CN1154657A - Mixing and delivery syringe assembly - Google Patents

Abstract

This is a device for intermixing a first component, such as a parenteral fluid (27) with a second component, such as an immobilized drug carried by a scaffold (50) to form a beneficial agent which, following the mixture step, can be dispensed directly from the device for infusion into a patient. The device includes novel mechanisms for mateably interconnecting a container, such as a glass vial (30), containing the first component with a housing (12) having a fluid outlet (22) which houses a sealed container (44) containing the second component, and then for controllably mixing the components under sterile conditions to form an ingestable soln. which is automatically dispensed through the fluid outlet of the device.

Description

Syringe components that can mix and deliver fluids

The present invention generally relates to syringes for administering drugs by subcutaneous injection. In particular, the present invention relates to a syringe of novel design in which a first component, such as a sterile diluent, and a second component, such as a medicament, can be intermixed to form an advantageous formulation that can be dispensed directly from the syringe.

Hypodermic syringes are commonly used to inject beneficial agents, such as medicaments in liquid form, into a patient. Typically, the cartridged formulation to be injected is drawn into the syringe from another container, such as a glass vial, carboy, etc., having a piercable self-sealing stopper. When a cartridgeed formulation such as a drug is in powder form prior to injection, it must also be mixed with a carrier liquid or diluent such as saline, dextrose solution, and sterile water.

Mixing powder drug and carrier liquid can be done in many ways, many of which are crude. For example, it is common practice to inject a small amount of carrier liquid into a vial to dissolve the powdered ingredients. The resulting solution is then injected using a cannula and syringe into a larger vessel containing the carrier fluid. This method is cumbersome and has a high potential for contamination and errors.

Because injecting drugs is often given in a hospital setting, it is nurses, doctors, and pharmacists who mix the drug and the diluent, usually shortly before administering the drug to a patient. This mixing step is time-consuming and dangerous, for example when toxic drugs are involved. In addition, because many prior art mixing devices are crude and imprecise, it is extremely difficult and time consuming to aseptically and accurately mix the drug and diluent thoroughly. Such devices are therefore not suitable for application in a domestic environment.

Several attempts have been made in the past to provide an injector device in which separate components can be mixed prior to injection into a patient. The devices disclosed in US Patent No. 2724 383 by Lockhart, US Patent No. 3 336 924 by Sarnoff et al. and US Patent No. 3477 432 by Shaw are examples of such prior art devices. The device of Lockhart comprises separate compartments in the form of receptacles which are connected and fitted with associated cannula means, while manipulating the cannula means allows communication between the compartments through the cannula means. The ingredients to be mixed are stored in cooperating containers which are properly manipulated to effect the mixing. Put into an empty container and handle the container properly for mixing. The device enters the "administration" state by ejecting an empty container into a hypodermic syringe-like configuration.

Sarnoff et al. disclose several syringe packages, each comprising: a vial containing the drug; a stopper to seal the vial; a connector part secured to the vial and extending out of the stopper; a syringe connected to the connector part. In one form invented by Sarnoff, the needle of the syringe is partially embedded in the stopper. In another form of the invention, a double needle device is incorporated into the connector part so that one needle can penetrate the stopper on the vial and the other needle can penetrate the stopper on the second container. In this last described embodiment, a dual needle device provides a flow path between the vial and the second container, thus allowing mixing of the components of the injectable solution.

Various forms of combined mixing and injection syringes are disclosed in the Shaw patent. Shaw's device allows the mixing of two ingredients, which can be powders or liquids, and can be injected immediately after the mixing step is complete.

The device of the present invention provides a completely novel method of precisely mixing two components and expelling the mixture from the device through a needle or blunt-tipped cannula. Specifically, the device includes a housing into which a fixed drug cartridge containing a selected drug or other beneficial agent can be inserted. The housing is open at one end and the opposite end has a needle extending inwardly and a blunt-ended cannula extending outwardly. The diluent assembly, including the sealed vial, is then inserted into the open end of the housing and pushed telescopically toward the interior of the housing. This causes the double-ended needle to simultaneously pierce the sealed vial and the rear seal on the drug cartridge, thereby placing the vial and drug cartridge in fluid communication. Continued application of inward force on the diluent assembly will cause a needle extending inside the housing to pierce the front seal of the drug cartridge, thereby placing the interior of the drug cartridge in fluid communication with the blunt-tipped cannula. As the diluent flows through the drug cartridge, it will controllably mix with the immobilized drug to form an injectable solution that can be expelled from the device through a blunt cannula.

