GB2167407B - Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof - Google Patents

Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof

Info

Publication number: GB2167407B
Authority: GB; United Kingdom
Prior art keywords: enantiomers; salts; phenoxy derivatives; benzyl morpholine; morpholine
Prior art date: 1984-11-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB08429546A

Other versions

GB8429546D0 (en

GB2167407A (en

Inventor

Piero Melloni

Arturo Della Torre

Giovanni Carniel

Alessandro Rossi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Italia SRL

Original Assignee

Farmitalia Carlo Erba SRL

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-22

Filing date

1984-11-22

Publication date

1988-05-11

1984-11-22 Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL

1984-11-22 Priority to GB08429546A priority Critical patent/GB2167407B/en

1985-01-03 Publication of GB8429546D0 publication Critical patent/GB8429546D0/en

1985-10-29 Priority to IT22645/85A priority patent/IT1190420B/en

1985-11-12 Priority to DE19853540093 priority patent/DE3540093A1/en

1985-11-20 Priority to JP60258816A priority patent/JPH0667916B2/en

1985-11-22 Priority to FR8517324A priority patent/FR2573425B1/en

1986-05-29 Publication of GB2167407A publication Critical patent/GB2167407A/en

1988-05-11 Application granted granted Critical

1988-05-11 Publication of GB2167407B publication Critical patent/GB2167407B/en

Status Expired legal-status Critical Current

Links

HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Natural products C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 title 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

GB08429546A 1984-11-22 1984-11-22 Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof Expired GB2167407B (en)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
GB08429546A GB2167407B (en)	1984-11-22	1984-11-22	Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof
IT22645/85A IT1190420B (en)	1984-11-22	1985-10-29	BENZYLMORPHOLINE-DERIVED PHENOXY-BASED ENANTIOMERS AND THEIR SALTS
DE19853540093 DE3540093A1 (en)	1984-11-22	1985-11-12	ENANTIOMERS OF PHENOXY DERIVATIVES OF BENZYLMORPHOLIN AND SALTS THEREOF, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THEM
JP60258816A JPH0667916B2 (en)	1984-11-22	1985-11-20	Enantiomers of phenoxy derivatives of benzylmorpholine and their salts
FR8517324A FR2573425B1 (en)	1984-11-22	1985-11-22	ENANTIOMERS OF PHENOXY DERIVATIVES OF BENZYLMORPHOLINE AND THEIR SALTS USEFUL IN PARTICULAR AS ANTIDEPRESSANTS AND THEIR MANUFACTURING METHOD

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB08429546A GB2167407B (en)	1984-11-22	1984-11-22	Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof

Publications (3)

Publication Number	Publication Date
GB8429546D0 GB8429546D0 (en)	1985-01-03
GB2167407A GB2167407A (en)	1986-05-29
GB2167407B true GB2167407B (en)	1988-05-11

Family

ID=10570118

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB08429546A Expired GB2167407B (en)	1984-11-22	1984-11-22	Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof

Country Status (5)

Country	Link
JP (1)	JPH0667916B2 (en)
DE (1)	DE3540093A1 (en)
FR (1)	FR2573425B1 (en)
GB (1)	GB2167407B (en)
IT (1)	IT1190420B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1305322B1 (en) *	1998-04-23	2001-05-04	Pharmacia & Upjohn Spa	Use of reboxetine for treating obsessive compulsive disorder and panic disorder
ATE319453T1 (en)	1999-07-01	2006-03-15	Pharmacia & Upjohn Co Llc	REBOXETINE FOR THE TREATMENT OF FIBROMYALGIA AND OTHER SOMATOFORM DISORDERS
EP1459751B1 (en) *	1999-07-01	2005-09-14	Pharmacia & Upjohn Company LLC	(S,S)-reboxetine for treating migraine headaches
US6387403B1 (en) *	1999-09-15	2002-05-14	Alza Corporation	Dosage forms and methods for providing effective reboxetine therapy with once-a-day dosing
DK1515959T3 (en) *	2002-06-17	2009-11-02	Pfizer Italia Srl	Pharmaceutical salts of reboxetine
AU2003261245A1 (en)	2002-08-23	2004-03-11	Eli Lilly And Company	Benzyl morpholine derivatives
WO2004017977A2 (en) *	2002-08-23	2004-03-04	Eli Lilly And Company	2- (phenoxymethyl)- and 2- (phenylthiomethyl)-morpholine derivatives for use as selective norepinephrine reuptake inhibitors
GB0219687D0 (en)	2002-08-23	2002-10-02	Lilly Co Eli	Benzyl morpholine derivatives
GB0319793D0 (en)	2003-08-22	2003-09-24	Lilly Co Eli	Pyridinylmorpholine derivatives
WO2005053663A2 (en) *	2003-11-24	2005-06-16	Eli Lilly And Company	Norepinephrine reuptake inhibitors useful for treatment of cognitive failure
PL1691811T3 (en)	2003-12-11	2014-12-31	Sunovion Pharmaceuticals Inc	Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
AU2005217217B2 (en) *	2004-02-20	2008-03-06	Pharmacia & Upjohn Company Llc	Method for the preparation of aryl ethers
WO2005082869A1 (en) *	2004-02-20	2005-09-09	Pharmacia & Upjohn Company Llc	Method for the preparation of aryl ethers
AP2006003771A0 (en) *	2004-04-30	2006-10-31	Warner Lambert Co	Substituted morpholine compounds for the treatmentof central nervous system disorders
GB0409744D0 (en) *	2004-04-30	2004-06-09	Pfizer Ltd	Novel compounds
RS51647B (en)	2006-10-18	2011-10-31	Pfizer Products Inc.	BIARIL ETAR UREE UNITS
US20100069389A1 (en) *	2008-09-06	2010-03-18	Bionevia Pharmaceuticals, Inc.	Novel forms of reboxetine
US20200147093A1 (en)	2018-10-15	2020-05-14	Axsome Therapeutics, Inc.	Use of esreboxetine to treat nervous system disorders such as fibromyalgia
US12565478B1 (en)	2025-01-21	2026-03-03	Axsome Therapeutics, Inc.	(S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)-4-nitrosomorpholine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL56369A (en) *	1978-01-20	1984-05-31	Erba Farmitalia	Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them

