IL274297A - Pyrazolo-piperidine substituted indole-2-carboxamides, compositions comprising same and uses thereof - Google Patents

Pyrazolo-piperidine substituted indole-2-carboxamides, compositions comprising same and uses thereof

Info

Publication number
IL274297A
IL274297A IL274297A IL27429720A IL274297A IL 274297 A IL274297 A IL 274297A IL 274297 A IL274297 A IL 274297A IL 27429720 A IL27429720 A IL 27429720A IL 274297 A IL274297 A IL 274297A
Authority
IL
Israel
Prior art keywords
carboxamides
pyrazolo
compositions
same
substituted indole
Prior art date
Application number
IL274297A
Other languages
Hebrew (he)
Original Assignee
Aicuris Gmbh And Company Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh And Company Kg filed Critical Aicuris Gmbh And Company Kg
Publication of IL274297A publication Critical patent/IL274297A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL274297A 2017-11-02 2020-04-27 Pyrazolo-piperidine substituted indole-2-carboxamides, compositions comprising same and uses thereof IL274297A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17199676 2017-11-02
PCT/EP2018/000503 WO2019086142A1 (en) 2017-11-02 2018-11-02 Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis b virus (hbv)

Publications (1)

Publication Number Publication Date
IL274297A true IL274297A (en) 2020-06-30

Family

ID=60201937

Family Applications (1)

Application Number Title Priority Date Filing Date
IL274297A IL274297A (en) 2017-11-02 2020-04-27 Pyrazolo-piperidine substituted indole-2-carboxamides, compositions comprising same and uses thereof

Country Status (22)

Country Link
US (1) US11236087B2 (en)
EP (1) EP3704119A1 (en)
JP (1) JP2021501768A (en)
KR (1) KR20200083552A (en)
CN (1) CN111527087A (en)
AR (1) AR115131A1 (en)
AU (1) AU2018361365C1 (en)
BR (1) BR112020008765A2 (en)
CA (1) CA3081399A1 (en)
CL (1) CL2020001146A1 (en)
CU (1) CU20200045A7 (en)
EA (1) EA202091114A1 (en)
EC (1) ECSP20029569A (en)
GE (2) GEP20227374B (en)
IL (1) IL274297A (en)
MA (1) MA50520A (en)
MX (1) MX2020004838A (en)
PH (1) PH12020550531A1 (en)
SG (1) SG11202003746UA (en)
TW (1) TW201925199A (en)
UY (1) UY37961A (en)
WO (1) WO2019086142A1 (en)

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EA202091113A1 (en) * 2017-11-02 2020-08-28 Айкурис Гмбх Унд Ко. Кг NEW HIGHLY ACTIVE AMINOTHIAZOL SUBSTITUTED INDOL-2-CARBOXAMIDES ACTIVE AGAINST HEPATITIS B VIRUS (HBV)
UY38437A (en) * 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg NEW UREA 6,7-DIHIDRO-4H-PIRAZOLO [1,5-A] PYRAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
PY1991603A (en) * 2018-11-02 2020-09-17 Aicuris Gmbh & Co Kg NEW 6,7-DIHYDRO-4H-PYRAZOLE [1,5-A] PYRAZINE INDOLE -2-CARBOXAMIDES ACTIVE AGAINST HEPATITIS B VIRUS (HBV)
AR117189A1 (en) * 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg DERIVATIVES OF 6,7-DIHIDRO-4H-PIRAZOLO [1,5-A] PIRAZIN INDOL-2-CARBOXAMIDAS ACTIVE AGAINST THE VIRUS OF HEPATITIS B (HBV)
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WO2020221824A1 (en) * 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv)
BR112021021564A2 (en) * 2019-04-30 2022-01-04 Aicuris Gmbh & Co Kg Innovative indole-2-carboxamides active against hepatitis b virus (hbv)
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US11858945B2 (en) 2021-11-12 2024-01-02 Enanta Pharmaceuticals, Inc. Alkyne-containing antiviral agents
WO2023107419A1 (en) 2021-12-08 2023-06-15 Enanta Pharmaceuticals, Inc. Saturated spirocyclics as antiviral agents
WO2023137007A1 (en) 2022-01-11 2023-07-20 Enanta Pharmaceuticals, Inc. Processes for the preparation of 4,6,7-trifluoro-1h-indole-2-carboxylic acid
WO2023196307A1 (en) 2022-04-05 2023-10-12 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
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Also Published As

Publication number Publication date
US11236087B2 (en) 2022-02-01
PH12020550531A1 (en) 2021-03-22
AU2018361365C1 (en) 2021-08-05
WO2019086142A1 (en) 2019-05-09
GEP20227374B (en) 2022-04-25
AU2018361365A1 (en) 2020-05-21
CL2020001146A1 (en) 2020-10-09
KR20200083552A (en) 2020-07-08
CU20200045A7 (en) 2021-03-11
MX2020004838A (en) 2020-10-16
TW201925199A (en) 2019-07-01
AR115131A1 (en) 2020-12-02
ECSP20029569A (en) 2020-07-31
CA3081399A1 (en) 2019-05-09
SG11202003746UA (en) 2020-05-28
AU2018361365B2 (en) 2021-04-01
GEAP202115353A (en) 2021-12-10
UY37961A (en) 2019-05-31
EP3704119A1 (en) 2020-09-09
JP2021501768A (en) 2021-01-21
BR112020008765A2 (en) 2020-10-20
EA202091114A1 (en) 2020-07-24
US20210179608A1 (en) 2021-06-17
MA50520A (en) 2020-09-09
CN111527087A (en) 2020-08-11

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