It is an object of the present invention to provide a device which allows precise mixing of a first component, such as a parenteral fluid, with a second component, such as a drug, to form an injectable solution which can be expelled from the device after mixing.

Another object of the present invention is to provide a device of the above character in which the first and second components are separately stored in sealed containers until they are mixed with the device for subsequent distribution. Shipping is partially combined.

Another object of the present invention is to provide a device as described in the previous sections, in which a second component, which may be any beneficial agent such as a medicament, drug or biological agent, is removably immobilized on a support such as On a rigid base, the base can be safely and conveniently stored in an airtight container until it is mixed with the first ingredient.

It is an object of the present invention to provide a device of the character described in the previous sections, which allows the addition of diluents or other parenteral liquids, selected elements, compounds in vials in a sterile environment and biologically active materials, including medicaments, drugs, biologics and other therapeutic agents (additives). This incorporation is by removably immobilizing the selected additives on various forms of support or rack which may be contained in a sealed container which may then be brought into fluid communication with the glass vial. The diluent in the vial thus rapidly becomes the therapeutically active agent as the additive carried by the backing reacts and is released into the diluent.

Another object of the present invention is to provide a device of the above nature in which the addition means carrying the second component or additive is maintained in a completely sterile environment prior to release of the additive and controlled mixing with the diluent. Store in an airtight container.

Another object of the present invention is to provide a device of the above type in which a wide selection of brake agents are removably secured to a support or a substrate stored in a sealed container, For controlled mixing with the liquid contained in the vial.

Another object of the present invention is to provide a device of the above type in which toxic or otherwise hazardous compounds, including compounds with a short therapeutic life, can be stored individually and safely, until they are stored in a diluent Mix the liquid compound in the vial immediately before use.

Another object of the present invention is to provide a device of the character described in the preceding sections, in which toxic or otherwise dangerous compounds to be mixed with liquid components can be handled separately and safely during manufacture, and can be safely stored In airtight container until use.

Another object of the present invention is to provide a device of the above type in which additives or beneficial formulation components such as medicaments or drugs can be uniformly deposited or removably fixed on a stent or additive support so that It is easy to release and separate the additives with the liquid ingredients and allow them to be completely mixed.

Another object of the present invention is to provide a mixing and dispensing device which is of simple construction and which can be easily and safely used by very unskilled personnel.

Another object of the present invention is to provide a device of the above character in which the first and second phases are automatically achieved by telescopically moving a sealed vial containing the first diluent into the hollow housing of the sealed container supporting the built-in stent. Precise mixing of the second component, which is fixed on the support.

Another object of the present invention is to provide a device as described in the previous section, in which the mixed solution can be automatically and controllably discharged from the device due to the telescopic movement of the sealed container into the hollow housing of the syringe .

A further object of the invention is to provide a device of the type described, comprising a minimum number of moving parts and a switch, which can be mass-produced at low cost and can therefore be economically discarded after use.

Figure 1 is a general perspective exploded view of one form of the mixing and dispensing device of the present invention;

Figure 2 is an enlarged, generally perspective exploded view of a sealed container containing a second component, such as a medicament or other beneficial agent, to be mixed with a first component, such as a diluent, contained in the first container shown at the top of Figure 1 ;

Figure 3 is a generally perspective exploded view showing the manner in which the first and second containers of the device fit into the hollow portion of the device used for dispensing the mixed solution;

Figure 4 is a general perspective view of the dispensing housing of the device showing a second container containing a beneficial agent disposed within the lumen of the dispensing housing;

Figure 5 is a partially cut away enlarged side view of one form of the device of the present invention, showing the internal structure of the device;

Fig. 6 is a cross-sectional view taken along line 6-6 of Fig. 5;

Figure 7 is a partial cross-sectional side view similar to Figure 5, showing the first and second component containers of the present invention partially mated with the dispensing housing of the device;

Figure 8 is a cross-sectional view taken along line 8-8 of Figure 7;

Figure 9 is a general perspective view of various forms of the support substrate or additive shelf of the present invention to which the second component is removably applied;

Figure 10 is an enlarged, partially cross-sectional side view similar to Figure 7, showing the position of the components after the first container has been telescopically moved towards the interior of the dispensing housing;

FIG. 11 is a cross-sectional view taken along line 11 - 11 of FIG. 10 .

