DE102018115270A1 - Preparation as a gel and plaster for topical treatment of skin and / or nail diseases - Google Patents

Abstract

[The invention relates on the one hand to a preparation (100) as a gel for the topical treatment of skin and / or nail diseases with at least one apple cider vinegar; a vegetable oil and an emulsifier. The invention also relates to a plaster (200) for the topical treatment of skin and / or nail diseases, in particular nail fungus, with a reservoir (210) with a contact surface (211) for contact with a surface (O) to be treated, in particular with one of Nail fungus infested nail (N). The reservoir (210) contains a preparation (100) for the topical treatment of skin and / or nail diseases with at least one apple cider vinegar; a vegetable oil and an emulsifier.]

Description

Technical field

The invention relates to a preparation as a gel and a plaster for the topical treatment of skin and / or nail diseases.

State of the art

Skin or nail diseases that are in principle easy to treat, such as herpes, eczema or nail fungus, are often treated by a specialized dermatologist, since there are no means available for simple, safe and effective self-treatment by the affected patients. As a result, the dermatologists are exposed to a high number of minor treatments, resulting in long waiting times and high costs for the health system.

The external treatment of eczema and nail fungus with vinegar is known from the prior art. For example, the publication describes CN102813703A a medication to treat athlete's foot and nail fungus that contains edible vinegar, salt, and eucalyptus leaf juice. The vinegar is said to have a bacteriostatic and bactericidal effect, efficacy against intestinal diseases, flu and respiratory diseases as well as a germicidal, beautifying and hypertension-relieving effect on skin or hair according to traditional Chinese medicine. The drug can be used as a hand or foot bath. However, this application is very impractical for the patient since the bath first has to be prepared with great effort and the patient can practically do no other things during the duration of the application.

The publication KR20100008400A discloses a formulation for the treatment of atopic dermatitis with vinegar. In addition to persimmon vinegar, the formulation contains oil from the seeds of the fragrant evening primrose (Oenothera onorata), wax, tannin, ascorbic acid and vegetable oil, such as lavender oil, rice oil or carrot oil. Contains the dosage form of the formulation KR20100008400A no exact information.

The external treatment of eczema with vegetable oil is, for example, from the publication US8932656B1 known that describes an oil mixture for the treatment of eczema. Coconut oil is the main ingredient because of its antifungal effects. The oil mixture is liquid, so it is difficult for a user to apply and hold it precisely at the treatment site.

The publication DE2654743A1 describes a therapeutic agent for the external treatment of psoriasis, lichen and eczema with coconut oil, palm kernel oil, laurel oil and an emulsifier, for example wool fat, wool wax alcohol, metal salts, mono- or diglycerides of aliphatic monocarboxylic acids. Contains the dosage form of the formulation DE2654743A1 no exact information.

The publication CN105079214A discloses an emulsion with sweet almond oil and extracts used in traditional Chinese medicine for the external treatment of eczema. According to CN105079214A The sweet almond oil has an anti-allergenic, anti-inflammatory, decongestant and pain and irritation relief. Since the emulsion is liquid, it is difficult for a user to apply and hold it precisely at the treatment site.

The publication DE60217880T2 describes a plaster for the treatment of nail fungus, which comprises a layer for contact with the nail and / or the surrounding skin, which contains an adhesive, a skin and / or nail permeation promoter and sertaconazole as active ingredient. DE60217880T2 lists a large number of permeation promoters that allow chemical substances to permeate through the nail. The patch can include additives such as other active ingredients, binders, crosslinking agents, plasticizers, solvents, fillers or antioxidants. Due to the large number of, especially synthetic, ingredients, there is a great risk of undesirable interactions, side effects or allergies when using the patch. These possible dangers are particularly problematic if the patch is used for self-treatment without specialist supervision.

The pamphlets WO9940955A2 and US005753256A also disclose plasters for treating nail fungus with an occlusive backing layer and a matrix layer for contact with the nail, the matrix layer containing an antifungal agent and an adhesive for fixing the matrix layer and optionally a permeation promoter. The same potential problems arise as with the plaster according to DE60217880T2 ,

US005464510A describes a plaster for treating nail fungus with a plaster preparation containing salicylic acid or a salt, an ester or a mixture thereof, and a carrier. No other active ingredients are described, so the risk of undesirable interactions, side effects or allergies is lower.

