DK225488D0 - Polypeptid - Google Patents

Polypeptid

Info

Publication number: DK225488D0
Authority: DK; Denmark
Prior art keywords: polypeptide; serine proteases; profile against; inhibition profile; against serine
Prior art date: 1988-04-26

Application number

DK225488A

Other languages

English (en)

Inventor

Kjeld Norris

Lars Christian Petersen

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-26

Filing date

1988-04-26

Publication date

1988-04-26

1988-04-26 Application filed by Novo Industri As filed Critical Novo Industri As

1988-04-26 Priority to DK225488A priority Critical patent/DK225488D0/da

1988-04-26 Publication of DK225488D0 publication Critical patent/DK225488D0/da

1989-04-25 Priority to ES89304122T priority patent/ES2061983T3/es

1989-04-25 Priority to PCT/DK1989/000096 priority patent/WO1989010374A1/en

1989-04-25 Priority to JP1505101A priority patent/JP2810743B2/ja

1989-04-25 Priority to AT89304122T priority patent/ATE103295T1/de

1989-04-25 Priority to US07/598,737 priority patent/US5373090A/en

1989-04-25 Priority to EP89304122A priority patent/EP0339942B1/en

1989-04-25 Priority to IE133489A priority patent/IE64230B1/en

1989-04-25 Priority to AU35603/89A priority patent/AU619553B2/en

1989-04-25 Priority to DE68914022T priority patent/DE68914022T2/de

1989-04-26 Priority to ZA893075A priority patent/ZA893075B/xx

1989-04-26 Priority to NZ228896A priority patent/NZ228896A/xx

1990-10-25 Priority to FI905275A priority patent/FI93964C/fi

1990-10-25 Priority to NO904622A priority patent/NO302950B1/no

1990-10-26 Priority to DK257990A priority patent/DK171417B1/da

1993-06-23 Priority to US08/084,718 priority patent/US5591603A/en

1995-05-18 Priority to US08/443,976 priority patent/US5618915A/en

1995-05-18 Priority to US08/443,977 priority patent/US5621074A/en

Links

229920001184 polypeptide Polymers 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
102000012479 Serine Proteases Human genes 0.000 abstract 1
108010022999 Serine Proteases Proteins 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical class C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK225488A 1987-08-28 1988-04-26 Polypeptid DK225488D0 (da)

Priority Applications (18)

Application Number	Priority Date	Filing Date	Title
DK225488A DK225488D0 (da)	1988-04-26	1988-04-26	Polypeptid
DE68914022T DE68914022T2 (de)	1988-04-26	1989-04-25	Aprotinin-Analoge und Verfahren zu ihrer Herstellung.
AU35603/89A AU619553B2 (en)	1988-04-26	1989-04-25	Aprotinin analogues and a process for the production thereof
PCT/DK1989/000096 WO1989010374A1 (en)	1988-04-26	1989-04-25	Aprotinin analogues and a process for the production thereof
JP1505101A JP2810743B2 (ja)	1988-04-26	1989-04-25	アプロチニン同族体およびその製造方法
AT89304122T ATE103295T1 (de)	1988-04-26	1989-04-25	Aprotinin-analoge und verfahren zu ihrer herstellung.
US07/598,737 US5373090A (en)	1988-04-26	1989-04-25	Aprotinin analogues and a process for the production thereof
EP89304122A EP0339942B1 (en)	1988-04-26	1989-04-25	Aprotinin analogues and process for the production thereof
IE133489A IE64230B1 (en)	1988-04-26	1989-04-25	Aprotinin analogues and process for the production thereof
ES89304122T ES2061983T3 (es)	1988-04-26	1989-04-25	Analogos de aprotinina y procedimiento para su produccion.
NZ228896A NZ228896A (en)	1988-04-26	1989-04-26	Aprotinin analogues having a selected inhibition profile against serine proteases, the analogues are produced recombinantly in a suitable yeast strain
ZA893075A ZA893075B (en)	1988-04-26	1989-04-26	Aprotinin analogues and process for the production thereof
FI905275A FI93964C (fi)	1988-04-26	1990-10-25	Menetelmä farmakologisesti aktiivisten aprotiniinianalogien valmistamiseksi
NO904622A NO302950B1 (no)	1988-04-26	1990-10-25	Fremgangsmåte for fremstilling av aprotininanaloger
DK257990A DK171417B1 (da)	1988-04-26	1990-10-26	Aprotininalaloger med Ala eller Gly i position 17 og fremgangsmåde til fremstilling deraf
US08/084,718 US5591603A (en)	1987-08-28	1993-06-23	Process for preparing aprotinin and aprotinin analogs in yeast cells
US08/443,976 US5618915A (en)	1987-08-28	1995-05-18	Aprotinin analogs
US08/443,977 US5621074A (en)	1987-08-28	1995-05-18	Aprotinin analogs

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK225488A DK225488D0 (da)	1988-04-26	1988-04-26	Polypeptid

Publications (1)

