GB1500043A - Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion - Google Patents

Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion

Info

Publication number
GB1500043A
GB1500043A GB6869/75A GB686975A GB1500043A GB 1500043 A GB1500043 A GB 1500043A GB 6869/75 A GB6869/75 A GB 6869/75A GB 686975 A GB686975 A GB 686975A GB 1500043 A GB1500043 A GB 1500043A
Authority
GB
United Kingdom
Prior art keywords
acid secretion
gastric acid
formula
preparation
benzimidazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6869/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hassle AB
Original Assignee
Hassle AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hassle AB filed Critical Hassle AB
Publication of GB1500043A publication Critical patent/GB1500043A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Compounds of the formula I <IMAGE> whose radicals are specified in Patent Claim 1, are obtained by reaction of a compound of the formula IV <IMAGE> containing radicals as in Patent Claim 1, with a compound of the formula V, Z<1>-B-Het, in which B is the group -CH2- or -CH(CH3)- and Z<1> denotes a reactive, esterified hydroxyl group or -SH. The compounds of the formula I can be used for affecting gastric acid secretion of mammals, in particular humans. They are best suited for the treatment, for example, of gastric ulcers or similar disorders.
GB6869/75A 1974-02-18 1975-02-18 Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion Expired GB1500043A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7402101A SE418966B (en) 1974-02-18 1974-02-18 ANALOGY PROCEDURE FOR THE PREPARATION OF COMPOUNDS WITH Gastric Acid Secretion Inhibitory Effects

Publications (1)

Publication Number Publication Date
GB1500043A true GB1500043A (en) 1978-02-08

Family

ID=20320233

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6869/75A Expired GB1500043A (en) 1974-02-18 1975-02-18 Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion

Country Status (23)

Country Link
JP (1) JPS5924157B2 (en)
AT (1) AT343659B (en)
AU (1) AU499639B2 (en)
BE (1) BE825655A (en)
CA (1) CA1060448A (en)
CH (1) CH616160A5 (en)
CS (1) CS194715B2 (en)
DD (1) DD119422A5 (en)
DE (1) DE2504252A1 (en)
DK (1) DK141122B (en)
FI (1) FI59590C (en)
FR (1) FR2261007B1 (en)
GB (1) GB1500043A (en)
HK (1) HK67080A (en)
HU (1) HU172141B (en)
IE (1) IE40858B1 (en)
LU (1) LU71872A1 (en)
MY (1) MY8100208A (en)
NL (1) NL7501917A (en)
NO (1) NO142401C (en)
SE (1) SE418966B (en)
SU (1) SU795476A3 (en)
ZA (1) ZA75558B (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182766A (en) * 1977-09-19 1980-01-08 Hoffmann-La Roche Inc. Naphth[2,3-d]imidazoles
GB2134523A (en) * 1983-02-11 1984-08-15 Haessle Ab Novel pharmacologically active compounds
US4746667A (en) * 1981-08-13 1988-05-24 Aktiebolaget Hassle Pharmaceutical composition containing 2-(2-benzimidazolyl thiomethyl) pyridine
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5008278A (en) * 1988-12-22 1991-04-16 Aktiebolaget Hassle Therapeutically active compound and a process for its preparation
EP0150586B1 (en) * 1983-12-05 1991-05-08 The Upjohn Company 2-(pyridylmethylthio)benzimidazoles and 2-(pyridylmethylsulfinyl)benzimidazoles
US5025024A (en) * 1988-12-22 1991-06-18 Aktiebolaget Hassle Therapeutically active fluoro-substituted compound
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
EP0233284B1 (en) * 1985-10-29 1992-08-19 Aktiebolaget Hässle Pharmacological compounds
EP0510719A1 (en) 1986-11-21 1992-10-28 Aktiebolaget Hässle Benzimidazole derivatives substituted with a radical group and their use for inhibiting gastric acid secretion
US5175286A (en) * 1988-09-20 1992-12-29 Hisamitsu Pharmaceutical Co., Inc. Dibenz[b,e]oxepin derivatives
US5441968A (en) * 1989-12-20 1995-08-15 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
LT3810B (en) 1986-11-21 1996-03-25 Haessle Ab New benzimidazole derivatives, a process for production thereof and a pharmaceuticalcomposition containing the same
LT3952B (en) 1990-06-20 1996-05-27 Astra Ab Substituted benzimidazoles, process for their preparation and their pharmaceutical use
LT3981B (en) 1988-12-22 1996-06-25 Haessle Ab Therapeutically active substituted benzimidazole and process for its preparation

