CN114288320A - Oral iron supplement for pigs and preparation method thereof - Google Patents
Oral iron supplement for pigs and preparation method thereof Download PDFInfo
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- CN114288320A CN114288320A CN202111634783.5A CN202111634783A CN114288320A CN 114288320 A CN114288320 A CN 114288320A CN 202111634783 A CN202111634783 A CN 202111634783A CN 114288320 A CN114288320 A CN 114288320A
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- iron supplement
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- iron
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 193
- 229910052742 iron Inorganic materials 0.000 title claims abstract description 92
- 239000013589 supplement Substances 0.000 title claims abstract description 56
- 241000282887 Suidae Species 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 150000004676 glycans Chemical class 0.000 claims abstract description 48
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 48
- 239000005017 polysaccharide Substances 0.000 claims abstract description 48
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 claims abstract description 30
- 229920000903 polyhydroxyalkanoate Polymers 0.000 claims abstract description 30
- 239000000796 flavoring agent Substances 0.000 claims abstract description 11
- 235000013355 food flavoring agent Nutrition 0.000 claims abstract description 10
- 239000008187 granular material Substances 0.000 claims description 21
- 239000011790 ferrous sulphate Substances 0.000 claims description 14
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 14
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 14
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
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- 238000005303 weighing Methods 0.000 claims description 9
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
- 229930195725 Mannitol Natural products 0.000 claims description 7
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 7
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- 238000006243 chemical reaction Methods 0.000 claims description 5
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- RXVWSYJTUUKTEA-UHFFFAOYSA-N D-maltotriose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 RXVWSYJTUUKTEA-UHFFFAOYSA-N 0.000 claims description 4
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 claims description 4
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- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 claims description 4
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 claims description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 229940069328 povidone Drugs 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
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- 229920001542 oligosaccharide Polymers 0.000 claims description 2
- 150000002482 oligosaccharides Chemical class 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 239000003054 catalyst Substances 0.000 claims 1
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Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fodder In General (AREA)
Abstract
The invention discloses an oral iron supplement for pigs and a preparation method thereof, belonging to the technical field of animal feeding. The pig oral iron supplement comprises a polysaccharide ferrous complex, polyhydroxyalkanoate and a taste flavoring agent, and the permeability of the polysaccharide ferrous complex on cell membranes is promoted by adopting the polyhydroxyalkanoate, so that the bioavailability of the pig oral iron supplement is improved; meanwhile, the trivalent organic iron exists in a complex form, so that the trivalent organic iron is insoluble in gastric acid and can not generate free iron, and can be absorbed in a molecular form in the digestive tract, thereby further improving the bioavailability. The oral iron supplement provided by the invention is simple and convenient to operate, good in palatability, convenient to feed, high in bioavailability and good in iron supplement effect, so that the growth performance of piglets can be improved.
Description
Technical Field
The invention relates to the technical field of animal feeding, in particular to an oral iron supplement for pigs and a preparation method thereof.
Background
Iron is one of trace elements necessary for the life activities of animals, participates in substance metabolism and energy metabolism in the life activities in various forms, and plays a very important role in the life activities of the animals. The iron content in animals varies with animal species, sex, age, nutrition and health.
For young animals, iron is one of the essential trace elements for their growth and development and for their normal life. The iron storage in the young newborn animals is less, the iron obtained by milk is very limited, and the young animals grow quickly during lactation and need a large amount of iron, so the young animals need to be supplemented with iron before feeding, otherwise the early development of the young animals is hindered due to iron deficiency, and the young animals grow slowly. Taking the newborn piglet as an example, the total iron storage in the newborn piglet is about 50mg (generally, each kilogram of body weight only contains about 28 mg), and the total iron element required by the newborn piglet when the newborn piglet normally develops to 3 weeks of age is about 200 mg. And each 100 g of breast milk contains only 0.2 mg of iron, so the amount of iron provided by the breast milk to the piglets is not more than 10% of the required amount, the normal level of hemoglobin in the blood of the piglets cannot be maintained only by lactation, the number of red blood cells is reduced, the piglets are susceptible to iron-deficiency anemia generally within 10 days of age, and the iron-deficiency anemia is characterized by lusterless fur, pale visible mucous membrane, pale skin, slightly swollen head, lassitude, anorexia, slow growth, easy white diarrhea and pneumonia, the sick pigs gradually lose weight and weakness, and death can be caused by severe illness. Therefore, the iron supplement mode is generally carried out on the newborn piglets by a direct iron supplement mode or an indirect iron supplement mode.
