JP2011102270A - Anti-saccharification agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a novel anti-saccharification agent relating to an anti-saccharification agent used as a cosmetic composition, a food composition or the like, an anti-aging agent, a damage inhibitor of skin collagen, and an inhibiting, preventing or improvement agent for fall of firmness or elasticity of skin, or a wrinkle of skin. <P>SOLUTION: The anti-saccharification agent, an anti-aging agent, a damage inhibitor of skin collagen, and an inhibiting, preventing or improvement agent for fall of firmness or elasticity of skin, or a wrinkle of skin includes Buddleja axillaris leaf extract as an active ingredient. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an anti-glycation agent, an anti-aging agent, a skin collagen damage inhibitor used as a cosmetic composition or a food composition, and the suppression or prevention of skin tension or elasticity reduction, or skin wrinkle. Or an improver.

  A saccharification reaction (Maillard reaction) occurs between a reducing sugar such as glucose and a protein, and a saccharification product is generated. Protein saccharification occurs in vivo, but if a hyperglycemic state continues due to diabetes, etc., or if the degradation reaction does not proceed easily due to aging, the production of glycation products tends to occur and the function of the protein is impaired. Saccharification products accumulate. This saccharification product finally becomes a terminal saccharification product (advanced glycation end products; hereinafter abbreviated as “AGEs”), but the generation of AGEs is an irreversible reaction. The produced AGEs are discharged from the body by metabolism, but with aging, the metabolic rate becomes slower and AGEs accumulate in each tissue in the living body.

AGEs cause various symptoms by accumulating in each tissue in the living body or binding to AGEs receptors. For example, when AGEs are generated and accumulated in the skin (epidermis, dermis), the overall skin declines (for example, skin tension and elasticity decreases, changes in skin color such as wrinkles, tarmi, yellowishness, transparency) Decrease, stains, etc.). In diabetic patients, AGEs caused by hyperglycemia cause complications such as cataracts, arteriosclerosis, and renal dysfunction. Therefore, in order to discharge the generated AGEs to the outside of the body, it is important to decompose the AGEs into a form that can be easily discharged outside the body.
Conventionally, in order to make it an active ingredient of a cosmetic composition or a food composition, a search for a component that suppresses the generation of AGEs and a component that decomposes AGEs has been conducted. For example, Patent Document 1 describes that citrus volatile oils inhibit the production of pentosidine, which is a part of the AGE structure. Patent Document 2 describes that an extract of olive oil in ethanol has an AGEs-decomposing action and suppresses skin dullness.
Carboxymethylarginine (CMA) is a type of AGEs structure that specifically accumulates in collagen. Patent Document 3 describes that a CMA production inhibitor can suppress the denaturation of biological proteins such as skin and blood vessels by inhibiting the conversion of collagen to AGEs, and is one of the indicators of skin aging. It is described as being useful.

JP2004-35424 JP 2001-122758 JP2009-96731

  The main object of the present invention is to provide a novel anti-glycation agent.

The present inventor repeated researches to solve the above problems, and obtained the following knowledge.
(i) Buddleja axillaris leaf extract effectively suppresses the production of AGEs by saccharification reaction between proteins such as collagen and reducing sugars. Thereby, damage to skin collagen is suppressed, and as a result, skin aging such as a decrease in skin tension or elasticity, or skin wrinkling is suppressed, prevented, or improved.
(ii) Ultraviolet rays promote saccharification reaction.
(iii) Budreja axillaris leaf extract also effectively suppresses the saccharification reaction promoted by ultraviolet rays. This suppresses skin collagen damage promoted by ultraviolet rays, and consequently suppresses skin aging promoted by ultraviolet rays, such as skin tension or a decrease in elasticity, or skin wrinkles.
The present invention has been completed based on the above findings, and has been completed. The following anti-glycation agent, anti-aging agent, skin collagen damage inhibitor, and skin tension or elasticity reduction, or skin An agent for suppressing, preventing or improving wrinkles is provided.

Item 1. An anti-glycation agent containing Budreja axillaris leaf extract as an active ingredient.
Item 2. Item 2. The budreja axillaris leaf extract is an extract of at least one solvent selected from the group consisting of water, monohydric alcohols having 1 to 4 carbon atoms, and polyhydric alcohols having 2 to 6 carbon atoms. Anti-glycation agent.
Item 3. Item 3. The anti-glycation agent according to Item 1 or 2, which is a cosmetic composition.
Item 4. Item 3. The anti-glycation agent according to Item 1 or 2, which is a food composition.
Item 5. An anti-aging agent comprising Budreja axillaris leaf extract as an active ingredient.
Item 6. Item 6. The budreja axillaris leaf extract is an extract of at least one solvent selected from the group consisting of water, monohydric alcohols having 1 to 4 carbon atoms, and polyhydric alcohols having 2 to 6 carbon atoms. Anti-aging agent.
Item 7. Item 7. The anti-aging agent according to Item 5 or 6, which is a cosmetic composition.
Item 8. Item 7. The anti-aging agent according to Item 5 or 6, which is a food composition.
Item 9. A skin collagen damage inhibitor comprising Budreja axillaris leaf extract as an active ingredient.
Item 10. Item 10. The Budreja axillaris leaf extract is an extract of at least one solvent selected from the group consisting of water, a monohydric alcohol having 1 to 4 carbon atoms, and a polyhydric alcohol having 2 to 6 carbon atoms. Skin collagen damage inhibitor.
Item 11. Item 11. The skin collagen damage inhibitor according to Item 9 or 10, which is a cosmetic composition.
Item 12. Item 11. The skin collagen damage inhibitor according to Item 9 or 10, which is a food composition.
Item 13. An agent for suppressing, preventing, or improving the reduction of skin tension or elasticity, or the reduction of skin wrinkles, comprising a Budreja axillaris leaf extract as an active ingredient.
Item 14. Item 14. The budreja axillaris leaf extract is an extract of at least one solvent selected from the group consisting of water, a monohydric alcohol having 1 to 4 carbon atoms, and a polyhydric alcohol having 2 to 6 carbon atoms. An agent for suppressing, preventing, or improving the decrease in skin tension or elasticity, or skin wrinkles.
Item 15. Item 15. The agent for suppressing, preventing, or improving the decrease in skin tension or elasticity or skin wrinkle according to Item 13 or 14, which is a cosmetic composition.
Item 16. Item 15. The agent for suppressing, preventing, or improving the decrease in skin tension or elasticity or skin wrinkle according to Item 13 or 14, which is a food composition.

The anti-glycation agent of the present invention can effectively inhibit saccharification reaction by containing a B. regex axillaris leaf extract, and this action can inhibit skin aging.
Specifically, glycation of skin proteins such as collagen can be achieved by applying a cosmetic composition containing Budreja axillaris leaf extract to the skin or ingesting a food composition containing Budreja axillaris leaf extract. It is possible to prevent, suppress, or improve the production of AGEs by aging, or the deterioration or aging of the skin caused by the accumulation thereof. Thereby, the impression of the whole skin is kept young and a youthful appearance is obtained. Examples of the deterioration of the skin include a decrease in skin tension or elasticity, wrinkles, rough skin, a decrease in skin texture, a dullness, and a decrease in transparency.

In addition, UV irradiation promotes the production of AGEs by saccharification of skin proteins such as collagen and promotes skin aging, but Budreja axialis leaf extract is aging of skin by saccharification promoted by UV irradiation. (Photoaging) can also be suppressed. Thus, the Budreja axillaris leaf extract can effectively suppress saccharification and aging due to ultraviolet irradiation. Moreover, although cut | disconnection and bridge | crosslinking of skin collagen arise with an ultraviolet-ray, the Budoreja axillaris leaf extract can suppress effectively the cut | disconnection and bridge | crosslinking of such skin collagen by an ultraviolet-ray.
Thereby, the budreja axillaris leaf extract can suppress aging such as skin tension or elasticity reduction due to ultraviolet irradiation, wrinkles, rough skin, skin texture reduction, dullness, and transparency.
In addition, the anti-glycation agent of the present invention is used for various diseases caused by AGEs (diabetic complications (cataract, arteriosclerosis, renal dysfunction, retinopathy, neuropathy, etc.), arteriosclerosis, malignant tumor, bone disease, Alzheimer's disease. It is expected to prevent or improve Parkinson's disease.

It is a figure which shows AGEs promotion by UVA irradiation. It is a figure which shows that Budoreja axillaris leaf extract suppresses AGEs production | generation under UVA irradiation. It is a figure which shows that Budoreja axillaris leaf extract suppresses the production | generation of CMA under UVA irradiation. It is a figure which shows that Budoreja axillaris leaf extract suppresses the production | generation of CMA under UVA irradiation. It is a figure which shows that the Budoreja axillaris leaf extract suppresses the production | generation of CMA under UVA irradiation. It is a figure which shows that a Budoreja axillaris leaf extract suppresses the production | generation of AGEs under UVA irradiation. It is a figure which shows that the Budoreja axillaris leaf extract suppresses the production | generation of pentosidine under UVA irradiation.

Hereinafter, the present invention will be described in detail.
As an anti-glycation agent, aging agent, skin collagen damage inhibitor, and skin tension or elasticity reduction, skin wrinkle suppression, prevention, or amelioration agent of the present invention, a Budereja axialis leaf extract is effective. Contains as an ingredient.
Budo holiday Aki sila squirrel leaf extract Budo holiday Aki sila squirrel leaf extract, Mandoreshi extract, also referred to as Man Dore Sea extract is obtained by extracting the leaves of Budo leisure Aki sila squirrel in a solvent. Budreja axillaris leaves may be subjected to extraction as they are, or may be cut, crushed, or pulverized for extraction. As for the extraction method, the temperature of the solvent, the weight ratio of the solvent to the leaves of Budella axillaris, or the extraction time can be arbitrarily set.

As the extraction solvent, either water or an organic solvent can be used. Examples of the organic solvent include methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, sec-butanol, monohydric alcohol having 1 to 4 carbon atoms such as tert-butanol; ethylene glycol, propylene glycol, 1, C2-C6 polyhydric alcohols or derivatives thereof such as 3-butylene glycol, hexylene glycol, ethylene glycol monomethyl ether; esters such as ethyl acetate; ketones such as acetone and methyl ethyl ketone; Nitriles; ethers such as diethyl ether and tetrahydrofuran; saturated hydrocarbons having 5 to 7 carbon atoms such as pentane, hexane, heptane, cyclopentane and cyclohexane; aromatics having 6 to 8 carbon atoms such as toluene and benzene Group hydrocarbons Examples include halogenated hydrocarbons such as dichloromethane and chloroform; dimethylformamide; dimethylsulfoxide and the like.
An extraction solvent can be used individually by 1 type or in combination of 2 or more types. Among these, water, a monohydric alcohol having 1 to 4 carbon atoms, and a polyhydric alcohol having 2 to 6 carbon atoms are preferable, and water, ethanol, propylene glycol, and butylene glycol are more preferable. When using 2 or more types in combination, it is preferable to use a mixture of ethanol and water. In this case, the use ratio of ethanol is preferably about 50 to 90% by volume, more preferably about 60 to 80% by volume, and most preferably about 70:30 (ethanol: water) by volume. preferable.

