KR20180058998A - Pharmaceutical composition and food composition for preventing, improving, or treating obesity, and a process for preparing them - Google Patents

Abstract

An aspect of the present invention provides a pharmaceutical composition for the treatment or prevention of obesity comprising willow, acacia, and forages as an active ingredient, and a method for producing the same. Another aspect of the present invention provides a food composition for improving or preventing obesity containing willow, acacia, and forages as an active ingredient, and a method for producing the same.

Description

TECHNICAL FIELD The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating obesity, a food composition, and a method for preparing the same,

The present invention relates to a pharmaceutical composition for preventing, improving or treating obesity, a food composition and a preparation method thereof, and more particularly to a composition for preventing obesity, To a pharmaceutical composition, a food composition and a preparation method thereof.

There are more than 20 billion adipocytes in the human body. When the supply is much higher than the demand of energy in the human body, it is stored in the fat cells as neutral fat. When the energy is depleted, it is decomposed into free fatty acid and glucose, . Obesity, which is about 30 ~ 40% of modern people, occurs when excessive energy accumulation occurs due to imbalance of this process, and fat cell size increases or increases.

Such obesity is closely related to the onset of various adult diseases, and the higher the obesity degree, the higher the prevalence of diabetes, gallstone disease, hypertension, heart disease and stroke. Obesity is known to be one of the many causes of diabetes mellitus.

The most reasonable way to treat these obesity is to consume all nutrients while limiting calories. The use of caloric restriction foods generally results in problems such as attachment to food, imbalance of nutrients, and more food after weight loss by severely limiting diet. It is necessary to develop a realistic method that can reduce weight by controlling the amount of food while taking all nutrients evenly and taking functional foods or functional supplements to help obesity without side effects.

In order for functional foods to exhibit anti-obesity effects, it would be more effective to suppress the absorption of the fat supplied to the diet, promote the degradation of the fat, and inhibit the synthesis of nutrients from the excess carbohydrate into the body fat . However, the simple mixing of the single components previously found to have the respective effects does not result in an anti-obesity effect or synergistic effect, and may even alleviate the effect or exhibit deleterious effects.

Salix glandulosa SEEM, Salix gracilistyla Miq, Salix babylonica L, S. dependens NAKAI and Salix glandulosa var. glabra NAKAI, Salix chaenomeloides, etc., and the branches are maintained. The roots and hairy roots are referred to as hairy roots, branches or root husks as milky white flowers, leaves are oiled leaves and flowers are oiled, etc. As pharmacological components, salicin ), Tannin and the like and has been reported to be used for the treatment of rheumatic pain and the like (Non-Patent Document 1). It is also known that extracts of willow are effective in amelioration of forgetfulness and treatment of degenerative brain diseases (Patent Document 1).

Acacia is a species of acacia marsii de wild, commonly known as black warts, Acacia mangium Willd., Acacia dealbata link, acacia deer, Acacia decurrens Willd., And Acacia pycnantha Benth., Among others. It has been known that tannins extracted from acacia honey or the bark thereof can be used as a leather tanning agent or an adhesive for wood. In recent years, it has been known that the extract of acacia has a selective inhibitory effect of COX-2 (Patent Document 2) It has been found that there is an oxygen scavenging effect (Patent Document 3) and a whitening effect by a tyrosinase inhibiting effect (Patent Document 4).

Forsythia koreana Nakai is an ash tree plant, a bushy tree with yellow flowers and is a Korean specialty, and it grows extensively throughout East Asia. It is known that the forages and leaves of the forsythia leaf are called allied leaf, and it is said to be effective for asthma, atopy, asthma, and allergic diseases. In addition, the Forsythia extract has been found to be effective for the prevention and treatment of bone diseases (Patent Document 5).

1. Korean Patent Publication No. 2014-0120667 2. Japanese Patent Publication 2004-532811 3. Japanese Patent Publication 2004-352639 4. Japanese Patent Laid-Open No. 10-025238 5. Korean Patent Publication 2016-85954

1. Information Sourcing, Daehee Jaejongjaejeon, Yeonglim, p527-530, 1998; www.floma.kr

It is an object of the present invention to provide an effective and safe pharmaceutical composition for the treatment or prevention of obesity.

It is another object of the present invention to provide a method for producing an effective and safe pharmaceutical composition for treating or preventing obesity.

It is another object of the present invention to provide an effective and safe food composition for the improvement or prevention of obesity.

