JPH06254166A - Injector - Google Patents

Abstract

PURPOSE:To carry out the pouring of medicine and compounding in a short time in a simple manner without generating contamination. CONSTITUTION:An injector 100 is constituted of an injector body 1 and a container 10. The injector body 1 is equipped with an outer cylinder 2, needle pipe 3 installed at the bottom part 2a of the outer cylinder 2, and a tubular body 4 which is installed in the outer cylinder 2 and communicates with the inside of the needle pipe 3, and a connection part 6 is formed on the rear edge side of the tubular body 4. The container 10 is constituted of a container body 11 and a gasket 12 which slides in liquidtight form along the inner surface of the container body 11, and inside the gasket 12, an engagement part 14 consisting of a recessed part is formed. Further inside the engagement part 14, a needle pipe 16 and an enclosed member 18 are erection-installed. When the connection part 16 and the engagement part 14 are screwed, the needle pipe 16 sticks the enclosed member 18 and a film 7 and inserted into a spread diameter part 42.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a syringe, and more particularly to a syringe used for compounding a liquid medicine.

[0002]

2. Description of the Related Art Prior to administering an infusion solution to a patient, the infusion solution filled in an infusion bag is optionally mixed with a drug such as vitamins, heparin, and antibiotics. There is.

In order to mix such drugs, first, the puncture needle of the syringe is inserted into the elastic stopper of the infusion bag, the plunger is pulled to collect the infusion solution in the infusion bag, and then the collected infusion solution is collected. Transfer to a container containing the drug to be blended (powdered), dissolve and mix the drug in the container, then again suck and sample the drug mixture with the syringe,
This is performed by inserting a puncture needle into the elastic stopper of the infusion bag and pushing the plunger to inject the drug mixture into the infusion bag.

However, the formulation of such a chemical solution is
It has the disadvantages that the operating procedure is complicated and that the time required for compounding is long. In particular, a rapid response is indispensable for an emergency patient, but it is disadvantageous when a drug solution to be administered to such a patient is mixed.

Further, most of the mixing operation of the above-mentioned chemicals, particularly the dissolution and mixing of the chemicals, is carried out in the state of being in contact with the atmosphere, so that there is a risk of bacterial contamination and contamination of foreign substances.

Further, when a plurality of kinds of drugs are mixed,
Since the above-mentioned blending operation is repeated, the above-mentioned drawback becomes more remarkable.

[0007]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a syringe capable of injecting and blending a drug without contamination and in a short time by a simple operation.

[0008]

The above object is achieved by the present invention described in (1) below. Also, the following (2)-
It is preferably (17).

(1) An inner surface of the container body having a syringe body having a tube body having a connecting portion on the rear end side thereof, a container body having a bottomed cylindrical shape, and a locking portion for locking the connecting portion. Having a gasket capable of sliding in a liquid-tight manner along the needle and at least one container constituted by a needle tube installed in the gasket, and inserting the needle tube into an inner cavity on the rear end side of the tube body. In addition, by moving the container body in the axial direction relative to the syringe body and sliding the gasket in the container body while the connecting portion and the locking portion are locked. A syringe which discharges at least the substance in the container through the tube.

(2) The syringe according to (1), wherein the syringe body has another needle tube on the distal end side of the tubular body.

(3) The syringe according to (2) above, which has a cap for enclosing the other needle tube.

(4) The syringe body is liquid-tightly fixed to a flexible bag so that the lumen of the tubular body and the inside of the bag can communicate with each other. Syringe.

(5) The syringe according to any one of the above (1) to (4), wherein the syringe body has an outer cylinder into which the container can be inserted, on the outer periphery of the tubular body.

(6) The syringe according to the above (5), which has a film for sealing the opening on the rear end side of the outer cylinder.

(7) The syringe according to any one of (1) to (6), wherein the syringe main body has a sealing means for sealing the lumen of the tubular body so as to be opened.

(8) The sealing means is a film provided on the rear end side of the tubular body, and is installed in the gasket in a state where the connecting portion and the engaging portion are engaged with each other. The syringe according to (7) above, wherein the needle tube is configured to penetrate the membrane.

(9) The connecting portion and the locking portion are
The syringe according to any one of (1) to (8) above, which is configured to lock and unlock these by relatively rotating them.

(10) The syringe according to any one of the above (1) to (9), wherein the gasket can be reciprocated in the container body by the engagement of the connecting portion and the engaging portion.

(11) The syringe according to any one of the above (1) to (10), which has a regulation means for regulating the axial position of the gasket with respect to the container body.

(12) The syringe according to any one of the above (1) to (11), which encloses a needle tube installed in the gasket and has an encapsulating member which can be pierced by the needle tube.

(13) The syringe according to any one of the above (1) to (12), which has a film for sealing the opening of the container body.

(14) The syringe according to any one of the above (1) to (13), wherein the substance in the container is a solid or liquid drug.

(15) The syringe according to any one of the above (1) to (14), wherein the inside of the container is in a depressurized state.

(16) The syringe according to any one of (1) to (15), wherein a holding member is attached to the bottom of the container body.

(17) The syringe according to any one of the above (1) to (16), wherein a plurality of containers each containing a drug having a different component are exchanged for use.

[0026]

DETAILED DESCRIPTION OF THE INVENTION The syringe of the present invention will be described below in detail with reference to the preferred embodiments shown in the accompanying drawings.

The syringe 100 of the present invention comprises a syringe body 1
And the container 10. Hereinafter, these configurations will be sequentially described.

FIG. 1 is a longitudinal sectional view showing a structural example of a syringe body according to the present invention, and FIG. 2 is a view taken along the line II-II in FIG. For convenience of explanation, the upper side in FIG. 1 is referred to as the front end and the lower side is referred to as the rear end. As shown in FIG. 1, the syringe body 1 has a cylindrical outer cylinder 2 having a bottom portion 2a on the distal end side.
A needle tube 3 protruding from the bottom portion 2a is installed at the tip of the.

