(=C[C@@H]4CC[C@@H](O)[C@H](C4)OC)C ZDQSOHOQTUFQEM-XCXYXIJFSA-N 0.000 claims 5
- 229920001577 copolymer Polymers 0.000 claims 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 2
- 206010013774 Dry eye Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- -1 polyoxyethylene Polymers 0.000 claims 2
- 206010027654 Allergic conditions Diseases 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000012929 tonicity agent Substances 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (10)
1. Офтальмическая композиция, адаптированная для местного введения в глаз один раз в день, которая содержит аскомицин.
2. Офтальмическая композиция, в частности композиция по п.1, содержащая аскомицин и по меньшей мере один полимер, выбранный из ряда, включающего
I) сополимер или блок-сополимер полиоксиэтилена и полиоксипропилена
II) гомо- или сополимер акриловой кислоты.
3. Композиция по п.2, где гомо- или сополимер акриловой кислоты является сшитым.
4. Композиция по п.2, дополнительно содержащая повышающий тоничность агент, буфер и консервант.
5. Композиция по п.2, дополнительно содержащая офтальмический носитель.
6. Композиция по п.3, дополнительно содержащая офтальмический носитель.
7. Композиция по п.1, где аскомицин представляет собой 33-эпихлор-33-дезоксиаскомицин.
8. Способ лечения состояний глаза, таких как опосредуемых иммунной системой состояний, аллергических состояний, воспалительных состояний, состояний после трансплантации роговицы или состояний, которые можно лечить с помощью аскомицина, отличающийся тем, что пациенту, нуждающемуся в таком лечении, вводят в глаз композицию, содержащую аскомицин.
9. Способ лечения “сухого глаза”, отличающийся тем, что пациенту, нуждающемуся в таком лечении, вводят в глаз эффективное количество композиции по одному из пп.1-7.
10. Применение композиции по одному из пп.1-7 для приготовления лекарственного средства, предназначенного для лечения “сухого глаза”.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31444801P | 2001-08-23 | 2001-08-23 | |
| US60/314,448 | 2001-08-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004108463A true RU2004108463A (ru) | 2005-05-10 |
| RU2313344C2 RU2313344C2 (ru) | 2007-12-27 |
Family
ID=23219986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004108463/15A RU2313344C2 (ru) | 2001-08-23 | 2002-08-22 | Офтальмические композиции, содержащие аскомицин |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US20030050255A1 (ru) |
| EP (1) | EP1420787B8 (ru) |
| JP (1) | JP2005501105A (ru) |
| KR (2) | KR20100089108A (ru) |
| CN (1) | CN100366251C (ru) |
| AR (1) | AR035293A1 (ru) |
| AT (1) | ATE452638T1 (ru) |
| AU (1) | AU2002331172B2 (ru) |
| BR (1) | BR0211972A (ru) |
| CA (1) | CA2457034C (ru) |
| CO (1) | CO5560568A2 (ru) |
| DE (1) | DE60234840D1 (ru) |
| EC (1) | ECSP044981A (ru) |
| ES (1) | ES2337130T3 (ru) |
| HU (1) | HUP0402396A3 (ru) |
| IL (1) | IL160374A0 (ru) |
| MX (1) | MXPA04001646A (ru) |
| MY (1) | MY157377A (ru) |
| NO (1) | NO20040775L (ru) |
| NZ (1) | NZ531224A (ru) |
| PE (1) | PE20030311A1 (ru) |
| PL (1) | PL208685B1 (ru) |
| PT (1) | PT1420787E (ru) |
| RU (1) | RU2313344C2 (ru) |
| TW (1) | TWI324925B (ru) |
| WO (1) | WO2003017990A2 (ru) |
| ZA (1) | ZA200400772B (ru) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| BE1015610A3 (nl) * | 2003-07-17 | 2005-06-07 | Corrutech Nv | Verbeterde lijm en werkwijze voor het vervaardigen ervan. |
| US7083802B2 (en) * | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| KR20060085246A (ko) | 2003-09-18 | 2006-07-26 | 마커사이트, 인코포레이티드 | 경공막 전달 |
| US7087237B2 (en) * | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| US7083803B2 (en) | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
| DK1848431T3 (en) | 2005-02-09 | 2016-04-18 | Santen Pharmaceutical Co Ltd | LIQUID FORMULATIONS FOR TREATMENT OF DISEASES OR CONDITIONS |
| EP1904056B1 (en) | 2005-07-18 | 2009-04-29 | Minu, L.L.C. | Use of a macrolide to restore corneal sensation |
| KR20140093764A (ko) | 2006-02-09 | 2014-07-28 | 산텐 세이야꾸 가부시키가이샤 | 안정한 제제와 그 제조 및 사용 방법 |
| ES2563288T3 (es) | 2006-03-23 | 2016-03-14 | Santen Pharmaceutical Co., Ltd | Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular |
| NZ582188A (en) * | 2007-07-11 | 2012-03-30 | Pfizer | Pharmaceutical compositions and methods of treating dry eye disorders |
| EP2278999B1 (en) | 2008-04-21 | 2025-01-29 | Dompé farmaceutici S.p.A. | Auris formulations for treating otic diseases and conditions |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| US8030297B2 (en) | 2008-05-14 | 2011-10-04 | Otonomy, Inc. | Controlled release corticosteroid compositions and methods for the treatment of OTIC disorders |
| US8648119B2 (en) | 2008-05-23 | 2014-02-11 | Otonomy, Inc. | Controlled release immunomodulator compositions and methods for the treatment of otic disorders |
