CN106388982B - A kind of Invasive lumbar fusion device - Google Patents
A kind of Invasive lumbar fusion device Download PDFInfo
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- CN106388982B CN106388982B CN201611073333.2A CN201611073333A CN106388982B CN 106388982 B CN106388982 B CN 106388982B CN 201611073333 A CN201611073333 A CN 201611073333A CN 106388982 B CN106388982 B CN 106388982B
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- 230000004927 fusion Effects 0.000 title claims abstract description 61
- 210000000988 bone and bone Anatomy 0.000 claims description 21
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 3
- 229920002635 polyurethane Polymers 0.000 claims description 3
- 239000004814 polyurethane Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims 1
- 239000011796 hollow space material Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 abstract description 25
- 238000006073 displacement reaction Methods 0.000 abstract description 5
- 238000001125 extrusion Methods 0.000 abstract description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 206010041591 Spinal osteoarthritis Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 208000036319 cervical spondylosis Diseases 0.000 description 1
- 239000012792 core layer Substances 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 208000005801 spondylosis Diseases 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
- A61F2/4465—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages having a circular or kidney shaped cross-section substantially perpendicular to the axis of the spine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
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Abstract
本发明涉及一种椎间融合器，该椎间融合器包括融合器主体，融合器主体包括上支撑部、下支撑部以及连接在上支撑部和下支撑部之间的中间支撑部，上支撑部与下支撑部之间具有缓冲槽，缓冲槽内嵌设有用于在上支撑部和下支撑部因受上下方向挤压力而发生变形时起支撑作用的柔性的嵌件。本发明在缓冲槽内嵌设柔性的嵌件，柔性的嵌件能够在上支撑部和下支撑部因上下方向挤压力而变形时，起到一定的支撑作用，同时保证上支撑部、下支撑部不会失去变形缓冲的功能，提高融合器的整体强度，起到抵抗下沉和防止移位的作用。
The present invention relates to an intervertebral fusion device. The intervertebral fusion device comprises a fusion device body. The fusion device body includes an upper support part, a lower support part and an intermediate support part connected between the upper support part and the lower support part. The upper support part There is a buffer groove between the upper support part and the lower support part, and the buffer groove is embedded with a flexible insert for supporting when the upper support part and the lower support part are deformed due to the pressing force in the up and down direction. In the present invention, a flexible insert is embedded in the buffer groove, and the flexible insert can play a certain supporting role when the upper support part and the lower support part are deformed due to the extrusion force in the up and down direction, and at the same time ensure that the upper support part, the lower support part The support part will not lose the function of deformation buffer, improve the overall strength of the fusion cage, and play a role in resisting sinking and preventing displacement.
Description
技术领域technical field
本发明涉及一种椎间融合器。The invention relates to an intervertebral fusion device.
背景技术Background technique
对于保守治疗无效的颈椎病患者，目前比较流行的方法是植骨融合术，由于植骨融合术容易造成供骨区疼痛，因此逐渐被融合器替代。For patients with cervical spondylosis who fail to respond to conservative treatment, bone graft fusion is currently the most popular method. Because bone graft fusion is likely to cause pain in the bone donor area, it is gradually replaced by cages.
如申请号为201410838729.6的中国发明专利申请公开的一种仿椎间盘脊椎融合器，该融合器包括直立的环形圆柱支架，即融合器主体，融合器主体的内部中间呈中空，形成一个植骨区，融合器主体内部填满芯层。该融合器植入后，椎内成骨细胞可在支架内芯的诱导下，进入支架内部贴附并增值，进而形成骨组织，诱导骨组织修复再生，实现椎间骨融合。For example, a Chinese invention patent application with the application number of 201410838729.6 discloses an imitation intervertebral disc spinal fusion device. The fusion device includes an upright circular cylindrical support, that is, the main body of the fusion device. The inside of the main body of the fusion device is hollow in the middle to form a bone grafting area. The interior of the fuser body is filled with the core layer. After the fusion device is implanted, intravertebral osteoblasts can be induced by the inner core of the stent, enter the stent, attach and increase in value, and then form bone tissue, induce bone tissue repair and regeneration, and achieve intervertebral bone fusion.
