HN2000000203A - Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. - Google Patents

Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Info

Publication number
HN2000000203A
HN2000000203A HN2000000203A HN2000000203A HN2000000203A HN 2000000203 A HN2000000203 A HN 2000000203A HN 2000000203 A HN2000000203 A HN 2000000203A HN 2000000203 A HN2000000203 A HN 2000000203A HN 2000000203 A HN2000000203 A HN 2000000203A
Authority
HN
Honduras
Prior art keywords
procedure
obtaining
tetrahydroquinolins
carboxyamin
substituted
Prior art date
Application number
HN2000000203A
Other languages
English (en)
Inventor
Derek Lawrence Tickner
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of HN2000000203A publication Critical patent/HN2000000203A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A INHIBIDORES DE LA PROTEINA DE TRANSFERENCIA DE ESTER COLESTERILICO (CETP) Y AUN PROCEDIMIENTO PARA LA OBTENCION DE TALES INHIBIDORES.
HN2000000203A 1999-11-30 2000-09-14 Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. HN2000000203A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
HN2000000203A true HN2000000203A (es) 2001-06-13

Family

ID=22609556

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2000000203A HN2000000203A (es) 1999-11-30 2000-09-14 Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Country Status (44)

Country Link
US (1) US6313142B1 (es)
EP (1) EP1125929B1 (es)
JP (1) JP3579345B2 (es)
KR (1) KR100408177B1 (es)
CN (1) CN1173953C (es)
AP (1) AP2000002011A0 (es)
AR (1) AR029775A1 (es)
AT (1) ATE315028T1 (es)
AU (1) AU784694B2 (es)
BG (1) BG105009A (es)
BR (1) BR0005636A (es)
CA (1) CA2327029C (es)
CO (1) CO5261552A1 (es)
CY (1) CY1104989T1 (es)
CZ (1) CZ20004407A3 (es)
DE (1) DE60025317T2 (es)
DK (1) DK1125929T3 (es)
DZ (1) DZ3079A1 (es)
EA (1) EA003668B1 (es)
EE (1) EE200000659A (es)
ES (1) ES2254109T3 (es)
GE (1) GEP20022798B (es)
GT (1) GT200000190A (es)
HN (1) HN2000000203A (es)
HR (1) HRP20000804A2 (es)
HU (1) HUP0004747A3 (es)
ID (1) ID28489A (es)
IL (1) IL139849A (es)
IS (1) IS5715A (es)
MA (1) MA25223A1 (es)
NO (1) NO20006039L (es)
NZ (1) NZ508509A (es)
OA (1) OA11494A (es)
PA (1) PA8503801A1 (es)
PE (1) PE20010913A1 (es)
PL (1) PL344208A1 (es)
SG (1) SG102603A1 (es)
SK (1) SK17792000A3 (es)
TN (1) TNSN00230A1 (es)
TW (1) TW591016B (es)
UA (1) UA65615C2 (es)
UY (1) UY26451A1 (es)
YU (1) YU71500A (es)
ZA (1) ZA200006947B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
WO2003053359A2 (en) 2001-12-19 2003-07-03 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
IL162533A0 (en) * 2001-12-19 2005-11-20 Atherogenics Inc Chalcone derivatives and their use to treat diseases
DE60323954D1 (de) * 2002-04-11 2008-11-20 Roar Holding Llc Ex-vivo-verfahren zur bestimmung der cetp-aktivität und der wirksamkeit der behandlung von herzerkrankungen
WO2004032848A2 (en) * 2002-10-04 2004-04-22 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7223870B2 (en) 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
JP2006513186A (ja) 2002-12-20 2006-04-20 ファイザー・プロダクツ・インク Ｃｅｔｐ阻害剤およびｈｍｇ−ｃｏａレダクターゼ阻害剤を含む剤形
EP1601655A2 (en) * 2003-03-04 2005-12-07 Takasago International Corporation Method for producing optically active amines
PT1603553E (pt) * 2003-03-17 2012-02-03 Japan Tobacco Inc Composições farmacêuticas de inibidores de cetp
WO2004082675A1 (en) * 2003-03-17 2004-09-30 Japan Tobacco Inc. Method for increasing the oral bioavailability of s-[2- ([[1- (2-ethylbutyl) cyclohexyl] carbonyl] amino) phenyl] 2-methylpropanethioate
TWI494102B (zh) * 2003-05-02 2015-08-01 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
DE602004023100D1 (de) * 2003-10-08 2009-10-22 Lilly Co Eli Verbindungen und verfahren zur behandlung von dyslipidemie
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
EA200700119A1 (ru) * 2004-06-24 2007-10-26 Эли Лилли Энд Компани Соединения и способы лечения дислипидемии
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
US7700774B2 (en) * 2004-12-20 2010-04-20 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds and their pharmaceutical compositions
WO2006091674A1 (en) * 2005-02-24 2006-08-31 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
UY30244A1 (es) 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
CL2008000684A1 (es) 2007-03-09 2008-08-01 Indigene Pharmaceuticals Inc Composicion farmaceutica que comprende metformina r-(+) lipoato y un inhibidor de reductasa hmg-coa; formulacion de dosis unitaria; y uso en el tratamiento de una complicacion diabetica.
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
TWI450896B (zh) 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
US12006305B2 (en) 2022-07-05 2024-06-11 Newamsterdam Pharma B.V. Salts of obicetrapib and processes for their manufacture and intermediates thereof

