IN2015DN00960A - - Google Patents

Download PDF

Info

Publication number
IN2015DN00960A
IN2015DN00960A IN960DEN2015A IN2015DN00960A IN 2015DN00960 A IN2015DN00960 A IN 2015DN00960A IN 960DEN2015 A IN960DEN2015 A IN 960DEN2015A IN 2015DN00960 A IN2015DN00960 A IN 2015DN00960A
Authority
IN
India
Prior art keywords
compounds
methods
general formula
provides novel
compositions including
Prior art date
Application number
Inventor
Jérôme Hert
Daniel Hunziker
Patrizio Mattei
Harald Mauser
Guozhi Tang
Lisha Wang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IN2015DN00960A publication Critical patent/IN2015DN00960A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein compositions including the compounds and methods of using the compounds.
IN960DEN2015 2012-09-25 2013-09-23 IN2015DN00960A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12185941 2012-09-25
PCT/EP2013/069679 WO2014048865A1 (en) 2012-09-25 2013-09-23 New bicyclic derivatives

Publications (1)

Publication Number Publication Date
IN2015DN00960A true IN2015DN00960A (en) 2015-06-12

Family

ID=47073290

Family Applications (1)

Application Number Title Priority Date Filing Date
IN960DEN2015 IN2015DN00960A (en) 2012-09-25 2013-09-23

Country Status (32)