上述融合器主体设计成环形圆柱状结构，虽然具有强度高和稳定性好的优点，但是这种融合器主体的弹性缓冲能力较差。当人的椎体活动时，相邻两椎体会对两椎体之间的融合器主体产生负载，由于该融合器主体弹性缓冲能力较差，容易造成关节活动不灵活，同时造成融合器主体内部应力集中，进而造成下沉、移位等并发症的发生，而加速相邻节段退变。The fusion device body is designed as a ring-shaped cylindrical structure. Although it has the advantages of high strength and good stability, the elastic buffering capacity of the fusion device body is relatively poor. When the human vertebral body moves, the adjacent two vertebral bodies will generate loads on the main body of the fusion device between the two vertebral bodies. Due to the poor elastic cushioning capacity of the main body of the fusion device, it is easy to cause joint movement inflexibility, and at the same time cause the main body of the fusion device to be inflexible. The internal stress is concentrated, which in turn causes complications such as subsidence and displacement, and accelerates the degeneration of adjacent segments.
如申请号为201110049494.9的中国发明专利申请公开了一种具有柔韧性的椎间融合器，在其中一个实施例中，如图1所示，该融合器包括椭圆形的骨架2，即融合器主体，具有空心的中空截面。该融合器主体的截面呈“工”字型，其包括一上一下设置的第一支撑部12和第二支撑部14，第一、第二支撑部实质上由具有U字形的闭合截面的板簧结构构成，第一支撑部和第二支撑部均为具有弹性的弹性部。缓解向脊椎的上下方向作用的负载，第一、第二弹性部之间由中间支撑部进行连接。从图1中可以看出，第一弹性部的下侧和第二弹性部的上侧之间具有一个开口朝外的缓冲槽，为第一弹性部和第二弹性部提供可变形缓冲的空间。For example, the Chinese invention patent application with application number 201110049494.9 discloses a flexible intervertebral fusion device. In one embodiment, as shown in Figure 1, the fusion device includes an elliptical skeleton 2, namely the main body of the fusion device , has a hollow hollow section. The cross section of the main body of the fusion device is "I" shape, which includes a first support part 12 and a second support part 14 arranged one above the other, and the first and second support parts are substantially composed of a plate with a U-shaped closed section. The spring structure constitutes, and the first supporting part and the second supporting part are elastic parts with elasticity. The load acting in the vertical direction of the spine is relieved, and the first and second elastic parts are connected by the intermediate support part. As can be seen from Figure 1, there is a buffer groove with an opening facing outward between the lower side of the first elastic part and the upper side of the second elastic part, providing a deformable buffer space for the first elastic part and the second elastic part .
该融合器虽然具有较好的弹性缓冲能力，但是由于第一、第二弹性部的外缘部分处于悬空无支撑的状态，受上下挤压作用时第一弹性部和第二弹性部的外缘部分发生变形而相互靠近，在上下椎体的反复挤压作用下，容易两弹性部之间的缓冲槽越来越窄小，造成第一弹性部和第二弹性部的外缘部分朝缓冲槽内部塌陷，同样容易造成融合器下沉而移位等并发症的发生。Although the fusion device has better elastic cushioning capacity, since the outer edges of the first and second elastic parts are in a suspended state without support, the outer edges of the first elastic part and the second elastic part The parts are deformed and close to each other. Under the repeated extrusion of the upper and lower vertebral bodies, the buffer groove between the two elastic parts is easy to become narrower and smaller, causing the outer edge parts of the first elastic part and the second elastic part to move toward the buffer groove. Internal collapse is also likely to cause complications such as fusion cage sinking and displacement.
发明内容Contents of the invention
本发明的目的在于提供一种椎间融合器，用以解决现有技术中椎间融合器容易下沉、移位的技术问题。The object of the present invention is to provide an intervertebral fusion device to solve the technical problem that the intervertebral fusion device is easy to sink and shift in the prior art.
为实现上述目的，本发明一种椎间融合器的技术方案是：In order to achieve the above object, the technical scheme of a kind of intervertebral fusion device of the present invention is:
一种椎间融合器，包括融合器主体，融合器主体包括上支撑部、下支撑部以及连接在上支撑部和下支撑部之间的中间支撑部，上支撑部与下支撑部之间具有缓冲槽，缓冲槽内嵌设有用于在上支撑部和下支撑部因受上下方向挤压力而发生变形时起到支撑作用的柔性的嵌件。An intervertebral fusion device, comprising a fusion device main body, the fusion device main body includes an upper support part, a lower support part and an intermediate support part connected between the upper support part and the lower support part, and a The buffer groove is embedded with a flexible insert for supporting when the upper support part and the lower support part are deformed due to the pressing force in the up and down direction.