The needle tube 3 in the illustrated configuration example is, for example,
It is a bottle needle that is pierced by an elastic stopper 106 that seals the opening of the infusion bag 105 (see FIGS. 4 and 5). A hole 31 is formed. The needle tube 3 is not limited to the bottle needle as shown, but may be a normal metal puncture needle or the like.

A tube body 4 is installed in the outer cylinder 2 substantially concentrically with the outer cylinder 2. In this case, the length of the tube body 4 is the outer cylinder 2
Is shorter than the length, that is, the rear end of the tube body 4 is located inside the outer cylinder 2 with respect to the rear end opening 2b of the outer cylinder 2.

The inner cavity 41 of the tubular body 4 communicates with the inner cavity of the needle tube 3 on the distal end side. In the illustrated example, the tube body 4 is integrally formed with the needle tube 3, and the bottom portion 2 a of the outer cylinder 2 is formed.
It is preferably fixed by fusion or adhesion.

On the rear end side of the tube body 4, an enlarged diameter portion 42 in which the diameter of the inner cavity 41 is enlarged is formed. This expanded portion 42
Is the one into which the tip of the needle tube 16 described later is inserted (see FIG. 4).
Larger than the outer diameter of.

A container 1 to be described later is provided on the outer peripheral portion of the expanded diameter portion 42.
The connecting portion 6 that is connected (screwed) to the locking portion 14 formed on the gasket 12 of No. 0 is formed. This connecting portion 6 is
As shown in FIG. 1, a male screw is formed on the outer peripheral portion of the convex portion having a circular cross section. The connecting portion 6
May be integrally formed with the tubular body 4 or may be a separate member joined.

Further, inside the connecting portion 6, a diameter-expanded portion 42 is provided as a sealing means for sealing the inner cavity 41 of the tubular body 4 so that it can be opened.
A film 7 is stretched to seal the rear end opening. This film 7
Can be pierced by a needle tube 16 described later, and for example, various rubber materials such as natural rubber, isoprene rubber, butadiene rubber, silicone rubber, and latex rubber,
Polyvinyl chloride, polyethylene, polypropylene, ionomer, polyester such as polyethylene terephthalate, polystyrene, poly- (4-methylpentene-
1), a single layer made of various resins such as polyamide or a metal foil such as an aluminum foil, or a laminated body in which two or more layers of these are laminated.

Between the rear end surface of the connecting portion 6 and the membrane 7, when a needle tube 16 described later is inserted into the membrane 7, the needle tube 16 is moved toward the base (rear end) side and deformed into a bellows shape. A space 5 for accommodating and holding the compressed envelope member 18 is formed.

Examples of the constituent materials of the outer cylinder 2, the needle tube 3, the tubular body 4 and the connecting portion 6 are, for example, polyvinyl chloride, polyethylene, polypropylene, polystyrene, poly- (4-methylpentene-1), polycarbonate,
Acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyester such as polyethylene terephthalate, butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6.6, nylon 6.1)
0, various resins such as nylon 12) or ceramics such as alumina. Among them, polypropylene, polyester,
Resins such as poly- (4-methylpentene-1) are preferred. It is preferable that these materials are substantially transparent in order to secure the internal visibility.

A plate-shaped flange 2c is formed integrally with the outer cylinder 2 around the rear end opening 2b of the outer cylinder 2. When inserting the container 10 to be described later into the outer cylinder 2 or when pulling out from the outer cylinder 2, the syringe body 1 is fixed by applying a finger to the flange 2c.

In the syringe body 1 when not in use,
A film 8 for sealing the rear end opening 2b of the outer cylinder 2 preferably in an airtight manner is attached to the rear end surface of the flange 2c. As a result, the inside of the syringe body 1 is prevented from being contaminated and sterility is maintained. The film 8 is peeled off when the syringe body 1 is used. At this time, a tab 81 is formed at the edge of the film 8 so that the film 8 can be easily peeled off.

The film 8 is a single layer made of polyester such as polyethylene, polypropylene, ionomer, polyethylene terephthalate, resin such as polystyrene, poly- (4-methylpentene-1) and polyamide, or metal foil such as aluminum foil. Or a laminate obtained by laminating two or more layers of these. Since the laminated body of the metal foil and the resin layer has a low gas permeability, the use of such a film as the film 8 improves the airtightness in the outer cylinder 2 and effectively prevents the invasion of bacteria and the like. It is preferable because it is possible.

A cap 9 for enclosing the needle tube 3 is attached to the distal end side of the outer cylinder 2. The cap 9 has functions of preventing danger and preventing contamination of the needle tube 3.

In the syringe of the present invention, unlike the syringe body 1 shown, the length of the tube 4 is longer than the length of the outer cylinder 2, that is, the rear end of the tube 4 is the rear end of the outer cylinder 2. Opening 2
It may be configured so as to project outside the outer cylinder 2 from b. The syringe body 1 may not have the outer cylinder 2.

Further, in the syringe of the present invention, the films 8 and 19 and the cap 9 may be provided as needed, and these need not be present.

FIG. 3 is a vertical cross-sectional view showing a structural example of the container according to the present invention. For convenience of explanation, the upper side in FIG. 3 is referred to as the front end and the lower side is referred to as the rear end.

As shown in FIG. 3, the container 10 is mainly composed of a bottomed cylindrical container body 11 having an open front end, and a gasket 12 that can slide in a liquid-tight manner along the inner surface of the container body 11. It is composed of.

The container body 11 is made of the same resin material or glass material as that of the outer cylinder 2 and the like, and is preferably substantially transparent in order to ensure the internal visibility.

