JP3272782B2 - Liquid processor - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid processor for filtering a body fluid such as blood by filtration.

[0002]

2. Description of the Related Art Conventionally, for example, when performing blood transfusion by a blood transfusion set, the blood to be transfused is supplied from a blood bag.
Aggregate filter, blood filter, through the drip chamber and the like, but flows mainly by drop, the blood in the blood bag is eliminated, no air entering the blood bag, or only slightly entered Therefore, blood remains in an aggregate filter, a blood filter, a drip tube, and a connection tube connecting these components, which are connected downstream from the blood bag. Therefore, in order to effectively use blood and the like remaining in the circuit, a method of recovering the blood and an improvement in the circuit structure are desired.

[0003] On the other hand, when performing component blood transfusion, a filtration method is employed as one method for increasing the purity of a red blood cell preparation. This filtration method is performed by the blood filter provided in the blood transfusion circuit. A conventional blood filter is configured by providing a filter member for removing white blood cells and platelets in a housing having a liquid inlet and a liquid outlet, and the liquid member on the liquid inlet side is provided in the housing by the filter member. It is divided into two parts, an inflow part and a liquid outflow part on the liquid outflow side.

When a conventional blood filter is used, it is necessary to first perform a priming operation with blood or a physiological saline solution in order to prevent an air block or the like and obtain a sufficient blood filter function. But,
In a blood filter in which the liquid inlet is provided at the upper portion of the blood filter and the liquid outlet is provided at the lower portion , a large-scale operation such as inverting the housing at the time of priming has to be performed. In order to simplify such a priming operation, for example, US Pat.
As described in Japanese Patent No. 923620, an apparatus having a blood inlet at the lower part and an outlet at the upper part,
As described in Japanese Patent No. 470, there has been proposed a device provided with a vent so that air in a housing escapes during priming.

[0005] With these structures, priming can be easily performed, but after the filtration process is completed, the body fluid remains in the housing, and the sufficient recovery as described above cannot be expected. Furthermore, in order to increase the recovery rate of the bodily fluid remaining in the housing, a configuration has been proposed in which a liquid communication tube connected to the liquid inlet side of the blood filter is provided with a gas communication portion that enables communication with the outside. However, after the filter member is wet with the bodily fluid, the inflowing gas cannot pass through the filter member, and only the bodily fluid on the liquid inlet side can be collected. Also, Japanese Patent Application Laid-Open No. 2-63470 discloses a structure in which a gas communication portion which is opened at the time of recovery is provided on the liquid outlet side of the filtration member, but does not have an exhaust function at the time of priming. In addition, the priming operation is troublesome as before.

Further, in the conventional filter described in the above publication, a detachable cap is provided in a gas communication portion having an exhausting function at the time of priming, and the gas communication portion is closed by closing the cap when priming is completed. It is said that the cap can be removed at the time of recovery so that the cap can also serve as a gas inlet.

[0007] However, the provision of such a cap becomes complicated, for example, it is necessary to mount the cap at the timing of priming completion, and it is difficult for a nurse or the like who is busy in other work to operate. The structure is not suitable. Furthermore, in practice, when the filter provided in the gas communication section comes into contact with body fluid after priming, proteins in the body fluid adhere to the filter, making it difficult for gas to ventilate, and the gas inlet during collection. There is a problem that it does not play a role as a.

[0008]

SUMMARY OF THE INVENTION An object of the present invention is to make it possible to perform priming for making full use of the performance of a liquid processor by a simple operation and to recover a high rate of body fluid in the liquid processor. It is an object of the present invention to provide a liquid processing device that can perform the above-described processing.

[0009]

This and other objects are achieved by the present invention described below.

(1) A housing, a filter member housed in the housing, and partitioning the inside of the housing into a liquid inflow space and a liquid outflow space, a liquid inflow port communicating with the liquid inflow space, and the liquid outflow space And a liquid outlet communicating with the liquid outlet, and an exhaust filter having a filter formed by stacking the hydrophilic filter and the hydrophobic filter so that the hydrophilic filter is on the liquid outlet space side such that the hydrophilic filter is on the liquid outlet space side. A communication passage, an intake communication passage communicating with the liquid outflow space, and having a filter having a dust removing and sterilizing action, and a ventilation hole communicating with the exhaust communication passage, wherein the exhaust communication passage and the intake air And a peelable seal member for simultaneously covering the communication passages, wherein the seal member shields the intake communication passages and releases the shielding when necessary. Master.

(2) a housing, a filter member housed in the housing, and dividing the inside of the housing into a liquid inflow space and a liquid outflow space, a liquid inflow port communicating with the liquid inflow space, and the liquid outflow space A liquid outlet, a main body provided in the housing, a valve body slidably inserted in the main body, and a main body provided in the main body so as to communicate with the liquid outflow space, and a hydrophobic filter. An exhaust communication passage having a filter provided with the main body so as to communicate with the liquid outflow space and having a dust removing and sterilizing action; and an exhaust communication passage formed in the valve body and having the exhaust communication passage. Having a passage and a ventilation hole connected to the intake communication passage, and changing a position of the valve body with respect to the main body, thereby allowing the exhaust communication passage and the intake communication passage to communicate with the ventilation hole. A liquid processor for switching connections.

