EP3732195A4 - THERAPEUTIC AGENT INDUCING CYTOTOXICITY - Google Patents

THERAPEUTIC AGENT INDUCING CYTOTOXICITY Download PDF

Info

Publication number
EP3732195A4
EP3732195A4 EP18895601.5A EP18895601A EP3732195A4 EP 3732195 A4 EP3732195 A4 EP 3732195A4 EP 18895601 A EP18895601 A EP 18895601A EP 3732195 A4 EP3732195 A4 EP 3732195A4
Authority
EP
European Patent Office
Prior art keywords
therapeutic agent
agent inducing
inducing cytotoxicity
cytotoxicity
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18895601.5A
Other languages
German (de)
French (fr)
Other versions
EP3732195A1 (en
Inventor
Shogo KAMIKAWAJI
Yasuko Kinoshita
Shinya Ishii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of EP3732195A1 publication Critical patent/EP3732195A1/en
Publication of EP3732195A4 publication Critical patent/EP3732195A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP18895601.5A 2017-12-28 2018-12-28 THERAPEUTIC AGENT INDUCING CYTOTOXICITY Pending EP3732195A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017254279 2017-12-28
PCT/JP2018/048409 WO2019131988A1 (en) 2017-12-28 2018-12-28 Cytotoxicity-inducing therapeutic agent

Publications (2)

Publication Number Publication Date
EP3732195A1 EP3732195A1 (en) 2020-11-04
EP3732195A4 true EP3732195A4 (en) 2022-02-09

Family

ID=67063760

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18895601.5A Pending EP3732195A4 (en) 2017-12-28 2018-12-28 THERAPEUTIC AGENT INDUCING CYTOTOXICITY

Country Status (5)