At present, the direct iron supplement method comprises feeding iron supplement and injection iron supplement. The injection iron supplement injection is an iron supplement method for suckling piglets which is commonly adopted in a pig farm at present, but the method needs a large amount of labor force and is complex to operate, and meanwhile, the iron injection can cause the piglets to generate strong stress, the absorption of the injection part is poor, and the problems of cross infection such as inflammation, red swelling and the like caused by the repeated use of the needle head exist. The iron content of the existing oral pig iron supplement agent in the market is very high, but the oral pig iron supplement agent is easily degraded into free iron in gastric acid, so that the absorption and utilization rate is low, the palatability is poor, the stress response of piglets is large, the piglets are easy to spit out to influence the dosage, the single-time iron supplement dosage is insufficient due to the administration dosage, and therefore multiple forced administrations are needed, and the labor intensity is increased.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide the pig oral iron supplement which has high bioavailability, good iron supplement effect and simple and convenient operation.
In order to solve the problems, the technical scheme adopted by the invention is as follows:
an oral iron supplement for pigs comprises the following raw materials in parts by weight: 80-90 parts of polysaccharide ferrous complex, 0.1-0.5 part of polyhydroxyalkanoate and 12-18 parts of taste flavoring agent.
As a preferred embodiment of the present invention, the iron content of the polysaccharide ferrous complex is not less than 40%.
In a preferred embodiment of the present invention, the polysaccharide ferrous complex is a complex of ferrous sulfate and one of maltose, glucose, isomaltose, maltotriose and starch-hydrolyzed polysaccharide.
The preparation process of the polysaccharide ferrous complex comprises the following steps: dissolving 25-35 parts by weight of ferrous sulfate in water, adding 15-25 parts of sodium hydroxide, sodium carbonate or sodium phosphate, reacting for 3-5 hours, performing centrifugal purification, controlling the conductivity of the filtrate to be not more than 4ms/cm, adding 8-15 parts of corresponding oligosaccharide syrup, adjusting the pH value to 11-14, reacting for 1-2 hours at 80-90 ℃, immediately finishing the reaction when the reaction solution is changed from turbid solution to solution, cooling to room temperature, and drying to obtain the polysaccharide ferrous complex.
As a preferred embodiment of the present invention, the taste flavor is at least one of mannitol, sucrose, steviosin, and aspartame.
The invention also aims to provide a preparation method of the oral iron supplement for pigs, which comprises the following steps: weighing the polysaccharide ferrous complex, the polyhydroxyalkanoate and the taste flavoring agent according to the formula ratio, placing the mixture in a bottom jet fluidized bed, introducing hot air, adding an adhesive for granulation, drying the obtained granules until the moisture is not more than 8%, and discharging to obtain the product.
In a preferred embodiment of the present invention, the temperature of the hot air is 60 to 70 ℃.
In a preferred embodiment of the present invention, the binder is one of water, a 5% povidone solution, and a 5% hypromellose E5 solution.
As a preferred embodiment of the invention, the particle size of the particles prepared in the granulation is 24-80 meshes.
In a preferred embodiment of the present invention, the drying temperature is 60 to 70 DEG C
Compared with the prior art, the invention has the beneficial effects that:
according to the oral iron supplement for pigs, the combination of the polyhydroxyalkanoate and the soluble polysaccharide ferrous complex is used as the oral iron supplement, and the polyhydroxyalkanoate is unexpectedly found to be capable of effectively promoting the permeability of the polysaccharide ferrous complex on cell membranes in the research process, so that the bioavailability of the oral iron supplement for pigs is improved; meanwhile, the organic iron exists in a complex form, so that the organic iron is insoluble in gastric acid and can not generate free iron, and can be absorbed in a molecular form in a digestive tract, so that the bioavailability is further improved, and the growth performance of piglets is well improved. The palatability of the iron supplement can be well improved by adding the taste flavoring agent, so that the stress reaction of piglets is reduced, and the feeding is convenient. When the iron supplement is used, the iron supplement can be dissolved in water or mixed milk powder to be directly fed to piglets, and the operation is simple and convenient once a day.