(3) a housing, a filter member housed in the housing and partitioning the interior of the housing into a liquid inflow space and a liquid outflow space, a liquid inflow port communicating with the liquid inflow space, and the liquid outflow space A liquid outlet, a main body provided in the housing, a valve body slidably inserted into the main body, and a hydrophobic filter provided in the valve body so as to communicate with the liquid outflow space. A communication path for exhaust having: a communication path for intake provided with a filter provided with dust removal and sterilization, provided to communicate with the valve body to the liquid outflow space, and a position of the valve body with respect to the main body. The liquid processing device, wherein the communication state of the exhaust communication path and the intake communication path is switched by changing the communication state.

(4) The liquid processor according to any one of (1) to (3), further comprising a ventilation means communicating with the liquid inflow space and capable of introducing air into the liquid inflow space.

(5) The liquid processing apparatus according to the above (4), wherein the ventilation means is provided at the highest position or in the vicinity of the highest position when the liquid processing apparatus is used.

(6) The exhaust communication passage and / or the intake communication passage may be arranged in a posture when the liquid processor is used.
The liquid processor according to any one of the above (1) to (5), which is provided at or near the highest position.

(7) A housing, a filter member housed in the housing, and partitioning the inside of the housing into a liquid inflow space and a liquid outflow space, a liquid inflow port communicating with the liquid inflow space, and the liquid outflow space A liquid processor having a liquid outlet communicating with the liquid processor, a liquid supply line connected to the liquid inlet of the liquid processor and having a connection tube, and a liquid supply line provided in the connection tube, to the liquid processor. A liquid processing circuit, comprising: a component for performing liquid supply and filtration of the liquid processing device, wherein the component is provided with a ventilation means capable of introducing air into the liquid supply line. Liquid sending circuit provided with.

(8) A housing, a filter member housed in the housing, and dividing the inside of the housing into a liquid inflow space and a liquid outflow space, a liquid inflow port communicating with the liquid inflow space, and the liquid outflow space A liquid processor having a liquid outlet communicating with the liquid processor, and a liquid supply line connected to the liquid inlet of the liquid processor, wherein the liquid supply line is provided in the liquid supply line. Ventilation means capable of introducing air into the liquid supply line, the ventilation means having a shielding means for shielding the introduction of air into the liquid supply line and releasing the shielding when necessary. Liquid circuit.

(9) The liquid feeding circuit according to the above (8), wherein the shielding means is constituted by detachably attaching a seal member to an air inlet for introducing air.

(10) The liquid sending circuit according to the above (8), wherein the shielding means is constituted by a lid that hermetically seals an air inlet for introducing air.

(11) A liquid feeding circuit comprising the liquid processing device according to (1) and a liquid supply line connected to a liquid inlet of the liquid processing device, wherein the liquid supply line A liquid feeding circuit comprising a liquid processor, wherein a ventilation means capable of introducing air into the liquid supply line is provided.

(12) The liquid supply circuit according to the above (11), wherein the liquid supply line includes a connection tube connected to the liquid inlet, and the ventilation means is provided in the connection tube.

(13) The liquid supply circuit according to (11), wherein the liquid supply line includes a connector connected to a liquid supply container, and the connector is provided with the ventilation means.

[0023]

[0024]

[0025]

The liquid flowing into the liquid inflow space in the housing from the liquid inflow port is filtered and separated by the filtration member.
The liquid flows out of the housing from the liquid outlet through the liquid outlet space. Here, when the liquid first flows into the empty housing, the liquid first starts to accumulate in the liquid inflow space, and moves to the liquid outflow space through the gas filtering member in the liquid inflow space. The gas is further discharged from the liquid outflow space to the outside of the housing via the exhaust communication passage.

Even if the housing is sufficiently filled with liquid,
The liquid does not flow out of the housing from the exhaust communication passage, being blocked by the hydrophobic filter in the exhaust communication passage.

When recovering the liquid in the housing,
The communication between the housing and the outside is enabled by releasing the shielding of the intake communication passage by the shielding means. Dust and bacteria are removed from the outside air flowing into the housing by the action of the filter of the intake communication passage.

If a ventilation means communicating with the liquid inflow space is provided, the liquid in the housing can be almost completely recovered.

On the other hand, in the liquid sending circuit to which the liquid processor is connected, by providing a ventilation means on the upstream side of the liquid processor, the liquid in the circuit on the upstream side of the liquid processor can be recovered. By using a processor provided with a suction passage in the liquid outflow space, it is possible to recover most of the remaining liquid in the circuit.

Specific examples of the liquid include blood,
Red blood cell preparations, platelet preparations, plasma and the like.

[0031]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of the present invention will be described below in detail with reference to the accompanying drawings. FIG. 1 is an overall sectional side view of a blood filter, and FIG. 2 is an overall view showing a blood transfusion set as an example of a liquid sending circuit using the blood filter.

The illustrated blood transfusion set 1 has an aggregate filter 2, a blood filter 3 as a liquid processor, and a drip tube 4. The aggregate filter 2 is provided integrally with a bottle needle 21 connected to a blood storage container such as a blood bag, and the blood outlet 22 of the aggregate filter 2 is connected to one end of a connection tube 51. I have. The drip tube 4 is for confirming the flow velocity. In addition, the present invention may be configured such that such an aggregate filter and a drip tube are not provided.

