JPWO2021087476A5 - - Google Patents

Description

In the claims and specification, "comprising", "containing", "carrying", "having", "accommodating", "accompanying", "holding" , "consisting of" and similar transitional phrases should be construed to mean open-ended, ie, including but not limited to. The only transitional phrases “consisting of” and “consisting essentially of” are closed or semi-closed transitional phrases, respectively, as described in Section 2111.03 of the United States Patent Office Manual of Patent Examination Procedures. .
In addition, some embodiments of the present invention are shown below.
[Aspect 1]
A biomedical packaging system comprising:
a first chamber configured to hold a liquid nutrient medium and a bioartificial organ (BAO);
a second chamber disposed adjacent to the first compartment and configured to be substantially liquid-free;
a baffle including a port and configured to separate the first chamber and the second chamber;
A biomedical packaging system comprising:
[Aspect 2]
The system of aspect 1, wherein the second chamber includes a flange.
[Aspect 3]
3. A system according to aspect 1 or 2, wherein each chamber includes a wall.
[Aspect 4]
4. The system of aspect 3, wherein the first chamber wall is integral with the second chamber wall.
[Aspect 5]
5. The system of any of aspects 1-4, wherein a wall of the second chamber includes a stepped edge configured to retain or support a perimeter of the baffle.
[Aspect 6]
5. The system of any of aspects 1-4, wherein a wall of the second chamber includes a recess configured to retain or support a perimeter of the baffle.
[Aspect 7]
at least one of a periphery of the baffle and an inner periphery of the first chamber wall and/or the second chamber wall to seal the baffle periphery with the first chamber wall and/or the second chamber wall; 7. A system according to any one of embodiments 1 to 6, comprising a material configured.
[Aspect 8]
8. The system of any of aspects 1-7, wherein the second chamber is sealed with an impermeable membrane directly above or above the flange.
[Aspect 9]
9. The system of any of aspects 1-8, wherein the port is centrally located on the baffle.
[Aspect 10]
10. The system according to any of aspects 1-9, wherein the port is closed via at least one closure system.
[Aspect 11]
11. The system according to any one of aspects 1-10, wherein the baffle is configured with a slope.
[Aspect 12]
12. The system of any of aspects 1-11, wherein a slope is formed from an edge of the baffle to a center of the baffle.
[Aspect 13]
13. The system according to aspect 11 or 12, wherein the slope is between about 5 degrees and 30 degrees.
[Aspect 14]
14. The system of any of aspects 1-13, wherein the baffle is configured to vent gas during filling of the first chamber with liquid.
[Aspect 15]
15. The system of any of aspects 1-14, wherein the baffle is sealed to at least one of the first chamber and the second chamber.
[Aspect 16]
16. The system of aspect 15, wherein the sealing comprises ultrasonic welding.
[Aspect 17]
11. The system of aspect 10, wherein the closure system is configured using a threaded fit.
[Aspect 18]
11. The system of aspect 10, wherein the closure system includes a spigot.
[Aspect 19]
11. The system of aspect 10, wherein the closure system includes a spigot and a corresponding receptacle.
[Aspect 20]
20. The system of aspect 19, wherein the stopper and the receptacle are coupled together via a threaded engagement.
[Aspect 21]
20. The system of aspect 19, wherein the stopper and the receptacle include a luer taper.
[Aspect 22]
22. The system according to any of aspects 19-21, wherein the bung and the receptacle are configured or additionally configured to frictionally fit each other.
[Aspect 23]
23. The system according to any of aspects 10-22, wherein the closure system further comprises a seal that is capable of tapering.
[Aspect 24]
20. The system according to aspects 18-19, further comprising at least one O-ring disposed on the bung.
[Aspect 25]
25. The system of aspect 24, wherein the receptacle includes at least one corresponding recess configured to receive at least one O-ring.
[Aspect 26]
26. The system of any of aspects 19-25, wherein at least one of the stopper and receptacle includes an interface for supporting at least one of a medical device or a BAO.
[Aspect 27]
27. The system of any of aspects 19-26, wherein the baffle port includes a neck configured to receive at least one of the bung and the receptacle.
[Aspect 28]
28. A system according to aspect 27, wherein the spigot and at least one of the receptacles and the neck portion include corresponding connection means configured to connect the at least one of the spigot and the receptacle and the neck portion.
[Aspect 29]
29. The system according to any of embodiments 1-28, further comprising a storage container.
[Aspect 30]
At least a portion of one or more of the first chamber, the second chamber, the baffle, and the storage container is transparent, medical grade, durable, non-degradable, susceptible to high temperatures, high pH and/or high humidity. 30. The system according to any one of aspects 1-29, wherein the system is made of a material having at least one of the following properties: there is substantially no release of excipient over time during exposure to the excipient.
[Aspect 31]
at least a portion of one or more of the first chamber, the second chamber, the baffle, and the storage vessel is made of at least one of polycarbonate, polyester resin, polyether amide, polyethylene terephthalate, and polyethylene co-glycol terephthalate. 30. A system according to any of embodiments 1-29, manufactured.
[Aspect 32]
A system, apparatus, apparatus, or method according to any of the disclosed embodiments.

Claims (15)

a first chamber (102) configured to hold a liquid nutrient medium and a bioartificial organ (BAO);
a second chamber (104) disposed adjacent to the first chamber and configured to be substantially liquid-free;
A biomedical packaging system (100) comprising an assembly comprising:
a baffle (106) including a port (108) and configured to separate the first chamber (102) and the second chamber (104 ) ;
A biomedical packaging system comprising : The system of claim 1, wherein the second chamber includes a flange (110) . 3. A system according to claim 1 or 2, wherein each chamber includes a wall (112), (114) . 4. The system of claim 3, wherein a wall (112) of the first chamber (102 ) is integral with a wall (114) of the second chamber (104) . The wall (114 ) of the second chamber (104 ) includes a stepped edge ( 116) configured to retain or support a perimeter (106a) of the baffle (106). 4. The system according to any one of 4. 5. The method of claim 1, wherein the wall (114 ) of the second chamber (104) includes a recess (114b) configured to retain or support the perimeter (106a) of the baffle (106). The system described in any one of these. At least one of the periphery (106a) of the baffle (106) and the inner periphery (112a, 114a) of the wall (112 ) of the first chamber (102 ) and/or the wall ( 114) of the second chamber ( 104) , comprising a material configured to seal the perimeter (106a) of said baffle (106 ) with a wall (112) of a first chamber (102 ) and/or a wall ( 114 ) of a second chamber (104 ). The system according to any one of items 1 to 6. System according to any one of claims 2 to 7, wherein the second chamber (104 ) is sealed with an impermeable membrane directly above or above the flange (110 ) . System according to any one of the preceding claims, wherein the port (108) is centrally located on the baffle (106) . System according to any one of the preceding claims, wherein the port (108) is closed via at least one closure system (120) . System according to any of the preceding claims, wherein the baffle (106) is configured with a slope. System according to any one of the preceding claims, wherein a slope is formed from the edge of the baffle (106 ) to the center of the baffle (106). 13. The system of claim 11 or 12, wherein the slope is between about 5 degrees and 30 degrees. A system according to any preceding claim, wherein the baffle (106) is configured to vent gas during filling of the first chamber (102) with liquid. A system according to any preceding claim, wherein the baffle (106) is sealed to at least one of the first chamber (102) and the second chamber (104) .