Description of the invention

Discussing the device of the invention below, the next terms have the following meanings:

Element - Any of the basic substances, which is composed of only one kind of atoms, which alone or in combination make up all matter.

Additive - An element, compound, substance, agent, biologically active material, pharmaceutically active material or other material intended to be added to the liquid contained in the container of the device of the present invention.

Parenteral Fluid - Any solution that is delivered to a patient by a route other than the digestive tract, including water, saline solutions, alkalizing solutions, dextrose solutions, acidifying solutions, electrolytes, reagents, solvents, and the like aqueous solution.

Beneficial Agent - any anesthetic, medicament, drug, medical polymer, enzyme, elemental compound or other material used in the diagnosis, treatment, analgesia, treatment or prevention of disease and in maintaining the health of a patient.

Bioactive Material - A biologically, immunochemically, physiologically or pharmaceutically active or reactive substance. Bioactive materials include at least one or more of the following substances: biochemical compounds (such as amino acids, carbohydrates, lipids, nucleic acids, proteins, and other biochemical reagents, and biochemical compounds that can complex or interact with biochemical compounds. Substances), which are biochemical compounds that act biologically as antibodies, antigenic substances, enzymes, cofactors, inhibitors, lectins, hormones, receptors for hormone-producing cells, coagulation factors, antifungal agents, growth-promoting agents, histones, peptides, vitamins, drugs, cell surface markers, toxins, including those well known to those skilled in the art. Among the bioactive materials in the above range, proteins are of current interest due to macromolecular genetically engineered biopharmaceuticals, since these nuclides can be immobilized on additive carriers described below. In European patent application 0430517, A2 the use of biomounted polymers as carriers for bioactive materials is disclosed.

Addition means - additive and means for delivering the additive to the liquid flowing through the liquid passage of the liquid delivery device of the present invention such that all or any portion of the additive is added to the liquid. The addition means comprises additives and additive supply means which take the form of supports, functional supports or carriers, dead supports, settling zones or element reservoirs, with or without some form of intermediate matrix e.g. as in EPO application 0 392 735AZ and an azlactone functional material forming a reactive intermediate support as described in EPO application WO 88/0706 2.

Additive providing device - any device that can provide additives to a liquid flowing through the device, such as a scaffold, functional support of a substrate. Scaffolds or functional substrates can include polymers, copolymers and interpolymers, ceramics, crystalline sponges, carbon-based matrices, cellulose, glass, plastic biomounting polymers, azlactone functional materials such as coatings, polymers Spheres, adduct spheres, carboxylate functional polymer spheres, resins, gels, filaments and similar supports.

The adding device of the present invention comes in several different forms such as that shown in FIG. 9 . However, in its preferred form, the incorporation means comprises a microstructure having interconnected voids, such as a cylindrical microporous polymeric functional support 50 (FIG. 2), comprising various additives of beneficial agents such as drugs, bioactive materials , various chemical elements and compounds are releasably attached to the support. These additives are carried by the support and extend into the void in such a way that even when the liquid in the second container, such as diluent, formulation or other aqueous solvent, flows through the entire support assembly in a manner to be described below, the The additive feeds the liquid stream and is effectively added to the liquid.

The additives themselves can also take various physical forms including liquids, solids, granules, powders, granules, gels, paraffin hydrocolloid carriers, resinous films like this, tablets, crystals, emulsions, microcrystals, microcapsules, Microspheres, spray-dried compounds, freeze-dried compounds, and saturants. The additives may be removably attached to or immobilized or permeated in or supported by the support means in a number of ways. Additives can be chemically or mechanically attached, fixed or bound by directly or indirectly cooperating with the intermediate matrix. They can be trapped, immobilized, linked, cross-linked, anchored on the surface of the support or on surfactants, or they can be absorbed, catalyzed, electrostatically sealed, attached to the surface of the carrier by chemical modification, Polymerized on or through a support, or immobilized, entrapped, deposited, suspended or occluded in voids, cells, tubules and pores formed in the support. An important method for removably attaching additives to functional support devices involves treating the functional support device with a compound having a reactive functional group, such as an azlactone functional compound having a large bonding capacity. In some applications, bioactive materials can be bound to the surface of biomosaic polymers by the method of EPO Patent No. 0430 517A2. Likewise, graft copolymers can also be used in the manner described in U.S. Patent No. 5,013,795 to Coleman et al. Complexing agents, catalysts and biological materials such as enzymes or other proteins and biomacromolecular materials can be attached to the support using this method.