The other end of the connection tube 51 is connected to a liquid inlet 31 of the blood filter 3, and one end of a connection tube 52 is connected to the liquid outlet 32 of the blood filter 3. The other end of the connection tube 52 is connected to the blood inlet 41 of the drip tube 4, and one end of the connection tube 53 is connected to the blood outlet 42 of the drip tube 4. The distal end 70 of the connection tube 53 is connected to a needle, a bag for collecting processed body fluid, or the like, or is connectable according to the purpose of use.

A clamp 11 is attached to the connection tube 51, and a clamp 12 is attached to the connection tube 53.

In such a configuration, blood first flows from the blood bag into the aggregate filter 2,
Here, the microaggregates are removed, and then flow into the blood filter 3 via the connection tube 51. Leukocytes and platelets are removed in the blood filter 3 and flow into the drip tube 4 via the connection tube 52. It is preferable to provide an aggregate filter because such foreign substances are removed in advance.

The blood filter 3 constituting the blood transfusion set 1 described above will be described. Blood filter 3
A housing 30, a filter member 33 housed in the housing 30, a liquid inflow space A and a liquid outflow space B defined by the inner wall of the housing 30 and the filter member 33, a liquid inflow space A and a liquid outflow It has a liquid inlet 31 and a liquid outlet 32 respectively formed at the upper end and the lower end at positions opposite to the filtering member 33 and communicating with the space B. Each of the liquid inlet 31 and the liquid outlet 32 is a tube extending vertically, and connection tubes 51 and 52 are respectively connected to ends of the tube.

A filter member 33 is housed in the housing 30. The filtration member 33 filters and separates white blood cells, platelets, and the like from the red blood cell preparation by transmitting the red blood cell preparation. Examples of the filter member having such an action include a porous body made of a synthetic resin, a woven or non-woven fabric of ultrafine fibers, and the like. As a constituent material of the porous body, for example, polyurethane resin, polyvinyl formal resin and the like, as a constituent material of the fiber,
For example, there are polyester resin, polypropylene resin, nylon resin and the like. These filtration members have a pore size of 1-60.
It has pores of μm.

A plurality of protrusions 3 are provided on the inner wall of the housing 30.
01, and a liquid flow space a,
b is formed. The erythrocyte preparation flowing into the housing 30 is filtered by the liquid flow spaces a and b so that
Uniformly and quickly over the entire surface of the The protrusion 301
As a result, contact between the inner wall of the housing 30 and the filter member 33 is prevented, so that smooth liquid flow is ensured. In addition, even if the red blood cell preparation soaks and the filter member 33 expands, a smooth liquid flow is similarly secured.

A communication portion 6 is provided on the side of the housing on the liquid outlet side with respect to the filter member 33. As shown in FIG. 1, the communication section 6 is located at the highest position in a posture in which the blood filter 3 is set almost vertically.

FIG. 3 is a plan view of the communication section 6, FIG. 4 is a sectional view of the exhaust communication path 6a, and FIG. 5 is a sectional view of the intake communication path 6b. The communication portion 6 has an exhaust communication passage 6a and an intake communication passage 6b. The communication passages 6a and 6b communicate with the holes 61a and 61b formed in the housing 30, the recesses 63a and 63b provided with the filters 62a and 62b, and the recesses 63a and 63b.
It has a projecting body 64 formed continuously around 3b, and a sealing material 65 for closing an open portion of the projecting body 64. The housing 30 communicates with the outside through the holes 61a and 61b and the recesses 63a and 63b. The diameter of the hole 61b is such that blood does not enter the recess 63b, and
It is sufficient that the size is such that it has sufficient air permeability, for example, it is sufficient that the size is about 0.5 to 3.0 mm. Alternatively, the hole 61b may be inclined downward so that blood does not enter the filter 62b.

Of the filters 62a and 62b, the filter 62a provided in the exhaust communication passage 6a is:
Hydrophilic filter 621a and hydrophobic filter 622a
And the hydrophilic filter 621a
Is fixed to the housing 30 side. The hydrophobic filter is made of a synthetic resin porous body or a nonwoven fabric, and preferably has a pore size of about 0.1 to 0.3 μm. The hydrophilic filter is made of a synthetic resin porous body or a woven or non-woven fabric of ultrafine fibers, is easily wettable by bodily fluids and has a bodily fluid holding power, and has a negative pressure due to a head applied below the exhaust communication passage. Therefore, those that do not allow outside air to pass through are preferred.

The filter 62b provided in the intake communication passage 6b is a filter having a dust removing and germicidal action.
Similar to the filter 62a provided in a, it is preferable that the filter 62a be made of a synthetic resin porous body or a nonwoven fabric, and have a pore diameter of about 0.1 to 0.3 μm.

In the communication passage 6a, the diameter of the hole 61a is set to such a size that the outside air does not enter the housing due to the surface tension of the liquid against the negative pressure caused by the liquid flowing out from the liquid outlet. It is also possible to adopt a structure that is as follows. In this case, the diameter of the hole 61a is preferably about 0.1 to 1 mm.

Note that these hydrophobic filters 622a,
A nonwoven fabric or the like having a lower melting point than the filters 622a and 62b may be provided on the surface of 62b as a sealing aid in order to improve the sealing performance with the housing.