It is a further object of the present invention to provide a method for the production of an effective and safe food composition for the improvement or prevention of obesity.

One aspect of the present invention is

The present invention provides a pharmaceutical composition for the treatment or prevention of obesity, which contains willow, acacia, and forages as an active ingredient.

In another aspect of the present invention,

A pulverizing step of grinding willow, acacia, and foraging;

Adding a binding liquid to the obtained crude drug powder to prepare a ring form;

And a step of drying the manufactured ring, in accordance with an aspect of the present invention, a method for preparing a pharmaceutical composition for treating or preventing obesity.

In another aspect of the present invention,

The present invention provides a food composition for improving or preventing obesity containing willow, acacia, and foraging as an active ingredient.

In another aspect of the present invention,

A pulverizing step of grinding willow, acacia, and foraging;

Adding a binding liquid to the obtained crude drug powder to prepare a ring form;

And drying the manufactured ring. The present invention also provides a method of producing a food composition for improving or preventing obesity according to one aspect of the present invention.

The pharmaceutical composition and the food composition according to one aspect of the present invention exhibit remarkably superior synergistic anti-obesity effect when the combination of the three herbs is used as an active ingredient, as compared with the case of using willow, acacia and forsythia respectively All. In addition, the pharmaceutical composition and the food composition are effective not only for the anti-obesity effect but also for the constipation and indigestion, thereby improving the obesity and improving the constipation and promoting digestion.

Hereinafter, the present invention will be described in more detail.

All technical terms used in the present invention are used in the sense that they are generally understood by those of ordinary skill in the relevant field of the present invention unless otherwise defined. In addition, preferred methods or samples are described in this specification, but similar or equivalent ones are also included in the scope of the present invention. Also, the numerical values set forth herein are considered to include the meaning of " about " unless explicitly stated. Whenever a component is referred to as " including "or" containing "an element in the specification, it is to be understood that the element may include other elements. The contents of all publications referred to in this specification are incorporated herein by reference in their entirety.

The inventors of the present invention have studied to develop a composition which is safe and highly effective for the treatment of obesity derived from a herbal composition and found that there is a remarkably excellent anti-obesity effect when a combination of willow, acacia, and foraging, A composition for obesity has been developed.

Accordingly, one aspect of the present invention provides a pharmaceutical composition for the treatment or prevention of obesity comprising willow, acacia, and forages as an active ingredient.

The willow, acacia, and forsythia can each independently be a variety of organs or parts (e.g., leaves, flowers, and stems) of each plant, and more specifically, each independently leaf, stem, or combination thereof For example, a branch with a mouth). In one embodiment, the willow, acacia, and forsythia may all be leaf-like branches.

The combination ratio of beeswax, acacia, and foraging which is a herbal medicine contained in the pharmaceutical composition is not particularly limited as long as it exhibits the anti-obesity effect. In one embodiment, acacia 1 ~ 3 parts by weight and 1 to 3 parts by weight of forages.

The pharmaceutical composition may contain the herbal medicine as an extract thereof, or may be contained as the extract itself or as a pulverized product without an extraction process.

The extract of the herbal medicine may be independently an extract of water, a lower alcohol having 1 to 3 carbon atoms, or a mixed solvent thereof. In one embodiment, the extract is a water extract. The extract may be prepared by any extraction method known in the art.

The herbal medicine extract obtained by the ordinary extraction method may be an extract of C1-C3 alcohol, more preferably ethanol extract, more preferably 70 to 100% ethanol extract. When extracting with a solvent, the extraction temperature may be carried out at room temperature, but it may be carried out under heating at a temperature of 40 to 80 ° C for more efficient extraction. The extraction time may be at least 72 hours at room temperature and 5 to 24 hours at elevated temperature.

The extract extracted by the above-described method may be used as it is or may be used in the form of concentrated extract, or it may be concentrated and then lyophilized and used as a lyophilized product. Specifically, it is used as a concentrated form so that it can be used at a sufficient concentration.

The pharmaceutical composition may contain willow, acacia, and foraging as a pulverized product of the herbal medicine itself or as dry pulverized product of the herbal medicine without extracting. The pulverized product can be produced according to any pulverized product manufacturing method known in the art.