Country Link
US (4) US20150353559A1 (en)
EP (2) EP3590940B1 (en)
JP (1) JP6285444B2 (en)
KR (1) KR102179599B1 (en)
CN (1) CN104684915B (en)
AR (1) AR092645A1 (en)
AU (1) AU2013322838B2 (en)
BR (1) BR112015004111A2 (en)
CA (1) CA2878442A1 (en)
CL (1) CL2015000706A1 (en)
CR (1) CR20150120A (en)
DK (1) DK2900669T3 (en)
EA (1) EA036630B1 (en)
ES (1) ES2753163T3 (en)
HR (1) HRP20191937T1 (en)
HU (1) HUE045797T2 (en)
IL (1) IL237126A (en)
IN (1) IN2015DN00960A (en)
LT (1) LT2900669T (en)
MA (1) MA37940B1 (en)
MX (1) MX368615B (en)
PE (1) PE20150758A1 (en)
PH (1) PH12015500263B1 (en)
PL (1) PL2900669T3 (en)
PT (1) PT2900669T (en)
RS (1) RS59512B1 (en)
SG (1) SG11201500572YA (en)
SI (1) SI2900669T1 (en)
TW (1) TWI609018B (en)
UA (1) UA116547C2 (en)
WO (1) WO2014048865A1 (en)
ZA (1) ZA201500345B (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014DN09346A (en) 2012-06-13 2015-07-17 Hoffmann La Roche
KR102179599B1 (en) 2012-09-25 2020-11-19 에프. 호프만-라 로슈 아게 New bicyclic derivatives
US9409895B2 (en) 2012-12-19 2016-08-09 Novartis Ag Autotaxin inhibitors
HK1212348A1 (en) 2012-12-19 2016-06-10 Novartis Ag Autotaxin inhibitors
AR095079A1 (en) * 2013-03-12 2015-09-16 Hoffmann La Roche DERIVATIVES OF OCTAHIDRO-PIRROLO [3,4-C] -PIRROL AND PIRIDINA-FENILO
JP6647592B2 (en) * 2013-07-03 2020-02-14 ルンドベック ラ ホーヤ リサーチ センター,インク. Pyrrolopyrrole carbamates and related organic compounds, pharmaceutical compositions, and medical uses thereof
WO2015048507A1 (en) 2013-09-26 2015-04-02 Mnemosyne Pharmaceuticals, Inc. Selective octahydro-cyclopenta[c] pyrrole negative modulators of nr2b
KR102515248B1 (en) 2013-11-22 2023-03-29 사브레 테라퓨틱스 엘엘씨 Autotaxin inhibitor compounds
CN105764905B (en) * 2013-11-26 2019-06-07 豪夫迈·罗氏有限公司 Novel octahydro-cyclobutadieno[1,2-c;3,4-c']dipyrrol-2yl
CN106103446B (en) * 2014-03-26 2019-07-30 豪夫迈·罗氏有限公司 Bicyclic compounds as inhibitors of autotaxin (ATX) and lysophosphatidic acid (LPA) production
WO2015144609A1 (en) 2014-03-26 2015-10-01 F. Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
US9051320B1 (en) 2014-08-18 2015-06-09 Pharmakea, Inc. Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor
JO3579B1 (en) 2014-09-26 2020-07-05 Luc Therapeutics Inc N-alkylaryl-5-oxyaryl- octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b
GB201501870D0 (en) 2015-02-04 2015-03-18 Cancer Rec Tech Ltd Autotaxin inhibitors
GB201502020D0 (en) 2015-02-06 2015-03-25 Cancer Rec Tech Ltd Autotaxin inhibitory compounds
MA41898A (en) 2015-04-10 2018-02-13 Hoffmann La Roche BICYCLIC QUINAZOLINONE DERIVATIVES
MX2017015225A (en) 2015-05-27 2018-02-19 Pharmakea Inc Autotaxin inhibitors and uses thereof.
AU2016270373A1 (en) 2015-06-05 2018-01-04 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
CA2992889A1 (en) 2015-09-04 2017-03-09 F. Hoffmann-La Roche Ag Phenoxymethyl derivatives
RU2018112230A (en) * 2015-09-24 2019-10-30 Ф. Хоффманн-Ля Рош Аг BICYCLE COMPOUNDS AS ATX INHIBITORS
CR20180057A (en) * 2015-09-24 2018-04-02 Hoffmann La Roche NEW BICYCLE COMPOUNDS AS DUAL INHIBITORS OF ATX / CA.
AU2016328365B2 (en) * 2015-09-24 2020-04-23 F. Hoffmann-La Roche Ag New bicyclic compounds as dual ATX/CA inhibitors