The outer diameter of the container body 11 is smaller than the inner diameter of the outer cylinder 2, and the inner diameter of the container body 11 is the same as that of the tubular body 4.
And larger than the connecting portion 6. Thereby, the container body 11
Can be inserted to the inner part of the outer cylinder 2.

Further, the total length of the container body 11 is preferably substantially equal to or longer than the total length of the outer cylinder 2,
In particular, when the container body 11 is inserted to the innermost part of the outer cylinder 2 so that the chemical liquid in the container 10 can be discharged as much as possible regardless of the posture of the container 10, the rear end surface 122 of the gasket 12 is Inner surface 113 of the bottom of the container body 11
It is preferable that the contact is made with the above.

The inner surface of the container body 11 and the tip opening 1
Predetermined distance from 11 to the rear end side (for example, about 5 to 20 mm)
A ring-shaped protrusion 112 is formed along the inner circumference of the container body 11 at the separated positions. This protrusion 112 is
It is a restricting means for locking the gasket 12 on a rear end surface 122, which will be described later, and restricting the axial position of the gasket 12 with respect to the container body 11. That is, when the pressure inside the container 10 is reduced, the gasket 12 is prevented from moving to the rear end side of the container body 11 due to the pressure difference from the atmospheric pressure, and the connecting portion 6 and the locking portion 14 are connected. When (screw)
A role of preventing the gasket 12 from being pressed by the piercing resistance of the needle tube 16 or the like and moving to the rear end side of the container body 11.
Alternatively, when moving the gasket 12 to the tip side of the container body 11 or when removing the container 10 from the syringe body 1,
It plays a role of preventing the gasket 12 from easily coming off from the container body 11.

In the unused container 10, the container body 1
A film 19 that seals the tip opening 111, preferably in an airtight manner, is attached to the tip of 1. As a result, the inside of the locking portion 14 of the gasket 12 is prevented from being contaminated and the sterility is maintained. Further, in the case where the inside of the container 10 is kept in a depressurized state when not in use, by using the gas impermeable film 19, the airtightness of the tip opening 111 is obtained even when the encapsulating member 18 is not provided. It is advantageous to maintain the reduced pressure state. As the film 19, the same film as the film 8 can be used.

The gasket 12 is made of various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber and silicone rubber (particularly vulcanized), polyurethane type, polyester type, polyamide. It is a substantially columnar member made of an elastic material such as various elastomers such as olefin, olefin, and styrene, or a mixture thereof. The gasket 12 is not limited to the one made of the above material in its entirety, and may be made of at least the projection 13 and the encapsulating member 18 made of the above material.

On the tip side of the gasket 12, a locking portion 14
Are formed. The locking portion 14 is composed of a concave portion having a circular cross section into which the connecting portion 6 can be fitted, and an internal thread 15 which can be screwed into the male screw 61 on the outer periphery of the connecting portion 6 is formed on the inner peripheral surface thereof. Has been done.

Further, the needle tube 1 is provided at the center of the locking portion 14.
6 are erected. The needle tube 16 has a collar 16 at the rear end.
2 and is fixed by embedding the collar portion 162 in the gasket 12 on the rear end side of the bottom surface 141 of the locking portion 14.

On the side portion near the tip of the needle tube 16, the needle tube 1
A plurality of side holes 161 that communicate with the inner lumens of 6 are formed. The rear end of the inner lumen of the needle tube 16 is open to the space 17. Thereby, when the needle tube 16 penetrates the covering member 18, the container 1 on the rear end side of the locking portion 14 and the gasket 12 is formed.
The interior of 0 communicates with the needle tube 16.

The outer diameter of the needle tube 16 is not particularly limited,
It is preferably about 0.1 to 5 mm, particularly about 0.5 to 2 mm.

As the constituent material of the needle tube 16 and the collar portion 162, the same material as that of the needle tube 3, in particular, a hard resin or a metal material such as stainless steel, titanium or aluminum can be used. Further, the needle tube 16 is not limited to the bottle needle type shown in the drawing, but may be a normal metal puncture needle or the like.

Around the needle tube 16, a covering member 18 for covering at least the tip of the needle tube 16 is installed. The encapsulating member 18 has a role of preventing contamination of the needle tube 16 when not in use and a role of preventing liquid leakage from the side hole 161.

The encapsulating member 18 is made of a film made of the same material as the gasket 12, and the needle tube 1
A tip which can be easily pierced by the tip of 6 is preferably used. Further, the rear end of the encapsulating member 18 is the bottom surface 1 of the locking portion 14.
Preferably, it is joined or integrated with 41.

The tip of the needle tube 16 and the wrapping member 18
It is preferable that the tip of the above does not protrude to the tip side from the tip surface 121 of the gasket 12.

On the outer peripheral surface 123 of the gasket 12, a plurality of ring-shaped protrusions 13 are formed over the entire circumference.
In the illustrated configuration, ring-shaped protrusions 13 are formed on the outer peripheral surface 123 near the front and rear ends of the gasket 12, respectively. When the gasket 12 slides, the protrusion 13 is in close contact with the inner peripheral surface of the container body 11 to maintain airtightness and also has a function of maintaining appropriate slidability.

In such a container 10, the container body 11 also has a function as a plunger for moving the gasket 12 with respect to the container body 11, and the gasket 12 seals the container body 11 in a sealed manner. It has both the function as a stop member and the function of obtaining communication / interruption with the inside of the tubular body 4. Therefore, the container 10 can be composed only of the container body 11 and the gasket 12 which are the minimum necessary members, and the number of parts is small as compared with the conventional container having a rubber stopper and a plunger rod exclusively for piercing a needle tube, The configuration is extremely simple and the operation is easy.