As the temperature of the extraction solvent, a room temperature or normal temperature solvent can be used, but a heating solvent or a thermal solvent (a solvent heated near the boiling point) can also be used. Specifically, when the extraction solvent is water, the temperature at the time of extraction is not particularly limited as long as it is not higher than the boiling point of the solvent, but is preferably about 40 to 100 ° C, more preferably about 60 to 100 ° C, and more preferably about 80 Even more preferred is ~ 100 ° C. If it is the said range, the component which has anti- glycation activity can fully be extracted. The extraction time is not particularly limited, but can be generally about 30 seconds to 4 hours, preferably about 3 to 50 minutes, and more preferably about 4 to 40 minutes.
Moreover, it can stir as needed and can extract at a normal pressure. However, the extraction method and extraction conditions are not particularly limited, and for example, pressure extraction can be performed. By performing the extraction treatment in this manner, a liquid Budreja axillaris leaf extract is obtained.
In the present invention, the extract can be used as it is, but when the organic solvent is contained, it is preferable to remove the organic solvent by vacuum distillation or the like. In the present invention, the Budoreja axillaris leaf extract may be used in a liquid form, but if necessary, the liquid content is reduced by performing drying treatment such as reduced pressure drying, freeze drying, spray drying and the like. Alternatively, a concentrated liquid, semi-solid, solid, or powder may be used by removing.
In addition, a commercially available product of Budreja axillaris leaf extract can also be purchased.

Cosmetic composition The anti-glycation agent, anti-aging agent, skin collagen damage inhibitor, and skin tension or elasticity reduction, skin wrinkle suppression, prevention, or improvement agent of the present invention is Budreja axillaris leaf extraction The product can be mixed with a known base or carrier acceptable as a cosmetic ingredient to form a cosmetic composition.
The form of the cosmetic composition is not particularly limited. For example, lotion, milky lotion, cream, cosmetic liquid, sunscreen cosmetics, basic cosmetics such as packs, hand creams, body lotions, body creams; Cosmetics for cleaning such as makeup remover, body shampoo, shampoo, rinse; makeup cosmetics such as foundation, makeup base, lip balm, lipstick, cheek color; bathing agent and the like.
The content of the extract of budreja axillaris leaf in the cosmetic composition may be, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 10% by weight, preferably about 0.001 to 5% by weight is more preferred. Within the above range, sufficient anti-glycation effect, anti-aging effect, skin collagen damage suppression effect, skin tension or elasticity reduction, or skin wrinkle suppression, prevention or improvement effect can be obtained with the usual use amount of cosmetics. It is done.

  Bases or carriers include paraffin, liquid paraffin, squalane, white wax, gelled hydrocarbon (such as plastic base), ozokerite, ceresin, petrolatum, hard fat, microcrystalline wax, α-olefin oligomer, light liquid paraffin, etc. Hydrocarbons; fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid; such as glyceryl tri-2-ethylhexanoate (trioctanoin), tri (caprylic acid / capric acid) glyceryl Tri-fatty acid glycerides; higher alcohols such as cetanol, stearyl alcohol, behenyl alcohol; methyl polysiloxanes, highly polymerized methyl polysiloxanes, dimethylsiloxane methyl (polyoxyethylene) siloxane methyl Polyoxypropylene) siloxane copolymer, dimethylsiloxane-methyl (polyoxyethylene) siloxane copolymer, dimethylsiloxane-methyl (polyoxypropylene) siloxane copolymer, polyoxyethylene-methylpolysiloxane copolymer, poly ( Oxyethylene / oxypropylene) / methylpolysiloxane copolymer, dimethylsiloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, alkyl acrylate copolymer methylpolysiloxane ester, cross-linked methyl Polysiloxane, cross-linked methylphenyl polysiloxane, cross-linked polyether-modified silicone, cross-linked alkyl polyether-modified silicone, cross-linked alkyl-modified silicone, decamethylcyclopenta Silicone such as siloxane, ethyltrisiloxane, methyltrimethicone, methylsiloxane network polymer, polyoxyethylene-methylpolysiloxane copolymer, methylhydrogenpolysiloxane, triethoxysilylethylpolydimethylsiloxyethylhexyl dimethicone, dimethylpolysiloxane Oils; glycol acetates such as ethylene glycol monoacetate, ethylene glycol diacetate, triethylene glycol diacetate, hexylene glycol diacetate, and 2-methyl-2-propene-1,1-diol diacetate Tart; Triethylene glycol divalerate, 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate, 2,2,4-trimethyl-1,3-pentanediol diisobut Glycol esters such as acrylates; such as ethylene glycol diacrylate, diethylene glycol diacrylate, propylene glycol monoacrylate, 2,2-dimethyl-trimethylene glycol diacrylate, and 1,3-butylene glycol diacrylate Glycol acrylates; glycol dinitrates such as ethylene glycol dinitrate, diethylene glycol dinitrate, triethylene glycol dinitrate, and propylene glycol dinitrate; 2,2 '-[1,4-phenylenedioxy] diethanol; ethylcellulose, hydroxy Cellulose derivatives such as propylcellulose, hydroxypropylmethylcellulose; polyvinylpyrrolidone; carrageenan; polyvinylbutyrate; Diethylene; Butylene glycol adipic acid polyester; Esters such as isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythrite tetra-2-ethylhexanoate; dextrin, malto Polysaccharides such as dextrin; lower alcohols such as ethanol and isopropanol; ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether ,Propylene glycol Examples thereof include glycol ethers such as monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether and dipropylene glycol monopropyl ether; aqueous bases such as water.

Among them, hydrocarbons (especially α-olefin oligomers, squalane, light liquid paraffin, liquid paraffin), trifatty acid glycerides (particularly glyceryl tri-2-ethylhexanoate, tri (caprylic acid / capric acid) glyceryl), higher alcohols ( In particular, cetanol, stearyl alcohol, behenyl alcohol), silicone oil (especially methylpolysiloxane, alkyl acrylate copolymer methylpolysiloxane ester, cross-linked methylpolysiloxane, decamethylcyclopentasiloxane, ethyltrisiloxane, methyltrimethicone, Methyl siloxane network polymer, polyoxyethylene / methyl polysiloxane copolymer, methyl hydrogen polysiloxane, triethoxysilylethyl polydimethylsiloxyethylhexyl dimethicone, dimethicone Polysiloxane), esters (especially isononyl isononanoate, pentaerythritol tetra-2-ethylhexanoate), polysaccharides (especially dextrin, maltodextrin), glycol ethers (especially diethylene glycol monoethyl ether), water are preferred. .
A base or a carrier can be used alone or in combination of two or more.

  In addition, the cosmetic composition is a known additive that is added to the cosmetic, for example, a surfactant, a thickener, a preservative, a pH adjuster, a chelating agent, a stable agent, as long as the effects of the present invention are not impaired. An agent, an irritation reducing agent, a preservative, a colorant, a dispersant, a fragrance, a pearl luster imparting agent, and the like can be added. An additive can be used individually by 1 type or in combination of 2 or more types.

  Examples of the surfactant include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate. Sorbitan fatty acid esters; glyceryl fatty acids such as glyceryl monostearate and glyceryl monostearate; polyglyceryl fatty acids such as polyglyceryl monostearate, polyglyceryl monoisostearate and polyglyceryl diisostearate; propylene glycol monostearate Propylene glycol fatty acid esters such as: polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor Hardened castor oil derivatives such as oil 50 (HCO-50), polyoxyethylene hardened castor oil 60 (HCO-60), polyoxyethylene hardened castor oil 80; polyoxyethylene (20) sorbitan monolaurate (polysorbate 20), Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene monooxylate (20) sorbitan (polysorbate 80), polyoxyethylene (20) sorbitan isostearate; Polyoxyethylene monococonut oil fatty acid glyceryl; glycerin alkyl ether; alkyl glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether; stearylamine, oleyl Amines such as tromethamine, polyoxyethylene-methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and the like silicone-based surfactants such as PEG-9 polydimethylsiloxyethyl dimethicone.

Among them, glycerin fatty acids (particularly glyceryl monostearate), polyglycerin fatty acids (particularly polyglyceryl monostearate), hardened castor oil derivatives (particularly polyoxyethylene hardened castor oil 50 (HCO-50), polyoxyethylene) Hydrogenated castor oil 60 (HCO-60)), polyoxyethylene sorbitan fatty acid esters (particularly polyoxyethylene (20) sorbitan isostearate, polyoxyethylene (20) sorbitan monostearate (polysorbate 60)), polyoxyalkylene Alkyl ether (especially polyoxyethylene cetyl ether), silicone surfactant (especially polyoxyethylene methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethyl) Lucyloxyethyl dimethicone) is preferred.
The content of the surfactant can be about 0.001 to 20% by weight based on the entire cosmetic composition.

Examples of thickeners include guar gum, locust bean gum, carrageenan, xanthan gum, dextran, methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, sodium alginate, propylene glycol alginate, polyvinyl Alcohol, polyvinyl pyrrolidone, polyvinyl methyl ether, carboxy vinyl polymer, alkyl methacrylate copolymer, sodium polyacrylate, polyethylene glycol, bentonite, dextrin fatty acid ester, pectin, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer The Chill distearyl ammonium hectorite, (ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymer, polyethylene glycol distearate, triisostearate, ethylene glycol, triisostearate, polyoxyethylene (20) and the like methyl glucoside.
Among them, xanthan gum, alkyl methacrylate methacrylate copolymer, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, polyethylene glycol, carboxyvinyl polymer, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer, dimethyl distearyl ammonium hectorite (Acryloyl dimethyl taurate ammonium / vinyl pyrrolidone) copolymer, polyethylene glycol distearate, ethylene glycol triisostearate, polyoxyethylene (20) methyl glucoside triisostearate.
The content of the thickener can be about 0.001 to 10% by weight with respect to the entire cosmetic composition.

Preservatives and preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, paraoxybenzoic acid Examples include benzyl, methyl paraoxybenzoate, and phenoxyethanol. Of these, methyl paraoxybenzoate, propyl paraoxybenzoate, and phenoxyethanol are preferable.
The content of the preservative and the preservative can be about 0.001 to 5% by weight based on the whole cosmetic composition.

Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, phosphoric acid, polyphosphoric acid, boric acid, etc.), organic acids (lactic acid, acetic acid, citric acid, sodium citrate, tartaric acid, malic acid, succinic acid, sodium succinate, Oxalic acid, gluconic acid, fumaric acid, propionic acid, acetic acid, aspartic acid, epsilon-aminocaproic acid, glutamic acid, aminoethylsulfonic acid, etc.), gluconolactone, ammonium acetate, inorganic base (sodium bicarbonate, sodium carbonate, hydroxylation) Potassium, sodium hydroxide, calcium hydroxide, magnesium hydroxide, etc.) and organic bases (monoethanolamine, triethanolamine, diisopropanolamine, triisopropanolamine, lysine, etc.). Among these, succinic acid, sodium succinate, citric acid, sodium citrate, triethanolamine, potassium hydroxide, and sodium hydroxide are preferable.
Content of a pH adjuster can be about 0.0001-5 weight% with respect to the whole cosmetics composition.