融合器主体的横截面呈“工”字型，所述缓冲槽为绕融合器主体周向延伸的环形槽，所述嵌件为环形嵌件。The cross section of the fuser body is "I"-shaped, the buffer groove is an annular groove extending around the circumference of the fuser body, and the insert is an annular insert.
上支撑部和下支撑部均为圆环形，中间支撑部为与上支撑部和下支撑部同轴设置的中空的圆柱，上支撑部和下支撑部中心的圆孔以及中间支撑部内部的中空部分形成贯穿融合器主体的植骨孔。Both the upper support part and the lower support part are ring-shaped, the middle support part is a hollow cylinder coaxially arranged with the upper support part and the lower support part, the round hole in the center of the upper support part and the lower support part and the inner part of the middle support part The hollow portion forms a bone graft hole that runs through the main body of the cage.
所述上支撑部和下支撑部均为实体板结构。Both the upper support part and the lower support part are of solid plate structure.
上支撑部的上侧面为平面，下支撑部的下侧面为平面。The upper side of the upper support part is a plane, and the lower side of the lower support part is a plane.
融合器主体为钛合金融合器主体。The fuser body is a titanium alloy fuser body.
所述嵌件为聚氨酯嵌件。The insert is a polyurethane insert.
本发明的有益效果是：本发明的椎间融合器包括上支撑部和下支撑部，上支撑部和下支撑部之间通过中间支撑部进行连接，上支撑部和下支撑部之间具有缓冲槽，缓冲槽为上支撑部和下支撑提供可变形缓冲的空间，缓冲沿上下方向的负载，不仅提高了关节灵活度，同时减小融合器内部的应力集中。在缓冲槽内嵌设柔性的嵌件，柔性的嵌件能够在上支撑部和下支撑部因上下方向挤压力而变形时，起到一定的支撑作用，同时保证上支撑部、下支撑部不会失去变形缓冲的功能，提高融合器的整体强度，起到抵抗下沉和防止移位的作用。The beneficial effects of the present invention are: the intervertebral fusion device of the present invention includes an upper support part and a lower support part, the upper support part and the lower support part are connected through an intermediate support part, and there is a buffer between the upper support part and the lower support part Groove, the buffer groove provides a deformable buffer space for the upper support part and the lower support, and buffers the load along the up and down direction, which not only improves the flexibility of the joint, but also reduces the stress concentration inside the fusion cage. A flexible insert is embedded in the buffer groove. The flexible insert can play a certain supporting role when the upper support part and the lower support part are deformed due to the extrusion force in the up and down direction, and at the same time ensure that the upper support part and the lower support part It will not lose the function of deformation buffer, improve the overall strength of the fusion cage, and play a role in resisting sinking and preventing displacement.
附图说明Description of drawings
图1为背景技术中一种椎间融合器的截面图；Fig. 1 is a sectional view of a kind of intervertebral fusion device in the background technology;
图2为本发明一种椎间融合器实施例1的整体结构示意图；Fig. 2 is a schematic diagram of the overall structure of Embodiment 1 of an intervertebral fusion device of the present invention;
图3为图2中融合器主体的结构示意图；Fig. 3 is a schematic structural view of the fuser main body in Fig. 2;
图4为图2中嵌件的结构示意图；Fig. 4 is a schematic structural view of the insert in Fig. 2;
图5为图2中植骨的结构示意图；Fig. 5 is the structural representation of bone graft in Fig. 2;
图6为本发明一种椎间融合器实施例2的截面示意图；6 is a schematic cross-sectional view of Embodiment 2 of an intervertebral fusion device of the present invention;
图7为本发明一种椎间融合器实施例3的截面示意图；7 is a schematic cross-sectional view of Embodiment 3 of an intervertebral fusion device of the present invention;
图8为本发明一种椎间融合器实施例4的截面示意图。Fig. 8 is a schematic cross-sectional view of Embodiment 4 of an intervertebral fusion device according to the present invention.
具体实施方式Detailed ways
下面结合附图对本发明的实施方式作进一步说明。Embodiments of the present invention will be further described below in conjunction with the accompanying drawings.