The preparation method provided by the invention is simple to operate, easy to realize and suitable for industrial production.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments.
An oral iron supplement for pigs comprises the following raw materials in parts by weight: 80-90 parts of polysaccharide ferrous complex, 0.1-0.5 part of polyhydroxyalkanoate and 12-18 parts of taste flavoring agent.
Wherein the polysaccharide ferrous complex is a complex of ferrous sulfate and one of maltose, glucose, isomaltose, maltotriose or starch hydrolyzed polysaccharide; the iron content of the polysaccharide ferrous complex is not less than 40%. The taste flavoring agent is at least one of mannitol, sucrose, steviosin, and aspartame.
The preparation method of the oral iron supplement for pigs comprises the following steps: weighing the polysaccharide ferrous complex, the polyhydroxyalkanoate and the taste flavoring agent according to the formula ratio, placing the mixture in a bottom jet fluidized bed, introducing hot air at the temperature of 60-70 ℃, adding an adhesive to granulate into 24-80-mesh granules, drying the obtained granules at the temperature of 60-70 ℃ until the moisture content is not more than 8%, and discharging to obtain the product.
Example 1
An oral iron supplement for pigs comprises the following raw materials in parts by weight: 100kg of polysaccharide ferrous complex (the content of iron element is 40.7%), 0.5kg of polyhydroxyalkanoate and 15kg of cane sugar. Wherein the polysaccharide ferrous complex is a complex of glucose and ferrous sulfate.
The preparation method comprises the following steps: weighing the polysaccharide ferrous complex, the polyhydroxyalkanoate and the sucrose according to the formula ratio, placing the mixture in a bottom jet fluidized bed, introducing hot air at the temperature of 65 ℃, adding 15kg of adhesive water, granulating to prepare 24-80-mesh granules, drying the obtained granules at the temperature of 65 ℃ until the moisture content is not more than 8%, and discharging to obtain the polysaccharide ferrous complex.
Example 2
An oral iron supplement for pigs comprises the following raw materials in parts by weight: 100kg of polysaccharide ferrous complex (the content of iron element is 41.5%), 0.35kg of polyhydroxyalkanoate, 18kg of lactose and 2kg of aspartame. Wherein the polysaccharide ferrous complex is complex of maltose and ferrous sulfate.
The preparation method comprises the following steps: weighing the polysaccharide ferrous complex, the polyhydroxyalkanoate, the lactose and the aspartame according to the formula ratio, placing the mixture in a bottom jet fluidized bed, introducing hot air at the temperature of 70 ℃, adding 15Kg of 5% povidone solution as an adhesive, granulating to prepare 24-80-mesh granules, drying the obtained granules at the temperature of 70 ℃ until the moisture content is not more than 8%, and discharging to obtain the product.
Example 3
An oral iron supplement for pigs comprises the following raw materials in parts by weight: 100kg of polysaccharide ferrous complex (the content of iron element is 42.8 percent), 0.15kg of polyhydroxyalkanoate, 0.2kg of steviosin and 20kg of mannitol. Wherein the polysaccharide ferrous complex is a complex of isomaltose and ferrous sulfate.
The preparation method comprises the following steps: weighing the polysaccharide ferrous complex, the polyhydroxyalkanoate, the lactose and the aspartame according to the formula ratio, placing the mixture in a bottom jet fluidized bed, introducing hot air at the temperature of 70 ℃, adding 15Kg of 5% hydroxypropyl methylcellulose solution serving as an adhesive, granulating the mixture to obtain 24-80-mesh granules, drying the obtained granules at the temperature of 70 ℃ until the moisture content is not more than 8%, and discharging the granules to obtain the polysaccharide ferrous complex.
Example 4
An oral iron supplement for pigs comprises the following raw materials in parts by weight: 100Kg of polysaccharide ferrous complex (the content of iron element is 43.2 percent), 0.25Kg of polyhydroxyalkanoate, 0.2Kg of steviosin, 3Kg of sucrose and 18Kg of mannitol. Wherein the polysaccharide ferrous complex is a complex of maltotriose and ferrous sulfate.