KR20180054830A (en) * 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 Bifunctional compounds as autotaxine (ATX) inhibitors
CN106986789B (en) * 2016-01-20 2019-07-16 中国人民解放军军事医学科学院生物医学分析中心 Hydroquinone compound and preparation method thereof and the application in antitumor or immunological regulation
US10781211B2 (en) 2016-05-12 2020-09-22 Lundbeck La Jolla Research Center, Inc. Spirocycle compounds and methods of making and using same
JOP20190107A1 (en) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc monoacylglycerol lipase (MAGL) inhibitors
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
US20200085791A1 (en) 2016-12-19 2020-03-19 Bayer Pharma Aktiengesellschaft [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
SG11201908560SA (en) 2017-03-16 2019-10-30 Hoffmann La Roche Heterocyclic compounds useful as dual atx/ca inhibitors
ES2747768T3 (en) 2017-03-20 2020-03-11 Forma Therapeutics Inc Pyrrolopyrrole compositions as pyruvate kinase activators (PKR)
JP7257387B2 (en) 2017-08-29 2023-04-13 ハー・ルンドベック・アクチエゼルスカベット Spirocyclic compounds and methods of making and using the same
CN111032034B (en) 2017-08-29 2023-05-02 H.隆德贝克有限公司 Spiro compounds and methods of making and using the same
JP7301390B2 (en) 2017-10-19 2023-07-03 ジェイエス・イノファーム・(シャンハイ)・リミテッド Heterocyclic compounds, compositions containing heterocyclic compounds, and methods of use thereof
TWI780281B (en) * 2017-12-14 2022-10-11 丹麥商Nmd藥品公司 Compounds for the treatment of neuromuscular disorders
ES2989438T3 (en) 2018-09-19 2024-11-26 Novo Nordisk Healthcare Ag Activation of pyruvate kinase R
US12053458B2 (en) 2018-09-19 2024-08-06 Novo Nordisk Health Care Ag Treating sickle cell disease with a pyruvate kinase R activating compound
CN111620866A (en) * 2019-02-27 2020-09-04 南京药石科技股份有限公司 Cis-7, 7-difluoro-hexahydro-1H pyrrolo [3,4-c ] pyridine derivative and preparation method thereof
US20220378756A1 (en) 2019-09-19 2022-12-01 Forma Therapeutics, Inc. Activating pyruvate kinase r
CN113549063B (en) * 2020-04-23 2024-04-05 南京药石科技股份有限公司 A method for preparing optically isomeric tert-butyl octahydro-2H-pyrrolo[3,4-c]pyridine-2-carboxylate
TW202211918A (en) * 2020-06-30 2022-04-01 印度商卡地拉保健有限公司 Novel inhibitors of autotaxin
TWI904281B (en) 2020-11-13 2025-11-11 丹麥商H 朗德貝克公司 A magl inhibitor
US20240327407A1 (en) 2021-01-05 2024-10-03 Cadila Heal Thcare Limited Novel inhibitors of autotaxin
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
CN113214111A (en) * 2021-04-30 2021-08-06 上海立科化学科技有限公司 Preparation method of 3- (2-cyanophenyl) propionic acid and 4-cyano-1-indanone
MX2023015436A (en) * 2021-06-26 2024-02-21 Cedilla Therapeutics Inc Cdk2 inhibitors and methods of using the same.
WO2023107705A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors
KR20250005229A (en) 2022-05-04 2025-01-09 하. 룬드벡 아크티에셀스카브 Crystalline form of 1,1,1,3,3,3-hexafluoropropan-2-yl (S)-1-(pyridazin-3-ylcarbamoyl)-6 azaspiro[2.5]octane-6-carboxylate as a monoacylglycerol lipase inhibitor
CN116270625B (en) * 2023-03-16 2025-06-24 宁夏医科大学 Application of starwort amine B in preparation of anti-neuroinflammatory drugs