Chelating agents include ethylenediaminetetraacetic acid (edetic acid), ethylenediaminetetraacetic acid salt (sodium salt (sodium edetate: Japanese Pharmacopoeia, EDTA-2Na, etc.), potassium salt, etc.), phytic acid, gluconic acid, polyphosphoric acid, metalin An acid etc. are mentioned. Of these, sodium edetate is preferable. The content of the chelating agent can be about 0.0001 to 5% by weight with respect to the entire cosmetic composition.
Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like. The content of the stabilizer can be about 0.0001 to 5% by weight with respect to the entire cosmetic composition.
Examples of the irritation reducing agent include licorice extract and sodium alginate. The content of the irritation reducing agent can be about 0.001 to 10% by weight based on the whole cosmetic composition.

Examples of the colorant include inorganic pigments and natural pigments. The content of the colorant can be about 0.00001 to 10% by weight with respect to the entire cosmetic composition.
Examples of the pearl luster imparting agent include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate. Of these, ethylene glycol distearate is preferable. The content of the pearly luster imparting agent can be about 0.0001 to 10% by weight based on the whole cosmetic composition.

In addition, the cosmetic composition contains a known anti-glycation component that can be added to cosmetics for the purpose of further enhancing the effects of the present invention of improving, suppressing, and preventing skin deterioration caused by accumulation of AGEs in the skin. Can be blended. Known anti-glycation components can be used singly or in combination of two or more.
Known anti-glycation components include, for example, evening primrose oil or evening primrose extract, Amla fruit, fruit juice or extracts thereof (JP 2006-028090, JP 2006-62989, etc.); L-arginine, L-lysine, Hydrolyzed casein (above, JP-A-2001-039816); hydrolyzable tannin (JP-A-9-40519); carnosine, α-lipoic acid (above, "Latest skin diagnostic manual for beauty", Fragrance Journal, Issued on August 15, 2006): Western rose flower / ovary, hybrid rose flower / ovary / gaku, leaf / stem, age, grape leaves, oyster leaves, apple leaves, marigold flowers, magnolia leaves Extract (above, JP 2006-273811 A); Button genus plant extract, Capsicum plant extract, Papaver plant extract, Sunflower plant extract, Aloe plant extract, Amadokoroma plant extract, Flax Extract, rose plant extract, linden plant extract, kangwei plant extract, genus plant extract, kanto plant extract, burdock plant extract, mint plant extract, elder plant extract Extract (above, JP 2003-212749); extract of Yoshitaka Odaka (JP 2006-62987); asunaro, asenyaku, Japanese knotweed, Ichiyakuso, apricot, kankanka, hakukayumatou, birch, hawthorn, achillea millefolium, codfish , Dokudami, tormentilla, bakumondou, hiba, grape, migrove willow, mugwort, mokka, litchi, roman chamomile extract (above, JP-A-2003-212770); American witch hazel, apricot, Ichiyakusou, waulushi, ouren, king beetle , Gennoshoko, Kohone, Pomegranate, Peonies, Extracts of Japanese Yuzusou, Daiou, Chanoki, Choujinoki, Chineberry Senna, Tencha, Tokkuri Strawberry, Tormentilla, Rose, Button, Yakuyo Salvia, Yachabushi, Yamamomo, Eucalyptus, Logwood, Walmoko (above, JP 2002-241299) ); Extract of akebi, aloe, apricot, hippopotamus, cypress, trash, sansitichin ginseng, taukogi, narukoyuri, chickweed, hamadisha, bukuryo, yuzu (above, JP 2002-241293); calkade, hibiscus, scallop, tonin , Extract of Maronnier, Keishi, Goshi, Sikon, Senna, Toshishi, Baccumber (above, JP-A-11-106336); Fruit kernel of jujube (acid nin), MACJONG fruit, pumpkin seeds, eucommia leaves, Salacia Root extract, Euglena spruce leaf extract (above, JP 2007-2543 45); extracts of amateurs, licorices, snow lotus flowers, devil crows, Ezoukogi, rosea and elcampure (above, JP 2007-254344); papaya extracts (JP 2006-298812); (Japanese Unexamined Patent Publication No. 2006-219447); extracts of the genus Genus (Japanese Unexamined Patent Publication No. 2006-117700); agrimony, ashwagandha, anise, amachazuru, sweet candy, ginkgo, fennel, witch hazel, turmeric, echinacea, Elder, Elba mate, plantain, olive, oregano, orange, persimmon, persimmon, persimmon, chamomile, guarana, cocoon grass, chrysanthemum, cat's claw, catnip, killaway, kingfisher, guava, cucumber, bear, cumixin, black soybean, Hoes, Cinnamon, Ketsumeishi, Goya, Cola Nuts, Gokahi, Gotsukora, Coriander , Comfrey, Saximas Sow, Safflower, Salacia Oblonga, Hawthorn, Sansine Carrot, Shiso, Juyaku, Juniper Berry, Ginger, Cedar, Sugina, Stevia, Spearmint, Sage, Savory, Hawthorn, Sakon, Thyme, Tahitibo, Dandelion, chervil, chanoch, chabot, daisy, clove, daisy, dill, eucommia, nutmeg, squash, nettle, hibiscus, white fox moth, white flower serpentine grass, cabbage, basil, lotus, half-branch, heath, peach, Hyssop, Biwa, Feverfu, Fukugi, Wisteria, Plantago sylum, Blueberry, Blue Mallow, Penny Royal, Safflower, Peppermint, Hop, Polyji, Pound Apple, Marshmallow, Marjoram, Marigold, Malene, Loose Mall, Mallow Blue, Mifuragi, Milk Thistle, Megurinoki, Medu Sweet, Mokka, Yaeyama Aoki, Yakulagiku, Yarrow Flower, Eucalyptus, Yokuinin, Artemisia, Raspberry, Lavender, Linden, Rooibos, Lemongrass, Lemon Thyme, Lemon Verbena, Lemon Verm, Rose Hip, Rose Pink Butts, Rosemary, Rose Red, Laurel, Rafu, Wild Strawberry Extract (above, JP-A-2004-250445); Akamegashiwa, Oyster, Mulberry, Hypericum perforatum, Azalea, Yakuyo Garega, Yaba Santa, Rosehip Extracts of sakura, red scenic sky, blueberries, bearberry, white yam, chickweed, himeweed, henna, and rarea (above, Japanese Patent Laid-Open No. 2001-3162) No. 21); extracts of yew, silkworm, spruce, goldfish, bay bay, sorghum, peony, sorghum, potato, potato, and carrot leaves (above, JP 8-259431); carrot leaf extract (JP 2004-51580) No.); Gambirium, birch, hawthorn, chanoki, clove, Japanese apricot, tormentilla, rose, grape, maroni, roman chamomile extract (above, JP 2005-35911); aminoguanidine or its salt (latest medicine, 49 Vol.2, No.2, p78-83,1994); black soybean seed coat, mate tea leaves (green), linden flowers, radish leaves, black rice seeds, willow bark / sprout, Ibright above ground, black cohosh root, agni fruit, artichoke leaves , Lychee seeds, cutlet bark, oat above ground, passion flower leaves, chadebugure leaves, buckwheat leaves, Saw fruit of rear thistle, leaves of tomorrow, devil's claw root, ipe bark, agaric mycelium, paffia root, acai fruit, mozuku whole plant and processed stalk and leaf (above, JP 2008-088102); Neem extract Aristine; glucosamine and the like. Among them, ingredients derived from plants such as evening primrose, amla, lychee, rose, maronie, maria thistle, neem (especially evening primrose oil or evening primrose extract, amlar extract, lychee seed extract, rose petal extract, maronie extract, maria thistle Extract, neem extract); hydrolyzable tannin (particularly derived from chestnut astringent skin); L-arginine or salt thereof; lysine or salt thereof; carnosine; α-lipoic acid; aminoguanidine or salt thereof;

The amount used in the case of using a known anti-glycation component can be, for example, about 0.00001 to 10% by weight with respect to the total cosmetic composition in terms of dry weight.
Furthermore, the cosmetic composition has an antioxidant component, an anti-aging component, an anti-inflammatory component, a whitening component, a keratin softening component, a cell activation component, vitamins, a blood circulation promoting component, as long as the effects of the present invention are not hindered. It may contain other active ingredients that can be added to cosmetics, such as moisturizing ingredients, ingredients that prevent and / or repair DNA damage, UV-absorbing ingredients, UV-scattering ingredients, cleaning ingredients, antibacterial ingredients, and astringent ingredients it can. Other active ingredients can be used singly or in combination of two or more.

Antioxidant components include components derived from plants (eg, grapes, ginseng, comfrey, etc.); proanthocyanidins, tocopherols and derivatives thereof, ascorbic acid and derivatives thereof, hesperidin, glucosyl hesperidin, ergothioneine, sodium bisulfite, erythorbine Examples thereof include acids and salts thereof, flavonoids, glutathione, glutathione peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, thiotaurine, and hypotaurine. Among them, grape seed extract, grape leaf extract, ginseng extract, comfrey leaf extract, proanthocyanidins, tocopherol and its derivatives (particularly δ-tocopherol, α-tocopherol), ascorbic acid and its derivatives (particularly ascorbic acid, ascorbic acid) Sodium phosphate ester, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), hesperidin, glucosyl hesperidin and ergothioneine are preferred.
The content of the antioxidant can be about 0.00001 to 10% by weight with respect to the entire cosmetic composition.

Antiaging components include hydrolyzed soy protein, retinoids (retinol and derivatives thereof, retinoic acid, retinal, etc.), pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L- Examples include serine and mevalonolactone. Of these, artemia extract, hydrolyzed soy protein, retinol, retinol acetate, and retinol palmitate are preferred.
The content of the anti-aging component can be about 0.0001 to 10% by weight based on the whole cosmetic composition.

Anti-inflammatory components include components derived from plants (eg Comfrey); allantoin, calamine, glycyrrhizic acid or derivatives thereof, glycyrrhetinic acid or derivatives thereof, zinc oxide, guaiazulene, pyridoxine hydrochloride, menthol, camphor, turpentine oil, indomethacin , Salicylic acid or a derivative thereof. Of these, Comfrey leaf extract, allantoin, dipotassium glycyrrhizinate, and stearyl glycyrrhetinate are preferable.
The content of the anti-inflammatory component can be about 0.0001 to 10% by weight with respect to the entire cosmetic composition.

Examples of whitening components include arbutin; hydroquinone; kojic acid; ellagic acid; phytic acid; lucinol; chamomile ET; ascorbic acid or a derivative thereof; vitamin E or a derivative thereof; pantothenic acid or a derivative thereof; Plant components (for example, plant extracts and essential oils) having Of these, arbutin, hydroquinone, kojic acid, ascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), and tranexamic acid are preferable.
The content of the whitening component can be about 0.0001 to 30% by weight with respect to the entire cosmetic composition.

Examples of the keratin soft component include lanolin, urea, phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, and citric acid. Of these, lactic acid, sodium lactate, glycolic acid, salicylic acid, and phytic acid are preferable.
The content of the keratin softening component can be about 0.0001 to 50% by weight based on the whole cosmetic composition.