Country Link
US (3) US11667713B2 (en)
EP (1) EP3732195A4 (en)
JP (3) JP7314146B2 (en)
TW (1) TWI817974B (en)
WO (1) WO2019131988A1 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3434767T (en) 2010-11-30 2026-01-23 Chugai Pharmaceutical Co Ltd Cytotoxicity-inducing therapeutic agent
CN109134658B (en) 2011-10-31 2022-10-14 中外制药株式会社 Antigen binding molecules that control association of heavy and light chains
KR102813659B1 (en) 2013-11-11 2025-05-28 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecule containing modified antibody variable region
MX2016014434A (en) 2014-05-13 2017-02-23 Chugai Pharmaceutical Co Ltd T cell-redirected antigen-binding molecule for cells having immunosuppression function.
TWI831044B (en) 2014-11-11 2024-02-01 日商中外製藥股份有限公司 Antigen-binding molecules, pharmaceutical compositions containing antigen-binding molecules, and methods of manufacturing and selecting antigen-binding molecules
WO2017086419A1 (en) 2015-11-18 2017-05-26 中外製薬株式会社 Method for enhancing humoral immune response
US11072666B2 (en) 2016-03-14 2021-07-27 Chugai Seiyaku Kabushiki Kaisha Cell injury inducing therapeutic drug for use in cancer therapy
TW201938194A (en) 2017-12-05 2019-10-01 日商中外製藥股份有限公司 Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137
JP7314146B2 (en) 2017-12-28 2023-07-25 中外製薬株式会社 Cytotoxicity-inducing therapeutic agent
US12247060B2 (en) 2018-01-09 2025-03-11 Marengo Therapeutics, Inc. Calreticulin binding constructs and engineered T cells for the treatment of diseases
CA3097193A1 (en) 2018-05-08 2019-11-14 Phanes Therapeutics, Inc. Anti-dll3 antibodies and uses thereof
TWI848953B (en) 2018-06-09 2024-07-21 德商百靈佳殷格翰國際股份有限公司 Multi-specific binding proteins for cancer treatment
CA3105448A1 (en) 2018-07-03 2020-01-09 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
MX2021000827A (en) 2018-08-03 2021-03-25 Chugai Pharmaceutical Co Ltd ANTIGEN-BINDING MOLECULE CONTAINING TWO ANTIGEN-BINDING DOMAINS THAT ARE LINKED TO EACH OTHER.
US12509524B2 (en) 2018-09-28 2025-12-30 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule comprising altered antibody variable region
CN119039441A (en) 2019-02-21 2024-11-29 马伦戈治疗公司 Antibody molecules that bind to NKP30 and uses thereof
GB2599228B (en) 2019-02-21 2024-02-07 Marengo Therapeutics Inc Multifunctional molecules that bind to T cell related cancer cells and uses thereof
AU2020416273A1 (en) 2020-01-03 2022-07-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
MX2022011387A (en) * 2020-03-31 2022-10-10 Chugai Pharmaceutical Co Ltd Method for producing multispecific antigen-binding molecules.
CR20220541A (en) 2020-03-31 2022-11-28 Chugai Pharmaceutical Co Ltd DELTA-LIKE LIGAND 3 (DLL3) DIRECTED MULTI-SPECIFIC ANTIGEN-BINDING MOLECULES AND THEIR USES
CN111499746B (en) * 2020-04-28 2020-11-24 优睿赛思(武汉)生物科技有限公司 High-affinity rabbit monoclonal antibody for human interleukin-2 and application thereof
EP4188430A4 (en) * 2020-07-28 2024-11-06 The Board Of Regents Of The University Of Texas System MONOCLONAL ANTIBODIES AGAINST LILRB1 FOR DIAGNOSTIC AND THERAPEUTIC USE
CA3199319A1 (en) * 2020-10-22 2022-04-28 Janssen Biotech, Inc. Proteins comprising delta-like ligand 3 (dll3) antigen binding domains and their uses
CA3204628A1 (en) * 2021-01-13 2022-07-21 John T. POIRIER Antibody-pyrrolobenzodiazepine derivative conjugate
MX2023008285A (en) * 2021-01-13 2023-09-12 Memorial Sloan Kettering Cancer Center Anti-dll3 antibody-drug conjugate.
JP2024523033A (en) 2021-06-17 2024-06-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel trispecific binding molecules
WO2023053272A1 (en) * 2021-09-29 2023-04-06 Chugai Seiyaku Kabushiki Kaisha Uses of dll3-targeting multispecific antigen-binding molecules
JP7557922B2 (en) 2021-09-29 2024-09-30 中外製薬株式会社 Uses of DLL3-targeting multispecific antigen-binding molecules
KR20240153575A (en) 2022-02-23 2024-10-23 암젠 인크 Cancer treatments targeting DLL3
US20250206841A1 (en) * 2022-03-28 2025-06-26 Adept Therapeutics Inc. Anti-trophoblast cell surface antigen 2 (trop-2) antibodies
JPWO2024111657A1 (en) 2022-11-25 2024-05-30
EP4712977A1 (en) 2023-05-19 2026-03-25 Boehringer Ingelheim International GmbH Uses of t cell engaging proteins in the treatment of cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017021349A1 (en) * 2015-07-31 2017-02-09 Amgen Research (Munich) Gmbh Bispecific antibody constructs binding dll3 and cd3
WO2017201442A1 (en) * 2016-05-20 2017-11-23 Abbvie Stemcentrx Llc Anti-dll3 drug conjugates for treating tumors at risk of neuroendocrine transition
US20170349668A1 (en) * 2014-07-31 2017-12-07 Amgen Research (Munich) Gmbh Optimized cross-species specific bispecific single chain antibody contructs
WO2019234220A1 (en) * 2018-06-09 2019-12-12 Boehringer Ingelheim International Gmbh Dll3-cd3 bispecific antibodies