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1252898B (en) 1965-06-12 1967-10-26 Bayer Ag Process for the preparation of copolymers of trioxane
US5240928A (en) 1989-07-03 1993-08-31 Merck & Co., Inc. Substituted quinazolinones as angiotensin II antagonists
DE3930262A1 (en) 1989-09-11 1991-03-21 Thomae Gmbh Dr K CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS
CA2037630C (en) 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
US5470975A (en) 1990-10-16 1995-11-28 E.R. Squibb & Sons, Inc. Dihydropyrimidine derivatives
US5290780A (en) 1991-01-30 1994-03-01 American Cyanamid Co. Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
US5238942A (en) 1991-05-10 1993-08-24 Merck & Co., Inc. Substituted quinazolinones bearing acidic functional groups as angiotensin ii antagonists
US5202322A (en) 1991-09-25 1993-04-13 Merck & Co., Inc. Quinazolinone and pyridopyrimidine a-II antagonists
US5532243A (en) 1992-02-14 1996-07-02 The Dupont Merck Pharmaceutical Company Antipsychotic nitrogen-containing bicyclic compounds
US5358951A (en) 1993-04-23 1994-10-25 American Cyanamid Company Angiotensin II receptor blocking 2, 3, 6 substituted quinazolinones
DE4407047A1 (en) * 1994-03-03 1995-09-07 Merck Patent Gmbh Acetamide
US20010016657A1 (en) * 1997-03-18 2001-08-23 Smithkline Beecham P.L.C. Substituted isoquinoline derivatives and their use as anticonvulsants
DE69922494T2 (en) 1998-02-04 2005-05-25 Banyu Pharmaceutical Co., Ltd. CYCLIC N-ACYLAMINE DERIVATIVES
JP2001039950A (en) 1999-07-30 2001-02-13 Banyu Pharmaceut Co Ltd N-acyl cyclic amine derivative
ATE250604T1 (en) 1999-10-27 2003-10-15 Millennium Pharm Inc PYRIDYL-CONTAINING SPIROCYCLIC COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELE AGGREGATION
EP1233787B8 (en) * 1999-11-09 2005-05-18 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Product inhibiting transduction of g heterotrimeric protein signals combined with another anti-cancer agent for therapeutic use in cancer treatment
CA2440803A1 (en) 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
EP1499306A4 (en) 2002-04-12 2007-03-28 Merck & Co Inc BICYCLIC AMIDES
GB0303852D0 (en) 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
WO2005023762A1 (en) 2003-09-04 2005-03-17 Abbott Laboratories Pyrrolidine-2-carbonitrile derivatives and their use as inhibitors of dipeptidyl peptidase-iv (dpp-iv)
SE0302811D0 (en) 2003-10-23 2003-10-23 Astrazeneca Ab Novel compounds
GB0324790D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Amide derivatives
US7226951B2 (en) 2003-12-17 2007-06-05 Allergan, Inc. Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435830B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
RU2006146608A (en) * 2004-06-09 2008-07-20 Ф.Хоффманн-Ля Рош Аг (Ch) OCTAGHYDROPYRROLO [3,4-c]-DERIVATIVES AND THEIR APPLICATION AS ANTIVIRAL AGENTS
ES2442857T3 (en) 2004-08-10 2014-02-13 Janssen Pharmaceutica Nv 1,2,4-Triazin-6-one HIV inhibitor derivatives
US7410949B2 (en) 2005-01-18 2008-08-12 Hoffmann-La Roche Inc. Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
CN101166736B (en) 2005-04-28 2013-02-06 惠氏公司 Polymorph form II of tanaproget
US7737279B2 (en) * 2005-05-10 2010-06-15 Bristol-Myers Squibb Company 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same
TW200800999A (en) 2005-09-06 2008-01-01 Astrazeneca Ab Novel compounds
PT1942108E (en) 2005-10-28 2013-10-24 Ono Pharmaceutical Co Compound containing basic group and use thereof
CA2629530C (en) * 2005-11-14 2014-07-08 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services N-substituted indenoisoquinolines and syntheses thereof
