CN119771230A

CN119771230A - Heterogeneous Substance Mixing Kit

Info

Publication number: CN119771230A
Application number: CN202311708294.9A
Authority: CN
Inventors: 金炳澈; 朴尚铉
Original assignee: Boditech Med Inc
Current assignee: Boditech Med Inc
Priority date: 2023-10-06
Filing date: 2023-12-12
Publication date: 2025-04-08
Also published as: EP4599932A1; WO2025075385A1; KR20250050998A

Abstract

The present invention relates to a heterogeneous material mixing kit comprising a first container member including a first filling space filled with a first material, a first shielding unit sealing an inlet of the first filling space, and a perforated member protruding a predetermined length in an axial direction from an inner bottom of the first filling space, and a second container member including a second filling space filled with a second material, which is inserted into an inside of the first container member through the inlet of the first container member when in use, and a second container member including a second shielding unit shielding one end of the second filling space and being openable through the perforated member when the first container member and the second container member are combined, and a third shielding unit shielding the other end of the second filling space and being openable when necessary.

Description

Heterogeneous material mixing kit

Technical Field

The present invention relates to a heterogeneous material mixing kit capable of safely storing a plurality of different materials used in combination with each other individually and, when in use, simply mixing the plurality of materials stored separately for use.

Background

Various chemical or biochemical test methods are known for measuring biological indicators associated with a particular disease, general health condition, or infection, etc. These chemical or biochemical test methods are typically performed by multi-step chemical reactions and physical manipulations using various reagents and instruments.

For example, in detecting a biochemical substance such as occult blood, a specific chemical substance or a protein contained in feces or mucus, it is necessary to collect a sample, place the collected sample in a certain container and react with one or more reagents, and then physically operate a plurality of steps of dispensing the reacted sample from the container before application to a test or reading device.

When a sample to be analyzed, such as blood, a detection antibody labeled with a fluorescent substance or the like, or whole blood is used, a solution (reagent) to which a reagent for lysing red blood cells is added is mixed in quantitative proportion, reacted, and then analyzed by loading the sample onto a sample pad of an analysis device or cartridge.

As the solution for chemical or biochemical tests and the like described above, a mixed solution obtained by mixing a plurality of different substances is often used. However, if a plurality of substances used in combination for disease diagnosis or the like are mixed in advance, they are liable to deteriorate due to being liable to evaporate or to be affected by moisture, in which case accurate diagnosis or analysis is difficult, and therefore they must be stored in separate containers. In addition, at the time of the test, the plurality of substances stored individually are metered and mixed one by one using an instrument such as a pipette (pipette), or by opening containers respectively storing the dissimilar substances to be mixed in a predetermined mixing ratio, pouring into one container and mixing, and then dispensing using a pipette.

Therefore, not only are various substances used as reagents and the like difficult to store, but also there is a problem in that the diagnosis or analysis work is quite complicated.

On the other hand, in the prior art 1, a dropper is disclosed in which a tip portion causing capillary phenomenon is provided at the lower end of the lower portion of an inflow pipe having a boric acid latex ball inside, so that blood, the boric acid latex ball, and a buffer solution can be mixed and dispensed by one dropper.

However, the conventional document 1 has a problem in that the tip end of the tip end portion is opened due to the nature of the dropper, so that it is necessary to manage in a separate package, and when both substances to be mixed are liquids, there is a problem that it cannot be used.

Disclosure of Invention

Problems to be solved by the invention

The present invention has been made in view of the above-described conventional problems, and an object thereof is to provide a heterogeneous material mixing kit which can safely and separately store a plurality of different substances used as diagnostic or analytical reagents and the like, and which can easily mix the separately stored heterogeneous materials for use at the time of use.

However, the object of the present invention is not limited to the above-described object, and other objects not mentioned can be clearly understood by those skilled in the art from the following description.

Means for solving the problems

In order to solve the above problems, a heterogeneous material mixing kit according to the present invention includes a first container member including a first filling space filled with a first material, a first shielding unit sealing an inlet of the first filling space, and a perforated member protruding a predetermined length in an axial direction from an inner bottom of the first filling space, and a second container member including a second filling space filled with a second material, which is inserted into an inside of the first container member through the inlet of the first container member when in use, and a second container member including a second shielding unit shielding one end of the second filling space and being openable through the perforated member when the first container member and the second container member are combined, and a third shielding unit shielding the other end of the second filling space and being openable when necessary.