Technical task

The object of the invention is to provide a preparation which is simple to produce and can be used simply, safely and reliably for effective topical treatment, in particular for self-treatment, of skin and / or nail diseases.

Technical solution

The object of the present invention provides a preparation which solves the technical problem according to the features of claim 1. The object is also achieved by a plaster according to claim 7. Advantageous refinements result from the dependent claims.

Description of the execution types

1. a) ein Apfelessig, insbesondere mit einem Anteil an der Zubereitung von 3 % bis 20 %;
2. b) ein Pflanzenöl, insbesondere ein Kokosöl und/oder Mandelöl mit einem Anteil an der Zubereitung von bis zu 90 %, und
3. c) einen Emulgator, insbesondere ein Lecithin mit einem Anteil an der Zubereitung von 2 % bis 15 %.

A preparation according to the invention is designed for the topical treatment of skin and / or nail diseases and comprises at least the following ingredients:

1. a) an apple cider vinegar, in particular with a share of 3% to 20% in the preparation;
2. (b) a vegetable oil, in particular a coconut oil and / or almond oil, with a share in the preparation of up to 90%, and
3. c) an emulsifier, in particular a lecithin with a share in the preparation of 2% to 15%.

The preparation is preferably in the form of a gel, in particular a cream. For the purposes of the invention, a gel is a disperse system which consists of at least two components. A solid component is a sponge-like, three-dimensional network, the pores of which are filled by the liquid component. The liquid component is thereby immobilized in the solid component. The liquid component of the preparation is, for example, apple cider vinegar and / or the solid component of the preparation is, for example, vegetable oil, which can be solid at a use temperature of the preparation. If necessary, the vegetable oil can be hardened.

The preparation as a gel has the advantage that it can be applied to the surface to be treated in a particularly simple and precise manner without running any further. Furthermore, the gel can remain on the surface to be treated for a longer period of time and form a larger active substance depot there than, for example, a liquid. This enables particularly safe and effective treatment.

The preparation can be designed as an emulsion, in particular for use in a plaster according to the invention. The apple cider vinegar can also be immobilized in a patch in a way other than by the solid component of a gel, for example in a reservoir. As an emulsion, the preparation can advantageously be easier to manufacture and process, in particular for integration into a plaster.

The gel can be, for example, a cream, that is to say a mixture of approximately equal proportions of oil and apple cider vinegar, or an ointment, that is to say a mixture with a high proportion of oil to which only a little vinegar is added. For many patients, creams are more pleasant than ointments because they are absorbed faster. If the skin is very dry, however, due to the high water content, they can increase the dryness of the skin, so that an ointment is preferred in this case.

Tests have shown that an apple cider vinegar content of 3% to 20%, in particular 5% to 15%, an emulsifier content of 2% to 15%, in particular 8% to 10%, and a vegetable oil content from 80% to 90% of the preparation result in a consistency which is particularly advantageous for the application and a good effectiveness of the preparation.

The preparation can consist, for example, of 10% apple cider vinegar, 2% lecithin and 88% coconut oil. Such a preparation has a pH of 4.8; forms a homogeneous emulsion at room temperature (approx. 20 ° C) and has a firm consistency and a white-yellowish color at refrigerator temperature (approx. 8 ° C).

The preparation can consist, for example, of 10% apple cider vinegar, 10% lecithin and 80% coconut oil. Such a preparation forms a very smooth emulsion at room temperature and has a firm consistency and a rather yellowish color at refrigerator temperature. A pleasant smell can be achieved by adding lavender oil.

According to the invention, a “nail” is understood to mean a fingernail, the toenail of a mammal, in particular a human.