WO2007058322A1 (en) 2005-11-18 2007-05-24 Ono Pharmaceutical Co., Ltd. Basic group-containing compound and use thereof
WO2007103719A2 (en) 2006-03-03 2007-09-13 Incyte Corporation MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
JP2008031064A (en) 2006-07-27 2008-02-14 Astellas Pharma Inc Diacyl piperazine derivatives
CA2663161C (en) 2006-09-11 2014-10-28 N.V. Organon Quinazolinone and isoquinolinone acetamide derivatives
AR062790A1 (en) 2006-09-15 2008-12-03 Schering Corp USEFUL AZETIDINE DERIVATIVES IN THE TREATMENT OF PAIN, DIABETES AND DISORDERS OF THE LIPID METABOLISM
US8735411B2 (en) 2006-10-02 2014-05-27 Abbvie Inc. Macrocyclic benzofused pyrimidine derivatives
US7915299B2 (en) 2006-11-15 2011-03-29 High Point Pharmaceuticals, Llc 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes
TW200831085A (en) 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
EP1975165A1 (en) 2007-03-27 2008-10-01 Boehringer Ingelheim Pharma GmbH & Co. KG Substituted pyrrolidinamides, their production and utilisation as medicine
BRPI0809617A2 (en) 2007-03-29 2014-09-16 Hoffmann La Roche NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
CL2008001002A1 (en) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION.
AU2008248996A1 (en) 2007-04-27 2008-11-13 Sanofi-Aventis 2 -heteroaryl- pyrrolo [3, 4-C] pyrrole derivatives and their use as SCD inhibitors
DE102007047737A1 (en) 2007-10-05 2009-04-30 Merck Patent Gmbh Piperidine and piperazine derivatives
ES2630406T3 (en) 2007-10-19 2017-08-21 Sarcode Bioscience Inc. Composition and procedures for the treatment of diabetic retinopathy
AR069126A1 (en) * 2007-10-31 2009-12-30 Janssen Pharmaceutica Nv BRIDGE DIAMINES OR FUSIONATED SUBSTITUTES WITH ARILO AS MODULATORS OF LEUCOTRENE A4 HYDROLASS
JP2009161449A (en) 2007-12-28 2009-07-23 Lion Corp PPAR activity promoters, cosmetic foods and drinks, skin external preparations and pharmaceuticals
AU2009261248A1 (en) 2008-06-19 2009-12-23 Banyu Pharmaceutical Co., Ltd. Spirodiamine-diarylketoxime derivative
WO2010028761A1 (en) 2008-09-09 2010-03-18 Sanofi-Aventis 2-heteroaryl-pyrrolo [3, 4-c]pyrrole derivatives and the use thereof as scd inhibitors
TW201020247A (en) 2008-11-06 2010-06-01 Gruenenthal Gmbh Substituierte disulfonamide
US8188090B2 (en) 2008-11-17 2012-05-29 Hoffman-La Roche Inc. Naphthylacetic acids
DE102008059578A1 (en) 2008-11-28 2010-06-10 Merck Patent Gmbh Benzo-naphthyridine compounds
WO2010063352A1 (en) 2008-12-01 2010-06-10 Merck Patent Gmbh 2, 5-diamino-substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors against cancer
TW201035102A (en) 2009-03-04 2010-10-01 Gruenethal Gmbh Sulfonylated tetrahydroazolopyrazines and their use as medicinal products
TW201038572A (en) 2009-03-25 2010-11-01 Gruenenthal Gmbh Substituted spiro-amide compounds
MX2011010218A (en) 2009-04-02 2011-10-10 Merck Patent Gmbh Autotaxin inhibitors.
KR20120027177A (en) 2009-04-02 2012-03-21 메르크 파텐트 게엠베하 Piperidine and piperazine derivatives as autotaxin inhibitors
BRPI1009800A2 (en) * 2009-04-02 2016-03-15 Merck Patent Gmbh heterocyclic compounds as autotaxin inhibitors
FR2945534B1 (en) 2009-05-12 2012-11-16 Sanofi Aventis CYCLOPENTAL [c] PYRROLE-2-CARBOXYLATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
BRPI1010974A2 (en) 2009-05-22 2019-09-24 Exelixis Inc benzoxazepines based on p13k / m inhibitors against proliferative diseases
WO2010141817A1 (en) 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase
DE102009033392A1 (en) 2009-07-16 2011-01-20 Merck Patent Gmbh Heterocyclic compounds as autotaxine inhibitors II
WO2011017350A2 (en) 2009-08-04 2011-02-10 Amira Pharmaceuticals, Inc. Compounds as lysophosphatidic acid receptor antagonists
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
AR079022A1 (en) 2009-11-02 2011-12-21 Sanofi Aventis DERIVATIVES OF CYCLIC CARBOXYL ACID SUBSTITUTED WITH ACILAMINE, ITS USE AS PHARMACEUTICAL PRODUCTS, PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD
BR112012016733A2 (en) * 2010-01-07 2015-09-01 Du Pont "compound, fungicidal composition and method"
US8815869B2 (en) 2010-03-18 2014-08-26 Abbvie Inc. Lactam acetamides as calcium channel blockers
CA2792234C (en) 2010-03-19 2014-05-27 Pfizer Inc. 2,3 dihydro-1h-inden-1-yl-2,7-diazaspiro [3.5] nonane derivatives and their use as antagonists or inverse agonists of the ghrelin receptor
CN102822171B (en) 2010-03-26 2015-09-02 默克专利有限公司 As the benzo naphthyridines amine of autotaxin inhibitors
GB201008005D0 (en) 2010-05-13 2010-06-30 Sentinel Oncology Ltd Pharmaceutical compounds
EP2575794A2 (en) 2010-06-04 2013-04-10 B.S.R.C. "Alexander Fleming" Autotaxin pathway modulation and uses thereof
AR082590A1 (en) 2010-08-12 2012-12-19 Hoffmann La Roche INHIBITORS OF THE TIROSINA-QUINASA DE BRUTON
US9000025B2 (en) * 2010-08-20 2015-04-07 Amira Pharmaceuticals, Inc. Autotaxin inhibitors and uses thereof
ES2530345T3 (en) * 2010-09-02 2015-03-02 Merck Patent Gmbh Pyrazolopyridinone derivatives as LPA receptor antagonists
EP2651405A2 (en) 2010-12-14 2013-10-23 Electrophoretics Limited Casein kinase 1 (ck1 ) inhibitors
US9260416B2 (en) 2011-05-27 2016-02-16 Amira Pharmaceuticals, Inc. Heterocyclic autotaxin inhibitors and uses thereof
ES2609579T3 (en) 2011-08-29 2017-04-21 VIIV Healthcare UK (No.5) Limited Spiro derivatives of bicyclic diamine as inhibitors of HIV binding
WO2013054185A1 (en) 2011-10-13 2013-04-18 Pfizer, Inc. Pyrimidine and pyridine derivatives useful in therapy
WO2013065712A1 (en) 2011-10-31 2013-05-10 東レ株式会社 Diazaspirourea derivative and pharmaceutical use thereof
US8809552B2 (en) 2011-11-01 2014-08-19 Hoffmann-La Roche Inc. Azetidine compounds, compositions and methods of use
WO2013079223A1 (en) 2011-12-02 2013-06-06 Phenex Pharmaceuticals Ag Pyrrolo carboxamides as modulators of orphan nuclear receptor rar-related orphan receptor-gamma (rorϒ, nr1f3) activity and for the treatment of chronic inflammatory and autoimmune diseases
TWI638802B (en) 2012-05-24 2018-10-21 芬蘭商奧利安公司 Catechol o-methyltransferase activity inhibiting compounds
ES2704744T3 (en) 2012-06-13 2019-03-19 Incyte Holdings Corp Substituted tricyclic compounds as FGFR inhibitors
IN2014DN09346A (en) * 2012-06-13 2015-07-17 Hoffmann La Roche
MX363388B (en) 2012-07-27 2019-03-20 Biogen Ma Inc Atx modulating agents.
EA027809B1 (en) 2012-07-27 2017-09-29 Биоген Айдек Ма Инк. Compounds that are s1p modulating agents and/or atx modulating agents
KR102179599B1 (en) 2012-09-25 2020-11-19 에프. 호프만-라 로슈 아게 New bicyclic derivatives
US10898500B2 (en) 2012-09-25 2021-01-26 Bayer Pharma Aktiengesellschaft Combination of regorafenib and acetylsalicylic acid for treating cancer
AR092742A1 (en) 2012-10-02 2015-04-29 Intermune Inc ANTIFIBROTIC PYRIDINONES
PT2912019T (en) 2012-10-25 2021-05-25 Tetra Discovery Partners Llc Heteroaryl inhibitors of pde4
WO2014133112A1 (en) 2013-03-01 2014-09-04 国立大学法人東京大学 8-substituted imidazopyrimidinone derivative having autotaxin inhibitory activity
WO2014139324A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Tetracyclic bromodomain inhibitors