Publication Number	Publication Date
DK225488D0 true DK225488D0 (da)	1988-04-26

Family

ID=8111114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK225488A DK225488D0 (da)	1987-08-28	1988-04-26	Polypeptid

Country Status (14)

Country	Link
US (1)	US5373090A (da)
EP (1)	EP0339942B1 (da)
JP (1)	JP2810743B2 (da)
AT (1)	ATE103295T1 (da)
AU (1)	AU619553B2 (da)
DE (1)	DE68914022T2 (da)
DK (1)	DK225488D0 (da)
ES (1)	ES2061983T3 (da)
FI (1)	FI93964C (da)
IE (1)	IE64230B1 (da)
NO (1)	NO302950B1 (da)
NZ (1)	NZ228896A (da)
WO (1)	WO1989010374A1 (da)
ZA (1)	ZA893075B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2208511A (en) *	1987-08-07	1989-04-05	Bayer Ag	Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US5223409A (en)	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
US7413537B2 (en)	1989-09-01	2008-08-19	Dyax Corp.	Directed evolution of disulfide-bonded micro-proteins
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
IL99585A0 (en) *	1990-10-01	1992-08-18	Novo Nordisk As	Aprotinin analogues,their production and pharmaceutical compositions containing them
EP1820858B1 (en)	1991-03-01	2009-08-12	Dyax Corporation	Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof
IL104314A0 (en) *	1992-01-07	1993-05-13	Novo Nordisk As	Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
JPH07509229A (ja) *	1992-07-13	1995-10-12	コルバス・インターナショナル、インコーポレイテッド	ウシ膵トリプシン阻害因子から誘導される因子Ｘａの阻害因子
EP0671944A4 (en) *	1992-09-25	1996-07-24	Corvas Int Inc	TISSUE VIA-THROMBOPLASTIN FACTOR COMPLEX INHIBITORS DERIVED FROM A BOVINE PANCREATIC TRYPSIN INHIBITOR.
ATE277081T1 (de)	1994-01-11	2004-10-15	Dyax Corp	Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) *	1994-03-04	1998-08-18	Genentech, Inc.	Factor VIIa inhibitors from Kunitz domain proteins
ZA963619B (en)	1995-05-08	1996-11-22	Scios Inc	Protease inhibitor peptides
US5786328A (en) *	1995-06-05	1998-07-28	Genentech, Inc.	Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) *	1995-06-05	1998-07-14	Genentech, Inc.	Kunitz type plasma kallikrein inhibitors
DE19629982A1 (de) *	1996-07-25	1998-01-29	Bayer Ag	Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) *	1997-06-13	1998-12-17	Bayer Ag	Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
ES2348230T3 (es)	2002-06-07	2010-12-01	Dyax Corp.	Prevención y reducción de la isquemia.
EP2386310B1 (en)	2002-08-28	2018-11-07	Dyax Corp.	Methods for preserving organs and tissues
DK1587907T3 (da) *	2003-01-07	2011-04-04	Dyax Corp	Kunitz-domænebibliotek
US6989369B2 (en) *	2003-02-07	2006-01-24	Dyax Corp.	Kunitz domain peptides
US20050089515A1 (en) *	2003-08-29	2005-04-28	Dyax Corp.	Poly-pegylated protease inhibitors
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US20060218667A1 (en) *	2004-10-12	2006-09-28	Vojdani Fakhrieh S	Plant-produced recombinant aprotinin and aprotinin variants
CA2591786C (en)	2004-12-23	2013-07-16	Bernhard Nieswandt	Prevention of thrombus formation and/or stabilization
US20090075887A1 (en) *	2007-08-21	2009-03-19	Genzyme Corporation	Treatment with Kallikrein Inhibitors
US8637454B2 (en) *	2009-01-06	2014-01-28	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
SMT201800552T1 (it)	2010-01-06	2018-11-09	Dyax Corp	Proteine che legano la callicreina plasmatica
KR102320178B1 (ko)	2011-01-06	2021-11-02	다케다 파머수티컬 컴패니 리미티드	혈장 칼리크레인 결합 단백질
US10428158B2 (en)	2014-03-27	2019-10-01	Dyax Corp.	Compositions and methods for treatment of diabetic macular edema
EP3387018A1 (en)	2015-12-11	2018-10-17	Dyax Corp.	Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
EP4090427A1 (en)	2020-01-13	2022-11-23	Takeda Pharmaceutical Company Limited	Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU560584B2 (en) *	1983-07-28	1987-04-09	Bayer Aktiengesellschaft	Homologues of aprotinin
GB2188322A (en) *	1986-03-26	1987-09-30	Bayer Ag	Aprotinin and analogues thereof produced by a recombinant host
GB2188933A (en) *	1986-04-10	1987-10-14	Bayer Ag	Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby
DE3724570A1 (de) *	1987-06-27	1989-01-05	Bayer Ag	Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
GB2208511A (en) *	1987-08-07	1989-04-05	Bayer Ag	Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology

1988
- 1988-04-26 DK DK225488A patent/DK225488D0/da unknown
1989
- 1989-04-25 DE DE68914022T patent/DE68914022T2/de not_active Expired - Fee Related
- 1989-04-25 ES ES89304122T patent/ES2061983T3/es not_active Expired - Lifetime
- 1989-04-25 AU AU35603/89A patent/AU619553B2/en not_active Ceased
- 1989-04-25 WO PCT/DK1989/000096 patent/WO1989010374A1/en not_active Ceased
- 1989-04-25 US US07/598,737 patent/US5373090A/en not_active Expired - Lifetime
- 1989-04-25 JP JP1505101A patent/JP2810743B2/ja not_active Expired - Fee Related
- 1989-04-25 AT AT89304122T patent/ATE103295T1/de not_active IP Right Cessation
- 1989-04-25 IE IE133489A patent/IE64230B1/en not_active IP Right Cessation
- 1989-04-25 EP EP89304122A patent/EP0339942B1/en not_active Expired - Lifetime
- 1989-04-26 ZA ZA893075A patent/ZA893075B/xx unknown
- 1989-04-26 NZ NZ228896A patent/NZ228896A/xx unknown
1990
- 1990-10-25 FI FI905275A patent/FI93964C/fi not_active IP Right Cessation
- 1990-10-25 NO NO904622A patent/NO302950B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI93964C (fi)	1995-06-26
DE68914022D1 (de)	1994-04-28
NZ228896A (en)	1991-08-27
IE64230B1 (en)	1995-07-26
WO1989010374A1 (en)	1989-11-02
AU619553B2 (en)	1992-01-30
FI905275A0 (fi)	1990-10-25
EP0339942A3 (en)	1990-05-30
ES2061983T3 (es)	1994-12-16
ATE103295T1 (de)	1994-04-15
NO302950B1 (no)	1998-05-11
IE891334L (en)	1989-10-26
AU3560389A (en)	1989-11-24
JP2810743B2 (ja)	1998-10-15
FI93964B (fi)	1995-03-15
NO904622D0 (no)	1990-10-25
JPH03504009A (ja)	1991-09-05
EP0339942B1 (en)	1994-03-23
ZA893075B (en)	1989-12-27
NO904622L (no)	1990-12-18
DE68914022T2 (de)	1994-07-07
EP0339942A2 (en)	1989-11-02
US5373090A (en)	1994-12-13

Publication	Publication Date	Title
DK225488D0 (da)	1988-04-26	Polypeptid
FI950168L (fi)	1995-03-10	Korkea-alkaliset seriiniproteaasit
ID21924A (id)	1999-08-12	Olanzapin dihidrat d
FI892714A0 (fi)	1989-06-02	Rekombinant-coccidiosisvaccin.
EP0602069A4 (en)	1995-05-03	RETROVIRASE PROTEASE INHIBITORS.
DE68924654D1 (de)	1995-11-30	Spezifische Protease.
FI925787L (fi)	1993-06-20	Proteolytiska enzymers sackarinderivatinhibitorer
FI892677L (fi)	1989-12-07	Polypeptidfoereningar.
NO895026D0 (no)	1989-12-14	Retrovirale proteasehemmere.
FI893833A7 (fi)	1990-03-01	Rekombinant aktivator foer naturliga doedarceller.
FI875295A0 (fi)	1987-12-01	Menetelmä hirudiinivariantin valmistamiseksi
IL92551A0 (en)	1990-08-31	Anticoagulant peptides
NO890174D0 (no)	1989-01-13	Rekombinante interleukin-1alfa-polypeptider.
FI906140A7 (fi)	1991-06-17	Retroviraalisten proteaasien inhibiittoreita
TW336938B (en)	1998-07-21	Calcium channel blocking polypeptides from filistata hibernalis
DE68922014D1 (de)	1995-05-11	Protease.
FR2631675B1 (fr)	1990-12-21	Vanne a soufflet
DE69014021D1 (de)	1994-12-15	Vorspannungsversorgungsschaltung.
ATE42082T1 (de)	1989-04-15	Verschleissschutzelement.
DK257990A (da)	1990-10-26	Aprotininalaloger og fremgangsmaade til fremstilling deraf
FI942623A7 (fi)	1994-07-21	Keinotekoisen proteolyyttisen pilkkomiskohdan sisältävät yhdistelmävir ukset
DE68907410D1 (de)	1993-08-05	Arbeitsprojektor.
SE9100284D0 (sv)	1991-01-30	Novel peptide
KR900701833A (ko)	1990-12-04	맥관형성 인자를 조력하는 맥관형성 조력 펩타이드(angiogenic potentiationg peptide)
KR900002041U (ko)	1990-01-19	다단 바이어스 공급회로

DK225488D0 - Polypeptid - Google Patents

Info

Links

Classifications

Landscapes

Priority Applications (18)

Applications Claiming Priority (1)

Publications (1)

Family

ID=8111114

Family Applications (1)

Country Status (14)

Families Citing this family (33)

Family Cites Families (5)

Also Published As

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