• - Alle Essigarten enthalten immunstärkende Bestandteile, Mineralsalze, Riboflavin, Vitamin B1, und Essigsäure.
• - Essig lindert Juckreiz und Trockenheit der Haut.
• - Apfelessig enthält Milchsäure, Essigsäure und Apfelsäure mit antibakteriellen und antimykotischen Eigenschaften, die trockene Haut und Hautinfektionen bekämpfen und Entzündungen, Juckreiz und Trockenheit lindern.
• - Apfelessig enthält eine Vielzahl essentieller Vitamine und Mineralien wie Pektin, Beta-Carotin und Natrium, Magnesium, Kalium, Kalzium, Eisen, Phosphor, Schwefel und Eisen, die das Immunsystem stärken.
• - Apfelessig enthält Antioxidantien wie Isoflavone und Beta-Carotin, die den Zellerneuerungsprozess der Haut verbessern.
• - Apfelessig ist reich an Kalium, das allergische Reaktionen lindert. Es wirkt auch als natürliches Adstringens, das den pH-Wert der Haut ausgleicht.

Apple cider vinegar has a number of beneficial properties for the treatment of skin and nail diseases:

• - All types of vinegar contain immune-boosting components, mineral salts, riboflavin, vitamin B1, and acetic acid.
• - Vinegar relieves itching and dryness of the skin.
• - Apple cider vinegar contains lactic acid, acetic acid and malic acid with antibacterial and antifungal properties that dry skin and Fight skin infections and relieve inflammation, itching and dryness.
• - Apple cider vinegar contains a variety of essential vitamins and minerals such as pectin, beta-carotene and sodium, magnesium, potassium, calcium, iron, phosphorus, sulfur and iron, which strengthen the immune system.
• - Apple cider vinegar contains antioxidants such as isoflavones and beta-carotene that improve the skin's cell renewal process.
• - Apple cider vinegar is rich in potassium, which relieves allergic reactions. It also acts as a natural astringent that balances the skin's pH.

The vegetable oil can prevent possible drying out of the skin by water contained in the apple cider vinegar and possible damage to the skin by acid contained in the apple cider vinegar. Furthermore, the vegetable oil can mask a smell of apple cider vinegar which may be unpleasant for a user of the preparation.

In contrast to other antifungal, antibacterial or antiviral active ingredients, apple cider vinegar and vegetable oil are not hazardous to health, even if they are inadvertently consumed, so that they enable particularly safe use of the preparation, in particular for self-treatment.

The emulsifier allows a stable mixing of apple cider vinegar and vegetable oil so that the active ingredients contained in the preparation are evenly distributed so that a predetermined dose of active ingredient can be reliably applied at the treatment site.

The skin and / or nail diseases can in particular include herpes, fungal diseases, for example skin fungus or nail fungus and / or eczema. Skin fungus is a disease caused by fungi growing on the skin of humans and animals. The most common are fungal skin diseases that affect the horny substance, they are called dermatophytoses. In addition, there are fungal diseases that also affect the deeper layers of the skin. Nail fungus, also known as nail mycosis or onychomycosis, is an infection of the toenails or fingernails by dermatophytes, yeasts or molds. Nail fungus is not a serious, but a common disease. Five to twelve percent of Europeans have dermatophytes in their nails, the frequency increases with age.

Eczema is an inflammatory skin disease that manifests itself in a non-infectious inflammatory reaction of the skin. Eczema can be caused by various triggers. They are characterized by a typical sequence of skin reactions (reddening of the skin, blistering, oozing, crusting, scaling).

The vegetable oil can comprise a coconut oil and / or almond oil. The advantage of coconut oil is that, especially when combined with apple cider vinegar, it has an antibacterial, antifungal and antiviral effect and has a pleasant smell. The antibacterial and antiviral effect is based on lauric acid contained in coconut oil, the antifungal effect on caprylic fatty acid. Coconut oil is also solid at room temperature, making it easy to create a gel. Coconut oil has a moisturizing effect on the skin and has a cooling effect.