AR095079A1 (en) 2013-03-12 2015-09-16 Hoffmann La Roche DERIVATIVES OF OCTAHIDRO-PIRROLO [3,4-C] -PIRROL AND PIRIDINA-FENILO
TWI593692B (en) 2013-03-12 2017-08-01 美國禮來大藥廠 Tetrahydropyrrolothiazine compounds
EP2970099A4 (en) 2013-03-12 2016-12-21 Acucela Inc SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS
US20160039825A1 (en) 2013-03-15 2016-02-11 Biogen Ma Inc. S1p and/or atx modulating agents
MX368059B (en) 2013-07-18 2019-09-18 Novartis Ag Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core.
PT3057959T (en) 2013-10-17 2018-06-04 Vertex Pharma Dna-pk inhibitors
KR102515248B1 (en) 2013-11-22 2023-03-29 사브레 테라퓨틱스 엘엘씨 Autotaxin inhibitor compounds
AR098475A1 (en) 2013-11-26 2016-06-01 Bayer Cropscience Ag PESTICIDE COMPOUNDS AND USES
CN105764905B (en) 2013-11-26 2019-06-07 豪夫迈·罗氏有限公司 Novel octahydro-cyclobutadieno[1,2-c;3,4-c']dipyrrol-2yl
CA2939865A1 (en) 2014-03-26 2015-10-01 Basf Se Substituted [1,2,4]triazole and imidazole compounds as fungicides
JO3512B1 (en) 2014-03-26 2020-07-05 Astex Therapeutics Ltd Quinoxaline derivatives useful as fgfr kinase modulators
CN106103446B (en) 2014-03-26 2019-07-30 豪夫迈·罗氏有限公司 Bicyclic compounds as inhibitors of autotaxin (ATX) and lysophosphatidic acid (LPA) production
WO2015144609A1 (en) 2014-03-26 2015-10-01 F. Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
MX2016013049A (en) 2014-04-04 2017-04-27 X-Rx Inc Substituted spirocydic inhibitors of autotaxin.
PT3207043T (en) 2014-10-14 2019-03-25 Vitae Pharmaceuticals Llc Dihydropyrrolopyridine inhibitors of ror-gamma
SG11201706451TA (en) 2015-02-15 2017-09-28 Hoffmann La Roche 1-(het)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as trpa1 antagonists
MA41898A (en) 2015-04-10 2018-02-13 Hoffmann La Roche BICYCLIC QUINAZOLINONE DERIVATIVES
CN104927727B (en) 2015-07-06 2017-01-11 香山红叶建设有限公司 Structural sealant for glass curtain walls and preparation method for structural sealant
CA2992889A1 (en) 2015-09-04 2017-03-09 F. Hoffmann-La Roche Ag Phenoxymethyl derivatives
PL415078A1 (en) 2015-09-04 2017-03-13 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Substituted amino triazoles, suitable as acidic mammalian chitinase inhibitors
CR20180057A (en) 2015-09-24 2018-04-02 Hoffmann La Roche NEW BICYCLE COMPOUNDS AS DUAL INHIBITORS OF ATX / CA.
AU2016328365B2 (en) 2015-09-24 2020-04-23 F. Hoffmann-La Roche Ag New bicyclic compounds as dual ATX/CA inhibitors
RU2018112230A (en) 2015-09-24 2019-10-30 Ф. Хоффманн-Ля Рош Аг BICYCLE COMPOUNDS AS ATX INHIBITORS
KR20180054830A (en) 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 Bifunctional compounds as autotaxine (ATX) inhibitors
JP6877414B2 (en) 2015-09-24 2021-05-26 アイオニス・ファーマシューティカルズ・インコーポレイテッドIonis Pharmaceuticals,Inc. KRAS expression modulator
MX2018006499A (en) 2015-11-25 2018-08-01 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibtors and uses thereof.
US10292395B2 (en) 2015-12-01 2019-05-21 Nihon Nohyaku Co., Ltd. 3H-pyrrolopyridine compound, N-oxide thereof or salt thereof, agricultural and horticultural insecticide comprising the compound and method for using the same
WO2017139978A1 (en) 2016-02-19 2017-08-24 吴伟东 Method and system for updating mobile phone app
SG11201908560SA (en) 2017-03-16 2019-10-30 Hoffmann La Roche Heterocyclic compounds useful as dual atx/ca inhibitors
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
ES2747768T3 (en) 2017-03-20 2020-03-11 Forma Therapeutics Inc Pyrrolopyrrole compositions as pyruvate kinase activators (PKR)