According to an embodiment of the present invention, the second shielding unit may be constituted by a intercepting shielding member integrally constituted with the second container member and having an annular intercepting line at an edge corresponding to an inner circumferential surface of the second filling space so as to be cut from the second container member by the perforated member when the first container member and the second container member are combined.

According to an embodiment of the present invention, the intercepting screen member may have a shape in which an edge portion is obliquely arranged to be recessed inside the second filling space.

According to an embodiment of the present invention, the second shielding unit may be constituted by a second sealing film (sealing membrane) pressed to one end of the second container member, through which the perforated member is able to penetrate when the first container member and the second container member are combined.

According to an embodiment of the invention, the perforated member may have a +shaped, Y-shaped or T-shaped cross-section.

According to an embodiment of the invention, the third shielding unit may be a third sealing film in the form of a peelable decal crimped or attached to the upper end of the second container member or a stopper switchably bonded to the upper end of the second container member.

ADVANTAGEOUS EFFECTS OF INVENTION

According to the heterogeneous material mixing kit of the present invention as described above, the first and second substances to be mixed can be stored in the first and second container members coupled to each other, respectively, and thus a plurality of different substances to be mixed for use in chemical or biochemical tests and the like can be safely stored in a separated state.

In addition, at the time of test or analysis, the separately stored plural substances can be easily mixed only by a simple action of combining the second container member with the first container member, and the mixed liquid can be easily taken out with a pipette or the like and dispensed by opening a stopper provided on the second container member.

Thus, there is no need to use different containers or instruments for storing and mixing the various substances to be mixed for use in diagnosis or analysis.

In addition, a plurality of substances to be mixed can be stored in the first container member and the second container member in a sealed state, respectively, and therefore, not only in the case where the plurality of substances are liquid and solid, but also in the case where the plurality of substances are liquid and liquid, can be safely stored and mixed, and there is an advantage in that a different substance can be stored and mixed regardless of the sampling volume.

Drawings

FIG. 1 is an exploded perspective view of a xenobiotic mixing kit according to the invention.

FIG. 2 is an exploded cross-sectional view of a xenobiotic mixing kit according to the invention.

Fig. 3 is a bottom view of a second container member of the xenobiotic mixing kit according to the invention.

Fig. 4 is a cross-sectional view showing a combined state of the heterogeneous material mixing kit according to the present invention.

Fig. 5 is a perspective view showing a method of using the heterogeneous material mixing kit according to the present invention.

Fig. 6 is a partially cut-away side view showing another embodiment of a third shielding unit of the xenobiotic mixing kit according to the invention.

Fig. 7 is an exploded perspective view showing another embodiment of the second shielding unit of the alien substance mixing kit according to the present invention.

Fig. 8 is a sectional view showing a combined state of the heterogeneous assay kit of the present invention to which the state of another embodiment as a second shielding unit shown in fig. 7 is applied.

Fig. 9 is a cross-sectional view taken along line IX-IX of fig. 8.

Description of the reference numerals

10 First container member

11 Main body

12 First filling space

14. 24A, a first water leakage preventing protrusion

15 Perforated member

16 Rib

17 Supporting part

18 First sealing film

20 Second container member

21 Main body

22 Second filling space

24B, 33, second water leakage preventing protrusion

25 Second sealing film

26 Intercepting the masking member

27 Line of interception

27A cutting guide groove

28 Inclined portion

29 Concave part

30 Plug

31 Shielding part

32 Insertion portion

34 Switch guide piece

40 Connecting piece

50 Third sealing film

L1 first substance

L2:second substance

Detailed Description

The specific features, other advantages, and methods of accomplishing the same may be apparent from the accompanying drawings and the examples described in detail below. However, the present invention is not limited to the embodiments described below, and may be implemented in various forms different from each other, and the present embodiment is only for enabling the present invention to be fully disclosed, so that those skilled in the art can fully understand the scope of the present invention, which is defined by the claims of the present invention. Throughout the specification, like reference numerals refer to like constituent elements.