Additives can also be separated immediately from the functional support device and added to or mixed with the fluid flowing through the device by one or more of the following various mechanisms: chemical reaction, decomposition, untethering, Decrosslinking, bioseparation, diffusion, washing, exfoliation, corrosion, dissociation, desorption, dissolution, leaching, enzymatic cleavage, bioreaction, permeation and other separation methods for separation from annular opening materials.

Referring to the drawings, and particularly to Figures 1, 2, 3 and 4, the apparatus of the present invention for mixing a first liquid component and a second component and then delivering the mixture therefrom is shown in exploded view in Figure 3. The illustrated embodiment of the invention includes a hollow housing 12 having an aperture 14 extending longitudinally along its wall and first and second ends 16,18. The opening 14 is covered by a detachable sterile cover 12b. As is clear from FIG. 3 , the second end 18 of the housing 12 is temporarily sealed by a removable cap 12 c , while the first end 1 b is closed by a closing wall 20 . Attached to the closure wall 20 and extending outwardly from the housing is a blunt cannula 22 which constitutes a liquid outlet from the housing 12 . The cannula 22 has an internal fluid passage 24 which communicates with a fluid flow passage 26 in an internally extending cannula 28 which is also connected to the end of the closure wall 20 . The channel 24 is temporarily closed by the cannula cover 22a.

Container means is removably connected to housing 12 for containing a first liquid component such as a diluent or other parenteral fluid 27 (FIG. 5). The container means is best shown in FIG. 1 and comprises a glass vial 30 having a closed end 32 and an open end 34 . The open end 34 of the vial 30 is sealed by a pierceable stopper 36 made of a resilient material suitable to be pierced by a needle, such as soft rubber. Stopper 36 travels telescopically within interior cavity 38 of glass vial 30 in a manner to be described below. To maintain sterility, a tearable cap 40 is provided so that it covers both the stopper 36 and the open end 34 of the vial 30 . The removable intermediate cap 40 and stopper 36 are fluid flow devices that allow the fluid contained in the glass vial to flow outward after the cap 40 is removed from the vial assembly. The fluidic means is in the form of a generally frusto-conical collapsible wall member 42 . As can be clearly seen in FIG. 5, member 42 includes a bottom flange portion 42a adapted to engage the outer surface of stopper 36, and a circular end wall portion 42b through which a double-ended cannula or needle 47 passes. through the end wall 42b. Needle 47 includes a liquid channel 47a which, after coupling the first container means with dispensing housing 12, allows the liquid in vial 30 to flow outwardly from the interior of the vial to housing 12 in a manner to be described below.

Forming a very important aspect of the device of the present invention is the means for adding a second ingredient, such as a drug or other beneficial agent, to the first liquid ingredient in the vial 30 . In the embodiment of the invention shown in the drawings, the joining device comprises components of the character clearly shown in FIG. 2 . In particular, the adding means includes a sleeve 44 having first and second open ends 44a and 44b. The open end 44a is sealed by a first sealing means, and the open end 44b is sealed by a second sealing means, the first and second sealing means being shown as penetrable seals 46 and 48, respectively, which are hermetically Fitted in the open end of the sleeve 44. The seals 46 and 48 are constructed of a resilient material, such as soft rubber or silicone, suitable for coreless needle penetration.

Disposed within the sleeve 44 is the additive carrier device of the present invention, shown as the cylindrical porous substrate of the holder 50 . The substrate 50 is preferably a microporous polymeric functional support to which various additives including beneficial agents such as drugs, bioactive materials and chemical elements and compounds are releasably attached. These additives are supported by the holder or backing 50 in such a manner that they act as liquid components such as diluents in glass vials. As the reagent or aqueous solvent flows through the stent, the additive will react with or be released from the liquid component, separate, or mix with the component. The additives will be uniquely provided to the liquid stream in the manner described below so that they can be effectively added to the first liquid component in the glass vial. Surrounding sleeve 44, which may also be made of glass, plastic or other suitable material, is a shrink wrap label or polyolefin overwrap 52 with printed indicia indicating the additive or beneficial agent affixed to bracket 50. The overwrap 52 also serves to immobilize the pierceable stoppers 46 and 48 located within the container 44 .