As a specific material of the membrane filter, for example, a material obtained by laminating polytetrafluoroethylene on a nonwoven fabric of polyethylene, a material obtained by coating an acetate film with a silicone resin, a membrane filter of polypropylene, polyester, polyethylene, or the like is used. can do.

The ventilation resistance of the filters 62a and 62b is as follows:
When the pressure difference is 10 cmH ₂ O, it is desirable that the ventilation rate is about 5 m1 / min or more.

The exhaust communication passage 6a and the intake communication passage 6b are provided adjacent to each other. As shown in FIG. 3, the protrusion 64 is formed between the exhaust communication passage 6a and the intake communication passage 6b. The provided filters 62a and 62b are simultaneously surrounded, and the projection 64 is also disposed between the filters 62a and 62b to separate the filters 62a and 62b separately.

A film-shaped sealing member 65 is releasably attached to the opening formed by the projection 64. The sticking of the seal member 65 interrupts the flow of gas in the intake communication passage 6b. The seal member 65 is also attached to the projection 64 surrounding the exhaust communication passage 6a at the same time, but a ventilation hole 650 is formed at that position, and the exhaust communication passage 6a is permeable. Has become.

The left and right ends of the seal member 65 are provided with handle portions 651, 652. The sealing member 65 is formed to be longer than the range in which the protrusion 64 is provided, and the portion protruding from the protrusion 64 is the handle portion 65.
1, 652, and the shape is not particularly limited.

As described above, since the grip portions 651 and 652 are provided so as to protrude left and right, the seal member 65 can be peeled off from either the left or right side, and it can be easily peeled off even by a person with a left or right arm. Further, even when a part of the handle is torn off before the seal member 65 is completely peeled off when peeled off from one side, the handle can be peeled off by the other handle. Defects can be eliminated.

Here, since the protrusions 64 for separately separating the filters 62a and 62b are provided at an angle to the peeling direction of the seal member 65, the protrusions 64 are used when peeling the seal member 65. The increase in resistance is suppressed.

The blood filter 3 configured as described above
The operation of will be described. Blood filter 3 is a transfusion set 1
Is set, that is, blood flows in with the liquid inlet 31 facing upward and the liquid outlet 32 facing downward. The inflowing blood accumulates in the liquid inflow space A on the liquid inlet 31 side of the filter member 33, and the gas present in the liquid inflow space A passes through the filter member 33 and passes through the liquid outlet space 32 on the liquid outlet 32 side. Flow into B. The blood that has flowed into the liquid inflow space A accumulates in the liquid inflow space A, and at the same time, passes through the filtering member 33 and flows into the liquid outflow space B.

The blood flowing into the liquid outflow space B accumulates from the lower side where the liquid outlet 32 is located, and the clamp 1
1 is closed, the air in the liquid outflow space B is not discharged from the liquid outflow port 32, but is discharged from the exhaust communication passage 6a of the communication portion 6 provided above the liquid outflow space B.

As described above, in the blood filter 3, the housing 30 can be filled with blood without performing a special priming operation. When the clamp 11 and the clamp 12 are removed, the blood flowing into the blood filter 3 is subjected to removal of white blood cells and platelets by the filtering member 33 and flows out of the liquid outlet 32. Housing 3
When the blood is filled in the filter 0, the blood comes into contact with the filter 62a provided in the exhaust communication passage 6a. However, since the filter 62a has hydrophobicity as described above, the blood seeps from the filter 62a. I will not give it out. Until the sealing member 65 is removed, the communication path 6b for intake is in a closed system, so that blood cannot flow into the recess 63b and does not contact the filter 62b.

In order to collect the blood in the blood filter 3 after the blood transfusion is completed, the seal member 65 provided in the communication section 6 is peeled off, and the communication path 6b for intake is brought into a communication state. When the intake communication passage 6b is in a communicating state, air flows into the liquid outflow space B, and blood in the liquid outflow space B is discharged from the liquid outflow port 32 by a head.

Bacteria and dust are removed from the air flowing through the intake communication passage 6b by the filter 62b. At this time, since the filter 62b is not wet, external air can easily flow in from the intake communication passage 6b.

In order to collect the blood on the liquid inlet 31 side,
The same ventilation means as the intake communication passage 6b is used for the filtering member 3
3 may be provided on the liquid inlet 31 side.

Here, the structure of the communication portion 6 is not limited to the above case, and may be, for example, a structure as shown in FIG. The communication portion 6 includes a main body 66 formed integrally with the housing 30 and a rod-shaped valve body 67 inserted into the main body 66.
a, 661b are formed, and filters 662a, 662b are provided in the holes 661a, 661b, respectively. As described above, the filter 662a is a filter having a hydrophobic property, and the filter 662b is a filter having a dust removing and bacteria removing action.

Similarly, a vent 671a,
671b is drilled. The valve element 67 has a structure that can slide in the axial direction with respect to the main body 66 while maintaining an airtight state.

The distance between the holes 661a and 661b and the distance between the ventilation holes 671a and 671b are set to different distances.
61a and 661b and the ventilation holes 671a and 671b can be separately connected one by one. A handle 672 for sliding operation is provided at an end of the valve body 67.