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773719A (en) 1966-12-06 1973-11-20 Hoffmann La Roche 2-aminoxy-2'-acyl-acetanilide
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
EP0281604B1 (en) 1986-09-02 1993-03-31 Enzon Labs Inc. Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5770701A (en) 1987-10-30 1998-06-23 American Cyanamid Company Process for preparing targeted forms of methyltrithio antitumor agents
US5606040A (en) 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
CA2026147C (en) 1989-10-25 2006-02-07 Ravi J. Chari Cytotoxic agents comprising maytansinoids and their therapeutic use
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
WO1996033735A1 (en) 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0585287T3 (en) 1990-07-10 2000-04-17 Cambridge Antibody Tech Process for producing specific binding pair elements
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ATE158021T1 (en) 1990-08-29 1997-09-15 Genpharm Int PRODUCTION AND USE OF NON-HUMAN TRANSGENT ANIMALS FOR THE PRODUCTION OF HETEROLOGUE ANTIBODIES
DE69222303T2 (en) 1991-04-30 1998-01-22 Eukarion Inc CATIONIZED ANTIBODIES AGAINST INTRACELLULAR PROTEINS
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
EP0605522B1 (en) 1991-09-23 1999-06-23 Medical Research Council Methods for the production of humanized antibodies
PT1024191E (en) 1991-12-02 2008-12-22 Medical Res Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
CA2131151A1 (en) 1992-03-24 1994-09-30 Kevin S. Johnson Methods for producing members of specific binding pairs
ES2301158T3 (en) 1992-07-24 2008-06-16 Amgen Fremont Inc. XENOGENIC ANTIBODY PRODUCTION.
DK0752248T3 (en) 1992-11-13 2000-11-13 Idec Pharma Corp Therapeutic use of chimeric and radiolabeled antibodies against human B lymphocyte restricted differentiation antibody
US5648267A (en) 1992-11-13 1997-07-15 Idec Pharmaceuticals Corporation Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same
US5635483A (en) 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US5780588A (en) 1993-01-26 1998-07-14 Arizona Board Of Regents Elucidation and synthesis of selected pentapeptides
JPH08509612A (en) 1993-04-26 1996-10-15 ジェンファーム インターナショナル インコーポレイテッド Transgenic non-human animal capable of producing heterologous antibody
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
WO1995015388A1 (en) 1993-12-03 1995-06-08 Medical Research Council Recombinant binding proteins and peptides
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
DE122009000068I2 (en) 1994-06-03 2011-06-16 Ascenion Gmbh Process for the preparation of heterologous bispecific antibodies
DE69535243T2 (en) 1994-07-13 2007-05-10 Chugai Seiyaku K.K. AGAINST HUMAN INTERLEUKIN-8 DIRECTED, RECONSTITUTED HUMAN ANTIBODY
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US20030180784A1 (en) 1997-04-04 2003-09-25 Millennium Pharmaceuticals, Inc. Novel human Delta3 compositions and therapeutic and diagnostic uses therefor
AU6952498A (en) 1997-04-04 1998-10-30 Millenium Pharmaceuticals, Inc. Novel human delta3 compositions and therapeutic and diagnostic uses therefor
US20060122373A1 (en) 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
ATE299938T1 (en) 1997-05-02 2005-08-15 Genentech Inc A METHOD FOR PRODUCING MULTI-SPECIFIC ANTIBODIES THAT POSSESS HETEROMULTIMER AND COMMON COMPONENTS
JP4332581B2 (en) 1998-02-19 2009-09-16 旭化成株式会社 Human delta-3
JP4139508B2 (en) 1998-02-19 2008-08-27 旭化成株式会社 Human delta 3
PL209392B1 (en) 1999-01-15 2011-08-31 Genentech Inc Polypeptide variants with altered effector function
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
AU2757500A (en) 1999-02-10 2000-08-29 Human Genome Sciences, Inc. 33 human secreted proteins
AU6913100A (en) 1999-08-19 2001-03-13 Chiron Corporation Notch receptor ligands and uses thereof
AU767394C (en) 1999-12-29 2005-04-21 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
WO2002014358A2 (en) 2000-08-11 2002-02-21 Eli Lilly And Company Novel secreted proteins and their uses
AU2002330039A1 (en) 2001-09-17 2003-04-01 Eos Biotechnology, Inc. Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer
US20050137130A1 (en) 2001-11-14 2005-06-23 Bodmer Mark W. Medical treatment
AU2003295328A1 (en) 2002-10-02 2004-04-23 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US20040115204A1 (en) 2002-12-11 2004-06-17 Fanger Gary R. Antibodies to treat cancer
US8337841B2 (en) 2003-01-21 2012-12-25 Chugai Seiyaku Kabushiki Kaisha Methods of screening for antibody light chains
EP2478912B1 (en) 2003-11-06 2016-08-31 Seattle Genetics, Inc. Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
US20050175619A1 (en) 2004-02-05 2005-08-11 Robert Duffy Methods of producing antibody conjugates
AU2006232287B2 (en) 2005-03-31 2011-10-06 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
WO2006132352A1 (en) 2005-06-10 2006-12-14 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition containing sc(fv)2