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416649B (en) * 1974-05-16 1981-01-26 Haessle Ab PROCEDURE FOR THE PREPARATION OF SUBSTANCES WHICH PREVENT Gastric acid secretion
JPS5364103A (en) * 1976-09-24 1978-06-08 Hitachi Ltd Waste heat recovery boiler
SE7804231L (en) * 1978-04-14 1979-10-15 Haessle Ab Gastric acid secretion
US4343805A (en) * 1978-12-16 1982-08-10 John Wyeth & Brother Limited Heterocyclic compounds
AT373888B (en) * 1979-01-10 1984-02-27 Janssen Pharmaceutica Nv METHOD FOR PRODUCING NEW 4-PIPERIDINE AMINES AND THEIR ACID ADDITION SALTS
CH644116A5 (en) * 1980-08-21 1984-07-13 Hoffmann La Roche IMIDAZOLE DERIVATIVES.
DE3047388A1 (en) * 1980-12-16 1982-07-15 Basf Ag, 6700 Ludwigshafen ISATOGEN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES
DE3216843C2 (en) * 1982-05-05 1986-10-23 Ludwig Heumann & Co GmbH, 8500 Nürnberg 3-Thiomethyl-pyridine derivatives, processes for their preparation and pharmaceuticals containing these compounds
US4552886A (en) * 1982-06-07 1985-11-12 Eli Lilly And Company Fungicidal pyridylmethyl-amines
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
US4503139A (en) * 1983-05-09 1985-03-05 Polaroid Corporation Photographic products and processes and novel compounds
US4767770A (en) * 1984-06-18 1988-08-30 Eli Lilly And Company Method of inhibiting aromatase
FR2593178B1 (en) * 1986-01-20 1988-04-29 Esteve Labor Dr 2-BENZIMIDAZOLYLALKYLTHIO (OR SULFINYL OR SULFONYL) DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS.
SE8600658D0 (en) * 1986-02-14 1986-02-14 Haessle Ab NOVEL COMPOSITION OF MATTER
SE8604566D0 (en) * 1986-10-27 1986-10-27 Haessle Ab NOVEL COMPUNDS
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
JPH021280U (en) * 1988-06-14 1990-01-08
JP2679745B2 (en) * 1989-06-29 1997-11-19 明治製菓株式会社 Azole derivatives and antiulcer agents containing them as active ingredients
JPH0347053U (en) * 1989-09-16 1991-04-30
FI964909L (en) * 1994-06-10 1996-12-09 Byk Gulden Lomberg Chem Fab Substituted arylalkylthioalkylpyridines for combating Helicobacter bacteria
CN1636564A (en) * 1999-08-26 2005-07-13 艾伊法马公司 Composition and pharmaceutical preparation containing alkoxy substituted benzimidazole compound and its preparation method
ES2300599T3 (en) 2002-03-27 2008-06-16 Nycomed Gmbh ALCOXIPIRIDINE DERIVATIVES.
ATE340175T1 (en) 2003-02-25 2006-10-15 Altana Pharma Ag IMIDAZO(4,5-BOEQUINOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF INDUCIBLE NO-SYNTHASE
DE602004014523D1 (en) * 2003-10-01 2008-07-31 Nycomed Gmbh IMIDAZOE4,5-BÜPYRIDINE DERIVATIVES AS INHIBITORS OF INDUCIBLE NO SYNTHASE
JP2007507467A (en) * 2003-10-01 2007-03-29 アルタナ　ファルマ　アクチエンゲゼルシャフト Imidazopyridine derivatives as inducible NO synthase inhibitors
ES2308260T3 (en) 2003-10-01 2008-12-01 Nycomed Gmbh DERIVATIVES OF IMIDAZOPIRIDINS AS INHIBITORS OF INDUCIBLE NON-SYNTHEASE.
BRPI0414873A (en) * 2003-10-01 2006-12-12 Altana Pharma Ag imidazopyridine derivatives as inducible no-synthase inhibitors
US7317021B2 (en) 2003-10-01 2008-01-08 Altana Pharma Ag Aminopyridine-derivatives as inductible no-synthase inhibitors
DK2003130T3 (en) * 2006-03-10 2011-12-12 Arigen Pharmaceuticals Inc New pyridine derivative with anti-helicobacter pylori activity
EP2070923A1 (en) 2007-12-11 2009-06-17 Bayer CropScience AG Insecticide iminoheterocycles
US8969349B2 (en) * 2010-05-26 2015-03-03 Sunovion Pharmaceuticals Inc. Substituted quinoxalines and quinoxalinones as PDE-10 inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234058A (en) * 1968-10-21 1971-06-03