In the inside of the gasket 12, at least one vent hole (one end is opened to the space 17 or the rear end face 122 on the rear end side of the collar portion 162 and the other end is opened to the outer peripheral face 123 of the gasket 12 ( (Not shown) may be formed. The vent holes are for discharging water vapor when the drug contained in the container 10 is freeze-dried. Therefore, this vent hole is provided as needed depending on the form of the drug contained in the container 10.

The inside of such a container 10 may be empty when not in use, but normally, it is preferable that a predetermined amount of the drug is put in advance. The drug may be liquid or solid (including semi-solid). A typical example of a solid drug is a tablet or a powder (granular) drug 109 as shown in the figure, and in particular, a powdered drug 109 is easily dissolved or dispersed by a liquid introduced into the container 10. Those are preferable. Such powdery medicine 109 can be easily obtained by, for example, freeze-drying.

When a solid drug is put in the container 10, the inside of the container 10 may be in a state substantially equal to the atmospheric pressure, but in a reduced pressure state (for example, 0.1 to 760).
mmHg) is preferred.

The drug 109 enclosed in one container 10 usually consists of a single active ingredient, but it may be a compounding agent containing two or more active ingredients.

Specific examples of the drug 109 include vitamin preparations (multivitamin preparations), various amino acids, antithrombotic agents such as heparin, insulin, antibiotics, antitumor agents, analgesics, cardiotonics, intravenous anesthetics, anti-thrombotic agents. Parkinson's agents, ulcer therapeutic agents, corticosteroids, arrhythmic agents, correcting electrolytes and the like can be mentioned.

In the present invention, in order to prevent the solid drug, which cannot be completely dissolved or dispersed in the container 10, from being discharged from the side hole 31 of the needle tube 3, the lumen 41 of the tube body 4 and the needle tube 16 are prevented. A filter (not shown) may be provided in the flow path such as the lumen or in the space 17 of the gasket 12 to prevent the passage of the solid drug. Examples of this filter include a membrane filter, a mesh,
Woven cloth, non-woven cloth and the like can be mentioned.

At least the inside of the syringe body 1 and the container 10 are preferably subjected to sterilization treatment such as high-pressure steam sterilization, gas sterilization or radiation sterilization in advance.

Next, an example of how to use the syringe 100 of the present invention will be described with reference to FIGS. 4 and 5.

A. How to use when the pressure inside the container 10 is reduced in advance

[1] First, as shown in FIG. 4, the cap 9 is removed, and the needle tube 3 of the syringe 100 is attached to the drug 109.
Is pierced through the elastic plug 106 that seals the opening of the infusion bag 105 to be blended.

[2] Next, the films 8 and 19 are peeled off, and the container 10 is inserted into the outer cylinder 2 from the front end side through the rear end opening 2b of the outer cylinder 2 so that the syringe body 1 and the container 10 are opposed to each other. And the engaging portion 14 is screwed together. As a result of this screwing, the tip of the needle tube 16 causes the encapsulating member 1 to move.
8 is pierced through the tip portion, and further, the membrane 7 is pierced, and the side hole 161
The needle tip portion including is inserted into the expanded diameter portion 42.

In this way, the interior of the container 10 and the inner cavity 41 of the tubular body 4 communicate with each other via the needle tube 16. However, since the interior of the container 10 has been depressurized in advance, the pressure difference from the atmospheric pressure causes The infusion solution 107 in the infusion bag 105 is, as shown by an arrow in FIG. 4, a side hole 31, an inner cavity of the needle tube 3, an inner cavity 41 of the tube body 4 and an enlarged diameter portion 42, an inner cavity and a space of the needle tube 16. 1
It is introduced into the container 10 through 7 sequentially.

It should be noted that the needle tube 16 is used as the encapsulating member 18 and the membrane 7.
Since the encapsulating member 18 does not cross the membrane 7 when the needle is pierced, the encapsulating member 18 is pushed toward the rear end side of the needle tube 16 and compressed and deformed into a bellows state, and in this state, the space 5 Stored and held inside.

[3] Next, the container 10 is shaken or vibrated to dissolve or disperse the drug 109 in the infusion solution introduced into the container 10, and the drug solution 1 containing the active ingredient of the drug 109.
08. In addition, as the chemical liquid 108, the medicine 10
9 solution, suspension (emulsion) and the like.

[4] Next, as shown in FIG. 5, the container 1
The rear end (bottom part) of 0 is pushed toward the front end, and the container body 11
Insert into the outer cylinder 2. Since the connecting portion 6 and the locking portion 14 are locked, only the container body 11 moves in the front end direction while the gasket 12 is connected to the rear end of the pipe body 4. As a result, the rear end of the gasket 12 and the container body 11
The volume of the portion surrounded by and decreases, and the liquid medicine 1 in the container 10
08 is the inner lumen of the needle tube 16, as indicated by the arrow in FIG.
The expanded portion 42 and the lumen 41 of the tubular body 4, the lumen and the side hole 31 of the needle tube 3 are sequentially injected into the infusion bag 105 and mixed into the infusion solution.

When the container body 11 is pushed and inserted into the outer cylinder 2, the inner surface of the outer cylinder 2 serves as a guide (guide surface) and does not rock or tilt.
Can be reliably moved in the axial direction of the tubular body 4.

[5] In the chemical liquid pouring operation of the above [4], even if the container body 11 is inserted into the outer cylinder 2 until the rear end surface 122 of the gasket 12 contacts the bottom inner surface 113 of the container body 11, The drug solution 10 in the body 4 or the needle tube 3
Since 8 remains, it is not possible to inject the entire amount of the medicinal solution 108 into the infusion bag 105 with one pushing operation of the container 10. Therefore, when the container body 11 is inserted into the outer cylinder 2 to a certain depth, the container body 11 is pulled to the rear end side, and the infusion solution 107 in the infusion bag 105 is introduced into the container 10 through the same route as described above. Then, the remaining chemical liquid 108 is diluted, and the container body 11 is pressed and inserted into the outer cylinder 2 again. By repeating such reciprocating movement of the container body 11 several times, the liquid medicine 10 can be used without waste.
5 can be dispensed, and an accurate amount of drug can be compounded.

