MXPA03010766A - Nuevos compuestos y composiciones como inhibicores de las catepsinas. - Google Patents

Nuevos compuestos y composiciones como inhibicores de las catepsinas.

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Publication number
MXPA03010766A
MXPA03010766A MXPA03010766A MXPA03010766A MXPA03010766A MX PA03010766 A MXPA03010766 A MX PA03010766A MX PA03010766 A MXPA03010766 A MX PA03010766A MX PA03010766 A MXPA03010766 A MX PA03010766A MX PA03010766 A MXPA03010766 A MX PA03010766A
Authority
MX
Mexico
Prior art keywords
compositions
novel compounds
cathepsin inhibitors
inhibitors
cathepsin
Prior art date
Application number
MXPA03010766A
Other languages
English (en)
Inventor
Zippel Sheila
Original Assignee
Axys Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axys Pharm Inc filed Critical Axys Pharm Inc
Publication of MXPA03010766A publication Critical patent/MXPA03010766A/es

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
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Abstract

La presente invencion se refiere a nuevos inhibidores selectivos de la catepsina S, sus sales y N oxidos farmaceuticamente aceptables, sus usos como agentes terapeuticos y los metodos para su fabricacion.
MXPA03010766A 2001-06-01 2002-06-03 Nuevos compuestos y composiciones como inhibicores de las catepsinas. MXPA03010766A (es)

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US29530101P 2001-06-01 2001-06-01
PCT/US2002/017411 WO2002098850A2 (en) 2001-06-01 2002-06-03 Chemical compounds and pharmaceutical compositions as cathepsin s inhibitors

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MXPA03010766A true MXPA03010766A (es) 2005-03-07

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US (1) US20040142999A1 (es)
EP (1) EP1397340A2 (es)
JP (1) JP2004535422A (es)
KR (1) KR20040015725A (es)
CN (1) CN1512983A (es)
AU (1) AU2002305790B2 (es)
BR (1) BR0210912A (es)
CA (1) CA2448418A1 (es)
EA (1) EA007335B1 (es)
HR (1) HRP20030995A2 (es)
IL (1) IL159125A0 (es)
MX (1) MXPA03010766A (es)
NO (1) NO20035328D0 (es)
NZ (1) NZ528944A (es)
PL (1) PL367128A1 (es)
RS (1) RS94603A (es)
WO (1) WO2002098850A2 (es)
ZA (1) ZA200308392B (es)

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CA2448418A1 (en) 2002-12-12
ZA200308392B (en) 2005-01-28
EA007335B1 (ru) 2006-08-25
RS94603A (sr) 2007-02-05
CN1512983A (zh) 2004-07-14
JP2004535422A (ja) 2004-11-25
NO20035328D0 (no) 2003-11-28
KR20040015725A (ko) 2004-02-19
WO2002098850A3 (en) 2003-04-24
IL159125A0 (en) 2004-05-12
US20040142999A1 (en) 2004-07-22
PL367128A1 (en) 2005-02-21
BR0210912A (pt) 2004-08-31
NZ528944A (en) 2007-09-28
EP1397340A2 (en) 2004-03-17
WO2002098850A2 (en) 2002-12-12
HRP20030995A2 (en) 2005-08-31
EA200301203A1 (ru) 2004-04-29
AU2002305790B2 (en) 2008-01-31

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