Referring now to Figures 3, 5 and 7, the filling device, indicated generally at 54 in Figure 3, is received within the interior cavity 12a of the dispensing housing 12 through the opening 14 formed along the wall. As shown in Figure 3, after removing the sterile cover 12a that sealably covers the opening 14, the assembly 54 can be installed in the opening 14 so that it is installed in the inner chamber 12a in the manner shown in Figure 7 middle. Assembly 54 may be of a polarized configuration as is known in the art, such as with shift detents, so that the assembly can only fit into cavity 12a in one orientation. A first container means, indicated generally at 56 in FIG. 5, is adapted to cooperate with housing 12 in a manner to be described. The first step in the mating process involves removing the cap 40 to form the subassembly indicated generally at 58 in FIGS. 3 and 7 . After removal of the cap 12c, the insertion end of the assembly 58 can be telescopically inserted into the open end 18 of the housing 12 in the manner shown in FIG. 7 to maintain a sterile flow path. Direct inward pressure on subassembly 58 in the direction of the arrow in Figure 10 will cause several events simultaneously. One such event, shown in FIG. 10, involves compressing the wall 42 of the flow device in such a manner that the double-ended needle 47 will simultaneously pierce the portion 36a of the pierceable stopper 36 of the container device and the sealable stopper 46 of the addition device. The pierceable portion 46a. This puts the interior of the vial 30 in fluid communication with the lumen of the sleeve 44 so that the liquid in the vial can flow into the lumen 44c of the sleeve 44 and then through the entire backing 50. Continuing to apply inward pressure to the glass vial in the direction of arrow 59 will cause the needle 28 of the housing assembly 12 to penetrate the portion 48a of the plug 48 of the adding device, thereby allowing the liquid to flow through the outlet of the adding device and dispensing subassembly or syringe housing 12. Or flow between cannula 22. The combined needle 28 and cannula 22 arrangement includes the second flow path arrangement of the present invention for fluid flow between the addition device and the outlet of the dispensing housing 12 .

When inward pressure is maintained on the glass vial, the pierceable stopper 36 will move longitudinally outward relative to the glass vial. This allows the liquid in the glass vial to flow quickly through the channel 47a in the double ended needle 47 and into the lumen 44c of the sleeve 44 . Liquid flowing through the pierceable plug 46 will be evenly distributed in an outward direction through the portion 46b of the plug and the adjoining surface of the porous support means 50 . As the liquid passes through the lumen of the sleeve, it will flow through the entire extent of the backing 50 so that additives affixed to the backing or removably attached to the backing can be separated by the liquid and completely mixed with the liquid, Thus an injection solution is formed. The pressure of the liquid flowing through the feeding device can control the ejection of the injection liquid through the channel 24 of the cannula 22 . Portion 48b of plug 48 acts as a fluid collecting means for collecting fluid from filter 49 and the distal interface conduit of backing 50, thereby focusing fluid flow towards channel 26 of the cannula. The filter 49 may be a polyethylene hydrophilic depth filter with a mesh floor placed between the bracket 50 and the plug 48 . A filter 49 is sealably combined with the inner wall of the glass tubule 44 and functions to trap particulate and gaseous substances that may be contained in the mixed solution. The configuration of the particulate filter and gas confinement device can be fabricated according to the particular application required.

Returning now to Figure 9, various other forms of addition means or additive assemblies are shown. Reference numeral 64, for example, designates an assembly comprising a plurality of layers 66 each coated with selected additives. In some cases, the assembly is surrounded by a microporous membrane or skin 66a to allow contamination-free operation. Layers 66 are stacked in the manner shown to form a plurality of exposed surfaces and alternately spaced reaction zones which are susceptible to the diluent as it flows through chamber 44c.

Reference numeral 68 denotes a porous substrate having open interstices cells or pores and interconnected voids, such as a porous ceramic having a coating of one or more additives deposited in the voids. Selected additives such as elements, compounds or drugs are included in the deposited material and are deposited or fixed thereon with or without an intermediate matrix by methods well known to those skilled in the art. As the diluent flows through lumen 44c, the additive contained in the interstices is of course susceptible to the diluent, separates from the stent, and then enters the sterile diluent or other liquid.