When the gasket 12 slides, a predetermined resistance is applied when the protrusion 13 passes through the protrusion 112 of the container body 11, so that the gasket 12 is prevented from being accidentally pulled out from the container body 11. It

[6] When a medicine having different components is further mixed in the infusion bag 105, the needle tube 3 is inserted into the elastic stopper 106 of the medicine solution bag 105, and the container 10 is in the opposite direction to the syringe body 1. The container 10 is rotated by rotating the connector 6 and the engaging portion 14 to be unscrewed to remove the container 10 from the syringe body 1, and then the same container 10 containing a drug to be newly mixed is added to the above [2]. The syringe body 1 is set in the same manner as above, and thereafter, the same operations as [3] to [5] are performed. As described above, when a plurality of types of drugs having different components are mixed, a plurality of containers 10 in which the respective drugs are stored may be prepared, and these may be appropriately exchanged and used, so that the operation is extremely simple. The time required for compounding is also short. Further, in the case of blending such a drug, the chance of contact with the outside air is extremely small, and there is no fear of bacterial contamination or foreign substance contamination.

The used container 10 has a gasket 1 in order to reduce the residual liquid amount in the container 10 as much as possible.
2 is preferably removed from the syringe body 1 while the rear end surface 122 of the container 2 is in contact with or close to the bottom inner surface 113 of the container body 11.

When the connecting portion 6 and the engaging portion 14 are unscrewed, the needle tube 16 is pulled out from the membrane 7, but the encapsulating member 18, which has been compressed in a bellows shape, instantly returns to its original shape. Since the needle tube 16 is restored and encapsulates the tip of the needle tube 16, it is possible to prevent the liquid from leaking from the side hole 161 and scattering around.

B. Usage method when the pressure in the container 10 is almost equal to atmospheric pressure

First, the films 8 and 19 are peeled off, the container 10 is inserted into the outer cylinder 2 from the front end side through the rear end opening 2b of the outer cylinder 2, and the connecting portion 6 and the engaging portion 14 are formed in the same manner as described above. And are screwed together to position the needle tip portion including the side hole 161 of the needle tube 16 in the enlarged diameter portion 42.

Next, the container body 11 is pushed toward the front end so that the container body 11 is inserted into the outer cylinder 2 to reduce the volume of the portion surrounded by the rear end of the gasket 12 and the container body 11. .

Next, the cap 9 is removed, and the needle tube 3 is inserted into the elastic plug 106 of the infusion bag 105. Note that this operation may be performed before the insertion operation of the container body 11 into the outer cylinder 2.

Next, the container body 11 is pulled toward the rear end side, and the infusion solution 107 in the infusion bag 105 is introduced into the container 10 by the same route as described above. Then, the same operations as those in [3] to [6] are performed.

C. Usage method when liquid medicine is stored in the container 10 in advance

After performing the same operations as [1] and [2], the same operations as [4] to [6] are performed.

In the syringe of the present invention, the container 10 has the above A to
Whatever form of C can be used by appropriately exchanging them for the syringe body 1.

The above-mentioned drug formulation (injection)
Is not limited to the infusion bag 105, and may be performed, for example, for a bag that stores a liquid other than the infusion such as physiological saline or dialysate, blood, plasma, or the like. Furthermore, it can also be used for administration of a medicinal solution to a living body such as intravenous injection, intraarterial injection and subcutaneous injection.

FIG. 6 is a plan view showing another constitutional example of the container of the present invention, FIG. 7 is a vertical sectional view showing the constitution of the tip portion of the container 10B shown in FIG. 6, and FIG. 8 is a gasket of the container 10B. It is a longitudinal section showing composition at the time of movement. For convenience of description, the upper side in FIGS. 7 and 8 is referred to as the front end, and the lower side is referred to as the rear end.

The container 10B shown in these figures is the same as the container 10 except for the structure of the gasket and the restricting means for restricting the axial position of the gasket with respect to the container body 11.

In the container 10B, the protrusion 112 is not provided on the inner peripheral surface of the container body 11.

In the gasket 20 of the container 10B, a core material 21 made of, for example, the resin as described above is embedded in the center portion thereof. In this case, the tip end side of the core material 21 projects a predetermined length from the tip end surface of the gasket 20.

A locking portion 22 similar to the locking portion 14 is formed inside the core material 21. Locking part 2
A female screw 23 that can be screwed into the male screw 61 on the outer periphery of the connecting portion 6 is formed on the inner peripheral surface of the second member 2.

A needle tube 24 similar to the needle tube 16 provided upright from the bottom surface of the locking portion 22 is provided at the center of the locking portion 22. A plurality of side holes 241 communicating with the inner cavity of the needle tube 24 are formed in the side portion near the tip of the needle tube 24. The rear end of the inner cavity of the needle tube 24 is open to the space 25 in the gasket 20. As a result, the locking portion 22 and the inside of the container 10 on the rear end side of the gasket 20 communicate with each other via the needle tube 24.

Further, three fan-shaped small pieces 27 are formed at the tip of the core member 21 and extend radially from the center of the core member 21 at intervals of 120 °.

On the other hand, a ring-shaped locking member 28 is fixed to the tip of the container body 11 by fitting it to the tip edge portion 114 of the container body 11. As shown in FIG. 7, the body portion 211 of the core member 21 protruding from the gasket 20 is inserted into the inner opening of the locking member 28.