Almond oil is anti-allergenic, anti-inflammatory, decongestant, and soothes pain and irritation. Almond oil is a very well tolerated and versatile base oil that is suitable for all skin types, especially for sensitive, dry and baby skin. When incorporated into creams, almond oil creates soft, smooth and nourishing consistencies. Almond oil penetrates the skin well and greases it. This is particularly soothing for dry skin. Therefore, almond oil is considered to be soothing, moisturizing and intensely nourishing. Furthermore, almond oil has a pleasant smell and is solid at room temperature, making it easy to create a gel.

The vegetable oil can, in particular in addition to the coconut oil and / or almond oil, comprise a lavender oil which can give the preparation a pleasant smell.

The emulsifier can be a natural emulsifier and can comprise, for example, at least one phospholipid, in particular a lecithin. Using a natural emulsifier reduces the risk of allergic reactions. Phospholipids moisturize the skin. In this way they prevent drying out after washing for normal and especially dry skin. They regulate the pH of the skin and support the natural protective coat against aggressive environmental influences. Their high content of linoleic and linolenic acid has a positive effect on skin diseases. Lecithins are approved in the EU as a food additive for food with a maximum quantity restriction only for baby food, so that they allow a particularly safe use of the preparation, especially for self-treatment.

The preparation advantageously contains no further ingredients apart from the apple cider vinegar, the vegetable oil and the emulsifier. A restriction to these ingredients reduces the risk of undesirable side effects, interactions or allergic reactions, which is particularly advantageous for safe self-treatment.

The preparation advantageously has a weakly acidic to acidic pH. A weakly acidic pH, in particular in the range from 4 to 6, for example at 4.8, supports the protective acid mantle from secretions of the skin glands, which is said to have a bactericidal effect.

A plaster according to the invention is designed for the topical treatment of skin and / or nail diseases, in particular nail fungus. The plaster comprises a reservoir with a contact surface for contact with the surface to be treated, in particular with a nail affected by nail fungus. The contact area can represent a physical boundary of the reservoir or at least comprise an opening, so that direct contact between a content of the reservoir and the surface to be treated is possible. In the simplest case, the entire contact area is exactly one opening.

The contact surface is advantageously shaped in such a way that when the plaster is used, the contact surface only comes into contact with the surface to be treated and not with a skin region adjacent to the surface to be treated. This prevents skin irritation from a component of the preparation, for example. In particular, the shape and / or size of the contact surface can be adapted to a fingernail or toenail. The plaster, in particular the contact area, can be cut to size so that it can be cut in shape and size by the user, for example with household scissors, to the surface to be treated.

1. a) einem Apfelessig;
2. b) einem Pflanzenöl und
3. c) einem Emulgator.

The reservoir advantageously contains a preparation for the topical treatment of skin and / or nail diseases with at least the following ingredients:

1. a) an apple cider vinegar;
2. b) a vegetable oil and
3. c) an emulsifier.

The preparation can in particular have one or more of the features of the preparation according to the invention described above, from which the effects disclosed there result.

The reservoir can comprise at least one cavity and / or at least one filler for receiving the preparation. The filler can advantageously adhere to the surface to be treated. As a result, the plaster can be securely fixed to the surface to be treated, in particular without the need for an additional adhesive. The filler can be, for example, a polymer matrix, in particular according to US5753256A (Col. 2, lines 6 - 41: "adhesive matrix"), DE602117880T2 (Par. [0054] [0056]: "adhesive"), WO9940955A2 (P. 7, line 30 - page 8, line 4: "pressure sensitive adhesives") or US5464610A (Col. 3, lines 33-55: "plaster").

Since active substances can only penetrate the nail slowly in the treatment of nail fungus, it is particularly advantageous if an active substance depot, for example the preparation in the reservoir, over a longer period of time, for example several hours or one day, on the one infected with nail fungus Nail is fixed.

The preparation in the plaster can be designed as a gel, in particular as the preparation according to the invention, which is designed as a gel. The preparation in the form of a gel has the particular advantage that no filler is required to take up the preparation. In particular, if direct contact of the preparation with the surface to be treated is possible, for example through a contact surface formed with at least one opening, this results in an unimpeded and therefore particularly precisely and reliably predictable release of active ingredient to the surface to be treated.

