IT201900024009A1 - NEW PROCEDURE FOR THE DIAGNOSIS OF A THYROID CANCER AND RELATED KIT - Google Patents

NEW PROCEDURE FOR THE DIAGNOSIS OF A THYROID CANCER AND RELATED KIT

Info

Publication number
IT201900024009A1
IT201900024009A1 IT102019000024009A IT201900024009A IT201900024009A1 IT 201900024009 A1 IT201900024009 A1 IT 201900024009A1 IT 102019000024009 A IT102019000024009 A IT 102019000024009A IT 201900024009 A IT201900024009 A IT 201900024009A IT 201900024009 A1 IT201900024009 A1 IT 201900024009A1
Authority
IT
Italy
Prior art keywords
diagnosis
thyroid cancer
new procedure
related kit
kit
Prior art date
Application number
IT102019000024009A
Other languages
Italian (it)
Inventor
Sebastiano Filetti
Cosimo Durante
Antonella Verrienti
Marialuisa Sponziello
Giorgio Grani
Original Assignee
Univ Degli Studi Roma La Sapienza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Roma La Sapienza filed Critical Univ Degli Studi Roma La Sapienza
Priority to IT102019000024009A priority Critical patent/IT201900024009A1/en
Priority to PCT/IB2020/061699 priority patent/WO2021116938A1/en
Priority to EP20841759.2A priority patent/EP4073274A1/en
Publication of IT201900024009A1 publication Critical patent/IT201900024009A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IT102019000024009A 2019-12-13 2019-12-13 NEW PROCEDURE FOR THE DIAGNOSIS OF A THYROID CANCER AND RELATED KIT IT201900024009A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT102019000024009A IT201900024009A1 (en) 2019-12-13 2019-12-13 NEW PROCEDURE FOR THE DIAGNOSIS OF A THYROID CANCER AND RELATED KIT
PCT/IB2020/061699 WO2021116938A1 (en) 2019-12-13 2020-12-09 A new method for diagnosing a thyroid tumour and kit thereof
EP20841759.2A EP4073274A1 (en) 2019-12-13 2020-12-09 A new method for diagnosing a thyroid tumour and kit thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000024009A IT201900024009A1 (en) 2019-12-13 2019-12-13 NEW PROCEDURE FOR THE DIAGNOSIS OF A THYROID CANCER AND RELATED KIT

Publications (1)

Publication Number Publication Date
IT201900024009A1 true IT201900024009A1 (en) 2021-06-13

Family

ID=70155050

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102019000024009A IT201900024009A1 (en) 2019-12-13 2019-12-13 NEW PROCEDURE FOR THE DIAGNOSIS OF A THYROID CANCER AND RELATED KIT

Country Status (3)

Country Link
EP (1) EP4073274A1 (en)
IT (1) IT201900024009A1 (en)
WO (1) WO2021116938A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117821596A (en) * 2024-02-20 2024-04-05 上海睿璟生物科技有限公司 NGS detection method for high-sensitivity auxiliary diagnosis of benign and malignant thyroid nodules

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118248319B (en) * 2024-02-20 2024-12-03 上海睿璟生物科技有限公司 Auxiliary diagnosis system for benign and malignant thyroid nodules based on the combination of genomic variation and abnormal expression

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012130909A1 (en) * 2011-03-30 2012-10-04 Universität Leipzig Method and means for distinguishing malignant from benign tumor samples, in particular in routine air dried fine needle aspiration biopsy (fnab)
US20170016076A1 (en) * 2014-05-13 2017-01-19 Rosetta Genomics, Ltd. Mirna expression signature in the classification of thyroid tumors
WO2017117523A1 (en) * 2015-12-31 2017-07-06 Quest Diagnostics Investments Llc Compositions and methods for screening mutations in thyroid cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012130909A1 (en) * 2011-03-30 2012-10-04 Universität Leipzig Method and means for distinguishing malignant from benign tumor samples, in particular in routine air dried fine needle aspiration biopsy (fnab)
US20170016076A1 (en) * 2014-05-13 2017-01-19 Rosetta Genomics, Ltd. Mirna expression signature in the classification of thyroid tumors
WO2017117523A1 (en) * 2015-12-31 2017-07-06 Quest Diagnostics Investments Llc Compositions and methods for screening mutations in thyroid cancer