The inner opening of the locking member 28 is a portion whose diameter is substantially equal to or slightly larger than the outer diameter of the body portion 211 of the core member 21 (to correspond to the small piece 27,
3 places are formed at 120 ° intervals from the center).
It has a shape in which inner diameter enlarged portions 29 having an inner diameter larger than the diameter of a circle connecting the outermost circumferences of the respective small pieces 27 are alternately arranged along the circumferential direction. In this case, each inner diameter enlarging portion 29
Are arranged at intervals of 120 ° from the center, and their inner diameter and opening angle are larger than those of the small pieces 27.

In the state shown in FIGS. 6 and 7, the front end surface of the gasket 20 abuts on the rear end surface (the inner surface of the container) of the locking member 28, and each small piece 27 of the core 21 is locked by the locking member 28. Since it is locked in a portion between the adjacent inner diameter enlarged portions 29 and is in a so-called locked state, movement of the gasket 20 toward the front end side and the rear end side is restricted.

Further, the core member 21 is set to 60 with respect to the locking member 28.
When the small pieces 27 are rotated and superposed on the corresponding inner diameter enlarging portion 29, the three small pieces 27 pass through the inner diameter enlarging portion 29 at the same time, and the movement of the gasket 20 to the rear end side is restricted as shown in FIG. After the release, the gasket 20 can slide in the container body 11 toward the rear end side.

FIG. 9, FIG. 11 and FIG. 13 are vertical sectional views showing another example of the constitution of the container according to the present invention, and FIG.
And FIG. 12 are bottom views of the container shown in FIGS. 9 and 11, respectively.

All of the containers shown in these figures have ring-shaped ribs 11 on the outer periphery of the rear end (bottom) of the container body 11.
5 is formed, and has gripping members (container moving aids) 30A to 30C which are engaged with the ribs 115 and fixedly attached to the bottom of the container body 11. Hereinafter, they will be sequentially described.

Grasping member 30A shown in FIGS. 9 and 10.
Has an engaging portion 300 that engages with the rib 115, and a flange 301 formed on the opposite side of the engaging portion 300.

Gripping member 30B shown in FIGS. 11 and 12.
Has an engaging portion 300 that engages with the rib 115, and a flange 302 formed on the opposite side of the engaging portion 300,
The engaging portion 300 and the flange 302 are connected by a shaft 303.

The gripping member 30C shown in FIG.
5 has an engaging portion 300 that engages with the engaging portion 5, and a concave portion 304 suitable for gripping with a finger or the like is formed on the outer periphery on the side opposite to the engaging portion 300.

In such a container, the holding members 30A-3
Since the operation of moving the container with respect to the syringe main body is performed while grasping the flanges 301 and 302 of 0C or the concave portion 304 with a finger or the like, it is possible to easily and reliably perform the operation, particularly the operation of moving the container in the direction of pulling out the container from the syringe main body. You can In particular, it is effective when the length of the container body 11 is relatively short.

The shape and structure of the holding member are not limited to those shown in the drawings. Further, in the configuration examples shown in FIGS. 9 to 13, the container body 11 and the grip members 30A to 30C are configured as separate members, but they may be integrally formed.

FIG. 14, FIG. 15, FIG. 16 and FIG.
FIG. 3 is a vertical cross-sectional view showing another configuration example of the syringe body of the present invention. The syringe body 1B, 1 shown in these
C, 1D, and 1E do not have the needle tube 3 in the syringe body 1, and the inner cavity 41 of the tube body 4 and the inside of the bag 103 communicate with the bag 103 in which the syringe body itself has flexibility. It is firmly fixed in a liquid-tight manner.
Hereinafter, they will be sequentially described. For convenience of explanation, the upper side in FIGS. 14 to 17 is referred to as the front end and the lower side is referred to as the rear end.

The syringe body 1B shown in FIG. 14 has the same structure as the syringe body 1 except that the needle tube 3 and the cap 9 are not provided. A resin sheet material is superposed on the tip of the outer cylinder 2 and Edge fusion (eg heat fusion, high frequency fusion)
Alternatively, a rear end portion of a bag (infusion bag) 103 formed by sealing with adhesive and forming a bag shape is fixed in a liquid-tight manner. As a result, the distal end surface 43 of the tubular body 4 is exposed inside the bag 103, and the inside of the bag 103 and the inner cavity 41 communicate with each other.

In the bag 103, for example, 5
An infusion solution 107 of about 0 to 2000 ml is contained.

The syringe main body 1B and the bag 103 are joined to each other by fusing or sealing the sheet material seal portion 104 formed at the rear edge of the bag 103 with the tip of the outer cylinder 2 sandwiched between the sheet materials. It is made by bonding.

As the sheet material constituting the bag 103, for example, soft polyvinyl chloride, polyethylene, polypropylene, polyester, ethylene-vinyl acetate copolymer, polyamide, polyurethane-based, polyester-based,
Examples include various elastomers such as polyamide-based, olefin-based, and styrene-based elastomers, or a flexible resin such as a mixture thereof.

In the injector body 1C shown in FIG. 15, almost the entire injector body 1C projects inside the bag 103, and the vicinity of the rear end of the outer cylinder 2 is liquid-tight in the seal portion 104 at the rear end of the bag 103. The structure is fixed and the other structure is the same as that of the syringe body 1B.

In the present invention, the syringe body 1B,
In addition to 1C, it can be fixed to the seal portion 104 of the bag 103 at any position on the way from the front end to the rear end of the outer cylinder 2.

The syringe body 1D shown in FIG. 16 does not have the outer cylinder 2 but has a structure in which the distal end of the tubular body 4 is liquid-tightly fixed in the seal portion 104 at the rear end of the bag 103. The configuration is the same as that of the syringe body 1B.