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248880A (en) 1977-09-19 1981-02-03 Hoffmann-La Roche Inc. Treatment of gastric ulcers with naphthimidazole derivatives
US4182766A (en) * 1977-09-19 1980-01-08 Hoffmann-La Roche Inc. Naphth[2,3-d]imidazoles
US4746667A (en) * 1981-08-13 1988-05-24 Aktiebolaget Hassle Pharmaceutical composition containing 2-(2-benzimidazolyl thiomethyl) pyridine
GB2134523A (en) * 1983-02-11 1984-08-15 Haessle Ab Novel pharmacologically active compounds
AU578891B2 (en) * 1983-02-11 1988-11-10 Aktiebolaget Hassle Substituted 2-pyridylobenzimidazole derivatives
EP0150586B1 (en) * 1983-12-05 1991-05-08 The Upjohn Company 2-(pyridylmethylthio)benzimidazoles and 2-(pyridylmethylsulfinyl)benzimidazoles
EP0233284B1 (en) * 1985-10-29 1992-08-19 Aktiebolaget Hässle Pharmacological compounds
LT3810B (en) 1986-11-21 1996-03-25 Haessle Ab New benzimidazole derivatives, a process for production thereof and a pharmaceuticalcomposition containing the same
EP0510719A1 (en) 1986-11-21 1992-10-28 Aktiebolaget Hässle Benzimidazole derivatives substituted with a radical group and their use for inhibiting gastric acid secretion
US5175286A (en) * 1988-09-20 1992-12-29 Hisamitsu Pharmaceutical Co., Inc. Dibenz[b,e]oxepin derivatives
US5008278A (en) * 1988-12-22 1991-04-16 Aktiebolaget Hassle Therapeutically active compound and a process for its preparation
LT3980B (en) 1988-12-22 1996-06-25 Haessle Ab New therapeutically active compound and a process for its preparation
US5025024A (en) * 1988-12-22 1991-06-18 Aktiebolaget Hassle Therapeutically active fluoro-substituted compound
LT3981B (en) 1988-12-22 1996-06-25 Haessle Ab Therapeutically active substituted benzimidazole and process for its preparation
LT3914B (en) 1988-12-22 1996-04-25 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
LT3809B (en) 1989-12-20 1996-03-25 Haessle Ab Therapeutically active fluoro substituted benzimidazoles, process for their preparation as well as their use
US5441968A (en) * 1989-12-20 1995-08-15 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
LT3952B (en) 1990-06-20 1996-05-27 Astra Ab Substituted benzimidazoles, process for their preparation and their pharmaceutical use
LT3977B (en) 1990-06-20 1996-06-25 Astra Ab Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use

Also Published As

Publication number Publication date
SU795476A3 (en) 1981-01-07
NL7501917A (en) 1975-08-20
DK54075A (en) 1975-10-20
CH616160A5 (en) 1980-03-14
MY8100208A (en) 1981-12-31
NO142401B (en) 1980-05-05
NO750541L (en) 1975-08-19
HU172141B (en) 1978-06-28
DK141122B (en) 1980-01-21
FI59590C (en) 1981-09-10
HK67080A (en) 1980-12-05
AU499639B2 (en) 1979-04-26
LU71872A1 (en) 1975-12-09
AU7820675A (en) 1976-08-19
DK141122C (en) 1980-07-07
DD119422A5 (en) 1976-04-20
NO142401C (en) 1980-08-13
JPS50116474A (en) 1975-09-11
CA1060448A (en) 1979-08-14
FI59590B (en) 1981-05-29
DE2504252C2 (en) 1989-02-02
FI750421A7 (en) 1975-08-19
CS194715B2 (en) 1979-12-31
IE40858L (en) 1975-08-18
BE825655A (en) 1975-08-18
FR2261007A1 (en) 1975-09-12
AT343659B (en) 1978-06-12
IE40858B1 (en) 1979-08-29
DE2504252A1 (en) 1975-08-21
ATA113775A (en) 1977-10-15
FR2261007B1 (en) 1978-11-24
SE7402101L (en) 1975-08-19
ZA75558B (en) 1976-01-28
JPS5924157B2 (en) 1984-06-07
SE418966B (en) 1981-07-06

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee