PT2593452T - HETEROCYCLICAL COMPOUNDS OF THE IP RECEIVER - Google Patents

HETEROCYCLICAL COMPOUNDS OF THE IP RECEIVER

Info

Publication number
PT2593452T
PT2593452T PT117324491T PT11732449T PT2593452T PT 2593452 T PT2593452 T PT 2593452T PT 117324491 T PT117324491 T PT 117324491T PT 11732449 T PT11732449 T PT 11732449T PT 2593452 T PT2593452 T PT 2593452T
Authority
PT
Portugal
Prior art keywords
receiver
heterocyclical
compounds
heterocyclical compounds
Prior art date
Application number
PT117324491T
Other languages
Portuguese (pt)
Inventor
John Charlton Steven
Leblanc Catherine
Carl Mckeown Stephen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT2593452T publication Critical patent/PT2593452T/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT117324491T 2010-07-14 2011-07-14 HETEROCYCLICAL COMPOUNDS OF THE IP RECEIVER PT2593452T (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36413510P 2010-07-14 2010-07-14

Publications (1)

Publication Number Publication Date
PT2593452T true PT2593452T (en) 2017-04-24

Family

ID=44628483

Family Applications (1)

Application Number Title Priority Date Filing Date
PT117324491T PT2593452T (en) 2010-07-14 2011-07-14 HETEROCYCLICAL COMPOUNDS OF THE IP RECEIVER

Country Status (35)

