LT3553084T - Anti-adrenomedulino (adm) antikūnas arba anti-adm antikūno fragmentas, arba anti-adm ne-ig karkasas, skirtas organų funkcijos sutrikimo arba organų nepakankamumo profilaktikai arba sumažinimui paciento, sergančio lėtine arba ūmine liga arba esančio ūminės būklės, organizme - Google Patents

Anti-adrenomedulino (adm) antikūnas arba anti-adm antikūno fragmentas, arba anti-adm ne-ig karkasas, skirtas organų funkcijos sutrikimo arba organų nepakankamumo profilaktikai arba sumažinimui paciento, sergančio lėtine arba ūmine liga arba esančio ūminės būklės, organizme

Info

Publication number: LT3553084T
Authority: LT; Lithuania
Prior art keywords: adm; antibody; acute; adrenomedullin; scaffold
Prior art date: 2011-11-16

Application number

LTEP19162009.5T

Other languages

English (en)

Inventor

Andreas Bergmann

Original Assignee

Adrenomed Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-11-16

Filing date

2012-11-16

Publication date

2023-03-10

2012-11-16 Application filed by Adrenomed Ag filed Critical Adrenomed Ag

2023-03-10 Publication of LT3553084T publication Critical patent/LT3553084T/lt

Links

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001144—Hormones, e.g. calcitonin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7095—Inflammation
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

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Veterinary Medicine (AREA)
Public Health (AREA)
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Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Heart & Thoracic Surgery (AREA)
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Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Biochemistry (AREA)
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LTEP19162009.5T 2011-11-16 2012-11-16 Anti-adrenomedulino (adm) antikūnas arba anti-adm antikūno fragmentas, arba anti-adm ne-ig karkasas, skirtas organų funkcijos sutrikimo arba organų nepakankamumo profilaktikai arba sumažinimui paciento, sergančio lėtine arba ūmine liga arba esančio ūminės būklės, organizme LT3553084T (lt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP11189447		2011-11-16
EP12160014		2012-03-16

Publications (1)

Publication Number	Publication Date
LT3553084T true LT3553084T (lt)	2023-03-10

Family

ID=48429015

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LTEP19162009.5T LT3553084T (lt)	2011-11-16	2012-11-16	Anti-adrenomedulino (adm) antikūnas arba anti-adm antikūno fragmentas, arba anti-adm ne-ig karkasas, skirtas organų funkcijos sutrikimo arba organų nepakankamumo profilaktikai arba sumažinimui paciento, sergančio lėtine arba ūmine liga arba esančio ūminės būklės, organizme
LTEP12784631.9T LT2780369T (lt)	2011-11-16	2012-11-16	Anti-adrenomedulino (adm) antikūnas arba anti-adm antikūno fragmentas, arba anti-adm ne-ig karkasas, skirtas pacientų su lėtine arba ūmine liga, arba ūmine būkle organų disfunkcijos arba organų nepakankamumo prevencijai arba sumažinimui

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
LTEP12784631.9T LT2780369T (lt)	2011-11-16	2012-11-16	Anti-adrenomedulino (adm) antikūnas arba anti-adm antikūno fragmentas, arba anti-adm ne-ig karkasas, skirtas pacientų su lėtine arba ūmine liga, arba ūmine būkle organų disfunkcijos arba organų nepakankamumo prevencijai arba sumažinimui

Country Status (18)

Country	Link
US (5)	US20140328853A1 (lt)
EP (3)	EP4086283A1 (lt)
JP (2)	JP6193871B2 (lt)
AU (1)	AU2012338731B2 (lt)
DK (2)	DK3553084T3 (lt)
ES (2)	ES2729710T3 (lt)
FI (1)	FI3553084T3 (lt)
HR (2)	HRP20230146T1 (lt)
HU (2)	HUE061696T2 (lt)
LT (2)	LT3553084T (lt)
NZ (1)	NZ624873A (lt)
PL (2)	PL2780369T3 (lt)
PT (2)	PT2780369T (lt)
RS (2)	RS58880B1 (lt)
SG (3)	SG10202006318TA (lt)
SI (1)	SI3553084T1 (lt)
WO (1)	WO2013072511A1 (lt)
ZA (2)	ZA201403552B (lt)