In embodiments of the present invention, the "first substance" and/or "second substance" may be a liquid or solid reaction reagent, specifically, silica particles, proteins, amino acids, nucleic acids, lipids, carbohydrates, metabolites, reagents used as carriers, antibodies for selectively separating proteins, detection agents, blocking agents, optical signal enhancers, optical signal quenchers, or other reagents, but are not limited thereto.

Hereinafter, a heterogeneous material mixing kit according to an embodiment of the present invention will be described with reference to the accompanying drawings.

Referring to fig. 1 to 4, a heterogeneous material mixing kit 1 according to the present invention basically includes a first container member 10 and a second container member 20 inserted into the first container member 10.

The first container member 10 may be filled with the first substance L1 in a sealed state to be stored. The first container member 10 may include a body 11 in the form of a tube (tube) having the first filling space 12 therein, and a perforated member 15 capable of opening a second shielding unit of the second container member 20 described below when combined with the second container member 20.

The main body 11 may take the form of an elongated cylindrical tube for easy gripping and dispensing, and one end (upper end) of the main body 11 is opened to serve as an inlet 12a of the first filling space 12. After filling the first substance L1, the inlet 12a of the main body 11 is closed by the first shielding unit so that the first substance L1 filled inside can be safely sealed.

The first shielding unit may be implemented in various forms. For example, the first shielding unit may be constituted by a conventional stopper (not shown in the drawings), or may be constituted by a first sealing film 18 crimped to one end of the main body 11 as shown in the drawings. Accordingly, a flange 13 (hinge) may be provided outwardly at the inlet 12 a-side end of the main body 11 so as to stably attach the first sealing film 18.

Wherein the first sealing film 18 may be torn by the second container member 20 when the first container member 10 and the second container member 20 are combined, or may have a form of a sticker that is peeled off from the first container member 10 in advance before combining the two, any form may be employed. The first substance L1 may be a liquid or a solid such as particles, and in this embodiment, a case of a liquid will be described as an example.

Preferably, at least one of the upper side of the inner periphery of the main body 11 of the first container member 10 and the outer periphery of the second container member 20 is preferably provided with annular first water leakage preventing protrusions 14, 24a. Preferably, for more reliable water tightness, the first water-leakage preventing protrusions may be provided on both the inner periphery of the first container member 10 and the outer periphery of the second container member 20, or two or more first water-leakage preventing protrusions may be arranged at intervals in the axial direction. As described below, the above-described first water leakage preventing protrusions 14, 24a can prevent the mixed solution from leaking when the first and second substances L1 and L2 are mixed in the first filling space 12 by shaking after the first and second container members 10 and 20 are combined. On the other hand, instead of the first water leakage preventing protrusions 14, 24a, O-rings may be provided on the outer periphery of the second container member 20.

The perforated member 15 and the main body 11 may be integrally formed. The perforated member 15 may be formed to protrude a predetermined length in the axial direction from the inner bottom 12b of the first filling space 12. Specifically, the perforated member 15 is formed to have a length such that the front end portion of the perforated member 15 sufficiently intrudes into a second shielding unit of the second container member 20 described below into the second filling space 22 when the first container member 10 and the second container member 20 are completely combined.

Such a perforated member 15 may have various forms, but preferably has a structure in which the second substance L2 filled in the second filling space 22 of the second container member 20 after the second shielding unit is opened can easily flow into the first filling space 12 of the first container member 10. Specifically, as shown in fig. 6 to 8, when a second shielding unit of the second container member 20 described below is constituted by the second sealing film 25 that is perforated, it is preferable that the perforated member 15 has a configuration in which the second sealing film 25 is easily torn by the bonding force between the first container member 10 and the second container member 20 when the first container member 10 and the second container member 20 are bonded. For this reason, as shown in the drawing, the perforated member 15 preferably has a +shaped cross section in which, for example, four ribs (rib) 16 are formed in a radial shape, because, when having a +shaped cross section instead of having a straight-shaped cross section or a circular cross section, it is advantageous not only to tear the second sealing film 25 but also to form a gap between the second sealing film 25 and the perforated member 15 after perforation.

In addition, although not separately illustrated, the perforated member 15 may have a Y-shaped cross section or a T-shaped cross section. The above-described cross-sectional shape is also advantageous in tearing the second sealing film 25 and in forming a gap between the second sealing film 25 and the perforated member 15 after perforation, as in the above-described + shaped cross section.