Another form of additive assembly represented by numeral 70 in FIG. 9 comprises a generally tubular member having a plurality of micropores 72 of alternating sizes filled with selected additives such as compounds, beneficial preparations or drugs.

Yet another form of additive package is indicated generally at 74 in FIG. 9 . The assembly comprises a cylindrical porous plug-like member consisting of a number of fused together microspheres 76 each coated with a separate or reactive coating which acts as a useful reactive carrier or adduct carrier for immobilizing an additive such as a bioactive material or other beneficial agent with chemical affinity and subsequently releasing the additive.

Another more complex additive package is designated by numeral 78. The assembly consists of a number of spaced apart porous disc-shaped discs 78a, 78b, 78c and 78d, each of the same or different structure or porosity and having a number of reaction zones which bring the liquid streams into contact with Special selection of specific classes of additives such as beneficial agents, elements or compounds allows for a variety of reactivity, selectivity and mixing. With this structure, a variety of fluid flow velocities, complex sequential separation and preferentially graded introduction into the outlet cannula can be obtained by specially designing each disc. Each specially designed disc has unique features that cooperate to form functional structural supports. Has affinity and separation properties.

The numeral 80 in Fig. 9 represents another form of additive device of the present invention. In this form of the invention, the generally cylindrical, insoluble functional support device is constructed of a bioembedded polymer 82, which is porous or non-porous, providing a multitude of possibilities for bioseparation tethered to the polymer surface. The reactive zone of the material.

Components 64 to 80, which may be soluble or insoluble, are for illustration only and are not limiting of the wide variety of materials, configurations, and pharmaceutical compounds or formulations used to introduce desired additives into the fluid stream entering the addition device lumen 44c combination and separation techniques. Vials 30 and 44 can also be made of various materials, such as plastic, instead of glass. Housing 12 can also be made of a variety of materials, including polyethylene, polyester, and polyamide. polycarbonate etc.

After the diluent or parenteral fluid is mixed with the additive in the inflow lumen 44c, the solution is dispensed from the device through the cannula 22 to the environment of use.

The present invention has been described in detail above in accordance with the requirements of the patent format, but those skilled in the art can change and modify the individual parts of the relevant components without difficulty in order to meet specific requirements or conditions. Such changes and modifications do not depart from the scope and spirit of the invention as set forth in the following claims.

Claims (23)

1. one kind mixes first liquid component and second composition mutually and with the device that this mixture is sent, comprising:

A) has the shell of inner chamber and outlet;

B) case connects above-mentioned shell, above-mentioned first liquid component that is used to pack into, and the said vesse device can move on to the second position from primary importance with respect to above-mentioned chamber;

C) be configured in adding apparatus in the above-mentioned inner chamber, be used for above-mentioned second composition is joined above-mentioned first liquid component, thereby be formed on just injectable mixture when making the said vesse device shift to said second position, above-mentioned adding apparatus comprises support, and above-mentioned second composition can be removed the ground carrier band on above-mentioned support;

D) liquid stream device can make liquid flow between above-mentioned adding apparatus and above-mentioned outlet when making the said vesse device shift to said second position, and thus, because the said vesse device is shifted to said second position, above-mentioned injectable mixture is sent by above-mentioned outlet.

2. device as claimed in claim 1, in this device, above-mentioned adding apparatus also comprises the container of the inner chamber with the above-mentioned support that is used to pack into.

3. device as claimed in claim 2, in this device, above-mentioned support comprises having the micropore parts that interconnect hole, above-mentioned second composition stretches into above-mentioned hole.

4. device as claimed in claim 3, in this device, above-mentioned first liquid component comprises without gastral liquid.

5. device as claimed in claim 4, in this device, above-mentioned second composition comprises useful preparation.

6. device as claimed in claim 4, in this device, above-mentioned second composition comprises medicine.

7. device as claimed in claim 4, in this device, above-mentioned second composition comprises medicament.

8. device is used to make first liquid component to mix mutually with second composition and forms Injectable solution, and this injection solution is dispensed into environment for use from this device, and said apparatus comprises:

A) has the hollow casing of inner chamber and first and second end;

B) be connected in the intubate of above-mentioned hollow casing the second end;

C) case is connected in the above-mentioned first end of above-mentioned hollow casing, so as in above-mentioned inner chamber from the telescopic second position that moves on to of primary importance;

D) adding apparatus, but demolition be contained in the above-mentioned inner chamber so that when making the said vesse device shift to said second position, above-mentioned second composition is joined above-mentioned first liquid component, above-mentioned adding apparatus comprises the end liner of fixing above-mentioned second composition;

E) the first liquid stream device, be used for when making the said vesse device shift to said second position, between above-mentioned adding apparatus and above-mentioned intubate, forming liquid stream, therefore, because the said vesse device is shifted to said second position, above-mentioned Injectable solution will be sent from this device by above-mentioned outlet.