Cell activation components include components derived from plants (for example, bilberry); amino acids such as γ-aminobutyric acid and ε-aminoproic acid; vitamins such as retinol and its derivatives, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids Α-hydroxy acids such as glycolic acid and lactic acid; tannins, flavonoids, saponins, allantoins, photosensitizer 301 and the like. Among them, bilberry leaf extract, retinol, retinol acetate, and retinol palmitate are preferable.
Content of a cell activation component can be about 0.0001-10 weight% with respect to the whole cosmetics composition.

  Vitamins include retinol, retinol acetate, retinol palmitate, etc., retinal, retinoic acid, methyl retinoic acid, ethyl retinoic acid, retinol retinoic acid, d-δ-tocopheryl retinoate, α-tocopheryl retinoate Vitamins such as β-tocopheryl retinoate; provitamins A such as β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthine, echinone; δ-tocopherol, α- Vitamin Es such as tocopherol, β-tocopherol, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate, δ-tocopherol, tocopherol nicotinate; riboflavin, flavin mononucleotide, flavin Vitamin B2 such as denine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinate; nicotinic acids such as methyl nicotinate, nicotinic acid, nicotinamide; stearic acid Ascorbyl, L-ascorbyl dipalmitate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbic acid Vitamin Cs such as glucoside; Vitamin Ds such as methyl hesperidin, ergocalciferol, and cholecalciferol; Vitamin Ks such as non- and farnoquinone; dibenzoyl thiamine, dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, Vitamin B1 such as thiamine triphosphate, thiamine monophosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, thiamine triphosphate monophosphate; pyridoxine hydrochloride Vitamin B6 such as pyridoxine acetate, pyridoxal hydrochloride, 5′-pyridoxal phosphate, pyridoxamine hydrochloride, vitamin B1 such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin Folic acids such as folic acid and pteroylglutamic acid; pantothenic acids such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-pantethein, D-panthetin, coenzyme A, pantothenyl ethyl ether; biotin, Biotins such as biocytin; in addition, vitamin-like agents such as carnitine, ferulic acid, α-lipoic acid, orotic acid, and γ-oryzanol are included.

Among them, vitamin A such as retinol, retinol acetate, retinol palmitate, etc .; vitamin C such as ascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate) Vitamin E such as δ-tocopherol and tocopherol nicotinate; nicotinic acid such as nicotinamide is preferred.
The content of vitamins can be about 0.001 to 30% by weight with respect to the entire cosmetic composition.

Examples of the blood circulation promoting component include plants (e.g., ginseng, ashitaba, arnica, ginkgo, fennel, enmelio, dutch oak, chamomile, roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake, hawthorn, prunus, nematode, Assembly, thyme, clove, chimney, spruce, spruce, spruce, carrot, garlic, butcher bloom, grape, button, maronier, melissa, yuzu, yokuinin, rosemary, rosehip, chimpy, touki, spruce, peach, apricot, walnut , A component derived from corn); tocopherol nicotinate, glucosyl hesperidin, hesperidin. Among these, ginseng extract, tocopherol nicotinate, glucosyl hesperidin, and hesperidin are preferable.
The content of the blood circulation promoting component can be about 0.00001 to 10% by weight with respect to the entire cosmetic composition.

Moisturizing ingredients include ingredients derived from plants (eg, Tigaya); amino acids and derivatives thereof such as alanine, serine, leucine, isoleucine, threonine, glycine, proline, hydroxyproline, glucosamine, theanine; collagen, gelatin, elastin Such proteins and peptides, hydrolysates thereof; polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, polyethylene glycol, dipropylene glycol, diglycerin; sugar alcohols such as sorbitol; lecithin, hydrogenated lecithin Phospholipids such as: hyaluronic acid, sodium hyaluronate, acetyl hyaluronic acid, sodium acetyl hyaluronate, heparin, chondroitin mucopolysaccharides; lactic acid, sodium pyrrolidone carboxylate NMF-derived components such as urea and urea; polyglutamic acid; polymers having a phospholipid polar group such as MPC polymer (for example, LIPIDURE (registered trademark)); polyoxypropylene methyl glucoside; trimethylglycine (betaine); hydroxyethyl Urea; acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer; sorbitol and the like. Among them, chigaya root extract, hydrolyzed collagen, hydrolyzed elastin, MPC polymer glycerin, 1,3-butylene glycol, polyethylene glycol, dipropylene glycol, diglycerin, polyoxypropylene methyl glucoside, trimethyl glycine (betaine), hydroxyethyl urea Acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer, hydrogenated lecithin, hyaluronic acid, sodium hyaluronate, acetyl hyaluronic acid, sodium acetyl hyaluronate, and sorbitol are preferred.
The content of the moisturizing component can be about 0.001 to 10% by weight with respect to the entire cosmetic composition.

The component having the action of preventing and / or repairing DNA damage includes a component derived from an animal (eg, Artemia); a component derived from a plant (eg, cat's claw); a DNA, DNA salt, RNA, RNA salt, etc. Examples include nucleic acid components. Of these, artemia extract and DNA-Na are preferred.
The content of the component having an effect of preventing and / or repairing DNA damage can be about 0.00001 to 0.1% by weight based on the whole cosmetic composition.

Examples of ultraviolet ray absorbing components include 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) ) Anilino] -1,3,5-triazine, dimethoxybenzylideneoxoimidazolidinepropionate 2-ethylhexyl, 2,4-bis-[{4- (2-ethylhexyloxy) -2-hydroxy} -phenyl] -6 (4-methoxyphenyl) -1,3,5-triazine and the like. Among them, 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino]- 1,3,5-triazine is preferred.
The content of the ultraviolet absorbing component can be about 0.01 to 20% by weight with respect to the entire cosmetic composition.

Ultraviolet scattering components include inorganic compounds such as zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, cerium silicate, hydrous silicic acid, and those inorganic compounds Coated with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica and talc, or compounded with resin powders such as polyamide, polyethylene, polyester, polystyrene and nylon, silicon oil and fatty acid aluminum salts, etc. And the like processed with. Of these, inorganic compounds such as zinc oxide, titanium oxide and iron oxide, and those inorganic compounds coated with inorganic powder such as aluminum hydroxide, hydrous silicic acid, mica and talc, and silicon oil are preferable.
The content of the ultraviolet scattering component can be about 0.001 to 35% by weight with respect to the entire cosmetic composition.

  As washing components, polyoxyalkylene alkyl (or alkenyl) ether sulfate, alkyl (or alkenyl) sulfate, higher fatty acid salt, ether carboxylate, amide ether carboxylate, alkyl phosphate ester salt, N-acyl amino acid Anionic surfactants such as salts, polyoxyalkylene fatty acid amide ether sulfates, acylated isethionates, acylated taurates; amine oxides, glycerin fatty acid esters, sorbitan fatty acid esters, alkyl saccharides, polyoxyalkylene alkyl ethers, fatty acid alkanolamides , Nonionic surfactants such as polyoxyalkylene hydrogenated castor oil; mono- or di-long alkyl quaternary ammonium having a linear or branched long-chain alkyl group, to which alkylene oxide may be added Cationic surfactants such as ium salts; carboxymethyl betaine, sulfobetaine, imidazolinium betaine, amphoteric surfactants such as amide betaine.

Of these, anionic surfactants, nonionic surfactants, and amphoteric surfactants are preferred. Anionic surfactants include higher fatty acid salts (particularly salts of higher fatty acids such as palmitic acid, lauric acid, myristic acid, stearic acid), N-acyl amino acid salts (particularly sodium N-lauroyl aspartate, potassium hydroxide / N-coconut oil fatty acid potassium acylglutamate, coconut oil fatty acid acylglycine sodium, myristoyl glutamic acid) are preferred. Among the nonionic surfactants, fatty acid alkanolamides (especially coconut oil fatty acid diethanolamide, coconut oil fatty acid monoethanolamide) and amine oxides (especially coconut oil alkyldimethylamine oxide, lauryldimethylamine oxide) are preferable. Amphoteric surfactants include imidazolinium betaines (especially 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-coconut oil fatty acid acyl-N-carboxymethoxyethyl-N-carboxymethylethylenediamine disodium. ) Is preferred.
The content of the cleaning component can be about 0.01 to 80% by weight based on the entire cosmetic composition.

Antibacterial components include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, popidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer No. 101 Photosensitive element 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, and the like. Among them, benzalkonium chloride, benzethonium chloride, gluconic acid and its derivatives, isopropylmethylphenol, triclocarban, triclosan, photosensitizer 101, photosensitizer 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride Are preferred, and benzalkonium chloride, gluconic acid and its derivatives, benzethonium chloride, and isopropylmethylphenol are more preferred.
The content of the antibacterial component can be about 0.0003 to 10% by weight with respect to the entire cosmetic composition.

Examples of the astringent component include metal salts such as alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc sulfate, and potassium aluminum sulfate; organic acids such as tannic acid, citric acid, lactic acid, and succinic acid. Among these, alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, aluminum potassium sulfate, and tannic acid are preferable.
The content of the astringent component can be about 0.0003 to 10% by weight with respect to the entire cosmetic composition.

  The cosmetic composition of the present invention can be prepared by mixing and stirring each component according to a conventional method. For example, an ingredient insoluble in a cosmetic base and an oil component can be mixed and stirred in advance, and then an aqueous component can be blended and mixed and stirred again. A stirrer such as a homomixer may be used to facilitate the dispersion of components insoluble in the base.

Preferred combinations of components Preferred combinations of Budreja axillaris leaf extract and other active ingredients include the following combinations.
When a known anti-glycation component is included, evening primrose oil or evening primrose extract, Amler extract, lychee seed extract, rose petal extract, malonie extract, Maria thistle extract, neem extract, hydrolyzable tannin, L-arginine or a salt thereof Lysine or a salt thereof, carnosine, α-lipoic acid, aminoguanidine or a salt thereof, aristine, or glucosamine,
When an antioxidant component is included, grape seed extract, grape leaf extract, ginseng extract, comfrey leaf extract, proanthocyanidins, tocopherol or a derivative thereof (δ-tocopherol, α-tocopherol), ascorbic acid or a derivative thereof (ascorbic acid, Sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), hesperidin, glucosyl hesperidin, or ergothioneine;
When it contains an anti-aging ingredient, hydrolyzed soy protein, retinol, retinol acetate, or retinol palmitate,

When containing an anti-inflammatory component, Comfrey leaf extract, allantoin, dipotassium glycyrrhizinate, or stearyl glycyrrhetinate
When whitening ingredients are included, arbutin, hydroquinone, kojic acid, ascorbic acid, sodium ascorbate phosphate sodium, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), or tranexamic acid,
When containing a keratin soft component, lactic acid, sodium lactate, glycolic acid, salicylic acid, or phytic acid,
When containing a cell activation component, bilberry leaf extract, retinol, retinol acetate, or retinol palmitate,
When vitamins are included, vitamins A (retinol, retinol acetate, retinol palmitate), vitamins C (ascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (tetra 2) -Ascorbyl hexyldecanoate)), vitamin Es (δ-tocopherol, tocopherol nicotinate), nicotinic acids (nicotinamide),