| US8846770B2 (en) | 2008-06-18 | 2014-09-30 | Otonomy, Inc. | Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders |
| US8349353B2 (en) | 2008-06-27 | 2013-01-08 | Otonomy, Inc. | Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders |
| WO2010011466A2 (en) | 2008-06-27 | 2010-01-28 | Otonomy, Inc. | Controlled-release cns modulating compositions and methods for the treatment of otic disorders |
| US8496957B2 (en) | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
| US8318817B2 (en) | 2008-07-21 | 2012-11-27 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
| US8399018B2 (en) | 2008-07-21 | 2013-03-19 | Otonomy, Inc. | Controlled release ion channel modulator compositions and methods for the treatment of otic disorders |
| EP2306975A4 (en) | 2008-07-21 | 2012-10-31 | Otonomy Inc | COMPOSITIONS WITH A TAXED RELEASE FOR MODULATING THE EARM STRUCTURE AND THE BORN IMMUNE SYSTEM, AND METHODS OF TREATING EAR OR DISEASE |
| CA2751761A1 (en) | 2008-10-22 | 2010-04-29 | House Ear Institute | Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor |
| JP2016534121A (ja) | 2013-08-27 | 2016-11-04 | オトノミ—，インク． | 小児の耳の病気の処置 |
| US20200155449A1 (en) | 2015-11-16 | 2020-05-21 | Medincell | Method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
| EP3512513A4 (en) | 2016-09-16 | 2020-04-15 | Otonomy, Inc. | OTIC GEL FORMULATIONS FOR THE TREATMENT OF EXTERNAL OTITIS |
| JP7699426B2 (ja) * | 2018-11-30 | 2025-06-27 | ロート製薬株式会社 | 光線による障害からの細胞保護用眼科組成物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0459148B1 (en) * | 1990-05-29 | 1996-01-03 | Ocular Research Of Boston Inc. | Dry eye treatment composition |
| US5247076A (en) * | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
| EP0551626A1 (en) * | 1991-12-19 | 1993-07-21 | LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. | Thermoreversible gel as a liquid pharmaceutical carrier for a galenic formulation |
| US5302584A (en) * | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
| JPH06345646A (ja) * | 1993-06-08 | 1994-12-20 | Fujisawa Pharmaceut Co Ltd | ローション剤 |
| CN100335063C (zh) * | 1994-10-26 | 2007-09-05 | 诺瓦蒂斯有限公司 | 药物组合物 |
| AR004480A1 (es) * | 1995-04-06 | 1998-12-16 | Amico Derin C D | Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen |
| EP0978288A4 (en) * | 1997-04-11 | 2006-07-12 | Astellas Pharma Inc | DRUG COMPOSITION |
| CZ287497B6 (cs) * | 1997-12-30 | 2000-12-13 | Galena, A. S. | Topické oční přípravky s imunosupresivními látkami |
| WO2000066122A1 (en) * | 1999-04-30 | 2000-11-09 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
-
2002
- 2002-08-21 TW TW091118911A patent/TWI324925B/zh not_active IP Right Cessation
- 2002-08-21 AR ARP020103137A patent/AR035293A1/es unknown
- 2002-08-22 RU RU2004108463/15A patent/RU2313344C2/ru not_active IP Right Cessation
- 2002-08-22 CA CA2457034A patent/CA2457034C/en not_active Expired - Fee Related
- 2002-08-22 KR KR1020107014068A patent/KR20100089108A/ko not_active Abandoned
- 2002-08-22 DE DE60234840T patent/DE60234840D1/de not_active Expired - Lifetime
- 2002-08-22 MY MYPI20023102A patent/MY157377A/en unknown
- 2002-08-22 BR BR0211972-2A patent/BR0211972A/pt active Search and Examination
- 2002-08-22 AT AT02767419T patent/ATE452638T1/de active
- 2002-08-22 ES ES02767419T patent/ES2337130T3/es not_active Expired - Lifetime
- 2002-08-22 WO PCT/EP2002/009408 patent/WO2003017990A2/en not_active Ceased
- 2002-08-22 IL IL16037402A patent/IL160374A0/xx unknown
- 2002-08-22 PT PT02767419T patent/PT1420787E/pt unknown
- 2002-08-22 HU HU0402396A patent/HUP0402396A3/hu unknown
- 2002-08-22 PE PE2002000808A patent/PE20030311A1/es not_active Application Discontinuation
- 2002-08-22 CN CNB028164466A patent/CN100366251C/zh not_active Expired - Fee Related
- 2002-08-22 JP JP2003522510A patent/JP2005501105A/ja active Pending
- 2002-08-22 PL PL367459A patent/PL208685B1/pl not_active IP Right Cessation
- 2002-08-22 NZ NZ531224A patent/NZ531224A/en not_active IP Right Cessation
- 2002-08-22 AU AU2002331172A patent/AU2002331172B2/en not_active Ceased
- 2002-08-22 KR KR10-2004-7002458A patent/KR20040030157A/ko not_active Ceased
- 2002-08-22 MX MXPA04001646A patent/MXPA04001646A/es active IP Right Grant
- 2002-08-22 EP EP02767419A patent/EP1420787B8/en not_active Expired - Lifetime
- 2002-08-23 US US10/227,086 patent/US20030050255A1/en not_active Abandoned
-
2004
- 2004-01-30 ZA ZA200400772A patent/ZA200400772B/en unknown
- 2004-02-17 NO NO20040775A patent/NO20040775L/no not_active Application Discontinuation
- 2004-02-18 EC EC2004004981A patent/ECSP044981A/es unknown
- 2004-02-18 CO CO04013810A patent/CO5560568A2/es not_active Application Discontinuation
-
2010
- 2010-11-30 US US12/955,950 patent/US20110071186A1/en not_active Abandoned
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