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CN111627559B (zh) *	2020-06-17	2023-08-29	北京大学第三医院（北京大学第三临床医学院）	预测患者死亡风险的系统
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2012
- 2012-11-16 LT LTEP19162009.5T patent/LT3553084T/lt unknown
- 2012-11-16 LT LTEP12784631.9T patent/LT2780369T/lt unknown
- 2012-11-16 HR HRP20230146TT patent/HRP20230146T1/hr unknown
- 2012-11-16 SG SG10202006318TA patent/SG10202006318TA/en unknown
- 2012-11-16 DK DK19162009.5T patent/DK3553084T3/da active
- 2012-11-16 JP JP2014541695A patent/JP6193871B2/ja active Active
- 2012-11-16 PT PT12784631T patent/PT2780369T/pt unknown
- 2012-11-16 SG SG11201402366PA patent/SG11201402366PA/en unknown
- 2012-11-16 HU HUE19162009A patent/HUE061696T2/hu unknown
- 2012-11-16 RS RS20190738A patent/RS58880B1/sr unknown
- 2012-11-16 HU HUE12784631 patent/HUE044383T2/hu unknown
- 2012-11-16 PL PL12784631T patent/PL2780369T3/pl unknown
- 2012-11-16 EP EP21216077.4A patent/EP4086283A1/en active Pending
- 2012-11-16 AU AU2012338731A patent/AU2012338731B2/en active Active
- 2012-11-16 EP EP12784631.9A patent/EP2780369B1/en active Active
- 2012-11-16 NZ NZ624873A patent/NZ624873A/en unknown
- 2012-11-16 DK DK12784631.9T patent/DK2780369T3/da active
- 2012-11-16 ES ES12784631T patent/ES2729710T3/es active Active
- 2012-11-16 WO PCT/EP2012/072930 patent/WO2013072511A1/en not_active Ceased
- 2012-11-16 SI SI201232021T patent/SI3553084T1/sl unknown
- 2012-11-16 PL PL19162009.5T patent/PL3553084T3/pl unknown
- 2012-11-16 US US14/358,334 patent/US20140328853A1/en not_active Abandoned
- 2012-11-16 EP EP19162009.5A patent/EP3553084B1/en active Active
- 2012-11-16 PT PT191620095T patent/PT3553084T/pt unknown
- 2012-11-16 SG SG10201801919QA patent/SG10201801919QA/en unknown
- 2012-11-16 FI FIEP19162009.5T patent/FI3553084T3/fi active
- 2012-11-16 RS RS20230115A patent/RS64060B1/sr unknown
- 2012-11-16 HR HRP20191010TT patent/HRP20191010T1/hr unknown
- 2012-11-16 ES ES19162009T patent/ES2938653T3/es active Active
2014
- 2014-05-15 ZA ZA2014/03552A patent/ZA201403552B/en unknown
2016
- 2016-02-16 US US15/044,474 patent/US10221238B2/en active Active
2017
- 2017-05-17 JP JP2017098527A patent/JP2017155051A/ja active Pending
2018
- 2018-09-20 US US16/136,892 patent/US10800842B2/en active Active
- 2018-12-10 US US16/214,963 patent/US11673949B2/en active Active
2019
- 2019-09-30 ZA ZA2019/06427A patent/ZA201906427B/en unknown
2023
- 2023-05-02 US US18/142,070 patent/US12338281B2/en active Active

Also Published As

Publication number	Publication date
ZA201906427B (en)	2020-08-26
US20160176960A1 (en)	2016-06-23
US12338281B2 (en)	2025-06-24
LT2780369T (lt)	2019-07-10
EP3553084A1 (en)	2019-10-16
JP2015501797A (ja)	2015-01-19
RS58880B1 (sr)	2019-08-30
HRP20191010T1 (hr)	2019-08-23
JP6193871B2 (ja)	2017-09-06
ES2938653T3 (es)	2023-04-13
EP2780369B1 (en)	2019-03-13
US20190092857A1 (en)	2019-03-28
US20240368268A1 (en)	2024-11-07
JP2017155051A (ja)	2017-09-07
SG10201801919QA (en)	2018-04-27
FI3553084T3 (fi)	2023-03-03
EP4086283A1 (en)	2022-11-09
NZ624873A (en)	2016-07-29
SG11201402366PA (en)	2014-06-27
AU2012338731A1 (en)	2014-05-29
US20190010226A1 (en)	2019-01-10
HUE044383T2 (hu)	2019-10-28
PT3553084T (pt)	2023-02-17
WO2013072511A1 (en)	2013-05-23
PL3553084T3 (pl)	2023-04-17
SI3553084T1 (sl)	2023-05-31
HRP20230146T1 (hr)	2023-04-28
DK2780369T3 (da)	2019-06-17
US11673949B2 (en)	2023-06-13
AU2012338731B2 (en)	2017-07-06
RS64060B1 (sr)	2023-04-28
US20140328853A1 (en)	2014-11-06
EP2780369A1 (en)	2014-09-24
EP3553084B1 (en)	2022-11-16
PL2780369T3 (pl)	2019-09-30
US10221238B2 (en)	2019-03-05
ES2729710T3 (es)	2019-11-05
HUE061696T2 (hu)	2023-08-28
US10800842B2 (en)	2020-10-13
PT2780369T (pt)	2019-06-18
SG10202006318TA (en)	2020-08-28
DK3553084T3 (da)	2023-02-20
ZA201403552B (en)	2024-06-26

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