The pharmaceutical compositions may be formulated into conventional pharmaceutical formulations known in the art. The pharmaceutical preparation may be formulated into any formulation including, but not limited to, oral administration formulations, injectable preparations, suppositories, percutaneous administration formulations, and expectorant formulations, and specifically includes solutions, suspensions, powders, granules, Such as tablets, capsules, pills, or powders, for oral administration. In one embodiment, the pharmaceutical composition is a pill.

When formulating into each of the above-mentioned formulations, it may be prepared by adding a pharmaceutically acceptable carrier or an additive necessary for the preparation of each of the formulations. Representative examples of the formulations for oral administration include at least one selected from the group consisting of diluents, lubricants, binders, disintegrants, sweeteners, stabilizers, and preservatives as the carrier when formulated. Examples of the additives include perfumes, vitamins, and antioxidants May be selected and used.

Examples of the diluent include lactose, corn starch, soybean oil, microcrystalline cellulose, or mannitol as the diluent, magnesium stearate or talc as the lubricant, polyvinylpyrrolidone as the binder, Or hydroxypropylcellulose are preferable. Examples of the disintegrant include carboxymethylcellulose calcium, sodium starch glycolate, polacrilin potassium, or crospovidone; examples of sweeteners include white sugar, fructose, sorbitol, or aspartame; stabilizers include sodium carboxymethylcellulose, Preferred examples of the antiseptic agent include methyl paraoxybenzoate, propyl paraoxybenzoate, and potassium sorbate.

In addition to the above components, natural additives such as natural flavors such as plum flavor, lemon flavor, pineapple flavor and herb flavor, natural fruit juice, natural coloring matters such as chlorophyllin and flavonoid, fructose, honey, sugar alcohol, sugar Or acidic agents such as citric acid and sodium citrate may be mixed and used.

In order to obtain an anti-obesity effect, the pharmaceutical composition may be orally administered in several divided doses so that the total dose per day of an adult of 60 kg body weight as an active ingredient is 8 - 50 mg as an extract and 1 - 100 g as a herbal medicine have. When administered in the form of a conventional pill (1 g / ring), it can be administered about 1 to 20 times a day, three times a day.

The dosage may vary depending on the progress of the obesity, the route of administration, sex, age, body weight, purpose of use, etc., and may be increased or decreased according to expert judgment.

The above-mentioned pharmaceutical composition was administered to 60 men and women aged 20 to 60 years, which were judged to be obese, to be administered 10 times at a time, three times a day for about 90 days, and then evaluated for body weight, body fat, It was found that significant weight, body fat, and waist circumference reduction effect can be obtained from most people (see Test Example 1).

In addition, the pharmaceutical composition of the present invention can have remarkably excellent synergistic anti-obesity effect when the combination of the three herbs is used as an active ingredient, as compared with the case of using willow, acacia and forages.

It has also been found that the pharmaceutical composition is effective not only in anti-obesity effect, but also in constipation and indigestion. Therefore, the pharmaceutical composition is preferable because it can exhibit constipation treatment or preventive effect and digestion promoting effect at the same time as it can obtain various effects at the same time in addition to the anti-obesity effect.

In another aspect of the present invention,

A pulverizing step to crush willow, acacia, and alum;

Adding a binding liquid to the obtained crude drug powder to prepare a ring form;

And drying the manufactured ring, according to an aspect of the present invention.

The details of the method for preparing a pharmaceutical composition for the treatment or prevention of obesity may be applied to the pharmaceutical composition for treating or preventing obesity according to one aspect of the present invention.

The binding liquid may be any binding liquid which can be used for the preparation of the pills, for example, arabic rubber powder, tragacanthar powder, syrup / glycerin (1: 1), rubber / glucose solution (gum arabic powder 20, Glucose 60, water 50), barley, gelatin solution, carboxymethyl cellulose (CMC) solution, gum arabic, tragacanth, and the like.

Optionally, excipients, disintegrants, or combinations thereof may be further added with the binder for the production of the pellets. The excipient may be any excipient that can be used for the manufacture of the pill, such as glucose, lactose, pre-classified, herbal powder and herbal extracts, oil-based materials, and inorganic materials. The disintegrant can be any disintegrant that can be used for the production of the pills, such as laminaria, agar, medicinal yeast, and the like.

The step of drying the poured ring can be carried out according to a conventional method of drying the pills, and the drying is naturally dried in a shade at room temperature.

In another aspect of the present invention,

And a composition for improving or preventing obesity, which comprises willow, acacia, and allium as an active ingredient.