Country Link
US (2) US8754085B2 (en)
EP (1) EP2593452B1 (en)
JP (1) JP5781159B2 (en)
KR (1) KR101491938B1 (en)
CN (1) CN103097385B (en)
AU (1) AU2011278279C1 (en)
BR (1) BR112013000946B1 (en)
CA (1) CA2804744C (en)
CL (1) CL2013000104A1 (en)
CO (1) CO6660445A2 (en)
CR (1) CR20130012A (en)
CU (1) CU24147B1 (en)
CY (1) CY1118819T1 (en)
DK (1) DK2593452T3 (en)
EA (1) EA022046B1 (en)
EC (1) ECSP13012385A (en)
ES (1) ES2622519T3 (en)
GT (1) GT201300018A (en)
HR (1) HRP20170617T1 (en)
HU (1) HUE031710T2 (en)
IL (1) IL224164A (en)
LT (1) LT2593452T (en)
MA (1) MA34373B1 (en)
MX (1) MX2013000537A (en)
MY (1) MY156795A (en)
NZ (1) NZ605528A (en)
PE (1) PE20130404A1 (en)
PH (1) PH12013500084A1 (en)
PL (1) PL2593452T3 (en)
PT (1) PT2593452T (en)
RS (1) RS55856B1 (en)
SG (1) SG186989A1 (en)
SI (1) SI2593452T1 (en)
UA (1) UA109786C2 (en)
WO (1) WO2012007539A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2593452T (en) 2010-07-14 2017-04-24 Novartis Ag HETEROCYCLICAL COMPOUNDS OF THE IP RECEIVER
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
US20150005311A1 (en) 2012-01-13 2015-01-01 Novartis Ag IP receptor agonist heterocyclic compounds
UY34572A (en) 2012-01-13 2013-09-02 Novartis Ag AGONIST HETEROCYCLIC COMPOUNDS OF THE IP RECEIVER
US20140357641A1 (en) 2012-01-13 2014-12-04 Novartis Ag IP receptor agonist heterocyclic compounds
US9174985B2 (en) 2012-01-13 2015-11-03 Novartis Ag Salts of 7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid as IP receptor agonists
US9115129B2 (en) 2012-01-13 2015-08-25 Novartis Ag Substituted pyrido[2,3-B]pyrazines as IP receptor agonists
CN105189500A (en) 2013-02-13 2015-12-23 诺华股份有限公司 IP receptor agonist heterocyclic compounds
UA119247C2 (en) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Spirocyclic compounds as tryptophan hydroxylase inhibitors
BR112016024484A2 (en) 2014-04-24 2017-08-15 Novartis Ag aminopyridine derivatives as phosphatidylinositol 3-kinase inhibitors
CA2945212A1 (en) 2014-04-24 2015-10-29 Novartis Ag Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
US9862711B2 (en) 2014-04-24 2018-01-09 Novartis Ag Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
US9611201B2 (en) 2015-03-05 2017-04-04 Karos Pharmaceuticals, Inc. Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
EP4302834A3 (en) * 2016-07-12 2024-07-17 Revolution Medicines, Inc. 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
MX2019006938A (en) 2016-12-14 2019-09-06 Respira Therapeutics Inc Methods and compositions for treatment of pulmonary hypertension and other lung disorders.
TWI800498B (en) 2016-12-21 2023-05-01 義大利商吉斯藥品公司 Bicyclic dihydropyrimidine-carboxamide derivatives as rho-kinase inhibitors
JP7240319B2 (en) 2017-01-23 2023-03-15 レヴォリューション・メディスンズ，インコーポレイテッド Bicyclic compounds as allosteric SHP2 inhibitors
KR20190110588A (en) 2017-01-23 2019-09-30 레볼루션 메디슨즈, 인크. Pyridine Compounds as Allosteric SHP2 Inhibitors
GEP20207202B (en) 2017-01-30 2020-12-25 Chiesi Farm Spa Tyrosine amide derivatives as rho-kinase inhibitors
CA3070073A1 (en) * 2017-07-18 2019-01-24 Nuvation Bio Inc. 1,8-naphthyridinone compounds and uses thereof
CN111163780A (en) 2017-07-18 2020-05-15 诺维逊生物股份有限公司 Heterocyclic compounds as adenosine antagonists
WO2019048479A1 (en) 2017-09-07 2019-03-14 Chiesi Farmaceutici S.P.A. Tyrosine analogues derivatives as rho- kinase inhibitors
TW201930292A (en) 2017-10-12 2019-08-01 美商銳新醫藥公司 Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors
JP7361693B2 (en) 2017-12-15 2023-10-16 レヴォリューション・メディスンズ，インコーポレイテッド Polycyclic compounds as allosteric SHP2 inhibitors
US11332468B2 (en) 2017-12-18 2022-05-17 Chiesi Farmaceutici S.P.A. Azaindole derivatives as Rho-kinase inhibitors
MA51283A (en) 2017-12-18 2021-05-26 Chiesi Farm Spa TYROSINE DERIVATIVES AS KINASE RHO INHIBITORS
EP3728247B1 (en) 2017-12-18 2021-09-22 Chiesi Farmaceutici S.p.A. Oxadiazole derivatives as rho-kinase inhibitors
AR114926A1 (en) 2018-06-13 2020-10-28 Chiesi Farm Spa AZAINDOL DERIVATIVES AS RHO-KINASE INHIBITORS
TW202019923A (en) 2018-07-16 2020-06-01 義大利商吉斯藥品公司 Tyrosine amide derivatives as Rho-kinase inhibitors
WO2020150676A1 (en) * 2019-01-18 2020-07-23 Nuvation Bio Inc. 1,8-naphthyridinone compounds and uses thereof
CN113613655A (en) * 2019-01-18 2021-11-05 诺维逊生物股份有限公司 Compound and use thereof
AU2020208644A1 (en) 2019-01-18 2021-08-26 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
US12569481B2 (en) 2020-06-12 2026-03-10 Vanderbilt University Methods of treatment for gastrointestinal motility disorders
EP4263546B1 (en) 2020-12-15 2025-07-02 Chiesi Farmaceutici S.p.A. Dihydrofuropyridine derivatives as rho- kinase inhibitors
CA3202146A1 (en) 2020-12-15 2022-06-23 Fabio Rancati Dihydrofuropyridine derivatives as rho- kinase inhibitors
MX2023005866A (en) 2020-12-15 2023-06-05 Chiesi Farm Spa Dihydrofuropyridine derivatives as rho- kinase inhibitors.
WO2023110700A1 (en) 2021-12-13 2023-06-22 Chiesi Farmaceutici S.P.A. Dihydrofuropyridine derivatives as rho-kinase inhibitors