In such a configuration, when priming is performed, the valve 67 is slid so that the ventilation holes 671
a and the hole 661a are connected to each other so that the gas can be exhausted.
When the priming is completed, the valve body 67 is slid so that the holes 661a and 661b
The valve body 67 is set at a position not connected to 1a and 671b.

In this state, the blood is filtered, and after the processing, the blood in the blood filter 3 is collected.
The valve body 67 is slid so that the ventilation 671b and the hole 661b are connected to each other so that the air can be taken in and the outside air flows.
Further, a rib may be provided between the valve body and the main body so that the valve body stops at a desired position.

In addition to the above configuration, for example, the valve 67
The air hole 671 may be formed as a single hole, and the air holes 671 may be alternately connected to the holes 661a and 661b. The air holes 671a and 671b may be bent in the axial direction of the valve body 67. As shown in FIGS. 8 and 9, one end of each of them is extended to both ends of the valve body 67 and opened, and the opening is provided with a hydrophobic filter 662a and a filter 662.
The structure provided with b may be adopted.

In the embodiment shown in FIG.
Is the same as that of the embodiment described with reference to FIG. 6, but the shape and structure of the valve element 67 inserted into the main body 66 are different. That is, the valve body 67 is a rod-shaped body having a circular cross-sectional shape, and is configured to be rotatable with respect to the main body 66 while maintaining an airtight state. In the valve body 67, ventilation holes 671a and 671b are formed at positions corresponding to the holes 661a and 661b formed in the main body 66 in the diametrical direction in the cross section. The ventilation holes 671a and 671b are formed in different directions, respectively, and at the same time, the holes 661a and 661b are formed.
b is not connected.

Depending on the rotational position of the valve body 67, the hole 661
a, 661b and the ventilation holes 671a, 671b are separately connected to each other, and the exhaust communication passage 6a and the intake communication passage 6 are connected to each other.
b are in communication with each other.

A handle 672 is provided at one end of the valve body 67. The handle portion 672 is provided so as to protrude in the radial direction of the cross section of the valve body 67, and the valve body 67 rotates inside the main body 66 by swinging the handle portion 672.

Further, a click may be provided between the valve body and the main body so that the valve body stops at a desired rotation angle.

FIG. 8 shows another structure of the communication section 6. The configuration in which the valve body 67 is slidably inserted into the main body 66 is the same as the configuration example shown in FIG. In this structure, the vent 671 is provided in the valve body 67.
1b is formed in the axial direction, and the ventilation holes 671a, 671
b has one end open to both ends of the valve body 67, and the opening has a filter 67 having hydrophobicity.
3a and a filter 673b having a dust removing and germicidal action
Are provided respectively.

The other ends of the ventilation holes 671a and 671b are bent in the radial direction of the cross section and open to the outer peripheral surface of the valve body 67. The other structure is the same as the structure shown in FIG. The openings of the ventilation holes 671a and 671b provided on the outer peripheral surface of the valve body 67 are arranged so that the valve body 67 faces the inside of the housing 30 at different rotation positions, and the two ventilation holes 671a and 671 are provided.
b are not simultaneously opened in the housing 30. The opening that does not open into the housing 30 is closed by the inner surface of the main body 66, and air does not flow.

The vent holes 671a and 671b and the filters 673a and 673b form an exhaust communication passage 6a and an intake communication passage 6b.

In addition to the configuration example of the communication section 6 described above, FIG.
As shown in FIG. 7, the exhaust communication passage 6a may have the structure shown in FIG. 8, and the intake communication passage 6b may have the structure shown in FIG. It can also be.

In the blood filter 3 described above,
The housing 30 is also provided on the liquid inlet 31 side of the filter member 33.
Ventilation means capable of introducing air into the inside can be provided.
By providing this ventilation means, the blood remaining on the liquid inlet 31 side of the filtration member 33 in the housing 30 can also be collected.

Next, a structure for collecting blood from the circuit of the blood transfusion set 1 will be described. It is possible to collect the remaining blood from the circuit by a head by providing a ventilation means capable of introducing air from the outside into the circuit. The closer the location of such a ventilation means to the connected blood bag, the greater the amount of collection. As the position where the ventilation means is specifically provided, for example, in the blood transfusion set 1 shown in FIG. 2, the connection tube 51 and a component attached to the connection tube 51 for smoothly performing liquid supply and filtration. For example, a bottle needle for connecting to a blood bag, an aggregate filter 2, a chamber, and the like can be given.

Such a ventilation means can also be applied to a liquid processor having a normal configuration without the above-described intake communication passage and exhaust communication passage. In this case, normal priming operation and filtration can be performed by, for example, inverting the processing device, and then recovery can be performed by the action of the ventilation means. In addition, the structure in which the intake and exhaust communication passages are further provided is preferable because the outlet side can be recovered.

FIG. 10 shows a structure in which a ventilation means is provided in the aggregate filter 2. Aggregate filter 2
Accommodates a cylindrical liquid filter 23 having a closed lower end in a housing 20 and a bottle needle 21 at the upper end.
Are fixed as one body. A channel 211 formed in the bottle needle 21 communicates with the inside of the liquid filter 23. The liquid filter 23 has, for example, an average pore diameter of 20.
A mesh of about 150 μm can be used,
Examples of the constituent material include plastics such as polyvinyl chloride, polypropylene, and nylon.