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FR7870M (es) * 1968-11-08 1970-04-27
US3971789A (en) 1972-10-21 1976-07-27 John Wyeth & Brother Limited O-(4-Quinolylamino)benzamides
GB8432091D0 (en) 1984-12-19 1985-01-30 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
US4839368A (en) 1986-05-02 1989-06-13 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
GB8804444D0 (en) 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5231102A (en) 1989-03-08 1993-07-27 Merck Sharp & Dohme, Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US6140342A (en) 1998-09-17 2000-10-31 Pfizer Inc. Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
US6147089A (en) 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Also Published As

Publication number Publication date
SG102603A1 (en) 2004-03-26
NZ508509A (en) 2001-06-29
EA200001129A2 (ru) 2001-06-25
DZ3079A1 (fr) 2004-10-24
ID28489A (id) 2001-05-31
DK1125929T3 (da) 2006-04-03
ES2254109T3 (es) 2006-06-16
NO20006039D0 (no) 2000-11-29
HRP20000804A2 (en) 2001-06-30
TNSN00230A1 (fr) 2005-11-10
EA200001129A3 (ru) 2001-10-22
IL139849A (en) 2006-10-31
EE200000659A (et) 2001-08-15
HK1038007A1 (en) 2002-03-01
HU0004747D0 (es) 2001-02-28
CA2327029C (en) 2005-08-09
CN1302800A (zh) 2001-07-11
CY1104989T1 (el) 2010-03-03
HUP0004747A2 (hu) 2001-10-28
EA003668B1 (ru) 2003-08-28
US6313142B1 (en) 2001-11-06
SK17792000A3 (sk) 2002-10-08
NO20006039L (no) 2001-05-31
AR029775A1 (es) 2003-07-16
CN1173953C (zh) 2004-11-03
EP1125929A1 (en) 2001-08-22
BG105009A (en) 2001-11-30
DE60025317D1 (de) 2006-03-30
KR100408177B1 (ko) 2003-12-01
EP1125929B1 (en) 2006-01-04
GEP20022798B (en) 2002-09-25
CA2327029A1 (en) 2001-05-30
PA8503801A1 (es) 2002-07-30
PL344208A1 (en) 2001-06-04
JP3579345B2 (ja) 2004-10-20
DE60025317T2 (de) 2006-08-03
UA65615C2 (uk) 2004-04-15
OA11494A (en) 2004-05-07
TW591016B (en) 2004-06-11
IS5715A (is) 2001-05-31
HUP0004747A3 (en) 2002-12-28
CZ20004407A3 (cs) 2002-06-12
GT200000190A (es) 2002-04-27
AU7178900A (en) 2001-05-31
ATE315028T1 (de) 2006-02-15
CO5261552A1 (es) 2003-03-31
PE20010913A1 (es) 2001-09-10
YU71500A (sh) 2003-02-28
AU784694B2 (en) 2006-06-01
ZA200006947B (en) 2002-05-27
KR20010052012A (ko) 2001-06-25
MA25223A1 (fr) 2001-07-02
IL139849A0 (en) 2002-02-10
JP2001163859A (ja) 2001-06-19
BR0005636A (pt) 2001-07-17
UY26451A1 (es) 2001-06-29
AP2000002011A0 (en) 2000-12-31

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