JPH0193505A - Method for controlling damage by blood-sucking insect pest - Google Patents

Abstract

PURPOSE:To effectively control damage by blood-sucking insect pests for a long period, by blending a specific cyclopropanecarboxylic acid derivative and an existing insect pest repellent, such as N,N-diethyl-m-toluamide, as active ingredients with a carrier and using the resultant composition. CONSTITUTION:A composition obtained by blending a cyclopropanecarboxylic acid derivative expressed by the formula (e.g. 1-ethynyl-2-methyl-pentenyl d,l-cis- trans-chrysanthemate) and one or more of existing insect pest repellent [especially preferably N,N-diethyl-m-toluamide, 2,3,4,5-bis(2-butylene)tetrahydro-2- furfural, etc.] (at 50:1-1:10 blending ratio) as active ingredients with a carrier (e.g. water, alcohols, ethers, etc.) is used to control damage by blood-sucking insect pests.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention comprises a cyclopropanecarboxylic acid derivative represented by the formula (hereinafter referred to as compound (11)) and one or more existing insect repellents as active ingredients, which are blended into a carrier. The present invention relates to a method for controlling damage caused by blood-sucking insect pests using the composition.

Conventionally, many insecticides have been known, and spraying insecticides has been used as a method for controlling damage caused by blood-sucking pests.

Although damage caused by blood-sucking pests can be controlled to some extent by spraying insecticides, when animals such as people, livestock, and pets move, it is necessary to spray insecticides at each location where they move. In particular, it is difficult to effectively control damage caused by blood-sucking pests outdoors.

In addition, the use of conventionally known insect repellents is not always effective in preventing damage, as their efficacy is insufficient or the time period for which their repellent action is effective is insufficient. I can't say it's satisfactory.

In view of this situation, the inventors of the present invention have conducted intensive studies and found that by combining and using a compound [IJ and a compound containing at least one of existing pest repellents as active ingredients] The present inventors have discovered that damage caused by blood-sucking pests to animals can be effectively controlled for a long period of time, leading to the present invention.

The cyclopropanecarboxylic acid conductor represented by formula [1] is an insecticidal compound described in Japanese Patent Publication No. 55-42045. Also, as an existing pest repellent, N,N-diethyl-m
-Toluamide, 2.8,4.5-bis(2-butylene)
Tetrahydro-2-furfural, di-n-propyl
Isocinconeronate and each 5ine, C, etc.F
arm Chemical Handbook Cf32
．． C170 and C171 (1987)], di-n-buty) IJ f succinate [Travis.

B0 etc. J, Econ, Entomol, J Vol. 44 @ p. 818 (1951), etc., as described in 3.

Blood-sucking pests whose damage can be effectively controlled by the use of this composition include mosquitoes such as Culex pipiens, Aedes albopictus, Aedes albopictus, Aedes albopictus, Aedes albopictus, fleas such as human fleas, cat fleas, and dog fleas, Formosan bed bugs,
Examples include lice such as the bed bug and pigeon bed bug, mites such as the house dust mite, common dust mite, and red chigger, blood-sucking flies such as the stable fly and the green staghorn fly, bed bugs, and the like.

In addition, although the compound [IJ has optical isomers and stereoisomers, each of these effective isomers can be used alone or as a mixture in the present invention.

Examples of the cyclopropanecarboxylic acid conductor according to the present invention represented by the above general formula [l] include the following.

Compound Compound Name Number According to the present invention, the compound [IJ and N,N-diethyl-m
- It can be used as a composition (hereinafter referred to as the present composition) in which a compound containing at least one of existing pest repellents such as toluamide as an active ingredient is blended and usually blended in a suitable carrier, for example, It is prepared and used in the form of liquid preparations such as lotion gel and aerosols, and ointments.

Examples of carriers used when preparing liquid preparations include:
Water, methanol, ethanol, glycerin, alcohols such as polyethylene glycol, tetrahydrofuran,
Examples include ethers such as dioxane, aliphatic hydrocarbons such as hexane, kerosene, paraffin, petroleum benzene, and esters such as ethyl acetate.

The liquid preparation may further contain conventional emulsifiers or dispersants, spreading/wetting agents, suspending agents, preservatives, propellants, and the like. Furthermore, ordinary coating film forming agents can also be blended.