The ventilation means 7 is provided above the housing of the aggregate filter 2. FIG.
2 shows an enlarged sectional view of the ventilation means 7. The ventilation means 7 is formed in the housing 20 and has a hole 71 for communicating the inside and the outside of the housing 20, a filter 72 provided to close the hole 71, and a cover for fixing the filter 72 from the outside. And a cap 73 to be fixed. The cap 73 is provided with a plurality of ventilation holes 731 to allow air to flow. In addition,
Such a cap structure may be applied to the communication section described above. In the intake communication passage, it is previously shielded by a pill seal or the like. Further, a chamber 24 is provided below the housing 20.

In the above configuration, when the bottle needle 21 of the aggregate filter 2 is first connected to the blood bag, blood accumulates in the housing 20 of the aggregate filter 2. When the blood reaches the position of the ventilation means 7, the volume is reduced by pressing the chamber 24 provided at the lower part of the housing 20 with a finger, and when the volume is restored, the blood in the housing 20 is removed by suction. 24. Next, when the blockage by the clamp 11 is released, the blood passes through the connection tube 51,
When the blood flows into the blood filter 3 and reaches the level of the exhaust passage 6a in the liquid outflow space B, the blood flow is stopped. Here, when the blockage by the clamp 12 is released, the blood supply from the blood bag is started.

During blood feeding, since the pressure loss due to the filtering member 33 in the blood filter 3 is large, air does not flow from the ventilation means 7 of the aggregate filter 2. When all of the blood in the blood bag flows out, a negative pressure due to the head is applied to the ventilation means 7, so that air flows in therefrom.

By the inflow of the air, the blood on the downstream side can be collected from the aggregate filter 2.

Such a ventilation means 7 can be provided in the bottle needle 21 as shown in FIG. In this case, an air passage 75 is formed in the bottle needle 21 and communicates with the inside of the housing 20. Filter 72, cap 73
The structure of the seal member 74 is the same as the structure shown in FIG.

Further, as another structure of the ventilation means 7, as shown in FIG.
In addition, a ventilation path 211 is provided. This ventilation path 2
One end of 11 is open at the tip of the bottle needle 21 and the other end is open inside the housing 20. The air in the housing 20 flows into the blood bag through the ventilation path 211, and at the same time, the blood flows from the flow path 212 into the housing 20.

When all the blood in the blood bag flows out, the air that first flows into the blood bag from the housing 20 flows into the housing 20 and allows the blood remaining in the housing 20 to be collected.

As shown in FIG. 2, in addition to the case where the bottle needle is provided integrally with the aggregate filter 2, the bottle needle and the aggregate filter 2 are connected by a connecting tube by using the bottle needle as a separate body. The structure may be modified. In this structure, as shown in FIG. 14, the bottle needle is provided with the ventilation means 7, and when the blood in the blood bag is exhausted, the ventilation means 7 is in a state capable of ventilation. The specific structure of the ventilation means 7 is the same as that described with reference to FIG.

As described above, if the aerating means 7 is provided in the bottle needle, almost all of the red blood cell preparation remaining in the blood transfusion set 1 from the bottle needle to the blood filter 3 can be collected.

As another example of the ventilation means 7, it can be provided on a connecting tube. FIG. 15 shows a structure in which the connection tube is provided with the ventilation means 7. An air filter 55 having a dust removing and germicidal action is connected to the branch pipe 54 provided with the connecting tube, and the air inlet of the air filter is closed by a seal member 56 which is peeled off when necessary. As the air filter, for example, a “GL filter” manufactured by Terumo Corporation can be used. Further, a cap member for hermetically sealing may be used instead of the seal member 56.

In addition to the case described above, the position where the ventilation means 7 is provided may be provided in another component of the liquid sending circuit. For example, when a chamber is provided on the upstream side of the blood filter 3, a ventilation means may be provided in the chamber.

With the configuration described above, it is possible to collect blood upstream of the blood filter. Specifically, when air is caused to flow in by the ventilation means on the liquid inflow side, the red blood cell preparation remaining on the downstream side from the ventilation means flows downstream, and flows out of the liquid inflow space in the blood filter through the filtering member, and the liquid outflow. Flow into space. By the way, since the pressure due to the head of the blood transfusion set is lower than the bubble point of the filtering member, the air flowing from the ventilation means does not flow downstream of the filtering member.

Here, as described above, by providing the ventilation means 7 in the circuit and using the above-described blood filter 3, almost all the red blood cell preparation remaining in the transfusion set 1 can be collected. .

The procedure will be briefly described. When the blood in the blood bag is emptied, the pressure in the blood transfusion set 1 becomes negative due to the head drop, and the outside air is introduced from the ventilation means, and the upstream side of the blood filter 3 is provided. Passes through the filter member 33 in the blood filter 3 and flows downstream. When the blood on the upstream side of the filtration member 33 has finished flowing to the downstream side, the seal member 65 of the communication portion 6 is peeled off, and the intake communication passage 6b is made permeable to air, and the blood on the downstream side of the filtration member 33 is dropped. To recover.

Although the blood transfusion set 1 provided with the aggregate filter 2 on the upstream side of the blood filter 3 has been described, the aggregate filter 2 can be omitted if necessary. In such a case, a bottle needle can be formed integrally with the blood filter 3, and the bottle needle can be provided with ventilation means.

