JP2009161440A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cosmetic which has high safety, improves skin roughness, and is excellent in an effect for regulating a skin state to give a normal skin state. <P>SOLUTION: Provided is the cosmetic having high safety, improving skin roughness, and excellent in an effect for regulating a skin state to give a normal skin state, characterized by compounding a combination of oligomeric proanthocyanidin with a polyquaternium compound. The oligomeric proanthocyanidin is preferably a pine bark extract. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a cosmetic having an excellent skin roughness improving effect and skin condition improving effect.

  With changes in the environment and diversification of eating habits, the deterioration of skin conditions such as sensitive skin and atopic dermatitis has become serious. In cosmetics, there are preparations intended to have an effect on the skin, and a moisturizing effect and a rough skin improving effect are one of the intended effects. As active ingredients such as cosmetics for the purpose of these effects, amino acids, polysaccharides, polyhydric alcohols (see Non-Patent Document 1), extracts of medicinal plants and the like (see Non-Patent Documents 2 to 5), etc. Is conventionally used. In particular, very active research has been conducted on plant extracts.

As described above, although many studies have been made on the active ingredient having the moisturizing effect and / or the rough skin improving effect, in any case, the moisturizing effect and the rough skin improving effect are not necessarily sufficient, and more excellent effects. Development of cosmetics containing the active ingredients and the ingredients has been desired.
Edited by Takeo Mitsui, “New Cosmetics”, 2nd edition, Nanzan-do, January 18, 2001, p. 152-156, and p. 187-188 Ichimaru Trade Manufacturing and Development Department, “Applications and Effects of Medicinal Plants”, Fragrance Journal, Fragrance Journal, 1979, Special Issue 1, p. 43-48 Masayuki Taguchi, “Use and safety of herbal medicines in Europe”, Fragrance Journal, Fragrance Journal, 1979, Special Issue 1, p. 66-74 Yoshiro Otsu, “Utilization and Issues of Plant Extracts for Cosmetics”, Fragrance Journal, Fragrance Journal, 1979, Special Issue 1, p. 84-87 “List of plant components of each company”, Fragrance Journal, Fragrance Journal, 1986, Special Issue 6, p. 324-349

  An object of the present invention is to provide a cosmetic having high safety and excellent skin roughening effect and skin condition improving effect.

  As a result of intensive studies to solve the above problems, the present inventors have found that cosmetics containing a combination of oligomeric proanthocyanidins and polyquaterniums have high safety and rough skin. Has been found to be excellent in the effect of adjusting the skin state to a normal skin state, and the present invention has been completed.

  According to the present invention, it is possible to provide a cosmetic that is highly safe, improves rough skin, and has an excellent effect of adjusting the skin state to a normal skin state.

  Hereinafter, embodiments of the present invention will be described. In addition, this invention should not be limited and interpreted by description of the following embodiment, A various change is possible within the range of description in a claim.

  Oligomeric proanthocyanidin (hereinafter referred to as OPC) used in the cosmetic composition of the present invention is a polymer having proanthocyanidins (flavan-3-ol and / or flavan-3,4-diol as a structural unit). Refers to a polycondensation polymer having a degree of polymerization of 2 to 4). Proanthocyanidins, a type of polyphenols, are powerful antioxidants produced by plants and are concentrated in plant leaves, bark, fruit peels or seed parts. Proanthocyanidins, especially OPCs, are specifically pine, persimmon, mountain peach bark, grapes, blueberries, strawberries, avocado, black acacia, cowberry fruit or seeds, barley, wheat, soybeans, black soybeans, cacao, red beans, It is contained in tochi shells, peanut skins, and ginkgo leaves. It is also known that cola nuts in West Africa, Latania roots in Peru, and Japanese green tea contain OPC. OPC is a substance that cannot be produced in the human body.

  As the proanthocyanidins contained in the cosmetic of the present invention, pharmaceuticals such as the bark, fruit or seed extract described above, quasi drugs, or cosmetic raw materials can be used. In particular, it is preferable to use an extract of pine bark. Pine bark is rich in OPC among proanthocyanidins, and is therefore preferably used as a raw material for proanthocyanidins.

  Hereinafter, a method for preparing proanthocyanidins will be described by taking an extract of pine bark rich in OPC as an example.

  Pine bark extracts include Pinus Martina, larch, black pine, Japanese red pine, Japanese pine, Japanese pine, Korean pine, Japanese pine, Ryukyu pine, Utsukushima, Japanese pine, Japanese pine The bark extract of plants belonging to is preferably used. Among them, the bark extract of French maritime pine (Pinus Martina) is preferable.