When it contains a blood circulation promoting component, ginseng extract, tocopherol nicotinate, glucosyl hesperidin, or hesperidin,
When moisturizing ingredients are included, chigaya root extract, hydrolyzed collagen, hydrolyzed elastin, MPC polymer glycerin, 1,3-butylene glycol, polyethylene glycol, dipropylene glycol, diglycerin, polyoxypropylene methylglucoside, trimethylglycine (betaine) ), Hydroxyethylurea, acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer, hydrogenated lecithin, hyaluronic acid, sodium hyaluronate, acetyl hyaluronic acid, sodium acetyl hyaluronate, or sorbitol,
When containing a component having an action of preventing and / or repairing DNA damage, Artemia extract or DNA-Na,

When an ultraviolet absorbing component or an ultraviolet scattering component is included, 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, or 2,4,6-tris [4 -(2-Ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, zinc oxide, titanium oxide, iron oxide, inorganic powders of these inorganic compounds (aluminum hydroxide, hydrous silicic acid, mica, or talc) Or coated with silicone oil,
When it contains a cleaning component, higher fatty acid salts (particularly salts of higher fatty acids such as palmitic acid, lauric acid, myristic acid, stearic acid), N-acyl amino acid salts (particularly sodium N-lauroyl aspartate, potassium hydroxide) / N-coconut oil fatty acid potassium acylglutamate, coconut oil fatty acid acylglycine sodium, myristoyl glutamic acid), fatty acid alkanolamide (especially coconut oil fatty acid diethanolamide, coconut oil fatty acid monoethanolamide), amine oxide (especially coconut oil alkyldimethyl) Amine oxide, lauryldimethylamine oxide), imidazolinium betaine (especially 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-coconut oil fatty acid acyl-N-carboxymethoxyethyl) Ru-N-carboxymethylethylenediamine disodium),
When it contains an antibacterial component, benzalkonium chloride, gluconic acid and its derivatives, benzethonium chloride, or isopropylmethylphenol,
When an astringent component is included, alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, aluminum potassium sulfate, or a combination with tannic acid can be used.

Among these, known anti-glycation components, antioxidant components, anti-aging components, anti-inflammatory components, keratin softening components, cell activation components, vitamins, blood circulation promoting components, moisturizing components, prevention and / or repair of DNA damage It is preferable to combine a component having an action, an ultraviolet absorption or scattering component, and a cleaning component. Among them, it is more preferable to combine a known anti-glycation component, an anti-aging component, a component having an action of preventing and / or repairing DNA damage, vitamins, and an antioxidant component.
Specific examples of preferred combinations of the budreja axillaris leaf extract and known anti-glycation components, anti-aging components, components that prevent and / or repair DNA damage, vitamins, and antioxidant components include the following: Combinations are listed.

Food Composition The anti-glycation agent, anti-aging agent, skin collagen damage inhibitor, and skin tension or elasticity reduction, or skin wrinkle suppression, prevention, or improvement agent of the present invention shall be a food composition. Can do.
This food composition can be suitably used as a health food or a nutritional supplement (including balanced nutritional foods, supplements, etc.). It is also suitable for health functional foods (including foods for specified health use (including disease risk reduction labeling, standard-standard foods), foods for condition specific health use, and foods with functional nutrition).
The dosage form is not particularly limited, but the Budreja axillaris leaf extract is used as it is or is mixed with excipients or additives usually used in foods, and tablets, pills, granules, powders, It can also be formulated by a known method into dosage forms such as powders, capsules (including soft capsules), wettable powders, emulsions, solutions, extracts, or elixirs. Among these, preparations such as beverages; powdered beverages; jelly agents, tablets, powders, granules, capsules, and drop agents are preferable because they are easy to take and carry. If necessary, mixed with food additives such as fats and oils, stabilizers, emulsifiers, dispersants, suspending agents, fragrances, thickeners, sweeteners, colorants, fragrances, preservatives, antioxidants, organic acids, etc. Then, it may be formulated.

  As fats and oils, natural vegetable oils such as peanut oil, cocoa butter, rice germ oil, perilla oil, linseed oil and the like, hardened oils thereof, fatty acid (including medium chain fatty acid) glycerides (glycerides, diglycerides, triglycerides, etc.), beeswax Etc. Of these, beeswax is preferred. Content of fats and oils can be made into about 0.001 to 10 weight% with respect to the whole food composition.

Examples of emulsifiers, dispersants, suspending agents, or stabilizers include polyhydric alcohols such as polyethylene glycol, propylene glycol, glycerin, and sorbitol; glycerin fatty acid esters; carboxymethylcellulose sodium. Among these, glycerin, glycerin fatty acid ester, and sodium carboxymethyl cellulose are preferable. The content of the emulsifier, dispersant, suspending agent, or stabilizer can be about 0.0001 to 10% by weight based on the whole food composition.
Examples of thickeners include locust bean gum, guar gum, xanthan gum, tamarind gum, pectin, and carrageenan. Of these, xanthan gum is preferable. The content of the thickener can be about 0.001 to 10% by weight based on the whole food composition.
Examples of the sweetener include sucrose, fructose, maltose, erythritol, trehalose, maltitol, licorice extract, stevia processed sweetener, aspartame, acesulfame potassium, sorbitol, xylitol and the like. The content of the sweetener can be about 0.0001 to 50% by weight based on the whole food composition.

Examples of the preservative include benzoic acid or a salt thereof, sorbic acid or a salt thereof, butyl paraoxybenzoate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, ethyl paraoxybenzoate, and the like. The content of the preservative can be about 0.001 to 10% by weight based on the whole food composition.
Antioxidants include ascorbic acid, sodium ascorbate, ascorbic acid stearate, sodium ascorbate stearate, ascorbyl palmitate, bisulfite, sodium hyposulfite, sulfur dioxide, disodium EDTA calcium, erythorbic acid, Examples include sodium erythorbate and tocopherol. Of these, ascorbic acid, ascorbyl palmitate, and tocopherol are preferable. The content of the antioxidant can be about 0.001 to 10% by weight based on the whole food composition.

Examples of the organic acid include citric acid, succinic acid, tartaric acid, aspartic acid, lactic acid, malic acid, malonic acid, fumaric acid, maleic acid and the like. The content of the organic acid can be about 0.001 to 10% by weight based on the whole food composition.
A food additive can be used alone or in combination of two or more.
Other active ingredients can be added to the formulation.
In the food composition, a known anti-glycation component that can be added to food is added as another active ingredient for the purpose of further enhancing the effects of the present invention such as anti-glycation, anti-aging, and suppression of skin collagen damage. Can do. Known anti-glycation components can be used singly or in combination of two or more.

  As the known anti-glycation component, the anti-glycation component described for the cosmetic composition can be used in the food composition. Preferred known anti-glycation components are also the same as in the cosmetic composition.

  As active ingredients other than known anti-glycation ingredients, vitamins such as vitamin A, vitamin B, vitamin C, vitamin E, vitamin D, vitamin K; threonine, methionine, phenylalanine, tryptophan, lysine, Amino acids such as glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine; taurine, collagen, glucosamine, acetylglucosamine, hyaluronic acid , Isoflavones, polyphenols (eg, polyphenols derived from plants such as chestnut astringent skin, grape seeds), biotin, whey peptides, soybean peptides, royal jelly, γ-oryzanol Orotic acid, rutin, hesperidin, carnitine, carnitine chloride, collagen peptide, elastin peptide, ceramide, lycopene, astaxanthin, lactic acid bacteria extract (eg LFK), glutathione, rutin, plant (eg cat's claw, grape, ginger, lotus, Ingredients derived from grapes, melons, Haematococcus algae, lychee seeds, rose petals, Amler extract), ubiquinone derivatives (for example, coenzyme Q10), spider webs and the like.

  Here, examples of vitamin A include retinal, retinol, retinoic acid, carotene, dehydroretinal, lycopene and the like, and examples of vitamin B include bistyamine, thiamine disulfide, thiamine dicetyl sulfate, benfotiamine, pro Sultiamine, fursultiamine, bisbenchamine, chicotiamine, octothiamine, allythiamine, thiamine propyl disulfide, thiamine tetrahydrofurfuryl disulfide, dicetiamine, bisibutiamine, thiamine monophosphate disulfide, thiamine pyrophosphate, chicotiamine, thiamineethyl disulfide, thiamine Propyl disulfide, riboflavin, flavin adenine dinucleotide, pyridoxine, pyridoxal, hydroxocobalamin, shear Examples include cobalamin, methylcobalamin, deoxyadenocobalamin, folic acid, tetrahydrofolic acid, dihydrofolic acid, nicotinic acid, nicotinic acid amide, nicotinic alcohol, pantothenic acid, panthenol, biotin, choline, inositol, etc. Examples include ascorbic acid, sodium ascorbate, ascorbic acid stearate, sodium ascorbate stearate, ascorbyl palmitate, erythorbic acid and the like, and vitamins D include ergocalciferol, cholecalciferol, hydroxycholecalciferol , Dihydroxycholecalciferol, dihydrotaxosterol, etc. can be exemplified, and examples of vitamin E include tocopherol and its derivatives .

Among other active ingredients, polyphenols (for example, polyphenols derived from plants such as chestnut astringent skin, grape seeds), soybean peptide, hyaluronic acid, collagen peptide, elastin peptide, ceramide, lycopene, coenzyme Q10, astaxanthin, melon extract Lactic acid bacteria extract (eg LFK), glutathione, rutin, cats claw extract, red grape leaf extract, hematococcus algae extract, ginger extract, lotus germ extract, ascorbic acid, tocopherol, amlar extract, rose petal extract, lychee Seed extract is preferred, Amler extract, rose petal extract, melon extract, lactic acid bacteria extract (eg LFK), lychee seed extract, polyphenol, ginger extract, ceramide, hyaluronic acid, tomato lycopies , Cat's Claw extract, or astaxanthin is more preferable.
Other active ingredients can be used singly or in combination of two or more.

Preferred combinations of components Preferred combinations of the Budreja axillaris leaf extract and other components include the following combinations.
If it contains fats and oils,
When it contains an emulsifier, dispersant, suspending agent, or stabilizer, glycerin, glycerin fatty acid ester, or sodium carboxymethyl cellulose,
When containing a thickener, xanthan gum,
When containing a sweetener, sucrose, fructose, maltose, erythritol, trehalose, maltitol, licorice extract, stevia processed sweetener, aspartame, acesulfame potassium, sorbitol, or xylitol,
When containing a preservative, benzoic acid or a salt thereof, sorbic acid or a salt thereof, butyl paraoxybenzoate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, or ethyl paraoxybenzoate,
In the case of containing an antioxidant, ascorbic acid, ascorbyl palmitate, or tocopherol,

When containing an organic acid, citric acid, succinic acid, tartaric acid, aspartic acid, lactic acid, malic acid, malonic acid, fumaric acid, or maleic acid,
When it contains a known anti-glycation component, Amlar extract, lychee seed extract, rose petal extract, maronier extract, maria thistle extract, neem extract, hydrolyzable tannin, L-arginine or salt thereof, lysine or salt thereof, Carnosine, α-lipoic acid, aminoguanidine or a salt thereof, aristine, glucosamine,
When other active ingredients are included, Amlar extract, rose petal extract, melon extract, lactic acid bacteria extract (eg LFK), lychee seed extract, polyphenol, ginger extract, ceramide, hyaluronic acid, tomato lycopene, cat's claw extract Or a combination with astaxanthin.