The plaster can comprise an adhesive surface connected to the reservoir for sticking to the surface to be treated and / or a skin area adjacent to the surface to be treated. In particular, if neither the preparation nor a filler adheres to the surface to be treated, the adhesive surface can fix the plaster securely. Since the surface to be treated may be sensitive to the adhesion of the patch, it may be advantageous if the adhesive surface is spaced from the contact surface. For example, the contact surface can be designed for contact with a nail and the adhesive surface for adhesion to the skin surrounding the nail.

The plaster can comprise a protective layer covering the reservoir at least on a side facing away from the surface to be treated and / or on a side facing the skin region adjacent to the surface to be treated. The protective layer is impermeable, at least for the preparation, in particular for the components of the preparation, at least for a typical duration of use of the patch, for example a few hours or a day. The protective layer prevents uncontrolled release of active ingredients to areas outside the surface to be treated. In particular, this avoids possible skin irritation outside the surface to be treated.

The protective layer is advantageously oxygen-tight for the typical duration of use of the patch. As a result, oxygen necessary for the growth of aerobic fungi can be kept away from the surface to be treated, so that the fungus growth is inhibited.

The protective layer can, for example, according to DE602117880T2 (Paragraph [0014] [0015]: “occlusive backing layer” or Paragraph [0024]: “layer”).

The plaster can comprise a covering of the contact surface which is removable, in particular in sections, and which is impermeable to the preparation for a typical application duration of, for example, a few hours or a day. The cover can comprise, for example, a self-adhesive film, in particular on both sides. The cover is advantageously divided into a plurality of, for example rectangular, sections which can be detached individually from the contact surface. This allows a user to remove precisely those sections whose removal exposes an area of the contact surface which corresponds in shape and size to the surface to be treated, for example a nail. This ensures that active ingredients from the preparation reach the surface to be treated precisely and not on an adjacent skin area that may be sensitive to the active ingredients.

The reservoir can comprise a transport layer on the contact surface for the controlled transport of at least one component of the preparation from the reservoir to the surface to be treated. The transport layer can ensure uniform release of active ingredient, in particular over the typical duration of use of the patch, so that effective treatment takes place without overdosing or underdosing the active ingredient. The transport layer can comprise a material with a preset conductivity for the component, for example for apple cider vinegar. The conductivity can be set, for example, by a density of the material or a number of channels for the component.

All of the features disclosed in the application documents are claimed as essential to the invention, provided that they are new to the prior art, individually or in combination.

list of figures

Further advantages, aims and properties of the invention are explained with the aid of the following description and attached drawings, in which objects according to the invention are shown by way of example. Features which at least essentially correspond in terms of their function in the figures can be identified with the same reference numbers, these features not having to be numbered and explained in all figures.

• [1] eine schematische Darstellung eines erfindungsgemäßen Pflasters und
• [2] eine schematische Darstellung eines weiteren erfindungsgemäßen Pflasters.

Show it:

• [ 1 ] a schematic representation of a plaster according to the invention and
• [ 2 ] a schematic representation of a further plaster according to the invention.

Fig.1

[ 1 ] shows a schematic representation of a plaster according to the invention 200 , The plaster shown 200 includes a reservoir 210 with a preparation 100 for topical treatment of skin and / or nail diseases, for example nail fungus. The preparation 100 contains at least apple cider vinegar, a vegetable oil, for example coconut oil, and an emulsifier, for example a lecithin. The preparation 100 can be formed, for example, as a gel or in a polymer matrix (not shown) of the reservoir 210 be immobilized.

The reservoir includes a contact area 211 , in the simplest case, an opening for contact with a surface to be treated O , for example a nail N , About the contact area 211 can active ingredients from the preparation to the surface to be treated O get to there or in under the surface O lying tissue, especially the nail N , to act.

The contact area 211 can be used as an adhesive surface to adhere the patch 200 on the surface to be treated O serve. For example, the preparation 100 or the polymer matrix on the surface O be designed to be liable.