EP1960552A2 (en) 2005-12-16 2008-08-27 Genentech, Inc. Method for diagnosing, prognosing and treating glioma
US20100184021A1 (en) 2006-01-16 2010-07-22 Compugen Ltd. Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis
EP2009101B1 (en) 2006-03-31 2017-10-25 Chugai Seiyaku Kabushiki Kaisha Antibody modification method for purifying bispecific antibody
EP3040347A3 (en) 2006-10-20 2016-09-21 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient
US8670504B2 (en) 2006-12-19 2014-03-11 Qualcomm Incorporated Beamspace-time coding based on channel quality feedback
ES2593484T3 (en) 2007-03-29 2016-12-09 Genmab A/S Bispecific antibodies and their production methods
EP2144931A2 (en) 2007-04-04 2010-01-20 The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services Monoclonal antibodies against dengue and other viruses with deletion in fc region
JP5545814B2 (en) 2007-06-18 2014-07-09 中外製薬株式会社 Antibody binding activity assay to mimic antibody-dependent cytotoxic activity
JP2011516520A (en) 2008-04-07 2011-05-26 アブリンクス エン．ヴェー． Amino acid sequence having directivity in Notch pathway and use thereof
WO2011028952A1 (en) 2009-09-02 2011-03-10 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
DE102009046158A1 (en) 2009-10-29 2011-05-05 Robert Bosch Gmbh Method for detecting objects with low height
DK2530091T3 (en) 2010-01-29 2018-05-28 Chugai Pharmaceutical Co Ltd ANTI-DLL3 ANTIBODY
HRP20241208T1 (en) 2010-04-20 2024-11-22 Genmab A/S HETERODIMER PROTEINS CONTAINING FC FRAGMENT OF ANTIBODIES AND PROCEDURES FOR THEIR PRODUCTION
CN103261220B (en) 2010-08-16 2016-06-15 诺夫免疫股份有限公司 For generating the method for polyspecific and multivalent antibody
ES2758994T3 (en) 2010-11-05 2020-05-07 Zymeworks Inc Stable heterodimeric antibody design with mutations in the Fc domain
PT3434767T (en) 2010-11-30 2026-01-23 Chugai Pharmaceutical Co Ltd Cytotoxicity-inducing therapeutic agent
BR112014010580B1 (en) 2011-11-04 2021-01-12 Zymeworks, Inc. isolated heteromultimeric fc construct, composition, use of an isolated heteromultimeric fc construct, nucleic acid composition and method for expressing the isolated heteromultimeric fc construct
US9326765B2 (en) 2012-02-22 2016-05-03 SafePath Medical, Inc. Suturing device having an internal suture dispensing mechanism
BR112014020826A8 (en) 2012-02-24 2017-09-19 Stem Centrx Inc ANTIBODY SPECIFICALLY BINDING TO AN Epitope, NUCLEIC ACID, VECTOR OR HOST CELL, DRUG CONJUGATE ANTIBODY, PHARMACEUTICAL COMPOSITION COMPRISING SAID ANTIBODY, USE THEREOF, KIT AND METHOD OF PREPARATION OF THE CONJUGATE
KR101327412B1 (en) 2012-02-24 2013-11-08 김영희 Power Transmission Mechanism and Safety Door Lock Using The Same
AU2013258834B2 (en) 2012-05-10 2017-09-07 Zymeworks Bc Inc. Heteromultimer constructs of immunoglobulin heavy chains with mutations in the Fc domain
IN2015DN01299A (en) 2012-07-23 2015-07-03 Zymeworks Inc
GB201302447D0 (en) * 2013-02-12 2013-03-27 Oxford Biotherapeutics Ltd Therapeutic and diagnostic target
MX2015017852A (en) 2013-06-24 2016-08-11 Chugai Pharmaceutical Co Ltd Therapeutic agent comprising humanized anti-epiregulin antibody as active ingredient for non-small-cell lung carcinoma excluding adenocarcinoma.
CN112552401B (en) * 2013-09-13 2023-08-25 广州百济神州生物制药有限公司 anti-PD 1 antibodies and their use as therapeutic and diagnostic agents
CA2939941A1 (en) 2014-02-21 2015-08-27 Abbvie Stemcentrx Llc Anti-dll3 antibodies and drug conjugates for use in melanoma
MX384418B (en) 2014-07-31 2025-03-14 Amgen Res Munich Gmbh Bi-specific single-chain antibody construct with enhanced tissue distribution.
EP2982692A1 (en) 2014-08-04 2016-02-10 EngMab AG Bispecific antibodies against CD3epsilon and BCMA
JP7082484B2 (en) 2015-04-01 2022-06-08 中外製薬株式会社 Method for Producing Polypeptide Heterogeneous Multimer
US9914777B2 (en) * 2015-07-10 2018-03-13 Merus N.V. Human CD3 binding antibody
WO2017086367A1 (en) * 2015-11-18 2017-05-26 中外製薬株式会社 Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function
UY37726A (en) 2017-05-05 2018-11-30 Amgen Inc PHARMACEUTICAL COMPOSITION THAT INCLUDES BISPECTIFIC ANTIBODY CONSTRUCTIONS FOR IMPROVED STORAGE AND ADMINISTRATION
TW201938194A (en) 2017-12-05 2019-10-01 日商中外製藥股份有限公司 Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137
JP7314146B2 (en) 2017-12-28 2023-07-25 中外製薬株式会社 Cytotoxicity-inducing therapeutic agent
BR112021005722A2 (en) 2018-09-28 2021-07-06 Chugai Pharmaceutical Co Ltd antigen-binding molecules capable of binding cd3 and cd137, but not simultaneously
CR20220541A (en) 2020-03-31 2022-11-28 Chugai Pharmaceutical Co Ltd DELTA-LIKE LIGAND 3 (DLL3) DIRECTED MULTI-SPECIFIC ANTIGEN-BINDING MOLECULES AND THEIR USES
CA3199319A1 (en) 2020-10-22 2022-04-28 Janssen Biotech, Inc. Proteins comprising delta-like ligand 3 (dll3) antigen binding domains and their uses
WO2023053272A1 (en) 2021-09-29 2023-04-06 Chugai Seiyaku Kabushiki Kaisha Uses of dll3-targeting multispecific antigen-binding molecules