FIG. 16 is a sectional side view of the blood filter 3. In this configuration, the liquid inlet 31 of the blood filter 3 is located at the lowermost part of the liquid inflow space A, and the liquid inlet 31 is provided with the flow path 341 of the bottle needle 34 formed integrally with the housing 30. It is connected. Channel 34
1 is formed continuously from the tip of the bottle needle 34 to the inside of the thick portion of the housing 30.

Further, a vent passage 35 is formed in the bottle needle 34 as a ventilation means through which air flows. It is open to.

With such a configuration, when blood first flows into the housing 30, the blood flows into the lowermost portion of the liquid inflow space A, and the blood is filled in order from the bottom. At the same time, the air in the liquid inflow space A is
5, the air in the liquid inflow space A flows into the blood bag, and the priming of the liquid inflow space A is completed.

When the blood in the blood bag runs out, the air that has flowed into the blood bag during priming and the air that has been in the blood bag from the beginning flow into the liquid inflow space A from the flow path 341. By the inflow of the air, the blood on the upstream side of the filtering member 33 can permeate and flow into the downstream side of the filtering member 33.

FIG. 17 shows an example of a configuration in which the ventilation means 7 is provided in the flow path 341 of the bottle needle 34. The configuration of the ventilation means 7 is the same as that of the ventilation means shown in FIG.

Although the above description has been made with reference to a blood transfusion set as an example, the liquid processor of the present invention or the above-described structure may be used in another liquid sending circuit. For example, the present invention may be applied to a filter used in a plasma purification system. The liquid processor of the invention may be used.

For example, the liquid processor of the present invention is used in a plasma purification system, and can also be used as a filter for filtering a high molecular weight protein component precipitated in plasma by a plasma protein fraction separating agent. FIG. 18 is a cross-sectional side view showing a configuration of the liquid processor of the present invention used as a filter of the plasma purification system.

The liquid processing device 8 includes a housing 8
0, a lid 81 put on the housing 80, and a lid 8
1 and a housing 80, a liquid inlet 82 and a liquid outlet 83 provided respectively in the housing 80, a filter member 84 provided in the housing 80, and a filter member 84 provided in the housing 80.
And a potting material 85 to be fixed inside. The liquid inlet 82 is constituted by a pipe 811 penetrating the lid 81.

As shown in FIG. 19, the filtering member 84 is formed by bonding two sheet-like filter media 841 and 842 at three ends to form a bag. And the tube 811 is inserted into the open end thereof. A potting material 85 is filled between the tube 811 and the filter member 84 and between the filter member 84 and the housing 80, The filtering member 84 is fixed.
When the plasma flows into the liquid processing device 8 configured as described above, the precipitate is separated by filtration when the plasma permeates from the inside to the outside of the filtering member 84.

Further, the communication section 9 is provided in the housing 80. The communication portion 9 is provided with the ventilation means described in FIG. 11 in addition to the structure described in FIGS.
a, It can also be used as the intake communication passage 9b. At this time, the seal member 94b as a peeling member may be provided only on the cap 93b of the intake communication passage 9b.

When priming is performed for the first time, as plasma accumulates from the lower side, the internal air is discharged from the exhaust communication passage 9a, and the priming operation can be easily performed without changing the attitude of the liquid processor 8. Can be completed.

When the plasma in the liquid processor 8 is to be recovered, when the seal member 94b is peeled off, air flows in from the intake communication passage 9b, and the plasma remaining in the housing 80 can be easily recovered.

The liquid processing device 8 may have a structure in which the filtering member 84 is not formed in a bag shape as shown in FIG. This structure allows the filter member 84
The two sheet-shaped filter media 841 and 842 constituting
The end is fixed to the inner wall of the housing 80 without being bonded at one end.

In this configuration, two liquid outflow spaces B defined by the filter medium are formed, and the two liquid outflow spaces B are connected to each other at the lower side of the housing.
A flow path (not shown) is formed and communicates with the liquid outlet.

In the liquid processing device 8 having such a configuration, communication portions 9 are provided on each side surface of the housing 80 facing the filter media 841 and 842, respectively. in this way,
When there are a plurality of partitioned liquid outflow spaces, by providing the communication portion 9 in each of them, the liquid in all the liquid outflow spaces can be collected.

In the above structure, when the plasma is filled, spaces independent from each other (no air flow) are formed between the inner wall of the filter member 84 and the inner wall of the housing 80. Is provided with a communication portion 9,
There is an advantage that priming and recovery of residual plasma can be performed easily and reliably.

[0107]

As described above, according to the liquid processor of the present invention, the body fluid in the liquid processor can be recovered at a high rate.

[Brief description of the drawings]

FIG. 1 is an overall sectional side view of a blood filter.

FIG. 2 is an overall view of a blood transfusion set.

FIG. 3 is a plan view of a communication portion.

FIG. 4 is a sectional view of an exhaust communication passage.

FIG. 5 is a sectional view of an intake communication passage.

FIG. 6 is a partially cutaway perspective view showing another example of the configuration of the communication portion.

FIG. 7 is a partially cutaway perspective view showing another example of the configuration of the communication portion.

FIG. 8 is a partially cutaway overall perspective view showing another configuration example of the communication portion.