  French coastal pine is a marine pine that grows on the Atlantic coast of southern France. This French coastal pine bark contains proanthocyanidins, organic acids, and other physiologically active ingredients, and it is known that proanthocyanidins, which are the main ingredients, have a strong antioxidant action to remove active oxygen. Yes.

  The pine bark extract is obtained by extracting the pine bark with water or an organic solvent. When water is used, warm water or hot water is preferably used. As an organic solvent used for extraction, an organic solvent that is acceptable for the production of food or drugs is used. For example, methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetone, hexane, cyclohexane , Propylene glycol, hydrous ethanol, hydrous propylene glycol, ethyl methyl ketone, glycerin, methyl acetate, ethyl acetate, diethyl ether, dichloromethane, edible oils and fats, 1,1,1,2-tetrafluoroethane, and 1,1,2- Trichloroethene is mentioned. These water and organic solvent may be used alone or in combination. In particular, hot water, hydrous ethanol, and hydrous propylene glycol are preferably used.

  The method for extracting proanthocyanidins from pine bark is not particularly limited, and is extracted by a conventional method. For example, a warm extraction method, a supercritical fluid extraction method, or the like is used.

  The extract derived from the raw material plant such as pine bark preferably contains OPC in terms of dry weight of 20% by weight or more, more preferably 30% by weight or more. Thus, a pine bark extract is preferably used as a raw material containing OPC in a high proportion.

  In addition, in the extract extracted from the plant body using water or ethanol as described above, pentamer or more proanthocyanidins are contained, but most of them are 10 to 10 from the solubility of proanthocyanidins in polar solvents. It is 20-mer or less.

  The plant extract preferably contains 5% by weight or more of catechins in addition to proanthocyanidins, particularly OPC, in the raw material plant extract. Catechin is a general term for polyhydroxyflavan-3-ol. As catechins, (+)-catechin, (−)-epicatechin, (+)-gallocatechin, (−)-epigallocatechin, epigallocatechin gallate, epicatechin gallate and the like are known. In addition to (+)-catechin, which is said to be a catechin in the narrow sense, gallocatechin, afuzerekin, and (+)-catechin or 3-galloyl derivatives of gallocatechin are isolated from extracts derived from raw material plants such as pine bark. Has been. Catechin has carcinogenic activity, arteriosclerosis preventive activity, fat metabolism abnormality suppressive effect, blood pressure increase inhibitory effect, platelet aggregation inhibitory effect, antiallergic effect, antiviral effect, antibacterial effect, caries preventive effect, bad breath prevention effect, It is known to have an intestinal flora normalizing action, an active oxygen and free radical scavenging action, an antioxidant action, and the like. Catechins are known to have an anti-diabetic effect that suppresses an increase in blood sugar. Catechins have the property of activating OPC while increasing water solubility in the presence of OPC.

  The catechins are preferably contained in an amount of 0.1 parts by weight or more with respect to 1 part by weight of proanthocyanidins in order to improve the solubility and function of OPC. More preferably, the raw material plant extract containing 20% by weight or more of OPC is prepared so that 5% by weight or more of catechins are contained. For example, when the catechin content of the pine bark extract is less than 5% by weight, the catechins may be added so as to be 5% by weight or more. It is most preferable to use a pine bark extract containing 5% by weight or more of catechins and 20% by weight or more of OPC.

  Since proanthocyanidins, especially OPCs are antioxidants as described above, they have particularly high whitening effects, wrinkle-preventing effects, and anti-inflammatory effects against atopic dermatitis, etc. Furthermore, the effects as condensed tannins, that is, skin The effect of preventing sagging due to the tightening effect is also obtained.

  Furthermore, OPC not only has an antioxidant effect, but also has a protective effect of vitamin C, so it enhances the ability to produce collagen in the skin and has an excellent skin quality improving effect.

  The cosmetic of the present invention contains proanthocyanidins, preferably 0.00001% to 5% by weight, more preferably 0.001% to 2% by weight, more preferably 0.01% in terms of dry weight in the composition. Contains 1% to 1% by weight.

  Polyquaterniums is a general term for polymer compounds having a quaternary amino group as a side chain. Polymer compounds having such a structure, which are recognized as cosmetic raw materials by the FDA, In addition, the number attached to the polyquaternium is the INCI name “INCI name” is the International Nomenclature Committee (International Nomenclature Committee) of the Cosmetic Association of the Cosmetic, Toiletry, and Fragrance Association (American Cosmetic Industry Committee). It is an international labeling name for cosmetic ingredients prepared according to the International Nomenclature of Raw Materials). Is registered. The polyquaterniums that can be used in the cosmetics of the present invention can be used without particular limitation as long as they are registered as INCI names. Among them, polyquaternium-51, polyquaternium-61, polyquaternium -64, polyquaternium-65 and the like can be suitably exemplified. In these, the form containing polyquaternium-51 is especially preferable. These can contain 1 type, and can also contain 2 or more types in combination. The preferred content of such polyquaterniums in the cosmetic of the present invention is 0.001 to 5% by weight, more preferably 0.01 to 1% by weight in a total amount in a form not containing a solvent.