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170349668A1 (en) * 2014-07-31 2017-12-07 Amgen Research (Munich) Gmbh Optimized cross-species specific bispecific single chain antibody contructs
WO2017021349A1 (en) * 2015-07-31 2017-02-09 Amgen Research (Munich) Gmbh Bispecific antibody constructs binding dll3 and cd3
WO2017201442A1 (en) * 2016-05-20 2017-11-23 Abbvie Stemcentrx Llc Anti-dll3 drug conjugates for treating tumors at risk of neuroendocrine transition
WO2019234220A1 (en) * 2018-06-09 2019-12-12 Boehringer Ingelheim International Gmbh Dll3-cd3 bispecific antibodies

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CLAUDIA BLUEMEL ET AL: "Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen", CANCER IMMUNOLOGY, IMMUNOTHERAPY, SPRINGER, BERLIN, DE, vol. 59, no. 8, 23 March 2010 (2010-03-23), pages 1197 - 1209, XP019842190, ISSN: 1432-0851 *
RODA-NAVARRO PEDRO ET AL: "Understanding the Spatial Topology of Artificial Immunological Synapses Assembled in T Cell-Redirecting Strategies: A Major Issue in Cancer Immunotherapy", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 7, 10 January 2020 (2020-01-10), XP055830746, DOI: 10.3389/fcell.2019.00370 *
STEFFEN DICKOPF ET AL: "Format and geometries matter: Structure-based design defines the functionality of bispecific antibodies", COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, vol. 18, 14 May 2020 (2020-05-14), Sweden, pages 1221 - 1227, XP055740966, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2020.05.006 *