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1454864A (en) 1974-03-05 1976-11-03 Wyeth John & Brother Ltd Thioureas
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
SG64322A1 (en) 1991-05-10 1999-04-27 Rhone Poulenc Rorer Int Bis mono and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
CA2090283A1 (en) 1992-02-28 1993-08-29 Nobuyuki Hamanaka Phenoxyacetic acid derivatives
US5516652A (en) 1993-10-06 1996-05-14 Merck Frosst Canada Inc. DNA encoding prostaglandin receptor IP
JP3692536B2 (en) 1994-02-10 2005-09-07 小野薬品工業株式会社 Prostaglandin I2 receptor
WO1996035713A1 (en) 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides which promote release of growth hormone
GB9622386D0 (en) 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
TWI242011B (en) 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
US6166037A (en) 1997-08-28 2000-12-26 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
DE19834044A1 (en) 1998-07-29 2000-02-03 Bayer Ag New substituted pyrazole derivatives
DE19834047A1 (en) 1998-07-29 2000-02-03 Bayer Ag Substituted pyrazole derivatives
UA71586C2 (en) 1998-12-04 2004-12-15 Smithkline Beecham Corp A vitronectin receptor antagonist
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
SK287418B6 (en) 1999-05-04 2010-09-07 Schering Corporation Pharmaceutical compositions comprising CCR5 antagonists and kit comprising this preparation
KR100439357B1 (en) 1999-05-04 2004-07-07 쉐링 코포레이션 Piperidine derivatives useful as CCR5 antagonists
GB9914255D0 (en) 1999-06-18 1999-08-18 Lilly Forschung Gmbh Pharmaceutical compounds
EG24179A (en) 1999-09-07 2008-09-28 Smithkline Beecham Corp Vitronectin receptor antagonists
DE19943634A1 (en) 1999-09-13 2001-04-12 Bayer Ag Novel dicarboxylic acid derivatives with pharmaceutical properties
DE19943635A1 (en) 1999-09-13 2001-03-15 Bayer Ag Novel aminodicarboxylic acid derivatives with pharmaceutical properties
DE19943639A1 (en) 1999-09-13 2001-03-15 Bayer Ag Dicarboxylic acid derivatives with novel pharmaceutical properties
DE19943636A1 (en) 1999-09-13 2001-03-15 Bayer Ag Novel dicarboxylic acid derivatives with pharmaceutical properties
ES2316383T3 (en) 1999-09-17 2009-04-16 Millennium Pharmaceuticals, Inc. RELATED BENZAMIDS AND INHIBITORS OF FACTOR XA.
PL355011A1 (en) 1999-11-08 2004-03-22 Merck & Co, Inc. Process and intermediates for the preparation of imidazolidinone alpha v integrin antagonists
US6822102B2 (en) 2000-01-03 2004-11-23 Pharmacia Corporation Dihydrobenzopyrans, dihydrobenzothiopyrans, and tetrahydroquinolines for the treatment of COX-2 mediated disorders
IL150963A0 (en) 2000-02-08 2003-02-12 Smithkline Beecham Corp Method and compositions for treating an inflammatory disease
KR100523119B1 (en) * 2000-03-16 2005-10-20 에프. 호프만-라 로슈 아게 Carboxylic acid derivatives as ip antagonists
US7119207B2 (en) 2000-04-10 2006-10-10 Pfizer Inc Benzoamide piperidine containing compounds and related compounds
HUP0300413A2 (en) * 2000-04-10 2003-06-28 Pfizer Products Inc. Benzoamide piperidine containing and related compounds, process for their preparation and pharmaceutical compositions containing them
AR031176A1 (en) 2000-11-22 2003-09-10 Bayer Ag NEW DERIVATIVES OF PIRAZOLPIRIDINA SUBSTITUTED WITH PIRIDINE
DE10110750A1 (en) 2001-03-07 2002-09-12 Bayer Ag Novel aminodicarboxylic acid derivatives with pharmaceutical properties
DE10110749A1 (en) 2001-03-07 2002-09-12 Bayer Ag Substituted aminodicarboxylic acid derivatives
TWI316055B (en) 2001-04-26 2009-10-21 Nippon Shinyaku Co Ltd
AR037517A1 (en) 2001-11-05 2004-11-17 Novartis Ag DERIVATIVES OF NAFTIRIDINES, A PROCESS FOR THE PREPARATION, PHARMACEUTICAL COMPOSITION AND THE USE OF THEM FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF AN INFLAMMATORY DISEASE
TW200305423A (en) 2002-02-14 2003-11-01 Ono Pharmaceutical Co N-carbamoyl nitrogen-containing condensed ring compound and medicament containing same as active ingredient
DE10220570A1 (en) 2002-05-08 2003-11-20 Bayer Ag Carbamate-substituted pyrazolopyridines
ES2201907B1 (en) 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. NEW DERIVATIVES OF INDOLILPIPERIDINE AS POWERFUL ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
SE0202483D0 (en) 2002-08-21 2002-08-21 Astrazeneca Ab Chemical compounds