The preparation method comprises the following steps: weighing the polysaccharide ferrous complex, the polyhydroxyalkanoate, the lactose and the aspartame according to the formula ratio, placing the mixture in a bottom jet fluidized bed, introducing hot air at the temperature of 70 ℃, adding 15Kg of 5% hydroxypropyl methylcellulose solution serving as an adhesive, granulating the mixture to obtain 24-80-mesh granules, drying the obtained granules at the temperature of 70 ℃ until the moisture content is not more than 8%, and discharging the granules to obtain the polysaccharide ferrous complex.
Example 5
An oral iron supplement for pigs comprises the following raw materials in parts by weight: 100Kg of polysaccharide ferrous complex (the content of iron element is 42.6 percent), 0.18Kg of polyhydroxyalkanoate, 0.1Kg of aspartame, 0.5Kg of steviosin, 1Kg of sucrose and 19Kg of mannitol. Wherein the polysaccharide ferrous complex is complex of maltose and ferrous sulfate.
The preparation method comprises the following steps: weighing the polysaccharide ferrous complex, the polyhydroxyalkanoate, the lactose and the aspartame according to the formula ratio, placing the mixture in a bottom jet fluidized bed, introducing hot air at the temperature of 70 ℃, adding 15Kg of 5% hydroxypropyl methylcellulose solution serving as an adhesive, granulating the mixture to obtain 24-80-mesh granules, drying the obtained granules at the temperature of 70 ℃ until the moisture content is not more than 8%, and discharging the granules to obtain the polysaccharide ferrous complex.
Example 6
An oral iron supplement for pigs comprises the following raw materials in parts by weight: 100Kg of polysaccharide ferrous complex (the content of iron element is 42.0 percent), 0.37Kg of polyhydroxyalkanoate, 0.7Kg of steviosin and 20Kg of mannitol. Wherein the polysaccharide ferrous complex is a complex of glucose and ferrous sulfate.
The preparation method comprises the following steps: weighing the polysaccharide ferrous complex, the polyhydroxyalkanoate, the lactose and the aspartame according to the formula ratio, placing the mixture in a bottom jet fluidized bed, introducing hot air at the temperature of 70 ℃, adding 15Kg of 5% hydroxypropyl methylcellulose solution serving as an adhesive, granulating the mixture to obtain 24-80-mesh granules, drying the obtained granules at the temperature of 70 ℃ until the moisture content is not more than 8%, and discharging the granules to obtain the polysaccharide ferrous complex.
Penetration-promoting effect test of polyhydroxyalkanoate
The iron supplement agent prepared under the same conditions as the example 1 without adding the polyhydroxyalkanoate and other components is used as a comparative example 1, ferrous sulfate is used as a comparative example 2, and the permeation promoting effect test is carried out on the oral iron supplement agent prepared in the example 1, and the specific test method is as follows: the samples of example 1 and comparative examples 1-2 containing 50mg of iron were weighed, placed in a percutaneous absorption apparatus respectively, artificial intestinal juice was used as a dissolution medium, craw of chicken was used as a transdermal carrier, and the iron content of the transdermal carrier was detected at different times respectively, and expressed as a percentage, and the results are shown in table 1.
TABLE 1 comparison of penetration promoting effects of example 1 and comparative examples 1-2
| Time | Example 1 | Comparative example 1 | Comparative example 2 |
| 0.5 hour | 30.5％ | 8.9％ | 6.6％ |
| 1.0 hour | 53.8％ | 12.3％ | 11.9％ |
| 1.5 hours | 76.4％ | 16.5％ | 15.4％ |
| 2.0 hour | 95.1％ | 17.6％ | 18.3％ |
The results in table 1 show that example 1 can promote the permeability of iron element in the polysaccharide complex by adding polyhydroxyalkanoate, thereby effectively improving the bioavailability of the oral iron supplement.