The tube body 4 of the syringe body 1D
The bag 103 is joined to the bag 103 by sandwiching the tip of the tubular body 4 between both sheet materials of the seal portion 104 and fusing or adhering.

In the syringe of the present invention, since the needle tube 16 is installed in the gasket, that is, on the side of the container 10 or 10B, the rear end of the tube body 4 can be formed even if the outer cylinder 2 is omitted like the syringe body 1D. There is no danger of exposing the needle tube to the side.

The syringe body 1E shown in FIG. 17 has the same construction as the syringe body 1B except that the construction of the sealing means for sealing the lumen 41 of the tubular body 4 so as to be opened is different. That is, in the syringe body 1E, the flexible tube 51 without the membrane 7 and the sealing member 52 liquid-tightly fitted into the tube 51 so as to seal the flow path in the tube 51. It has the sealing means 50 comprised by.

The sealing member 52 is composed of a cylindrical body whose tip is closed by a solid columnar portion 53, and a thin and fragile break portion 54 is formed on the outer periphery thereof. Pinch the tip of the tube 51 from the outside of the bag 103 with fingers or the like,
The solid columnar portion 53 is bent together with the tube 51, and the broken portion 5 is formed.
The flow path can be opened by breaking 4 and separating the solid columnar portion 53. It should be noted that the tube 51 has a function of preventing the sharp edge portion generated by the breakage from damaging the sheet material of the bag 103 when the solid columnar part 53 is broken and separated.

Examples of the constituent material of the sealing member 52 include hard resins such as hard polyvinyl chloride, polycarbonate, and polyester such as polyethylene terephthalate.

As such a sealing member 52, a product name: click chip manufactured by Terumo Corp. can be used.

As the constituent material of the tube 51,
Examples thereof include soft resins such as soft polyvinyl chloride, polyethylene and polypropylene, silicone rubbers, various elastomers such as urethane series, polyester series, polyamide series, olefin series and styrene series, or a mixture thereof.

In the syringe main body 1E, the separated solid columnar portion 53 comes out of the tube 51 and the bag 10 is removed.
It is also possible to provide means for preventing it from falling into 3. As an example of this means, there is a configuration in which a ring (not shown) having an inner diameter smaller than the outer diameter of the solid columnar portion 53 is fitted into the tip of the tube 51 as a stopper for the separated solid columnar portion 53. Can be mentioned.

In the present invention, as the sealing means for sealing the inner cavity 41 of the tubular body 4 so that it can be opened, it can be opened by breaking the membrane 7 or the sealing means 50 which can be broken by the above-mentioned needle tube or the like. However, the member is not limited to this, and may be, for example, a member that can be pressed and closed by sandwiching the tube 51, or a plug body that is detachably fitted to the tip of the tube body 4.

The syringe bodies 1B to 1E are attached to the bag 10
The position fixed to 3 is not limited to the rear edge portion of the bag 103 as shown in the figure, but may be the front edge portion or the side edge portion,
Alternatively, it may be the front surface or the back surface in FIGS. 14 to 17.

18 and 19 are partial vertical cross-sectional views showing still another example of the construction of the syringe body of the present invention. The syringe bodies 1F and 1 shown in these figures
G has the same structure as that of the syringe bodies 1B and 1C, and is liquid-tight so that the lumen 41 of the tube body 4 and the inside of the bag communicate with a bag in which the syringe body itself has flexibility. It is fixed. Hereinafter, they will be sequentially described. For convenience of explanation, the upper side of FIGS. 18 and 19 is referred to as the front end, and the lower side is referred to as the rear end.

The bag to which the syringe main bodies 1F and 1G are fixed is the infusion bag 200 containing the infusion solution 107 which has been used conventionally. This infusion bag 200 is obtained by sealing and cutting both ends of a resin-made sheet material similar to the above, which is formed into a tubular shape, by fusion (for example, heat fusion or high frequency fusion) or adhesion, and the tip end. A hole 202 for hooking the infusion bag 200 on a hook or the like to hang it is formed in the center portion of the seal portion 201 on the side in the bag width direction, and a center portion of the seal portion 203 on the rear end side in the bag width direction is formed. A discharge port 204 for the infusion solution 107 is formed.

The syringe body 1F shown in FIG. 18 has a seal portion 201 on the distal end side of the infusion bag, and the distal end portion (opening 2b side) of the outer tube 2 is sandwiched between both sheet materials to be fused or adhered to each other. The bag 200 is liquid-tightly fixed. In this case, almost the entire syringe body 1F projects inside the infusion bag 200.

Further, in the syringe body 1G shown in FIG. 19, in the seal portion 203 on the rear end side of the infusion bag, the front end portion (bottom portion 2a side) of the outer cylinder 2 is sandwiched between the two sheet materials to be fused or bonded. Thus, the liquid is firmly fixed to the infusion bag 200. In this case, almost the entire syringe body 1G projects to the outside of the infusion bag 200.

Unlike the illustration, in the seal portion 201 on the distal end side of the infusion bag, almost all of the syringe main body 1F projects to the outside of the infusion bag 200, and in the seal portion 203 on the rear end side of the infusion bag, Body 1G
May be configured so that almost all of the above is projected inside the infusion bag 200.

Further, the injector main body fixed to the infusion bag 200 may have the same structure as the injector main body 1D or 1E. In this case, the syringe body 1
Since D does not have the outer cylinder 2, one end of the tube body 4 is fixed at the seal portion 201 or 203 so that almost the entire syringe body 1D projects to the outside of the infusion bag 200.