Among them, Budreja axillaris leaf extract, Amler extract, rose petal extract, melon extract, lactic acid bacteria extract (eg LFK), lychee seed extract, polyphenols, ginger extract, ceramide, hyaluronic acid, tomato lycopene , Cats claw extract, or astaxanthin is preferably combined.
In the case where the food composition is formulated into a supplement such as the above-described supplement, the content of the Budreja axillaris leaf extract is about 0.0001 in terms of dry weight with respect to the whole food composition. -20% by weight is preferred, about 0.001-10% by weight is more preferred, and about 0.01-5% by weight is even more preferred. If it is in the above range, in a food composition of an amount that can be ingested without difficulty, sufficient anti-glycation effect, anti-aging effect, skin collagen damage suppression effect, skin tension or elasticity reduction, or skin wrinkle suppression, A Budreja axillaris leaf extract that only provides a preventive or ameliorating action will be included.

<General food composition>
Moreover, this food composition can be prepared by adding a Budreja axillaris leaf extract to a general food. Examples of foods include milk, milk drinks, lactic acid bacteria drinks, soft drinks with fruit juice, carbonated drinks, vegetable juice drinks, tea drinks, fruit juice drinks, ion drinks, sports drinks, functional drinks, vitamin supplement drinks, nutrition supplement balance drinks , Beverages such as jelly drinks, alcoholic drinks, soups; puddings such as custard pudding, milk pudding, pudding with fruit juice, jelly, dressing, gel-like confectionery such as cream, chewing gum, bubble gum Gum (plate gum, sugar-coated grain gum, etc.), chocolate (solid chocolate, coated chocolate, chocolate with flavor such as strawberry chocolate, blueberry chocolate, melon chocolate, etc.), soft candy (caramel, nougat, gummy candy) , Including marshmallows) Mels, biscuits (hard biscuits, soft biscuits, soft cookies, crackers, semi-biscuit biscuits, etc.), cakes and other confectionery; ice cream, ice milk, lacto ice, sorbet, frozen confectionery such as ice confectionery; breads; noodles; Pet food etc. are mentioned.
In the case where the food composition is obtained by adding an active ingredient to a general food, the content of the budreja axillaris leaf extract is about 0.0001 to the whole food composition, in terms of dry weight. 20 wt% is preferred, about 0.001 to 10 wt% is more preferred, and about 0.01 to 5 wt% is even more preferred. If it is in the above range, in a food composition of an amount that can be ingested without difficulty, sufficient anti-glycation effect, anti-aging effect, skin collagen damage suppression effect, skin tension or elasticity reduction, or skin wrinkle suppression, A Budreja axillaris leaf extract that only provides a preventive or ameliorating action will be included.
The form of the food composition is a beverage (especially, a lactic acid bacteria beverage, a consumer with difficulty in swallowing or swallowing tablets, granules, capsules, etc.) Fruit juice soft drinks, functional drinks), jellys, and gel-like confectionery are preferred, and lactic acid bacteria drinks and functional drinks are more preferred.

How to Use The cosmetic composition may be applied in the usual manner of use and the number of uses.
In addition, in the food composition, the daily intake of Budreja axillaris leaf extract is, for example, about 0.01 to 20000 mg, preferably about 0.1 to 10000 mg, more preferably about 50 to 1000 mg in terms of dry weight. Should be taken.
The use target of the agent of the present invention is not particularly limited, but for cosmetic compositions, the elderly, skin aging caused by the generation or accumulation of AGEs (decrease in tension or elasticity, wrinkles, rough skin, skin texture) Suitable subjects include humans who have a decrease, dullness, decreased transparency, etc., particularly humans in whom skin aging due to generation or accumulation of AGEs by ultraviolet rays is observed.
In addition to the above-mentioned humans, the food composition includes diabetic patients (especially patients causing cataract, arteriosclerosis, renal dysfunction, retinopathy, neuropathy, etc.), arteriosclerosis patients, malignant patients Tumor patients, bone disease patients, Alzheimer's disease patients, Parkinson's disease patients and the like are also suitable subjects.
In addition, in both cases of cosmetic compositions and food compositions, healthy people can also be targeted, thereby preventing skin aging due to the generation or accumulation of AGEs due to aging, ultraviolet rays, etc. Can be slowed down.

Container The composition according to the agent of the present invention can be used by being contained in a container having a shape and material appropriately selected according to the purpose and application of use. Examples of container shapes include bottle types, tube types, jar types, spoid types, dispenser types, stick types, pouch bags, cheer packs, and the like. Examples of the material include polyethylene terephthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, metal (aluminum, etc.), and the like. In addition, these materials are variously coated in consideration of strength, flexibility, weather resistance, component stability, etc., and these materials are combined, for example, mixed or laminated, It can be used as a container material.

EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited to these Examples.
Reference Example 1 (Acceleration of AGE generation by ultraviolet rays)
A collagen gel was prepared using a collagen gel culture kit (trade name: Cellmatrix, manufactured by Nitta Gelatin Inc.). Next, this collagen gel was subjected to a saccharification reaction by dissolving D-ribose (Aldrich) in PBS to a final concentration of 50 mM and incubating in a 50 mM ribose solution at 37 ° C. for 2 weeks. During this incubation, UVA was irradiated under conditions where the irradiation intensity was 5 J / cm ² .
Next, collagen gel was dissolved by collagenase treatment, and the amount of AGEs produced was measured by ELISA using the solution. For the measurement, an AGEs antibody (Anti AGEs Monoclonal Antibody Clone No. 6D12 Peroxidase conjugated, Transgenic) was used and developed with TMB reagent (Dako).
Further, in the above method, the same operation was performed except that UVA irradiation was not performed, and used as a control. The AGE generation reaction was performed 4 times.
The results are shown in FIG. The vertical axis in FIG. 1 indicates the relative value when the AGE generation amount of the control is 100. Moreover, what is shown in FIG. 1 is an average value ± standard deviation. From FIG. 1, it can be seen that UVA irradiation significantly promoted the generation of AGEs.

Test example 1 (suppression of AGEs generation by UVA irradiation)
A collagen gel was prepared using a collagen gel culture kit (trade name: Cellmatrix, manufactured by Nitta Gelatin Inc.). When the collagen solution was gelled, a Budella axillaris leaf extract (ethanol extract) was added to a final concentration of 0.01 w / v% or 0.001 w / v%. Note that the Budreja axillaris leaf extract is a powder. Next, the collagen gel was incubated in a 50 mM ribose solution at 37 ° C. for 2 weeks to carry out a saccharification reaction. During this incubation, UVA was irradiated under conditions where the irradiation intensity was 5 J / cm ² .
The measurement was performed according to the method of Reference Example 1.
In addition, a control similar to the above was performed except that the Budreja axillaris leaf extract was not added. The AGE generation reaction was performed 4 times.
The results are shown in FIG. The vertical axis | shaft of FIG. 2 shows a relative value when the amount of AGEs produced | generated when a Budreja axillaris leaf extract is not added is set to 100. As shown in FIG. Moreover, what is shown in FIG. 2 is an average value ± standard deviation. From FIG. 2, it can be seen that the Budreja axillaris leaf extract significantly and dose-dependently inhibited the production of AGEs under UVA irradiation.

Reference Example 2 (Promotion of CMA generation by ultraviolet rays)
A collagen gel was prepared using a collagen gel culture kit (trade name: Cellmatrix, manufactured by Nitta Gelatin Inc.). Next, this collagen gel was subjected to saccharification reaction by dissolving D-ribose (Aldrich) in PBS to a final concentration of 50 mM and incubating in a 50 mM ribose solution at 37 ° C. for 2 weeks. During this incubation, UVA was irradiated under conditions where the irradiation intensity was 5 J / cm ² .
Next, collagen gel was dissolved by collagenase treatment, and the amount of carboxymethylarginine (CMA), which is one of AGEs, was measured by ELISA using the solution. AGEs antibody (monoclonal anti-CMA (3F5), Nihon Women's University, distributed by Professor Nagai) is used as the primary antibody, and Anti-Mouse Immunogloblins / HRP (manufactured by Dako) is used as the secondary antibody. Color was developed with Dako).
Further, in the above method, the same operation was performed except that UVA irradiation was not performed, and used as a control. CMA production reaction was performed 4 times.
The results are shown in FIG. The vertical axis in FIG. 3 represents a relative value when the CMA production amount of the control is 100. Moreover, what is shown in FIG. 3 is an average value ± standard deviation. From FIG. 3, it can be seen that UVA irradiation significantly promoted the production of CMA.

Test example 2 (suppression of CMA production by UVA irradiation)
A collagen gel was prepared using a collagen gel culture kit (trade name: Cellmatrix, manufactured by Nitta Gelatin Inc.). When the collagen solution was gelled, a Budella axillaris leaf extract (ethanol extract) was added to a final concentration of 0.01 w / v% or 0.001 w / v%. Next, this collagen gel was subjected to saccharification reaction by dissolving D-ribose (Aldrich) in PBS to a final concentration of 50 mM and incubating in a 50 mM ribose solution at 37 ° C. for 2 weeks. During this incubation, UVA was irradiated under conditions where the irradiation intensity was 5 J / cm ² .
The measurement was performed according to the method of Reference Example 2.
In addition, a control similar to the above was performed except that the Budreja axillaris leaf extract was not added. The AGE generation reaction was performed 4 times.
The results are shown in FIG. The vertical axis in FIG. 4 shows relative values when the amount of CMA produced in the case where no Budreja axillaris leaf extract is added is 100. Moreover, what is shown in FIG. 4 is an average value ± standard deviation. From FIG. 4, it can be seen that the Budreja axillaris leaf extract significantly and dose-dependently suppressed the production of CMA under UVA irradiation.

Test example 3 (suppression of CMA production)
A collagen gel was prepared using a collagen gel culture kit (trade name: Cellmatrix, manufactured by Nitta Gelatin Inc.). When gelling the collagen solution, add a final concentration of 0.01 w / v% Budreja axillaris leaf extract (ethanol extract) or a final concentration of 0.1 w / v% aminoguanidine (AG). did.
Next, this collagen gel was subjected to a saccharification reaction by dissolving D-ribose (Aldrich) in PBS to a final concentration of 50 mM and incubating in a 50 mM ribose solution at 37 ° C. for 2 weeks.
The measurement was performed according to the method of Reference Example 2.
Moreover, except having not added budreja axillaris leaf extract or aminoguanidine, operation similar to the above was performed and it was set as control. CMA production reaction was performed 4 times.
The results are shown in FIG. The vertical axis in FIG. 5 shows relative values when the amount of CMA produced when no Budreja axillaris leaf extract or aminoguanidine is added is taken as 100. Moreover, what is shown in FIG. 5 is an average value ± standard deviation. FIG. 5 shows that the Budreja axillaris leaf extract significantly suppressed the production of CMA under UVA irradiation. In addition, the degree of inhibition was stronger than that of aminoguanidine, which is known to have various AGEs structure production inhibitory effects.