Secondly, screening the use amount of the polyhydroxyalkanoate:
under the same conditions as those of example 1, the iron supplement agents prepared by respectively adding polyhydroxyalkanoate with different proportions are used as comparative examples 3, 4, 5, 6 and 7, and the iron supplement agent for oral administration prepared by example 1 is subjected to the penetration-promoting effect test, and the specific test method is as follows: samples of example 1, comparative example 3, comparative example 4, comparative example 5, comparative example 6 and comparative example 7 containing 50mg of iron are weighed respectively and placed in a transdermal absorption instrument, artificial intestinal juice is used as a dissolution medium, the craw of chicken is used as a transdermal carrier, the iron content of the transdermal carrier is detected at different times respectively and is expressed by percentage, and the results are shown in table 2.
TABLE 2 penetration-promoting Effect of example 1 compared with comparative examples 1 to 2
| Time | Comparative example 3 | Comparative example 4 | Comparative example 5 | Comparative example 6 | Comparative example 7 |
| Ratio of polyhydroxyalkanoate | 0.05％ | 0.1％ | 0.3％ | 0.5％ | 0.8％ |
| 0.5 hour | 21.8％ | 29.0％ | 31.2％ | 29.9％ | 31.6％ |
| 1.0 hour | 42.1％ | 51.3％ | 52.4％ | 53.8％ | 53.0％ |
| 1.5 hours | 56.4％ | 74.6％ | 75.9％ | 74.3％ | 75.1％ |
| 2.0 hour | 80.7％ | 93.9％ | 92.6％ | 93.1％ | 94.2％ |
The results in table 2 show that the permeation promoting effect of the polyhydroxyalkanoates is not significantly different from that of 0.1-0.8%, and the dosage of the polyhydroxyalkanoates is determined to be 0.1-0.5% in consideration of the production cost.
Third, evaluation test of iron supplement effect
The oral iron supplement agent prepared in example 1, example 2, example 3, example 4, example 5 and example 6 was used to evaluate the iron supplement effect of oral ferrous sulfate as comparative example 8 and dextran iron injection as comparative example 9, and the specific test methods are as follows: the results of using 15 piglets as a group, treating the piglets for 3 days by respectively using example 1, example 2, example 3, example 4, example 5, example 6, comparative example 8 and comparative example 9, supplementing iron to each piglet every day by 300mg of iron element, and measuring the hemoglobin content in the blood of the piglet after 24 hours to examine the comparative iron supplementing effect are shown in table 2.
TABLE 3 comparison of iron supplementing effects of examples 1 to 6 and comparative examples 8 to 9
| Time | Day 0 | 1 day | 2 days | 3 days |
| Example 1 | Average 110.5g/L | Average 113.1g/L | Average 112.8g/L | Average 110.8g/L |
| Example 2 | Average 112.1g/L | Average 110.9g/L | Average 111.0g/L | Average 112.4g/L |
| Example 3 | Average 109.4g/L | Average 111.7g/L | Average 110.4g/L | Average 106.5g/L |
| Example 4 | Average 111.9g/L | Average 108.8g/L | Average 109.3g/L | Average 114.6g/L |
| Example 5 | Average 108.7g/L | Average 109.9g/L | Average 111.3g/L | Average 107.9g/L |
| Example 6 | Average 103.6g/L | Average 107.2g/L | Average 106.6g/L | Average 113.3g/L |
| Comparative example 8 | Average 112.3g/L | Average 106.9g/L | Average 97.4g/L | Average 87.6g/L |
| Comparative example 9 | Average 111.9g/L | Average 111.5g/L | Average 115.9g/L | Average 113.1g/L |
Note: an anemia is one in which the hemoglobin content is less than 90 g/L.
The results in table 3 show that comparative example 8, which is orally administered with ferrous sulfate, has poor iron supplementing effect at the same dosage, and hemoglobin shows a descending trend along with the increase of time, so that piglets are anaemic; the iron supplementing effect of the embodiments 1-6 is basically consistent with that of the comparative example 9 in which iron dextran is injected, so that the oral iron supplementing agent prepared by the invention has high bioavailability and good iron supplementing effect, effectively improves the immunity and growth performance of piglets, and does not cause the problems of oxidative stress and iron overload.