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
AGRAWAL N ET AL.: "Integrated genomic Characterization of papillary Thyroid Carcinoma", CELL, vol. 159, 2015, pages 676 - 690, XP029084865, DOI: 10.1016/j.cell.2014.09.050
ANNA B. BANIZS ET AL: "The utility of combined mutation analysis and microRNA classification in reclassifying cancer risk of cytologically indeterminate thyroid nodules", DIAGNOSTIC CYTOPATHOLOGY, vol. 47, no. 4, 22 November 2018 (2018-11-22), pages 268 - 274, XP055719010, ISSN: 8755-1039, DOI: 10.1002/dc.24087 *
BANIZS ABSILVERMAN JF: "The utility of combined mutation analysis and microRNA classification in recrusifying cancer risk of cytologically indeterminate thyroid nodules", DIAGNOSTIC CYTOPATHOLOGY, vol. 47, 2019, pages 268 - 274
CELANE M ET AL.: "MicroRNAs as Biomarkers in Thyroid Carcinoma", INTERNATIONALJOURNAL OF GENOMICS, 2017, pages 6496570
CHEN-KAI CHOU ET AL: "MicroRNA-146b: A Novel Biomarker and Therapeutic Target for Human Papillary Thyroid Cancer", INT. J. MOL. SCI., vol. 18, no. 3, 15 March 2017 (2017-03-15), pages 636, XP055718958, ISSN: 1661-6596, DOI: 10.3390/ijms18030636 *
DURING C ET AL.: "The Diagnosis and Management of Thyroid Nodules: A Review", JAMA, vol. 319, 2018, pages 914 - 924
GRAINS G ET AL.: "Reducing the number of unnecessary thyroid biopsies while improving diagnostic accuracy: Toward the ''right'' TI RADS", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2018
LABORIER E ET AL.: "Molecular Testing for Mirna, mRNA, and DNA on Fine-Needle aspiration improves the preoperative Diagnosis of Thyroid Nodules with certain Cytology", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 100, 2015, pages 2743 - 2750
LANDA I ET AL., THE JOURNAL OF CLINICAL INVESTIGATION, vol. 126, 2016
LITHWICK-YANAI G ET AL.: "Multicentre validation of a microRNA-based assay for indeterminate dynosid nodules useful fine needle aspirated smears", JOURNAL OF CLINICAL PATHOLOGY, vol. 70, 2017, pages 500 - 507
NIKIFOROVA MN ET AL.: "Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules", CANCER, vol. 124, 2018, pages 1682 - 1690
PATEL KN ET AL.: "Performance of a genomic Sequencing Classifier for the preoperative Diagnosis of Cytologically Incertain Thyroid Nodules", JAMA SURGERY, vol. 153, 2018, pages 817
ROSIGNOLO F ET AL.: "MicroRNA-based molecular classification of papillary thyroid carcinoma", INTERNATIONAL JOURNAL OF CANCER, vol. 50, 2017, pages 1767 - 1777
SARA JACKSON ET AL: "Incremental utility of expanded mutation panel when used in combination with microRNA classification in indeterminate thyroid nodules", DIAGNOSTIC CYTOPATHOLOGY, vol. 48, no. 1, 1 November 2019 (2019-11-01), pages 43 - 52, XP055718997, ISSN: 8755-1039, DOI: 10.1002/dc.24328 *
SPONZIELLO M, B ET AL.: "Whole extent sequencing identifies a germline met mutation in two sizes with heritary wild-type RET medullary thyroid cancer", HUMAN MUTATION, vol. 39, 2018, pages 371 - 377
STEWARD DL ET AL.: "Performance of a Multigene Genomic Classifier in Thyroid Nodules with Indeterminate Cytology", JAMA ONCOLOGY, vol. 5, 2019, pages 204

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117821596A (en) * 2024-02-20 2024-04-05 上海睿璟生物科技有限公司 NGS detection method for high-sensitivity auxiliary diagnosis of benign and malignant thyroid nodules

Also Published As

Publication number Publication date
EP4073274A1 (en) 2022-10-19
WO2021116938A1 (en) 2021-06-17

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