The details of the food composition may be applied to the pharmaceutical composition according to one aspect of the present invention, except that the pharmaceutical composition is a food.

The dose of the food composition is not particularly limited, but it is optionally administered orally divided into several times so that a total daily dose of 8 to 50 mg as an extract and 1 to 100 g as a medicament based on a 60 kg body weight as an active ingredient . As a typical form of pills, about 1 to 20 pills can be administered at a time, three times a day. The dose may vary depending on the progress of obesity, sex, age, weight, purpose of use (prevention or improvement, hair growth), and may be appropriately added or subtracted.

The food composition may be used as a health functional food. "Health functional food" refers to foods prepared and processed using raw materials or ingredients having useful functions in the human body pursuant to Law No. 6727 on Health Functional Foods, and the term "functional" It is intended to take nutrients for the purpose of controlling nutrients and obtaining effects that are useful for health use such as physiological action.

The above food composition may contain conventional food additives. Unless otherwise specified, the suitability of the food additive as a "food additive" shall be determined by the Food and Drug Administration in accordance with the General Regulations of the Food Additives Ordinance and the General Test Methods, And standards.

Examples of the substances described in the above-mentioned "Food Additive Code" include natural compounds such as ketones, chemical compounds such as glycine, potassium citrate, nicotinic acid and cinnamic acid, persimmon extracts, licorice extract, crystalline cellulose, high- - Mixed preparations such as a sodium glutamate preparation, a noodle-added alkaline agent, a preservative preparation, a tar coloring agent and the like.

The health functional food may be prepared by conventional formulations such as powders, sausages, breads, chocolates, candies, and the like, such as powders, granules, tablets, pills, capsules, suspensions, emulsions, syrups, , Beverages, tea, drinks, alcoholic beverages and vitamin complexes, such as, for example, beverages, snacks, snacks, confectionery, pizza, ramen, other noodles, gums, jellies, ice creams, . A pharmaceutically acceptable carrier or additive may be used for the formulation of the health functional food, and any carrier or additive known to be usable in the art for the preparation of the formulation to be produced may be used.

In one embodiment, the health functional food is a pill.

As the above-mentioned additives, there can be used various nutrients, vitamins, electrolytes, flavors, colorants, pectic acids and salts thereof, alginic acid and its salts, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, Carbonating agents, and the like. In addition, it may contain natural fruit juice, fruit juice beverage and flesh for the production of vegetable beverages. These additive components may be used independently or in combination, and the proportion of the additive is not critical, but may be selected in the range of 0.01 to 0.1 parts by weight per 100 parts by weight of the composition for health functional foods.

The beverage may further contain ingredients other than the above-mentioned active ingredients, and may further contain various flavors or natural carbohydrates commonly used in beverages. Examples of the natural carbohydrate include conventional sugars such as monosaccharides such as glucose and fructose; disaccharides such as maltose and sucrose; polysaccharides such as dextrin and cyclodextrin; and sugars such as xylitol, sorbitol, erythritol, Of sugar alcohols may be contained. In addition, as a flavoring agent, a natural flavoring agent (e.g., tau Martin, stevia extract, etc.) and a synthetic flavoring agent (e.g., saccharin, aspartame, etc.) may be contained. The ratio of the natural carbohydrate is preferably about 1 to 20 g, preferably about 5 to 12 g per 100 mL of beverage.

The food composition is effective not only for improving or preventing obesity but also for constipation and indigestion. Therefore, the food composition has an advantage of being able to exhibit various effects, such as improving or preventing constipation and promoting digestion, in addition to improving or preventing obesity.

In another aspect of the present invention,

A pulverizing step of pulverizing sesame, pine nut, garlic, and hemp;

Adding a binding liquid to the obtained crude drug powder to prepare a ring form;

And drying the manufactured ring. The present invention also provides a method of producing a food composition for improving or preventing obesity according to one aspect of the present invention.

The details of the method of manufacturing the food composition for improving or preventing obesity may be applied to the description of the composition for improving or preventing obesity according to one aspect of the present invention.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, these embodiments are provided to aid understanding of the present invention, and the scope of the present invention is not limited thereto in any sense.

Example 1: Preparation of a pill (1)

The leaves of willow, acacia, and forsythia were selected from each raw material, cleaned, shade shade, and powdered.