In conclusion, the polyhydroxy fatty acid ester and the polysaccharide ferrous complex are compounded, so that the permeability of the polysaccharide ferrous complex on cell membranes can be effectively promoted, and the bioavailability of the oral iron supplement for pigs is improved; meanwhile, the organic iron exists in a complex form, so that the organic iron is insoluble in gastric acid and can not generate free iron, and can be absorbed in a molecular form in a digestive tract, so that the bioavailability is further improved, and the growth performance of piglets is well improved.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (10)
1. An oral iron supplement for pigs, which is characterized in that: the composite material comprises the following raw materials in parts by weight: 80-90 parts of polysaccharide ferrous complex, 0.1-0.5 part of polyhydroxyalkanoate and 12-18 parts of taste flavoring agent.
2. The oral iron supplement for pigs of claim 1, wherein: the iron content of the polysaccharide ferrous complex is not less than 40%.
3. The oral iron supplement for pigs according to claim 1 or 2, wherein: the polysaccharide ferrous complex is a complex of ferrous sulfate and one of maltose, glucose, isomaltose, maltotriose or starch hydrolyzed polysaccharide.
4. The oral iron supplement for pigs of claim 3, wherein: the polysaccharide ferrous complex is prepared by the following steps: dissolving 25-35 parts by weight of ferrous sulfate in water, adding 15-25 parts of sodium hydroxide, sodium carbonate or sodium phosphate, reacting for 3-5 hours, performing centrifugal purification, controlling the conductivity of the filtrate to be not more than 4ms/cm, adding 8-15 parts of corresponding oligosaccharide syrup, adjusting the pH value to 11-14, reacting for 1-2 hours at 80-90 ℃, immediately finishing the reaction when the reaction solution is changed from turbid solution to solution, cooling to room temperature, and drying to obtain the iron-based catalyst.
5. The oral iron supplement for pigs of claim 3, wherein: the taste flavoring agent is at least one of mannitol, sucrose, steviosin and aspartame.
6. A method for preparing the oral iron supplement for pigs as claimed in any one of claims 1 to 5, wherein the method comprises the following steps: the preparation process comprises the following steps: weighing the polysaccharide ferrous complex, the polyhydroxyalkanoate and the taste flavoring agent according to the formula ratio, placing the mixture in a bottom jet fluidized bed, introducing hot air, adding an adhesive for granulation, drying the obtained granules until the moisture is not more than 8%, and discharging to obtain the product.
7. The method for preparing the oral iron supplement for pigs according to claim 6, wherein the method comprises the following steps: the temperature of the hot air is 60-70 ℃.
8. The method for preparing the oral iron supplement for pigs according to claim 6, wherein the method comprises the following steps: the adhesive is one of water, 5% povidone solution and 5% hypromellose E5 solution.
9. The method for preparing the oral iron supplement for pigs according to claim 6, wherein the method comprises the following steps: the particle size of the particles prepared in the granulation is 24-80 meshes.
10. The method for preparing the oral iron supplement for pigs according to claim 6, wherein the method comprises the following steps: the drying temperature is 60-70 ℃.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060134227A1 (en) * | 2004-12-22 | 2006-06-22 | Bortz Jonathan D | Compositions including iron |
| US20080214496A1 (en) * | 2005-02-09 | 2008-09-04 | Vifor (International) Ag | Use Of Iron(III) Complex Compounds |
| WO2009063018A1 (en) * | 2007-11-13 | 2009-05-22 | Agilan Gmbh | Aqueous iron dextran preparation having one or more para-hydroxybenzoate compounds and/or salts thereof |
| CN102167752A (en) * | 2011-05-23 | 2011-08-31 | 华南理工大学 | Preparation method of water-soluble soybean polysaccharide ferrous coordination compound |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060134227A1 (en) * | 2004-12-22 | 2006-06-22 | Bortz Jonathan D | Compositions including iron |
| US20080214496A1 (en) * | 2005-02-09 | 2008-09-04 | Vifor (International) Ag | Use Of Iron(III) Complex Compounds |
| WO2009063018A1 (en) * | 2007-11-13 | 2009-05-22 | Agilan Gmbh | Aqueous iron dextran preparation having one or more para-hydroxybenzoate compounds and/or salts thereof |
| CN102167752A (en) * | 2011-05-23 | 2011-08-31 | 华南理工大学 | Preparation method of water-soluble soybean polysaccharide ferrous coordination compound |
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