Fig.2

[ 2 ] shows a schematic representation of a further plaster according to the invention 200 , In addition to the in 1 Features shown can be the pavement 200 have the following characteristics:

The reservoir 210 can, especially on the surface to be treated O sides facing away (in the illustration above, right and left), of one for the preparation 100 impermeable protective layer 230 to be enveloped.

The contact area 211 can from a cover 250 , for example a self-adhesive film, may be covered. The cover 250 can spread over the contact area 211 beyond, for example, down to the protective layer 230 , extend. The cover 250 is, advantageously in sections, from the contact surface 211 solvable so that one area the contact area 211 , in particular in the shape and size of the surface to be treated O corresponds, can be exposed.

For example on the protective layer 230 can be an adhesive surface 220 for sticking the patch 200 to the surface to be treated O surrounding skin area H be provided.

The reservoir 210 can on the contact surface 211 a transport layer 240 to control the transport of at least one component of the preparation 100 to the surface to be treated O include. The transport layer 240 may comprise a number of channels (not shown) with a preset fluid conductivity for the component, for example apple cider vinegar.

LIST OF REFERENCE NUMBERS

100

preparation

200

band Aid

210

reservoir

211

contact area

220

adhesive surface

230

protective layer

240

transport layer

250

cover

H

skin area

N

nail

O

surface to be treated

QUOTES INCLUDE IN THE DESCRIPTION

This list of documents listed by the applicant has been generated automatically and is only included for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Patent literature cited

• CN 102813703 A [0003]
• KR 20100008400 A [0004]
• US 8932656 B1 [0005]
• DE 2654743 A1 [0006]
• CN 105079214 A [0007]
• DE 60217880 T2 [0008, 0009]
• WO 9940955 A2 [0009, 0038]
• US 005753256 A [0009]
• US 005464510 A [0010]
• US 5753256 A [0038]
• DE 602117880 T2 [0038, 0044]
• US 5464610 A [0038]

Claims (11)

[Preparation (100) as a gel for the topical treatment of skin and / or nail diseases with at least the following ingredients: a) an apple cider vinegar; b) a vegetable oil and c) an emulsifier. Preparation (100) after Claim 1 , characterized in that the preparation has an apple cider vinegar portion of from 3% to 20%, preferably 5% to 15%, an emulsifier portion of 2% to 15%, preferably from 8% to 10%, and a vegetable oil portion contains from 80% to 90%. Preparation (100) according to one of the Claims 1 to 2 , characterized in that the skin and / or nail diseases include fungal diseases and / or eczema. Preparation (100) according to one of the Claims 1 to 3 , characterized in that the vegetable oil comprises a coconut oil. Preparation (100) according to one of the Claims 1 to 4 , characterized in that the emulsifier is a natural emulsifier and preferably comprises at least one lecithin. Preparation (100) according to one of the Claims 1 to 5 , characterized in that the preparation (100) apart from the apple cider vinegar, the vegetable oil and the emulsifier comprises no further ingredients and / or has a weakly acidic pH. Plaster (200) for the topical treatment of skin and / or nail diseases, in particular nail fungus with a reservoir (210) with a contact surface (211) for contact with a surface to be treated (O), in particular with a nail (N) affected by nail fungus , characterized in that the reservoir (210) contains a preparation (100) for the topical treatment of skin and / or nail diseases with at least the following ingredients: a) an apple cider vinegar; b) a vegetable oil and c) an emulsifier. Plaster (200) after Claim 7 , characterized in that the preparation (100) as a gel, preferably according to one of the Claims 1 to 6 is trained. Patch (200) according to one of the Claims 7 to 8th , characterized by a protective layer () which surrounds the reservoir (210) at least on a side facing away from the surface to be treated (O) and / or on a side facing the surface to be treated (O) and which is impermeable to the preparation (100) ( 230). Patch (200) according to one of the Claims 7 to 9 , characterized by a cover (250) of the contact surface (211) which is removable, in particular in sections, and which is impermeable to the preparation (100). Patch (200) according to one of the Claims 7 to 10 , characterized in that the reservoir (210) on the contact surface (211) comprises a transport layer (240) for the controlled transport of at least one component of the preparation from the reservoir (210) to the surface (O) to be treated.

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