Also Published As

Publication number Publication date
US20260042839A1 (en) 2026-02-12
EP3732195A1 (en) 2020-11-04
JP2021509403A (en) 2021-03-25
US12479915B2 (en) 2025-11-25
JP2023134614A (en) 2023-09-27
JP7314146B2 (en) 2023-07-25
US20240150465A1 (en) 2024-05-09
JP7715765B2 (en) 2025-07-30
TW201936636A (en) 2019-09-16
US11667713B2 (en) 2023-06-06
US20210363250A1 (en) 2021-11-25
JP2025157417A (en) 2025-10-15
TWI817974B (en) 2023-10-11
WO2019131988A1 (en) 2019-07-04

Similar Documents

Publication Publication Date Title
EP3732195A4 (en) THERAPEUTIC AGENT INDUCING CYTOTOXICITY
EP3619238A4 (en) THERAPEUTIC AGENT INDUCING CYTOTOXICITY
MA40764A (en) THERAPEUTIC AGENT INDUCING CYTOTOXICITY
DK3706796T3 (en) Exosomes as RNA therapeutic agents
GB201709456D0 (en) Therapeutic agents
EP3463464A4 (en) COMBINATION THERAPY
EP3368656A4 (en) TARGETED ANTICANCER THERAPY
PL3423087T3 (en) COMBINATION ANTI-CANCER THERAPY
DK3107563T3 (en) GLYCOM TARGETED THERAPEUTIC AGENTS
MA41794A (en) MODIFIED THERAPEUTIC AGENTS AND ASSOCIATED COMPOSITIONS
DK3612624T3 (en) GEN THERAPY
EP3310376A4 (en) MODIFIED THERAPEUTIC AGENTS AND COMPOSITIONS THEREOF
EP3735463A4 (en) CYTOTOXICITY-INDUCING THERAPEUTIC
GB201603104D0 (en) Therapeutic agents
EP3860585A4 (en) THERAPEUTIC COMPOSITIONS
DK3723488T3 (en) THERAPEUTIC BACTERIOCINS
IL262851A (en) Primary-impulse therapeutic combination
DK3408265T3 (en) THERAPEUTIC RELATIONS
DK3393478T3 (en) combination therapy
EP3362091A4 (en) COMBINATION THERAPY
EP3541931A4 (en) FRACTAL COMBINATION THERAPY
HUE060732T2 (en) Therapeutic agent for fibrosis
GB201509888D0 (en) Therapeutic agents
EP3738601A4 (en) CYTOCIDAL AGENT
EP3496736A4 (en) THERAPEUTIC AGENTS TARGETING TLR9

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20200728

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/13 20060101ALI20210930BHEP

Ipc: A61P 35/00 20060101ALI20210930BHEP

Ipc: A61K 39/395 20060101ALI20210930BHEP

Ipc: C07K 16/18 20060101AFI20210930BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20220110

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/13 20060101ALI20220103BHEP

Ipc: A61P 35/00 20060101ALI20220103BHEP

Ipc: A61K 39/395 20060101ALI20220103BHEP

Ipc: C07K 16/18 20060101AFI20220103BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20230726