Test Example 4 (Suppression of AGE generation)
A collagen gel was prepared using a collagen gel culture kit (trade name: Cellmatrix, manufactured by Nitta Gelatin Inc.). Collagen gel under preparation has a final concentration of 0.1 w / v% or 0.01 w / v% budreja axialis leaf extract (ethanol extract) or a final concentration of 0.1 w / v% aminoguanidine (AG) Was added. Next, this collagen gel was subjected to saccharification reaction by dissolving D-ribose (Aldrich) in PBS to a final concentration of 50 mM and incubating in a 50 mM ribose solution at 37 ° C. for 2 weeks.
The measurement was performed according to the method of Reference Example 1.
Moreover, except having not added Budreja axillaris leaf extract or aminoguanidine, the same operation as above was performed and it was set as control. The AGE generation reaction was performed 4 times.
The results are shown in FIG. The vertical axis | shaft of FIG. 6 shows a relative value when the amount of AGEs produced | generated when a Budreja axillaris leaf extract or aminoguanidine is not added is set to 100. Moreover, what is shown in FIG. 6 is an average value ± standard deviation. From FIG. 6, it can be seen that the Budreja axillaris leaf extract significantly and dose-dependently suppressed the production of AGEs under UVA irradiation. In addition, the degree of inhibition was stronger than that of aminoguanidine, which is known to have various AGEs structure production inhibitory effects.

Test Example 5 (Inhibition of pentosidine production)
A collagen gel was prepared using a collagen gel culture kit (trade name: Cellmatrix, manufactured by Nitta Gelatin Inc.). Collagen gel under preparation has a final concentration of 0.1 w / v% or 0.01 w / v% budreja axialis leaf extract (ethanol extract) or a final concentration of 0.1 w / v% aminoguanidine (AG) Was added. Next, this collagen gel was subjected to saccharification reaction by dissolving D-ribose (Aldrich) in PBS to a final concentration of 50 mM and incubating in a 50 mM ribose solution at 37 ° C. for 2 weeks. Next, collagen gel was dissolved by collagenase treatment, and the amount of pentosidine produced was measured by ELISA. The primary antibody was AGEs antibody (Anti Pentosidine Monoclonal Antibody Clone No. PEN-12 Peroxidase conjugated, Transgenic), and developed with TMB reagent (Dako).
Further, the same operation as described above was performed except that Budreja axillaris leaf extract or aminoguanidine was not added. The pentosidine production reaction was performed 4 times.
The results are shown in FIG. The vertical axis | shaft of FIG. 7 shows a relative value when the amount of pentosidine production | generation when not adding a Budreja axillaris leaf extract or an aminoguanidine is set to 100. In FIG. Moreover, what is shown in FIG. 7 is an average value ± standard deviation. From FIG. 7, it can be seen that the Budreja axialis leaf extract significantly and dose-dependently inhibited the production of pentosidine. In addition, the degree of inhibition was stronger than that of aminoguanidine, which is known to have various AGEs structure production inhibitory effects.
It is known that when collagen is saccharified, AGEs structures such as pentosidine are generated, and among them, CMA is known as a collagen-specific saccharification reaction product. Since collagen is mainly present in the dermis, UVA reaches the dermis. From the above examples, Budreja axialis leaf extract is collagen that is promoted by glycation of collagen in the dermis and ultraviolet rays in the dermis. It can be seen that the saccharification of the dermis and, in turn, the damage of the dermal collagen by ultraviolet rays can be effectively suppressed.

Test example 6 (use test)
When the cosmetic composition of Example 1 having the composition shown in Table 1 above was prepared and a 30-year-old female (3 persons) used this cosmetic in an appropriate amount twice a day (morning and night) for 2 weeks, There was a tendency to finish.

Example
(1) Cosmetic composition The unit of the numerical value in the Example of the following cosmetic composition is "weight%". Further, the weight of the Budreja axillaris leaf extract (extract) is a dry weight.
In the entire formulation of the cosmetic composition, an ethanol extract is preferable as the Budreja axillaris leaf extract.

Formulation example
(1) Cosmetic Composition The unit of numerical values in the following cosmetic composition formulation examples is “% by weight”.
Example 2 Transparent lotion Budreja axillaris leaf extract 0.1
Meadow foam oil 0.1
Amler extract 0.01
Lysine 1
Hydrolyzed soy protein 0.5
Proanthocyanidins 0.0005
MPC polymer 0.01
Glycerin 4
1,3-butylene glycol 6
Polyoxyethylene hydrogenated castor oil 0.5
Preservatives (methyl paraoxybenzoate, propyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Example 3 Transparent lotion Budreja axillaris leaf extract 0.01
Grape seed extract 0.001
α-Tocopherol 0.1
Ascorbic acid 0.5
Comfrey leaf extract 0.001
Dipropylene glycol 15
Polyoxyethylene sorbitan isostearate (20EO) 0.5
Hydroxyethyl cellulose 0.01
Preservatives (methyl paraoxybenzoate, phenoxyethanol) Appropriate amount pH adjuster Appropriate amount Perfume Appropriate amount
Water balance
Total 100

Example 4 Emulsifying lotion Budreja axillaris leaf extract 1
Cariocarbrasiliense fruit oil 0.1
Arginine 0.5
Carnosine 0.01
Retinol acetate 0.01
Grape seed extract 0.01
Polyoxypropylene methyl glucoside 1
Hyaluronic acid 0.05
1,3-butylene glycol 13
Polyoxyethylene hydrogenated castor oil 0.5
Tri (caprylic / capric) glyceryl 0.2
Glyceryl tri-2-ethylhexanoate 0.2
Xanthan gum 0.1
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Example 5 Emulsifying lotion Budreja axillaris leaf extract 1
Meadow foam oil 0.3
γ-linolenic acid 0.05
Arginine 0.7
Arginine hydrochloride 0.3
Hydrolyzed soy protein 0.2
Grape seed extract 0.1
Magnesium ascorbate phosphate 0.01
MPC polymer 0.1
Dipropylene glycol 8
Glycerin 1
1,3-butylene glycol 0.5
Polyoxyethylene hydrogenated castor oil 0.5
Tetra-2-ethylhexanoic acid pentaerythrit 0.5
Acrylic acid / alkyl methacrylate copolymer 0.25
Hydroxyethyl cellulose 0.01
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Example 6 Emulsifying lotion Budreja axillaris leaf extract 1
Evening primrose oil 0.05
Linoleic acid 0.01
Lychee seed extract 0.001
Rose petal extract 0.001
Hydrolyzed soy protein 0.001
d-δ-tocopherol 0.01
Proanthocyanidins 0.001
Sodium ascorbate phosphate 0.1
1,3-butylene glycol 7
Diglycerin 3
Polyoxyethylene sorbitan isostearate (20EO) 0.5
Glyceryl tri-2-ethylhexanoate 1
Hydroxyethyl cellulose 0.05
Carboxyvinyl polymer 0.1
Chelating agent Appropriate amount of preservative (propyl paraoxybenzoate, phenoxyethanol) Appropriate amount pH adjuster Appropriate amount of perfume Appropriate amount
Water balance
Total 100

Example 7 Latex Budreja axillaris leaf extract 0.001
Evening primrose oil 0.4
Lychee seed extract 0.2
Carnosine 0.1
Hydrolyzed soy protein 0.5
d-δ-tocopherol 0.01
Nicotinamide 1.5
Hydrolyzed collagen 0.05
Comfrey leaf extract 0.1
Bilberry leaf extract 0.0001
Dipropylene glycol 3
1,3-butylene glycol 10
POE sorbitan monostearate (Polysorbate 60) 0.8
Tetra-2-ethylhexanoic acid pentaerythrit 5
Glyceryl tri-2-ethylhexanoate 2
Squalane 1
Methyl trimethicone 0.1
Decamethylcyclopentasiloxane 0.2
Behenyl alcohol 0.4
Acrylic acid / alkyl methacrylate copolymer 0.1
Xanthan gum 0.1
(Hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer
0.8
Chelating agent
Water balance
Total 100

Example 8 Latex Budreja axillaris leaf extract 0.3
Cario Calbrasiliense fruit oil 0.05
Meadow Foam Oil 0.8
Lychee seed extract 0.2
Lysine 0.5
Hydrolyzed soy protein 1
d-δ-tocopherol 0.1
α-Tocopherol 0.9
Chigaya Root Extract 0.5
Polyoxypropylene methyl glucoside 0.1
Allantoin 0.005
Lactic acid 0.5
Dipropylene glycol 1
Glycerin 4
1,3-butylene glycol 10
Glyceryl monostearate 0.2
Polyoxyethylene cetyl ether 0.8
Tetra-2-ethylhexanoic acid pentaerythrit 3
Methyl polysiloxane 0.5
Ethyltrisiloxane 3
Acrylic acid / alkyl methacrylate copolymer 0.75
Carboxyvinyl polymer 0.001
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Example 9 Cream Budreja Axillaris leaf extract 0.001
Evening primrose oil 1
Shea fat 0.3
Retinol palmitate 0.5
d-δ-tocopherol 0.005
α-Tocopherol 0.005
Amler Extract 1
Nicotinamide 0.5
Hydrolyzed collagen 0.01
Hydrolyzed elastin 0.01
Hydrogenated soybean phospholipid 0.3
Hyaluronic acid 0.1
Glycerin 2
1,3-butylene glycol 5
Polyoxyethylene hydrogenated castor oil 3
Tri (caprylic / capric) glyceryl 2
Tetra-2-ethylhexanoic acid pentaerythrit 3
Squalane 7
Cetanol 1
Stearyl alcohol 0.5
Acrylic acid / alkyl methacrylate copolymer 0.3
Chelating agent Appropriate amount of preservative (methyl paraoxybenzoate, methyl paraoxybenzoate) Appropriate amount pH adjuster Appropriate amount of perfume Appropriate amount
Water balance
Total 100

Example 10 Cream Budreja axillaris leaf extract 0.5
Shea fat 5
γ-linolenic acid 0.5
Linoleic acid 0.3
Rose petal extract 0.5
Hydrolyzed soy protein 0.8
Grape seed extract 0.1
Tocopherol nicotinate 0.3
Polyoxypropylene methyl glucoside 3
Panax ginseng extract 0.1
Bilberry leaf extract 0.1
Dipropylene glycol 1.5
Glycerin 2
1,3-butylene glycol 3.5
Polyethylene glycol 0.01
Polyoxyethylene hydrogenated castor oil 2
Glyceryl monostearate 1
Tri (caprylic / capric) glyceryl 5
Squalane 2
Liquid paraffin 1
Methyl polysiloxane 0.1
Cyclomethicone 0.1
Cetanol 2
Carboxyvinyl polymer 0.4
Chelating agent Suitable amount Preservative (Methyl paraoxybenzoate, phenoxyethanol) Suitable amount pH adjuster Suitable amount
Water balance
Total 100

Example 11 Cream Budreja axillaris leaf extract 1
Meadow Foam Oil 0.2
Shea fat 1.5
Amler extract 0.01
Arginine 0.01
Retinol 0.1
α-Tocopherol 0.5
Ascorbyl tetraisopalmitate 0.5
Artemia extract 0.001
DNA-Na 0.05
2-Ethylhexyl paramethoxycinnamate 8
Diethylaminohydroxybenzoyl hexyl benzoate 2
Silicone-coated zinc oxide 0.1
Silicone-coated titanium oxide 10
1,3-butylene glycol 8
Polyethylene glycol 0.03
Lauryl PEG-9 polydimethylsiloxyethyl dimethicone 3
PEG-9 polydimethylsiloxyethyl dimethicone 1.5
Tri (caprylic / capric) glyceryl 4
Methyltrimethicone 35
Methylsiloxane network polymer 3
Cross-linked methylpolysiloxane 0.5
Acrylic acid / alkyl methacrylate copolymer 0.2
Carboxyvinyl polymer 0.05
Dimethyl distearyl ammonium hectorite 1.5
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Example 12 Cream Budreja axillaris leaf extract 0.005
Evening primrose oil 3
Lychee seed extract 0.1
α-Lipoic acid 0.01
Hydrolyzed soy protein 0.1
Grape Seed Extract 0.005
Chigaya Root Extract 0.001
Artemia extract 0.5
2-Ethylhexyl paramethoxycinnamate 10
Diethylaminohydroxybenzoyl hexyl benzoate 5
2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] 1,3,5-triazine 3
Silicone coated zinc oxide 5
Silicone-coated titanium oxide 1
Inorganic compound-coated zinc oxide 0.05
Glycerin 5
1,3-butylene glycol 2
Lauryl PEG-9 polydimethylsiloxyethyl dimethicone 1
PEG-9 polydimethylsiloxyethyl dimethicone 1
Glyceryl tri-2-ethylhexanoate 1.5
Methyl polysiloxane 3
Decamethylcyclopentasiloxane 30
Methylsiloxane network polymer 5
Alkyl acrylate copolymer methyl polysiloxane ester 0.1
Acrylic acid / alkyl methacrylate copolymer 0.05
Mica 2
Chelating agent Appropriate amount of preservative (propyl paraoxybenzoate, phenoxyethanol) Appropriate amount pH adjuster Appropriate amount of perfume Appropriate amount
Water balance
Total 100

Example 13 Cleansing cream Budreja axillaris leaf extract 0.02
Evening primrose oil 0.01
Lychee seed extract 0.005
Arginine 0.1
Hydrolyzed soy protein 0.5
d-δ-tocopherol 0.01
Comfrey leaf extract 0.001
Glycyrrhizic acid 2K 0.1
Glycerin 0.01
1,3-butylene glycol 1
Diglycerin 5
Glyceryl monostearate 0.5
Polyglyceryl monostearate 2
Tri (caprylic / capric) glyceryl 10
Liquid paraffin 3
Light liquid paraffin 10
Ethyltrisiloxane 0.5
Stearyl alcohol 3
Carboxyvinyl polymer 0.5
Chelating agent Suitable amount Preservative (Methyl paraoxybenzoate, phenoxyethanol) Suitable amount pH adjuster Suitable amount
Water balance
Total 100

Example 14 Cleansing cream Budreja axillaris leaf extract 0.5
γ-linolenic acid 1
Amler extract 0.01
Grape seed extract 0.01
Panax ginseng extract 0.1
Allantoin 0.0001
Dipropylene glycol 7
1,3-butylene glycol 0.01
Glyceryl monostearate 1
Monostearic acid POE sorbitan 2
Tetra-2-ethylhexanoic acid pentaerythlit 8
Glyceryl tri-2-ethylhexanoate 8
Squalane 1
Liquid paraffin 7
Methyl polysiloxane 2
Behenyl alcohol 1
Carboxyvinyl polymer 0.5
Chelating agent
Water balance
Total 100

Example 15 Face-wash milk Budreja axillaris leaf extract 0.01
Cariocarbrasiliense fruit oil 0.1
Shea fat 0.1
Amler Extract 1
Lysine 0.01
Grape Seed Extract 0.005
MPC polymer 0.5
Acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer
3
Allantoin 0.001
1,3-butylene glycol 2
Palm oil fatty acylglycine Na 5
Hydroxylated K / N-coconut oil fatty acid acyl glutamic acid K 15
N-coconut oil fatty acid acyl-N-carboxymethoxyethyl-N-carboxymethylethylenediamine 2Na 4
Coconut oil alkyldimethylamine oxide 1
Polyethylene glycol distearate 1
Triisostearic acid polyoxyethylene methyl glucoside 3
Pearl luster imparting agent 2
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Example 16 Face-wash milk Budreja axillaris leaf extract 0.5
Meadow foam oil 0.1
γ-linolenic acid 0.3
Linoleic acid 0.2
Rose extract 0.1
Arginine 0.01
Hydrolyzed soy protein 0.01
α-Tocopherol 0.1
Polyoxypropylene methyl glucoside 3
Sorbitol 1
Hyaluronic acid 0.1
Panax ginseng extract 0.0001
Comfrey leaf extract 0.1
Dipropylene glycol 1
Lauroyl aspartate Na 10
Palm oil fatty acid monoethanolamide 7
Myristoyl glutamate Na 5
2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine 3.5
Polyethylene glycol distearate 4
Pearl luster imparting agent 1
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Example 17 Gel Budreja axillaris leaf extract 0.003
δ-tocopherol 0.05
Magnesium ascorbate phosphate 3.0
Allantoin 0.1
1,3-butylene glycol 5.0
POE-hardened castor oil 60 2.0
Macadamia nut oil 1.5
Glyceryl tri-2-ethylhexanoate 1.5
Glycerol monostearate 0.5
Methylphenyl polysiloxane 0.5
Carboxyvinyl polymer 0.4
Dextrin palmitate 0.3
Hydroxypropyl methylcellulose 0.2
Hydrogenated soybean phospholipid 0.05
Sodium polyacrylate 0.01
pH adjuster Appropriate amount Chelating agent Appropriate amount
Purified water balance
100

Example 18 Pack Budreja axillaris leaf extract 1
δ-tocopherol 1.0
Polyvinyl alcohol 10.0
Ethanol 8.0
Glycerin 3.0
Polyethylene glycol 0.4
Perfume appropriate amount Preservative appropriate amount
Purified water balance
100

Example 19 Cream Budreja axillaris leaf extract 0.005
δ-tocopherol 4.0
γ-tocopherol 1.0
Pyridoxine hydrochloride 0.1
Retinol 0.01
White petrolatum 25.0
Stearyl alcohol 10.0
Propylene glycol 5.0
Behenyl alcohol 5.0
POE-hardened castor oil 60 4.0
Glycerol monostearate 1.0
Dibutylhydroxytoluene 0.01
Preservative appropriate amount
Purified water balance
100

Example 20 Latex Budreja axillaris leaf extract 0.01
Artemia extract 0.0004
Erythritol 0.02
Homarine HCl 0.002
2-Ethylhexyl paramethoxycinnamate 10
Silicone-treated zinc oxide 5
Glyceryl tri-2-ethylhexanoate 4
Diethylaminohydroxybenzoyl hexyl benzoate 1
Alkyl acrylate copolymer methylpolysiloxane ester 0.2
Acrylic acid / alkyl methacrylate copolymer 0.05
Decamethylcyclopentasiloxane 16
Methyl trimethicone 3
Lauryl PEG-9 polydimethylsiloxyethyl dimethicone 2.6
Dibutylhydroxytoluene 0.02
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount perfume appropriate amount
Water balance
100

(2) Food composition In the formulation examples of the following food compositions, the weight of the Budreja axillaris leaf (extract) is a dry weight.
In the entire formulation of the food composition, an ethanol extract is preferable as the Budreja axillaris leaf extract.

Example 21 Beverage Mandolée extract 0.10 g
Fructose glucose solution 1.00g
Ascorbic acid 0.05g
Malic acid 0.05g
Fragrance 0.1g
Purified water 48.79g
Total 50.00g (1 bottle)
This drink is taken once every three meals a day.

Example 22 Tablet
Mandolée extract 100mg
Crystalline cellulose 113.5mg
Sucrose fatty acid ester 5mg
Maltitol 30mg
Sodium citrate 50mg
Vitamin B1 1mg
Vitamin B2 0.5mg
Total 300mg (1 tablet)
Three tablets of this tablet are taken every three meals a day.

Example 23 Powdered drink Mandolecy extract 0.30 g
Agar 1.50g
Lactose 2.70g
Citric acid 0.50g
Reduced maltose 0.495g
Matcha flavor 0.005g
Total 5.5g (1 pack)
This powdered beverage is taken every three meals a day by dissolving one pack in water.

Example 24 Granules Mandolecy extract 200mg
Lactulose 500mg
Xylooligosaccharide 200mg
Citric acid 100mg
Total 1000mg
Divide the pack so that it is 300 mg per pack, and take 3 packs as a daily dose.

Example 25 Jelly agent Mandrel extract 500 mg
Lactulose 200mg
Orange concentrate 1500mg
Marine collagen peptide 2000mg
Sodium citrate 500mg
Citric acid 420mg
L-tartaric acid 210mg
DL-malic acid 70mg
Gelling agent (Sankara) 480mg
Gua gum 60mg
Calcium lactate 200mg
Sucralose 6mg
Fragrance 100mg
Total 6246mg
The above components were dissolved in 120 ml of white hot water so as to include the above blending amount as a daily amount, and then agar was added to prepare a jelly agent at about 21 g per piece. Take 6 of this product as a daily dose for an adult.

Example 26 Soft capsules Capsule contents mandrel extract 120 mg
Hydrolyzable tannin 20mg
Hydrolyzed soy protein 20mg
Lotus germ extract 5mg
Ceramide 3mg
Hyaluronic acid 0.5mg
CoQ10 2mg
Haematococcus alga pigment extract (containing astaxanthin) 4mg
Vitamin C 1mg
Glycerin fatty acid ester 10mg
Beeswax 5mg
Capsule film gelatin 92mg
Pullulan 3mg
Glycerin 35mg
Coloring agent 3mg
Total 323.5mg (1 capsule)
This soft capsule is ingested 2 capsules every 3 meals per day.

  The budreja axillaris leaf extract suppresses the generation of AGEs and further the generation of AGEs by ultraviolet irradiation. Therefore, the cosmetic composition or food composition containing the Budreja axillaris leaf extract as an active ingredient can be suitably used for suppressing skin aging due to accumulation of AGEs.

Claims (7)

  An anti-glycation agent containing Budreja axillaris leaf extract as an active ingredient.   The budreja axillaris leaf extract is an extract of at least one solvent selected from the group consisting of water, a monohydric alcohol having 1 to 4 carbon atoms, and a polyhydric alcohol having 2 to 6 carbon atoms. The anti-glycation agent as described.   An anti-aging agent comprising Budreja axillaris leaf extract as an active ingredient.   A skin collagen damage inhibitor comprising Budreja axillaris leaf extract as an active ingredient.   An agent for suppressing, preventing, or improving the reduction of skin tension or elasticity, or the reduction of skin wrinkles, comprising a Budreja axillaris leaf extract as an active ingredient.   The anti-glycation agent according to claim 1 or 2, which is a cosmetic composition.   The anti-glycation agent according to claim 1 or 2, which is a food composition.