Specifically, for example, soaps, polyoxyethylene oleyl alcohol ethers such as polyoxyethylene oleyl ether, polyoxyethylene alkylaryl ethers such as polyoxyethylene nonylphenyl ether, polyoxyethylene fatty acid esters, fatty acid glycerides, etc. , emulsifiers such as sorbitan fatty acid esters, sulfuric esters of higher alcohols, alkylaryl sulfonates such as sodium dodecylbenzenesulfonate, spreading and wetting agents such as glycerin and polyethylene glycol,
Suspending agents such as casein, gelatin, alginic acid, carboxymethylcellulose, gum arabic, hydroxypropylcellulose, bentonite, preservatives such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, dimethyl ether, Examples include propellants such as chlorofluorocarbon and carbon dioxide, cellulose derivatives such as nitrocellulose, acetylcellulose, acetylbutyrylcellulose, and methylcellulose, vinyl resins such as vinyl acetate resin, and various film forming agents such as polyvinyl alcohol. .

In addition, examples of carriers used when preparing ointments include a mixture of beeswax and vegetable oil, a mixture of white wax and white petrolatum, and the like.
Examples of the vegetable oil include soybean oil and sesame oil.

Furthermore, it can also be prepared in a microencapsulated form and formulated into low silane, aerosol, etc. for use.

This composition may also contain synergists, antioxidants, other additives, and the like.

Examples of the synergist include piperonyl butoxide, inbornyl thiocyanate, riesene, and S-421, and examples of the antioxidant include butylhydroxyanisole, dibutylhydroxytoluene, tocopherol, and γ-oryzanol.

The amount of these additions is not limited, but the amount of compound [I]
It is usually appropriate to use 1,150 to 10 times the size of the mackerel. Also, other additives, Example A-1! PC
MX, d-BCA, salicylic acid, benzoic acid, sorbic acid, 1-oxy-8-methyl-4-isopropylbenzene, OPP.

Examples include volatile antibacterial/antifungal agents such as hinokitiol, coloring and flavoring agents, and the like. The amount of the volatile antibacterial/antifungal agent added to the formulation is usually up to 70%, preferably 0.1 to 50%.
It is appropriate to

Next, formulation examples are shown.

Formulation Example 1 0.5 parts of empenthrin and 5 parts of N,N-diethyl-n-toluamide are dissolved in polyethylene glycol to make a total of 50 parts, and the solution is filled into an aerosol container. Next, after attaching a valve, 50 parts of Freon 12 (propellant) is filled under pressure through the valve portion to obtain an oil-based aerosol.

Formulation Example 2 0.5 parts of empenthrin and the main part of N,N-diethyl-m-tolua are dissolved in 61.5 parts of soybean oil and thoroughly mixed with 88 parts of beeswax to obtain an ointment.

Formulation Example 8 1 part of empenthrin and 1 part of N,N-diethyl-toluamide
0 parts of oleic acid, 2 parts of oleic acid, and 1.5 parts of Atmos 800 (emulsifier whose main component is glycerol monooleate, registered trademark of Atlas Chemical Co., Ltd.) are mixed to obtain an oil phase stock solution.

Next, the above oil phase stock solution is gradually added to the water phase stock solution obtained by mixing 0.5 parts of triethanolamine and 86 parts of distilled water, and emulsification is completely performed to form a homogeneous liquid. Mix to obtain low silane.

The composition prepared as described above can be applied directly to the skin, etc., or can be applied, impregnated, mixed, or dropped onto a suitable substrate such as a sheet, film, mesh, or strip in advance. The base material can be used by coating exposed areas of the skin or clothes with the base material. The material of the base material includes polyethylene, polypropylene, polyvinyl chloride, polyvinylidene chloride, polyester, vinylon,
Examples include synthetic fibers such as nylon, resins, animal and plant fibers such as silk, cotton, and wool, inorganic fibers such as aluminum, and mixtures thereof. When using a mesh-like base material, the finer the mesh is, the more preferable it is, but in general, a mesh size of about 16 meshes or less is sufficiently effective.

In this composition, the compound [I] of fish varies depending on the dosage form and application method, but for example, when it is used in a liquid preparation or ointment such as lotion, aerosol, etc., or when it is contained in a base material, the compound [I] [! ] is 0.01 to 10% by weight, preferably 0.1 to 2% by weight. On the other hand, the amount of existing pest repellents such as N,N-diethyl-m-toluamide is 0.1
~20%, preferably 1~10ilfi%.

In addition, the blending ratio of compound [I] and existing pest repellents such as N,N-diethyl-m-toluamide is
It is 1 to 99, preferably 4 to 19, compared to existing pest repellents.