FIG. 9 is a partially cutaway overall perspective view showing another configuration example of the communication portion.

FIG. 10 is a partial cross-sectional side view of an aggregate filter provided with a ventilation unit.

FIG. 11 is an enlarged sectional view of the ventilation means.

FIG. 12 is a partial cross-sectional side view of an aggregate filter having a bottle needle provided with a ventilation unit.

FIG. 13 is a partial cross-sectional side view of an aggregate filter having a ventilation passage as a ventilation means in a bottle needle.

FIG. 14 is a partial cross-sectional side view of a bottle needle showing a structure in which a single bottle needle is provided with ventilation means.

FIG. 15 is a partial perspective view of the connection tube, showing a structure in which ventilation means is provided in the connection tube.

FIG. 16 is an overall cross-sectional side view of a bottle-needle-integrated blood filter having a ventilation path as ventilation means.

FIG. 17 is a partial cross-sectional view of a bottle-needle-integrated blood filter in which a ventilation means is provided in the bottle needle.

FIG. 18 is an overall sectional side view of a liquid processor used as a filter of the plasma purification system.

19 is a sectional view taken along line AA in FIG.

FIG. 20 is a plan sectional view showing another configuration example of the liquid processor used as a filter of the plasma purification system.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Blood transfusion set (liquid sending circuit) 2 Aggregate filter 20 Housing 21 Bottle needle 211 Air passage 212 Flow path 22 Blood outlet 23 Liquid filter 24 Chamber 3 Blood filter (liquid processor) 30 Housing 31 Liquid inlet 32 Liquid outlet 33 Filtration Member 34 Bottle Needle 341 Channel 35 Air Vent 4 Drip Cylinder 41 Blood Inlet 42 Blood Outlet 51-3 Connection Tube 54 Branch Pipe 55 Air Filter 56 Seal Member 6 Communication Portion 6a Exhaust Communication Channel 6b Intake Communication Channel 61a, b hole 62a, b filter 621a hydrophilic filter 622a hydrophobic filter 63a, b concave portion 64 protruding body 65 sealing member 650 vent hole 651-2 handle portion 66 body 661a, b hole 662a, b filter 67 valve body 671a, b vent 672 Hand part 673a, b Filter 7 Ventilation means 71 hole 72 Filter 73 Cap 731 Vent hole 75 Ventilation path 8 Liquid processor 80 Housing 81 Lid 811 Tube 82 Liquid inlet 83 Liquid outlet 84 Filtration member 841-2 Filter material 85 Potting Material 9 Communication section 9a Exhaust communication path 9b Intake communication path 91a, b hole 92a, b filter 93a, b cap 94b sealing member 11 clamp 12 clamp A liquid inflow space a liquid circulation space B liquid outflow space b liquid circulation space

Continuation of the front page (58) Field surveyed (Int.Cl. ⁷ , DB name) A61M 1/22 510

Claims (4)

(57) [Claims] A housing, a filter member housed in the housing, and partitioning the inside of the housing into a liquid inflow space and a liquid outflow space; a liquid inflow port communicating with the liquid inflow space; A liquid outlet that communicates with the liquid outlet, and an exhaust line that has a filter formed by stacking the hydrophilic filter and the hydrophobic filter such that the hydrophilic filter is on the liquid outlet space side such that the hydrophilic filter is on the liquid outlet space side. A passage communicating with the liquid outflow space, a suction communication passage having a filter having a dust removing and sterilizing action, and a ventilation hole communicating with the exhaust communication passage, wherein the exhaust communication passage and the intake A liquid member having a peelable seal member that simultaneously covers the communication passage, wherein the seal member shields the intake communication passage and releases the shield when necessary. Vessel. 2. A housing, a filter member housed in the housing, and dividing the inside of the housing into a liquid inflow space and a liquid outflow space, a liquid inflow port communicating with the liquid inflow space, and a liquid outflow space. A liquid outlet communicating with the main body, a main body provided on the housing, a valve body slidably inserted into the main body, and a hydrophobic filter provided on the main body so as to communicate with the liquid outflow space. An exhaust communication passage, an intake communication passage provided in the main body so as to communicate with the liquid outflow space, and having a filter having a dust removing and sterilizing action; and an exhaust communication passage formed in the valve body. And a ventilation hole connected to the intake communication passage. By changing a position of the valve body with respect to the main body, the exhaust communication passage and the intake communication passage and the ventilation hole are formed. A liquid processor for switching connections. 3. A housing, a filter member housed in the housing, and dividing the interior of the housing into a liquid inflow space and a liquid outflow space, a liquid inflow port communicating with the liquid inflow space, and a liquid outflow space. A liquid outlet communicating with the body, a main body provided in the housing, a valve body slidably inserted into the main body, and a hydrophobic filter provided on the valve body so as to communicate with the liquid outflow space. An exhaust communication passage having an air communication passage having a filter provided with the valve body to communicate with the liquid outflow space and having a dust-removing and bacteria-removing action; and changing a position of the valve body with respect to the main body. The liquid processing device is configured to switch a communication state between the exhaust communication path and the intake communication path. 4. The liquid processor according to claim 1, further comprising a ventilation unit communicating with the liquid inflow space and capable of introducing air into the liquid inflow space.