A plurality of syringe main bodies 1D to 1F having the same or different structures may be provided for one infusion bag 200. In this case, for example, when the syringe bodies 1D to 1F are provided in the seal portions 201 and 203, respectively, and when the syringe body 1D to 1F are provided on both sides of the hole 202 of the seal portion 201, the discharge port of the seal portion 203 is provided. The case where the syringe bodies 1D to 1F are provided on both sides of the 204, respectively, can be cited.

With such a structure, the existing infusion bag 2
00 has the advantage that the syringe of the present invention can be combined, manufacturing is easy, and the existing infusion bag and the like can have both uses and functions.

Although the syringe of the present invention has been described with respect to each structural example shown in the accompanying drawings, the present invention is not limited to these. For example, the configuration of the connecting portion and the locking portion is not limited to those configured by the convex portion and the concave portion as shown in the figure, and those that lock and unlock these by relatively rotating them, for example, The surfaces may be joined to each other. In this case, the gasket 12 is attached to the container body 11 by inserting the container body 11 into the outer cylinder 2 or the like.
On the other hand, it is only possible to slide it to the rear end side.

[0136]

As described above, according to the syringe of the present invention, it is possible to inject a liquid into a bag or mix a drug with a simple operation in a short time, and to cope with an emergency. Be advantageous. In addition, during operations such as compounding of medicines, there is very little chance that various parts of the syringe, such as the inside of the container, come into contact with the outside air, so that it is possible to prevent bacterial contamination and contamination with foreign substances.

In particular, when a plurality of drugs having different active ingredients are blended, a plurality of containers each containing a different drug may be appropriately exchanged and used while the syringe body is bonded to a bag or the like. The effects of the above excellent operability and sterility are more effectively exhibited. In this case, drugs having different forms, for example, liquid and solid, can be mixed from separate containers.

Further, in the syringe of the present invention, since the needle tube is installed in the gasket of the container, the structure of the syringe main body can be simplified by omitting the outer cylinder and the manufacturing is easy.

When the gasket can be reciprocated in the container body by the engagement of the engaging portion and the connecting portion, the medicine in the container can be discharged without waste.

[Brief description of drawings]

FIG. 1 is a vertical sectional view showing a configuration example of a syringe body in the present invention.

FIG. 2 is a view taken along line II-II in FIG.

FIG. 3 is a vertical cross-sectional view showing a structural example of a container according to the present invention.

FIG. 4 is a vertical cross-sectional view showing a usage state of the syringe of the present invention.

FIG. 5 is a vertical cross-sectional view showing a usage state of the syringe of the present invention.

FIG. 6 is a plan view showing another configuration example of the container according to the present invention.

7 is a vertical cross-sectional view showing the configuration of the tip portion of the container shown in FIG.

FIG. 8 is a vertical cross-sectional view showing the configuration of the tip portion of the container shown in FIG. 6 (when the gasket is moved).

FIG. 9 is a vertical cross-sectional view showing another configuration example of the container in the present invention.

FIG. 10 is a bottom view of the container shown in FIG.

FIG. 11 is a vertical cross-sectional view showing another configuration example of the container according to the present invention.

12 is a bottom view of the container shown in FIG. 11. FIG.

FIG. 13 is a vertical cross-sectional view showing another configuration example of the container according to the present invention.

FIG. 14 is a vertical cross-sectional view showing another configuration example of the syringe body of the present invention.

FIG. 15 is a vertical cross-sectional view showing another configuration example of the syringe body of the present invention.

FIG. 16 is a vertical cross-sectional view showing another configuration example of the syringe body of the present invention.

FIG. 17 is a vertical cross-sectional view showing another configuration example of the syringe body of the present invention.

FIG. 18 is a partial vertical cross-sectional view showing another configuration example of the syringe body of the present invention.

FIG. 19 is a partial vertical cross-sectional view showing another configuration example of the syringe body of the present invention.

[Explanation of symbols]

 100 Syringe 1, 1B, 1C, 1D, 1E, 1F, 1G Syringe body 2 Outer cylinder 2a Bottom part 2b Rear end opening 2c Flange 3 Needle tube 31 Side hole 4 Tubular body 41 Inner lumen 42 Expanding part 5 Space 6 Connecting part 61 Male screw 7 Membrane 8 Film 81 Tab 9 Cap 10, 10B Container 11 Container Body 111 Tip Opening 112 Projection 113 Bottom Internal Surface 114 Tip Edge 115 Rib 12 Gasket 121 Tip Surface 122 Rear End Surface 123 Outer Surface 13 Projection 14 Locking Portion 141 Bottom Surface 15 Female thread 16 Needle tube 161 Side hole 162 Collar part 17 Space 18 Encapsulating member 19 Film 20 Gasket 21 Core material 211 Body part 22 Locking part 23 Female screw 24 Needle tube 241 Side hole 25 Space 27 Small piece 28 Locking member 29 Inner diameter expanding part 30A , 30B, 30C gripping member 300 engaging portion 301, 30 Flange 303 Shaft 304 Recessed portion 50 Sealing means 51 Tube 52 Sealing member 53 Solid columnar portion 54 Broken portion 103 Bag 104 Sealing portion 105 Infusion bag 106 Elastic stopper 107 Infusion 108 Chemical liquid 109 Drug 200 Infusion bag 201 Sealing portion 202 Hole 203 Seal Part 204 outlet

Claims (1)

[Claims] 1. A syringe body having a tube body having a connecting portion on the rear end side, a container body having a bottomed cylindrical shape, and a locking portion for locking the connecting portion, and an inner surface of the container body. The container has at least one container constituted by a gasket capable of sliding in a liquid-tight manner along the needle and a needle tube installed in the gasket, and the needle tube is inserted into an inner cavity on the rear end side of the tubular body. Together with the connecting portion and the locking portion in a locked state, by moving the container body in the axial direction relative to the syringe body and sliding the gasket in the container body, A syringe which discharges at least a substance in the container through the tube.