Also Published As

Publication number Publication date
PT2900669T (en) 2019-10-29
MX2015002090A (en) 2015-05-11
JP2015531360A (en) 2015-11-02
EP3590940A1 (en) 2020-01-08
EP2900669A1 (en) 2015-08-05
US10669268B2 (en) 2020-06-02
EA036630B1 (en) 2020-12-02
US20200339570A1 (en) 2020-10-29
ZA201500345B (en) 2015-12-23
PL2900669T3 (en) 2020-01-31
HK1206722A1 (en) 2016-01-15
AU2013322838A1 (en) 2015-01-29
ES2753163T3 (en) 2020-04-07
TW201422618A (en) 2014-06-16
PE20150758A1 (en) 2015-05-15
AU2013322838B2 (en) 2018-02-01
SG11201500572YA (en) 2015-02-27
SI2900669T1 (en) 2019-12-31
LT2900669T (en) 2019-11-11
US20170050960A1 (en) 2017-02-23
EP3590940B1 (en) 2021-06-09
UA116547C2 (en) 2018-04-10
PH12015500263A1 (en) 2015-03-30
EP2900669B1 (en) 2019-09-04
DK2900669T3 (en) 2019-11-04
MA37940B1 (en) 2018-09-28
US20180118741A1 (en) 2018-05-03
KR20150060713A (en) 2015-06-03
CN104684915B (en) 2017-10-31
BR112015004111A2 (en) 2017-07-04
PH12015500263B1 (en) 2022-06-17
CL2015000706A1 (en) 2015-08-07
WO2014048865A1 (en) 2014-04-03
MA37940A2 (en) 2016-06-30
CA2878442A1 (en) 2014-04-03
JP6285444B2 (en) 2018-02-28
EA201590534A1 (en) 2015-07-30
CN104684915A (en) 2015-06-03
TWI609018B (en) 2017-12-21
US20150353559A1 (en) 2015-12-10
HUE045797T2 (en) 2020-01-28
HRP20191937T1 (en) 2020-01-10
AR092645A1 (en) 2015-04-29
MX368615B (en) 2019-10-09
IL237126A (en) 2016-12-29
RS59512B1 (en) 2019-12-31
CR20150120A (en) 2015-04-14
KR102179599B1 (en) 2020-11-19

Similar Documents

Publication Publication Date Title
IN2015DN00960A (en)
PH12014502697B1 (en) New diazaspirocycloalkane and azaspirocycloalkane
MX2014014531A (en) Aminoquinazoline and pyridopyrimidine derivatives.
MY169267A (en) New aryl-quinoline derivatives
MY169043A (en) New dihydroquinoline-2-one derivatives
IN2014MN02574A (en)
MY163187A (en) Novel imidazo-oxazine compound or salt thereof
PH12014501179B1 (en) New bicyclic dihydroisoquinoline-1-one derivatives
MX341133B (en) Compounds and methods.
MX2012008141A (en) Compounds and methods.
MX2018001890A (en) Bicyclic compounds as atx inhibitors.
MX2015007097A (en) Novel bi-ring phenyl-pyridines/pyrazines for the treatment of cancer.
MX2015001099A (en) New bicyclicpyridine derivatives.
IN2015DN00598A (en)
MX341456B (en) Amino-quinolines as kinase inhibitors.
MX2015010106A (en) Flap modulators.
PH12016500643A1 (en) New octahydro - cyclobuta [1,2-c;3,4-c`] dipyrrol -2- yl
PH12015500315A1 (en) Substituted pyrozales as n-type calcium channel blockers
MX346980B (en) New hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds.
MX2015016332A (en) Pyrrolotriazines as alk inhibitors.
MX2015014470A (en) Combretastatin analogs.
MX342311B (en) New azaspirodecanone compounds as hsl inhibitors.
MX2013009386A (en) New azaspirodecanone compounds.
MX344429B (en) New hexahydropyrroloimidazolone compounds.
MX2015009377A (en) Radiolabeled compounds.