The amount of treatment of this composition on the surface of the skin is ! ! 11a
Existing pest repellents contain 0.04119% or more of compound [I] per 11%, preferably 0.04 to 0.419%. 0.04 M9 or more - Preferably, the amount contains 0.04 M9 to 0.76 ■.

Next, a test example is shown.

Test Example 1 An aerosol containing 1 part of empenthrin and 5 parts of N,N-diethyl-m-toluamide, or N,N-diethyl-m-toluamide 10B as active ingredients was administered from the skin of the subject's left leg from the knee to the ankle. The agent was sprayed intermittently for about 5 seconds at a distance of 10 to 150 mm, and after spraying, the sprayed area was rubbed with both hands to ensure that the agent was spread evenly.

Stand for a certain period of time with your right foot as a reference, and then
The blood-sucking status of Simulium aok (Simulium aok) was observed. Two hours after spraying, the same observation was made. The blood sucking inhibition rate was determined using the following formula.

The aerosol used in this test contained 1 portion of the specified active ingredient.
．． 1,1. - It was prepared by dissolving it in trichloroethane to give a concentration of 6ON and pressurizing it with 40% by weight of Freon 12.

The results are shown in Table 1.

As is clear from Table 1, immediately after spraying, all showed excellent blood sucking inhibiting effects. However, after about 2 hours of spraying, N, N-
A decrease in effectiveness was already observed in the aerosol treated group with 10 parts of diethyl-m-toluamide.

On the other hand, in the group treated with aerosol mixture of 1 part of empenthrin and 5 parts of N,N-diethyl-m-toluamide, an excellent blood absorption inhibiting effect was observed, which was the same as the effect immediately after spraying.

Test Example 2 1 part of empenthrin, 5 parts of N,N-diethyl-m-toluamide, or 1 part and 5 parts of empenthrin and N,N-diethyl-m-)ylamide, respectively, were placed on the right leg of the subject between the knee and the ankle. 0.6 parts and 5 parts or 0.25 parts
10 parts and 5 parts of an aerosol containing 10 parts as active ingredients from the skin.
-15 enslli L/ was sprayed intermittently for about 6 seconds, and after spraying, the sprayed area was rubbed with both hands so that the drug was spread evenly.

In the large room (8X4X2.8m)
After releasing approximately 100 adult female insects (Es albopictus), the blood feeding status of the Aedes albopictus was observed for 20 minutes in a large room using the subject's left foot as a control. The same observation was made 4 hours after spraying.

The aerosol used in this test was prepared by dissolving a prescribed active ingredient in isopropanol to form a 60-glue shape, and filling it with LPG gas under pressure at 40x evacuation%.

The results are shown in Table 2.

Second! R As is clear from the table, all of them showed excellent blood absorption inhibiting effects immediately after spraying. However, after about 4 hours of spraying, 1 part of empenthrin and N were added.

A decrease in effectiveness was already observed in the aerosol treated group with 5 parts of N-diethyl-m-)ylamide. On the other hand, 0.25.0.5 parts of empenthrin and 1 part of N,N-diethyl-m-
In the group treated with a mixture aerosol containing 5 parts of toluamide, an excellent blood absorption prevention effect was observed, which was the same as the effect immediately after spraying.

Claims (5)

[Claims] (1) Using a composition in which a cyclopropanecarboxylic acid derivative represented by the formula [I] ▲There are mathematical formulas, chemical formulas, tables, etc.▼ and one or more existing pest repellents are blended into a carrier as active ingredients. A method for controlling damage caused by blood-sucking pests characterized by: (2) The pest repellent is N,N-diethyl-m-toluamide, 2,3,4,5-bis(2-butylene)tetrahydro-2-furfural, di-n-propylisocincomeronate or di- The method for controlling damage caused by blood-sucking pests according to claim 1, which is n-butyl succinate. (3) The method for controlling damage caused by blood-sucking pests according to claim 1, wherein the mixing ratio of the cyclopropanecarboxylic acid derivative of formula [I] and an existing pest repellent is 50:1 to 1:10. (4) The method for controlling damage caused by blood-sucking pests according to claim 1, wherein the composition is a liquid or an ointment. (5) A method for controlling damage caused by blood-sucking pests according to claim 1, which comprises applying the composition to the skin. (6) A method for controlling damage caused by blood-sucking pests according to claim 1, which comprises covering the skin with a substrate treated with the composition.