On the other hand, a support portion 17 may be provided at the other end (lower end) of the first container member 10 so that the first container member 10 in a state of being coupled to the second container member 20 can be safely erected at the time of dispensing using the pipette P or the like.

The second container member 20 has a second filling space 22 so that the second substance L2 to be mixed with the first substance L1 can be filled and stored in a sealed state. The second filling space 22 may be formed by penetrating the cylindrical body 21 in the axial direction. The lower end opening 22b (inserted to one side of the first container member) of the second filling space 22 may be sealed by a second shielding unit that can be opened by the perforated member 15 when the first container member 10 and the second container member 20 are combined. In addition, the upper end opening 22a of the second filling space 22 may be sealed by a third shielding unit that may be opened when necessary (when in use). The upper end periphery of the main body 21 is provided with a flange 23 to stably contact and support the third shielding unit. In this embodiment, the second substance L2 may be a solid such as a liquid or a particle (granule), and in the same manner as the first substance L1, a case of a liquid will be described as an example.

For example, the second shielding unit may be constituted by a intercepting shielding member 26, which intercepting shielding member 26 is integrally constituted with the second container member 20, and may be cut from the second container member 20 by the perforated member 15 when the first container member 10 and the second container member 20 are combined.

The intercepting screen member 26 may be configured to have a disk shape integrally formed with the inner surface of the lower end opening 22b of the second filling space 22, and to have an annular intercepting line 27 at an edge corresponding to the inner circumferential surface of the second filling space 22. Due to the cut inducing groove 27a concavely formed from the surface of the intercepting screen member 26, the intercepting line 27 has a very thin thickness compared to that of the intercepting screen member 26, so that it is easily torn and cut due to the force applied to the intercepting screen member 26 by the perforated member 15 when the first container member 10 and the second container member 20 are combined. Preferably, the cutting inducing groove 27a is formed at a side contacting the perforated member 15.

The intercepting screen member 26 described above may be configured in a flat plate shape, but preferably has a shape recessed inside the second filling space 22 so as to be more easily cut when the first container member 10 and the second container member 20 are combined. For this purpose, the intercepting screen member 26 is constituted by an inclined portion 28, the edge portion of the inclined portion 28 is suitably inclined to the second filling space 22 side, and the intercepting screen member 26 has a recess 29 on the lower surface in which the front end portion of the perforated member 15 is seated.

For example, the third shielding unit may be constituted by a stopper 30 capable of opening and closing the upper end opening 22a of the second container member 20. The stopper 30 may include a disk-shaped shielding portion 31 and a cylindrical insertion portion 32, the shielding portion 31 being in contact with the flange 23 of the second container member 20, the insertion portion 32 being formed to protrude from a lower surface of the shielding portion 31 and being inserted into the second filling space 22 through the upper end opening 22a of the second container member 20. The second water leakage preventing protrusions 33, 24b may be provided at least one of the outer circumference of the insertion portion 32 of the above-described stopper 30 or the upper inner circumference of the second filling space 22 of the second container member 20. The second water leakage preventing protrusions 33, 24b prevent the second substance L2 filled in the second filling space 22 from leaking during storage, and may be formed at the outer circumference of the insertion portion 32 and the inner circumference of the second filling space 22 at the same time in order to more reliably prevent water leakage.

In addition, a switch guide piece 34 may be provided at one side of the shielding part 31 of the stopper 30 to easily open and close the stopper 30. The plug 30 may be configured to be separate from the second container member 20, or may be configured to be integrally connected by a tab 40, as shown.

On the other hand, as shown in fig. 6, when the third shielding means is used in a state of being pressure-bonded or attached to the upper end of the second container member 20, that is, the third shielding means may be constituted by a third sealing film 50 in the form of a sticker which is peelable from the second container member 20 after the first container member 10 and the second container member 20 are mutually bonded.

The method of using the heterogeneous assay kit 1 of the present invention as described above will be described with reference to FIG. 5.