Thereafter, 1 kg of the willow powder, 2 kg of acacia powder, and 3 kg of foraging powder were mixed. Then, 10 parts by weight of a 10 wt% aqueous solution of carboxymethylcellulose sodium (CMC-Na) was mixed with 100 parts by weight of the powder mixture to prepare a crude drug mixture. A ring form was prepared from the mixture (1 g / ring) and the resulting ring was sufficiently dried at room temperature in the shade to complete the ring.

Example 2: Preparation of a pill (2)

In Example 1, a ring was completed in the same manner as in Example 1, except that 1 kg of willow powder, 2 kg of acacia powder, and 2 kg of foraging powder were mixed.

Example 3: Preparation of a pill (3)

In Example 1, a ring was completed in the same manner as in Example 1, except that 1 kg of willow powder, 3 kg of acacia powder, and 2 kg of foraging powder were mixed.

Comparative Example 1: Preparation of a pellet (4)

In Example 1, the ring was completed in the same manner as in Example 1, except that only 6 kg of willow powder was mixed instead of three herbal ingredients.

Comparative Example 2: Production of a pellet (5)

In Example 1, the ring was completed in the same manner as in Example 1, except that only 6 kg of acacia powder was mixed in place of the combination of three herbal ingredients.

Comparative Example 3: Preparation of pills (6)

In Example 1, the ring was completed in the same manner as in Example 1, except that only 6 kg of the tofu powder was mixed instead of the three herbal ingredients combinations.

Experimental Example 1: Anti-obesity effect test (1)

The obese people were administered the pill of Example 1, and the body weight change and the body fat were measured before and after the administration, and the weight control and the anti-obesity effect were confirmed.

Sixty men and women aged 20-60 years who agreed to this study were tested. Subjects were selected to have a body mass index (BMI) of 23 or more or a circumference of 90 cm for men and 80 cm or more for women.

Ten patients were randomly assigned to each test group, 10 times at a time, and three times a day for about 60 days. Diets should be eaten as usual, but unusual binge eating and bingeing are prohibited.

Body weight, body fat, and waist circumference were measured before and after administration for 60 days, respectively, and evaluation scores were assigned according to the following criteria.

According to the results, in Examples 1 to 3, most of the subjects showed significantly superior body weight, body fat, and waist circumference reduction effects, and significantly superior to the administration groups of Comparative Examples 1 to 3.

Claims (16)

A method for treating or preventing obesity, which comprises willow, acacia, and foraging as an active ingredient. The pharmaceutical composition according to claim 1, wherein 1 to 3 parts by weight of acacia and 1 to 3 parts by weight of forages are contained relative to 1 part by weight of willow. The pharmaceutical composition according to claim 1, which contains the extracts of willow, acacia, and forages. The pharmaceutical composition according to claim 3, wherein the extract is an extract of water, a lower alcohol having 1 to 3 carbon atoms, or a mixed solvent thereof. The pharmaceutical composition according to claim 1, which contains the willow, acacia, and powder of forsythia. 2. The pharmaceutical composition according to claim 1, which is orally administered. The pharmaceutical composition according to claim 1, which is an acid, a granule, a tablet, a capsule, a liquid, or a pill. A pulverizing step of grinding willow, acacia, and foraging;
Adding a binding liquid to the obtained crude drug powder to prepare a ring form; And
And drying the produced ring.
A method for the manufacture of a pharmaceutical composition for treating or preventing obesity according to any one of claims 1, 2, and 5 to 7. A method for improving or preventing obesity, which comprises willow, acacia, and forage as an active ingredient. The food composition according to claim 9, which comprises 1 to 3 parts by weight of acacia and 1 to 3 parts by weight of tofu relative to 1 part by weight of willow. 10. The food composition according to claim 9, which contains extracts of willow, acacia, and forsythia. 12. The food composition according to claim 11, wherein the extract is an extract of water, a lower alcohol having 1 to 3 carbon atoms, or a mixed solvent thereof. The food composition according to claim 9, which contains the willow, acacia, and powder of forsythia. 14. The food composition according to any one of claims 9 to 13, wherein the food is a health functional food. 15. The food composition according to claim 14, wherein the health functional food is a powder, a granule, a tablet, a capsule, a liquid, or a pill. A pulverizing step of grinding willow, acacia, and foraging;
Adding a binding liquid to the obtained crude drug powder to prepare a ring form; And
9. A method for the manufacture of a food composition for improving or preventing obesity according to any one of claims 9, 10, and 13 to 15, comprising drying the prepared ring.