CA2497903A1 (en) 2002-09-18 2004-04-01 Ono Pharmaceutical Co., Ltd. Triazaspiro[5.5]undecane derivatives and drugs comprising the same as the active ingredient
JP2006096662A (en) 2002-09-18 2006-04-13 Sumitomo Pharmaceut Co Ltd Novel 6-substituted uracil derivatives and therapeutic agents for allergic diseases
JP2004107299A (en) 2002-09-20 2004-04-08 Japan Energy Corp Novel 1-substituted uracil derivatives and therapeutic agents for allergic diseases
PE20040950A1 (en) 2003-02-14 2005-01-01 Theravance Inc BIPHENYL DERIVATIVES AS AGONISTS OF ß2-ADRENERGIC RECEPTORS AND AS ANTAGONISTS OF MUSCARINAL RECEPTORS
JP2007524596A (en) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド Co-crystal pharmaceutical composition
CA2518443A1 (en) 2003-03-12 2004-09-30 Abbott Laboratories Naphthyridine derivatives as antibacterial agents
MXPA05011523A (en) 2003-04-30 2006-01-23 Inst For Pharm Discovery Inc Substituted heteroaryls as inhibitors of protein tyrosine phosphatases.
WO2005020926A2 (en) 2003-08-28 2005-03-10 Pharmacia Corporation Treatment or prevention of vascular disorders with cox-2 inhibitors in combination with cyclic amp-specific phosphodiesterase inhibitors
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
KR20060101500A (en) 2003-11-25 2006-09-25 노보 노르디스크 에이/에스 New Salicylic Acid Anilide
AU2004309420B2 (en) 2003-12-23 2008-10-30 Novartis Ag Bicyclic heterocyclic p-38 kinase inhibitors
GB0413960D0 (en) 2004-06-22 2004-07-28 Novartis Ag Organic compounds
AR051780A1 (en) 2004-11-29 2007-02-07 Japan Tobacco Inc FUSIONED RING COMPOUNDS CONTAINING NITROGEN AND USING THEMSELVES
EP2392328A1 (en) 2005-05-09 2011-12-07 Hydra Biosciences, Inc. Compounds for modulating TRPV3 Function
ES2270715B1 (en) 2005-07-29 2008-04-01 Laboratorios Almirall S.A. NEW DERIVATIVES OF PIRAZINA.
RU2008110908A (en) 2005-08-25 2009-09-27 Шеринг Корпорейшн (US) IMIDAZOLE DERIVATIVES AS A FUNCTIONALLY SELECTIVE ALFA-2C ADRENORE RECEPTORS
GB0601951D0 (en) * 2006-01-31 2006-03-15 Novartis Ag Organic compounds
US7541371B2 (en) 2006-02-20 2009-06-02 Eisai R&D Management Co., Ltd. Method for treating a motor neuron disease
US20080064871A1 (en) 2006-05-26 2008-03-13 Japan Tobacco Inc. Production Method of Nitrogen-Containing Fused Ring Compounds
US20080305169A1 (en) 2006-05-26 2008-12-11 Japan Tobacco Inc. Pharmaceutical Compositions Comprising Nitrogen-Containing Fused Ring Coumpounds
US8163817B2 (en) 2007-05-11 2012-04-24 Canon Kabushiki Kaisha Aqueous ink, ink set, image forming method and image forming apparatus
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US20090054304A1 (en) * 2007-08-23 2009-02-26 Kalypsys, Inc. Heterocyclic modulators of tgr5 for treatment of disease
WO2010008864A2 (en) 2008-06-24 2010-01-21 Amira Pharmaceuticals, Inc. Cycloalkane[b]indole angtagonists of prostaglandin d2 receptors
CA2730606A1 (en) 2008-07-16 2010-01-21 Schering Corporation Bicyclic heterocycle derivatives and methods of use thereof
DE102008039082A1 (en) 2008-08-21 2010-02-25 Bayer Schering Pharma Aktiengesellschaft Azabicyclic-substituted 5-aminopyrazoles and their use
TWI368513B (en) 2009-04-30 2012-07-21 Univ Kaohsiung Medical Synthesis of pulmodil and pulmodil-1, two chlorophenylpiperazine salt derivatives, and rhokinase-dependent inhibition activity on pulmonary artery endothelium dysfunction, medial wall thickness and vascular obstruction thereof
WO2011111880A1 (en) 2010-03-08 2011-09-15 주식회사 메디젠텍 Pharmaceutical composition for treating or preventing diseases caused by the nuclear export of gsk3, including a compound for inhibiting the nuclear export of gsk3
PT2593452T (en) 2010-07-14 2017-04-24 Novartis Ag HETEROCYCLICAL COMPOUNDS OF THE IP RECEIVER
UY34572A (en) 2012-01-13 2013-09-02 Novartis Ag AGONIST HETEROCYCLIC COMPOUNDS OF THE IP RECEIVER
US20150005311A1 (en) 2012-01-13 2015-01-01 Novartis Ag IP receptor agonist heterocyclic compounds
US9174985B2 (en) 2012-01-13 2015-11-03 Novartis Ag Salts of 7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid as IP receptor agonists
US9115129B2 (en) 2012-01-13 2015-08-25 Novartis Ag Substituted pyrido[2,3-B]pyrazines as IP receptor agonists
US20140357641A1 (en) 2012-01-13 2014-12-04 Novartis Ag IP receptor agonist heterocyclic compounds
WO2013105058A1 (en) 2012-01-13 2013-07-18 Novartis Ag 7,8- dihydropyrido [3, 4 - b] pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders

Also Published As

Publication number Publication date
CU24147B1 (en) 2016-02-29
SG186989A1 (en) 2013-02-28
BR112013000946A2 (en) 2016-05-17
EP2593452A1 (en) 2013-05-22
ECSP13012385A (en) 2013-03-28
WO2012007539A9 (en) 2012-11-01
CN103097385A (en) 2013-05-08
CU20130009A7 (en) 2013-04-19
US9132127B2 (en) 2015-09-15
CY1118819T1 (en) 2018-01-10
NZ605528A (en) 2015-02-27
CA2804744A1 (en) 2012-01-19
CO6660445A2 (en) 2013-04-30
US8754085B2 (en) 2014-06-17
UA109786C2 (en) 2015-10-12
CA2804744C (en) 2019-05-28
EA201300118A1 (en) 2013-06-28
PE20130404A1 (en) 2013-04-17
MX2013000537A (en) 2013-01-29
US20140243346A1 (en) 2014-08-28
WO2012007539A1 (en) 2012-01-19
KR20130038924A (en) 2013-04-18
MY156795A (en) 2016-03-31
EA022046B1 (en) 2015-10-30
IL224164A (en) 2016-08-31
CL2013000104A1 (en) 2013-05-17
EP2593452B1 (en) 2017-01-18
CR20130012A (en) 2013-02-19
RS55856B1 (en) 2017-08-31
LT2593452T (en) 2017-04-10
ES2622519T3 (en) 2017-07-06
KR101491938B1 (en) 2015-02-10
BR112013000946B1 (en) 2020-09-08
US20130102611A1 (en) 2013-04-25
SI2593452T1 (en) 2017-06-30
DK2593452T3 (en) 2017-04-24
JP2013531025A (en) 2013-08-01
AU2011278279C1 (en) 2014-11-27
JP5781159B2 (en) 2015-09-16
HUE031710T2 (en) 2017-07-28
MA34373B1 (en) 2013-07-03
AU2011278279A1 (en) 2013-02-21
GT201300018A (en) 2015-11-24
PH12013500084A1 (en) 2015-09-11
HRP20170617T1 (en) 2017-06-30
CN103097385B (en) 2016-08-03
PL2593452T3 (en) 2017-07-31
AU2011278279B2 (en) 2014-08-07

Similar Documents

Publication Publication Date Title
PT2593452T (en) HETEROCYCLICAL COMPOUNDS OF THE IP RECEIVER
DK2821407T3 (en) PIPERIDINONCARBOXAMIDAZAINDAN-CGRP RECEPTOR ANTAGONISTS
DK2648516T3 (en) SUBSTITUTED PYRIDINON-PYRIDINYL COMPOUNDS
EP2638390A4 (en) ALCOOTEST MULTIFUNCTION
CR20130271A (en) ESPIRO-OXINDOL MDM2 ANTAGONISTS
BR112013009935C8 (en) compounds
PL2614063T3 (en) Substituted Imidazopyridazines
BR112013013263A2 (en) connection set
PT2566327T (en) INDOLES
BRPI1013614A2 (en) substituted spiro-amide compounds
CO6801726A2 (en) Compounds
EP2665707A4 (en) Mineralocorticoid receptor antagonists
PT2626350E (en) CYLOPROPANE COMPOUND
DK2649070T3 (en) TRIAZOLPYRIDINE COMPOUNDS
DE112011104183A5 (en) readjustment
BR112013010643A2 (en) heterocyclic compounds
DK2539323T3 (en) Phobic compounds such as bradykinin-B1 antagonists
EP2627329A4 (en) TRPA1 RECEIVER ANTAGONIST
EP2560655A4 (en) SUBSTITUTED PYRIMIDINES
BR112013007056A2 (en) imine compounds
EP2765859A4 (en) MINERALOCORTICOID RECEPTOR ANTAGONISTS
EP2566494A4 (en) CXCR4 RECEPTOR COMPOUNDS
DK2655360T3 (en) PROCEDURE FOR THE PREPARATION OF N-SULPHONYL-SUBSTITUTED OXINDOLS
EP2525500A4 (en) RECEIVER
PT2546255T (en) BENZAZEPINE COMPOUND