First, after peeling and removing the first sealing film 18 sealing the inlet 12a of the first container member 10 or in a state where the first sealing film 18 is attached, the second container member 20 is inserted to the inlet 12a side of the opening of the first container member 10. Then, the second container member 20 is inserted into the first filling space 12 of the first container member 10 so that the two can be integrally combined. At this time, when the second container member 20 is inserted in a state where the first sealing film 18 is attached, the first sealing film 18 is torn by the first container member 20 so that the two can be integrally combined.

At the same time, the front end portion of the perforated member 15 contacts and presses the lower surface of the intercepting screen member 26 of the second container member 20, whereby the intercepting line 27 formed at the edge of the intercepting screen member 26 is torn, cut from the second container member 20, and thus the lower end opening 22b of the second container member 20 can be opened. Then, the first filling space 12 and the second filling space 22 communicate with each other, so that the second substance L2 filled in the second filling space 22 of the second container member 20 can easily flow into the first filling space 12 of the first container member 10 through the open lower end opening 22b of the second container member 20.

In this state, when the heterogeneous mixture kit 1 of the present invention combined with each other is properly shaken, the first substance L1 and the second substance L2 can be surely mixed in the first filling space 12 of the first container member 10.

Next, the third shielding unit of the second container member 20 coupled to the first container member 10 is opened. At this time, if the third shielding means is constituted by the stopper 30, the stopper 30 is opened, and if the third shielding means is constituted by the third sealing film, it is peeled off and removed from the second container member 20. Thereby, the upper end opening 22a of the second filling space 22 of the second container member 20 is opened, so that the first filling space 12 can be opened. In this state, a tool such as a pipette P may be inserted into the first filling space 12 through the second filling space 22 of the open second container member 20 to extract and dispense the mixed solution.

Fig. 7 to 9 show another embodiment of the second shielding unit of the xenobiotic mixing kit 1 according to the invention.

In the present embodiment, in the above-described structure of the example, the second shielding means is pressure-bonded to the lower end of the second container member 20, and is constituted by the second sealing film 25 which is penetrable by the perforated member 15 when the first container member 10 and the second container member 20 are coupled.

In the embodiment of the above configuration, as shown in fig. 8, when the first container member 10 and the second container member 20 are combined, the second sealing film 25 is torn and penetrated by the perforated member 15, so that the second filling space 22 is communicated with the first filling space 12 through the inlet hole 25a bored in the second sealing film 25, so that the second substance L2 can flow into the first filling space 12.

It will be understood by those skilled in the art to which the present invention pertains that other specific forms can be easily modified without changing the technical spirit or essential features of the present invention. Accordingly, it should be understood that the above-described embodiments are illustrative only in all respects, and are not limited thereto. The scope of the invention is indicated by the appended claims rather than by the foregoing detailed description, and all changes and modifications that come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Claims

1. A heterogeneous material mixing kit, comprising:

A first container member including a first filling space filled with a first substance, a first shielding unit sealing an inlet of the first filling space, and a perforated member protruding a predetermined length in an axial direction from an inner bottom of the first filling space, and

A second container member including a second filling space filled with a second substance, which is inserted into the interior of the first container member through the inlet of the first container member in use;

The second container member includes a second shielding unit shielding one end of the second filling space and being openable by the perforated member when the first container member and the second container member are combined, and a third shielding unit shielding the other end of the second filling space and being openable when necessary.

2. The heterogeneous mixing kit according to claim 1, wherein the second shielding unit is constituted by a intercepting shielding member integrally constituted with the second container member and having an annular intercepting line at an edge corresponding to an inner peripheral surface of the second filling space so as to be cut from the second container member by the perforated member when the first container member and the second container member are combined.

3. The heterogeneous material mixing kit according to claim 2, wherein the intercepting and shielding member has a shape in which an edge portion is inclined so as to be recessed inside the second filling space.

4. The heterogeneous mixing kit according to claim 1, wherein the second shielding means is constituted by a second sealing film which is pressed against one end of the second container member, and the perforated member is capable of penetrating the second sealing film when the first container member and the second container member are combined.

5. The heterogeneous material mixing kit according to claim 2, wherein the perforated member has a +shaped, Y-shaped or T-shaped cross section.

6. The heterogeneous mixing kit according to any one of claims 1 to 5, wherein the third shielding unit is a third sealing film in the form of a peelable sticker that is crimped or attached to the upper end of the second container member or a stopper that is switchably coupled to the upper end of the second container member.