1984
- 1984-11-22 GB GB08429546A patent/GB2167407B/en not_active Expired
1985
- 1985-10-29 IT IT22645/85A patent/IT1190420B/en active
- 1985-11-12 DE DE19853540093 patent/DE3540093A1/en not_active Withdrawn
- 1985-11-20 JP JP60258816A patent/JPH0667916B2/en not_active Expired - Lifetime
- 1985-11-22 FR FR8517324A patent/FR2573425B1/en not_active Expired

Also Published As

Publication number	Publication date
IT1190420B (en)	1988-02-16
GB8429546D0 (en)	1985-01-03
DE3540093A1 (en)	1986-05-28
FR2573425A1 (en)	1986-05-23
JPH0667916B2 (en)	1994-08-31
IT8522645A0 (en)	1985-10-29
GB2167407A (en)	1986-05-29
JPS61129174A (en)	1986-06-17
FR2573425B1 (en)	1988-12-23

Legal Events

Date	Code	Title	Description
2004-12-15	PE20	Patent expired after termination of 20 years	Effective date: 20041121

Publication	Publication Date	Title
GB2167407B (en)	1988-05-11	Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof
PL253108A1 (en)	1985-12-17	Method of obtaining novel derivatives of 1,4-dihydronaphtidrine and their salts
GB2163432B (en)	1988-06-22	Piperazine derivatives
PH21588A (en)	1987-12-11	Pleuromutilin derivatives and method of use thereof
EP0154969A3 (en)	1987-04-15	Piperazine derivatives and their acid addition salts
GB8419683D0 (en)	1984-09-05	3-substituted derivatives of 1-amino-2-hydroxy-propane
GB8319317D0 (en)	1983-08-17	Piperazine derivatives and salts
EP0145019A3 (en)	1986-03-26	Pyridazinone derivatives and salts thereof
DE3565538D1 (en)	1988-11-17	Phenylpiperazine derivatives and their acid addition salts
DE3569737D1 (en)	1989-06-01	Salts of oxazaphosphorine derivatives
DE3567016D1 (en)	1989-02-02	Benzamides and salts
PL255515A1 (en)	1986-12-30	Method of obtaining 8-halogen-5,6-dialkoxyquinazolinodiones and their salts
GB2162843B (en)	1988-04-20	Piperazine derivatives
PL252376A1 (en)	1985-12-17	Fungicide and method of obtaining novel derivatives of thiovcyanopyridine
PH23442A (en)	1989-08-07	Cephalosporin derivatives and salts thereof
AU578677B2 (en)	1988-11-03	cephalosporin derivatives and salts thereof
GB8501038D0 (en)	1985-02-20	Phenoxy benzaldehyde derivatives
PH21201A (en)	1987-08-19	Cephalosporin derivatives and salts thereof
DE3568039D1 (en)	1989-03-09	Polyfunctional acrylate derivatives of caprolactone-polyols
AU4166985A (en)	1986-10-30	New salts of fosfomycin with imidazole and its derivatives
CS904587A1 (en)	1990-02-12	Piperazine derivatives, their salts and method of their preparation
DE3565101D1 (en)	1988-10-27	Ethynylphenoxy and ethynylthiophenoxy derivatives of diphenylhexafluoropropane
DE3362916D1 (en)	1986-05-15	New derivatives of 1-alkylamine-(4(p-alkyloxy-benzamide)phenoxy)-2-propanol, having beta-sympatholytic activity, their salts, and production processes thereof
GB2162187B (en)	1987-10-28	New derivatives of 11-deoxo-glycyrrhetinic acid
PH21648A (en)	1988-01-13	1-(alkanoylamino-aryloxy)-2-hydroxy-3-(alkinylamino)-propanes and salts thereof