9. device as claimed in claim 8, in this device, above-mentioned adding apparatus comprises the container of the above-mentioned end liner of packing into, said vesse comprises by the first end of first sealing device sealing and the second end that is sealed by second sealing device.

10. device as claimed in claim 9, in this device, the said vesse device comprises the vial with chamber, this chamber first fluid composition that is used to pack into, the above-mentioned chamber of above-mentioned vial is by the plug seal that can be pierced.

11. device as claimed in claim 10 also comprises the second liquid stream device, this device when the said vesse device is shifted to the second position in the above-mentioned chamber of above-mentioned vial with comprise between the container of above-mentioned end liner and form flow of liquid.

12. device as claimed in claim 11, in this device, the above-mentioned second liquid stream device is included in and is used for penetrating simultaneously the above-mentioned double needle that pierces through the stopper and above-mentioned first sealing device of the said vesse of the above-mentioned end liner of packing into when the said vesse device is shifted to said second position.

13. as right 12 described devices, in this device, the above-mentioned first liquid stream device comprises the pin with the centre bore that communicates with above-mentioned intubate, above-mentioned pin structure like this and configuration make it can penetrate above-mentioned second sealing device of the said vesse of the above-mentioned end liner of packing into when the said vesse device is shifted to said second position.

14. device as claimed in claim 13, in this device, above-mentioned second composition comprises useful preparation.

15. device as claimed in claim 13, in this device, above-mentioned second composition comprises medicament.

16. device as claimed in claim 13, in this device, above-mentioned support comprises porous circular cylinder, and above-mentioned second composition is fixed in the micropore of this cylinder.

17, device as claimed in claim 13, in this device, above-mentioned support comprises that biology inlays polymer.

18. device as claimed in claim 13, in this device, above-mentioned support comprises the adduct supporting arrangement.

19. device as claimed in claim 13, in this device, above-mentioned shell has the longitudinal extension perforate of accepting above-mentioned adding apparatus.

20. one kind is mixed and injection device, comprising:

A) have the hollow casing of longitudinal extension perforate and first and second end, above-mentioned the second end opens wide;

B) outwardly directed intubate, the first end of being close to above-mentioned shell connects;

The intubate of c) inwardly stretching out, the first end of being close to above-mentioned shell connects, and communicates with above-mentioned protruding intubate liquid;

D) can be contained in seal sleeve in the above-mentioned longitudinal extension perforate in the above-mentioned hollow casing, the above-mentioned sleeve of adding apparatus of packing into comprises the end liner that is suitable for removably supporting useful preparation, and have first and second ends, above-mentioned first end is by the first sealing member sealing that can be pierced, and above-mentioned the second end is by the second sealing member sealing that can be pierced.

E) Mi Feng liquid container, in telescopic above-mentioned second open end that is contained in above-mentioned shell, so that move between first and second positions, the aforesaid liquid container comprises liquid component and has:

(i) Mi Feng first end;

The (ii) the second end of Chang Kaiing;

(iii) the stopper that can be pierced is placed in the above-mentioned unlimited the second end hermetically, so that can move with respect to the aforesaid liquid container;

(iv) cannula assembly, near above-mentioned unlimited the second end configuration, but above-mentioned cannula assembly comprises the wall of deformation and extends through the intubate of above-mentioned wall, above-mentioned intubate has to be close to and above-mentionedly pierces through the first end of stopper configuration and stretch into the second end in the above-mentioned hollow casing, and the first end of above-mentioned intubate is suitable for piercing through the above-mentioned stopper that pierces through when above-mentioned wall deformation.

21. device as claimed in claim 20, in this device, the aforesaid liquid composition comprises diluent.

22. device as claimed in claim 20 also comprises the end liner that can be contained in the above-mentioned seal sleeve, above-mentioned useful preparation removably is fixed on the above-mentioned end liner.

23. device as claimed in claim 22, in this device, above-mentioned useful preparation comprises medicament.

Images