  In addition to the above-mentioned proanthocyanidins and polyquaterniums, the cosmetics of the present invention may contain other components usually used in quasi-drugs, cosmetics and the like as long as the effects of the cosmetics are not impaired. . Examples of such components include water, other medicinal ingredients, other oils, moisturizers, surfactants, ultraviolet absorbers, absorption accelerators, fragrances, dyes, preservatives, thickeners, chelating agents, antiseptics A glaze etc. can be mentioned. Examples of other medicinal ingredients include active oxygen scavengers, antioxidants, anti-inflammatory analgesics, antihistamines, antipruritics, bactericides, vitamins, and hormonal agents.

  An antioxidant may be added for the purpose of increasing the stability of proanthocyanidins. Thereby, the oxidation of skin protein and fats and oils can be prevented, and the effect which improves and protects skin quality can be acquired.

  Examples of the antioxidant include carotenoids such as vitamin A, vitamin Bs, ascorbic acid, vitamin E, and derivatives or salts thereof.

  Among them, ascorbic acid not only enhances the stability of proanthocyanidins, but also synergistically exerts an effect on the skin, improving the skin quality (for example, the effect of improving elasticity and gloss) and the blood vessel protecting effect. . When ascorbic acid is added, it is contained in the cosmetic of the present invention so that the weight ratio with respect to proanthocyanidins is preferably 1: 0.1-50, more preferably 1: 0.2-20. Can be done. The amount of ascorbic acid may be larger than the above ratio.

  The cosmetics of the present invention can be prepared by mixing proanthocyanidins and polyquaterniums with other components by a commonly used method, and can be used as pharmaceuticals, quasi drugs, cosmetics, and toiletries. For example, lotion, cosmetic cream, milky lotion, cream, pack, hair tonic, hair cream, shampoo, hair rinse, treatment, body shampoo, facial cleanser, soap, foundation, lipstick, lip gloss, blusher, hair conditioner, hair restorer, aqueous An ointment, an oily ointment, a ship, a gel, etc. are mentioned. In addition, it can be locally administered for a long time by a method such as holding or absorbing in a carrier such as ship or gel or a cross-linking agent and applying it to a local area.

  The daily application amount of the cosmetic of the present invention is not particularly limited, and is preferably in the range of 0.00001 g to 1 g as proanthocyanidins. The amount of polyquaternium suitable for proanthocyanidins within this range is preferably 0.001 g to 1 g.

  When an appropriate amount is applied, the cosmetic of the present invention has an effect of improving rough skin, adjusting the skin condition, and preparing a normal skin condition. In particular, when an extract containing 20% by weight or more of OPC in terms of dry weight is used as proanthocyanidins, an excellent effect is obtained.

  Examples of the present invention will be described below. It should be noted that the present invention should not be construed as being limited to the following examples, and various modifications can be made within the scope of the claims.

  A cream having the formulation shown in Table 2 was prepared by a conventional method.

  Samples were applied twice a day (morning and evening) for 4 consecutive weeks for 10 subjects (25 to 48 years old) complaining of rough skin, dry skin, etc., and the effects after 4 weeks were evaluated. The test results were obtained by examining the number of people who answered that the rough skin was improved, the rough feel was improved, the rough feel was improved, and the skin was smooth against the rough skin feeling and the rough skin feeling.

  Compared with Comparative Example 1 and Comparative Example 2 in which pine bark extract and polyquaternium were respectively blended with Comparative Example 3 as a basis from the results in Table 2, Example 1 was carried out by adjusting the blending amount of the components and blending them together. It was shown that Example 2 and Example 3 were superior in terms of rough skin improvement effect, crispness and smoothness.

  INDUSTRIAL APPLICABILITY The present invention can be used as a pharmaceutical, a quasi-drug, a cosmetic, and a toiletry product that are excellent in rough skin improvement effect and / or skin condition improvement effect.

Claims (3)

  A cosmetic comprising an oligomeric proanthocyanidin and a polyquaternium.   The cosmetic according to claim 1, wherein the oligomeric proanthocyanidin is a pine bark extract.   The cosmetic according to claim 1 or 2, wherein the polyquaternium has a crosslinked structure.