DK0933082T3 - Fremgangsmåde til manipulation af celledifferentiering - Google Patents

Fremgangsmåde til manipulation af celledifferentiering

Info

Publication number
DK0933082T3
DK0933082T3 DK99101561.1T DK99101561T DK0933082T3 DK 0933082 T3 DK0933082 T3 DK 0933082T3 DK 99101561 T DK99101561 T DK 99101561T DK 0933082 T3 DK0933082 T3 DK 0933082T3
Authority
DK
Denmark
Prior art keywords
cell differentiation
toporythmic protein
fragment
cell
manipulating cell
Prior art date
Application number
DK99101561.1T
Other languages
English (en)
Inventor
Spyridon Artavanis-Tsakonas
Original Assignee
Indiana University Foundation
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0933082(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Indiana University Foundation, Univ Yale filed Critical Indiana University Foundation
Application granted granted Critical
Publication of DK0933082T3 publication Critical patent/DK0933082T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK99101561.1T 1991-05-03 1992-05-01 Fremgangsmåde til manipulation af celledifferentiering DK0933082T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US79192391A 1991-11-14 1991-11-14
EP92911557A EP0576623B2 (en) 1991-05-03 1992-05-01 Binding domains in notch proteins

Publications (1)

Publication Number Publication Date
DK0933082T3 true DK0933082T3 (da) 2010-10-25

Family

ID=27105529

Family Applications (4)

Application Number Title Priority Date Filing Date
DK99101563T DK0930366T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Delta-proteiner
DK99101561.1T DK0933082T3 (da) 1991-05-03 1992-05-01 Fremgangsmåde til manipulation af celledifferentiering
DK92911557T DK0576623T4 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Notch-proteiner
DK99101562T DK0930365T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Serrate-protein

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK99101563T DK0930366T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Delta-proteiner

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK92911557T DK0576623T4 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Notch-proteiner
DK99101562T DK0930365T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Serrate-protein

Country Status (12)

Country Link
US (1) US5849869A (da)
EP (4) EP0576623B2 (da)
JP (7) JPH07503123A (da)
AT (4) ATE397661T1 (da)
AU (1) AU675203B2 (da)
CA (1) CA2102208C (da)
DE (4) DE69232832T3 (da)
DK (4) DK0930366T3 (da)
ES (4) ES2310933T3 (da)
IE (2) IE85350B1 (da)
IL (1) IL101728A (da)
WO (1) WO1992019734A1 (da)

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US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
DE69638023D1 (de) * 1995-06-28 2009-10-22 Univ Yale Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
US6337387B1 (en) 1995-11-17 2002-01-08 Asahi Kasei Kabushiki Kaisha Differentiation-suppressive polypeptide
EP0869802A4 (en) * 1995-11-22 2001-11-14 Univ Yale DELTEX PROTEINS, NUCLEIC ACIDS, AND ANTIBODIES OF VERTEBRATES, AS WELL AS THESE PROCEDURES AND COMPOSITIONS
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US6436650B1 (en) 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
CA2309897A1 (en) 1997-11-22 1999-06-03 Hyseq, Inc. A novel egf motif protein obtained from a cdna library of fetal liver-spleen
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US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US20020151487A1 (en) * 2000-08-31 2002-10-17 Loyola University Chicago Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway
WO2002059285A1 (en) * 2000-10-27 2002-08-01 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
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AU2002364537A1 (en) * 2001-12-07 2003-06-23 Regents Of The University Of Michigan Prospective identification and characterization of breast cancer stem cells
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AU2006259583A1 (en) * 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
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ES2413087T3 (es) 2006-06-13 2013-07-15 Oncomed Pharmaceuticals, Inc. Composiciones y métodos para el diagnóstico y tratamiento del cáncer
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RU2448979C2 (ru) * 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
AU2007333805B2 (en) 2006-12-18 2013-07-25 Genentech, Inc. Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
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WO2008092002A2 (en) * 2007-01-24 2008-07-31 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
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US8068607B2 (en) 2007-07-31 2011-11-29 Ricoh Company, Limited Information processing apparatus and information processing method
KR101323126B1 (ko) 2007-11-12 2013-10-30 가부시키가이샤 지에스 유아사 리튬 이차전지의 제조방법
CN102112490B (zh) 2008-07-08 2014-10-22 昂考梅德药品有限公司 Notch1受体结合剂和其使用方法
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
SG190568A1 (en) 2008-09-26 2013-06-28 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
HUE029661T2 (en) 2009-10-16 2017-03-28 Oncomed Pharm Inc A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
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US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
JPH08509358A (ja) * 1992-12-11 1996-10-08 アメリカ合衆国 神経内分泌腫瘍で発現されるδ様遺伝子

Also Published As

Publication number Publication date
US5849869A (en) 1998-12-15
JP2007330259A (ja) 2007-12-27
AU1919792A (en) 1992-12-21
ES2181674T3 (es) 2003-03-01
DK0576623T4 (da) 2008-01-02
EP0576623A1 (en) 1994-01-05
CA2102208A1 (en) 1992-11-12
JP4430891B2 (ja) 2010-03-10
ES2303363T3 (es) 2008-08-01
IL101728A0 (en) 1992-12-30
JP2011135886A (ja) 2011-07-14
IE85350B1 (en) 2009-10-14
EP0930365A2 (en) 1999-07-21
IE20030774A1 (en) 2003-12-10
ES2181674T5 (es) 2008-03-01
DK0930365T3 (da) 2008-06-02
EP0576623B1 (en) 2002-10-23
EP0930365B1 (en) 2008-02-13
EP0576623A4 (en) 1995-01-18
JP4604227B2 (ja) 2011-01-05
DE69233735D1 (de) 2008-07-17
ATE397661T1 (de) 2008-06-15
JP2004065243A (ja) 2004-03-04
ATE473754T1 (de) 2010-07-15
EP0576623B2 (en) 2007-10-03
EP0930365A3 (en) 1999-07-28
DE69232832T2 (de) 2003-06-18
DK0576623T3 (da) 2003-02-24
EP0930366A3 (en) 1999-07-28
DK0930366T3 (da) 2008-10-13
JPH07503123A (ja) 1995-04-06
JP2007330258A (ja) 2007-12-27
DE69233724T2 (de) 2009-04-02
ES2348919T3 (es) 2010-12-16
WO1992019734A1 (en) 1992-11-12
JP4604228B2 (ja) 2011-01-05
DE69233724D1 (de) 2008-03-27
EP0933082A1 (en) 1999-08-04
ATE226633T1 (de) 2002-11-15
DE69232832D1 (de) 2002-11-28
IL101728A (en) 2007-08-19
DE69232832T3 (de) 2008-02-28
IE921367A1 (en) 1992-11-04
EP0930366A2 (en) 1999-07-21
EP0930366B1 (en) 2008-06-04
AU675203B2 (en) 1997-01-30
EP0933082B1 (en) 2010-07-14
JP2011155979A (ja) 2011-08-18
ES2310933T3 (es) 2009-01-16
DE69233791D1 (de) 2010-08-26
ATE386116T1 (de) 2008-03-15
JP2008005843A (ja) 2008-01-17
CA2102208C (en) 2003-04-29

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