本发明的一种椎间融合器的具体实施例1，如图2至图5所示，该椎间融合器包括融合器主体1和柔性的嵌件2，融合器主体1和嵌件2的材质不同，融合器主体1为钛合金融合器主体，嵌件2为聚氨酯嵌件。融合器主体1包括上支撑部11、下支撑部12以及连接在上支撑部和下支撑部之间的中间支撑部13，上支撑部11的下侧和下支撑部12的上侧之间具有缓冲槽14，嵌件2嵌设在缓冲槽14内，对上、下支撑部起到支撑作用，实现抵抗下沉与防止移位的作用。优选地，融合器主体1的横截面为“工”字型，缓冲槽14为绕融合器主体周向延伸的环形槽，嵌件2为圆环状。上支撑部11和下支撑部12均为圆环形，且上支撑部和下支撑部均为实体板状结构。中间支撑部13为中空的圆柱体，上支撑部11、中间支撑部13和下支撑部12同轴设置，上支撑部11和下支撑部12中心的圆孔以及中间支撑部的中部内部形成上下贯穿融合器主体的植骨孔15，植骨孔15内用植骨3进行填充并压实，植骨3取自与人体松质骨弹性模量特征相同的同种异体松质骨。嵌件2具有弧形的外侧面和内侧面以及平面结构的上端面和下端面，嵌件2的上端面与上支撑部11的下侧面紧密粘接，嵌件2的下端面与下支撑部12的上侧面紧密粘接，使得嵌件2与融合器主体无缝连接，嵌件2的弧形外侧面与上支撑部、下支撑部的弧形外侧面半径相等并对齐。A specific embodiment 1 of an intervertebral fusion device of the present invention, as shown in Figures 2 to 5, the intervertebral fusion device includes a fusion device main body 1 and a flexible insert 2, and The materials are different, the cage body 1 is a titanium alloy cage body, and the insert 2 is a polyurethane insert. The fusion device main body 1 comprises an upper support part 11, a lower support part 12 and an intermediate support part 13 connected between the upper support part and the lower support part. The buffer groove 14, the insert 2 is embedded in the buffer groove 14, plays a supporting role for the upper and lower supporting parts, and realizes the functions of resisting subsidence and preventing displacement. Preferably, the cross section of the cage body 1 is "I"-shaped, the buffer groove 14 is an annular groove extending around the cage body, and the insert 2 is circular. Both the upper support part 11 and the lower support part 12 are annular, and both the upper support part and the lower support part are solid plate-shaped structures. The middle support part 13 is a hollow cylinder, the upper support part 11, the middle support part 13 and the lower support part 12 are coaxially arranged, and the round hole at the center of the upper support part 11 and the lower support part 12 and the middle part of the middle support part form an upper and lower The bone graft hole 15 that runs through the main body of the cage is filled and compacted with bone graft 3. The bone graft 3 is taken from allogeneic cancellous bone with the same elastic modulus characteristics as human cancellous bone. The insert 2 has an arc-shaped outer surface and an inner surface, and an upper end surface and a lower end surface of a planar structure. The upper side of 12 is tightly bonded, so that the insert 2 is seamlessly connected with the fuser main body, and the arc-shaped outer side of the insert 2 is equal in radius to and aligned with the arc-shaped outer sides of the upper support part and the lower support part.
本实施例中，上支撑部11的上侧面为平面结构，下支撑部12的下侧面为平面结构，当融合器植入时，在上下椎体之间连接钢板对融合器进行限位，阻止柔和器向脊椎的椎孔位置移动而触碰椎孔中的血管和神经。其它实施例中，上支撑部11的上侧面和下支撑部12的下侧面还可以为内凹的曲面，上支撑部的上侧和下支撑部的下侧还可以设置锯齿形凸起，防止融合器本体移动。In this embodiment, the upper side of the upper support part 11 is a planar structure, and the lower side of the lower support part 12 is a planar structure. When the fusion device is implanted, a steel plate is connected between the upper and lower vertebral bodies to limit the fusion device and prevent The softener moves toward the foramen of the spine to touch the blood vessels and nerves in the foramen. In other embodiments, the upper side of the upper support part 11 and the lower side of the lower support part 12 can also be concave curved surfaces, and the upper side of the upper support part and the lower side of the lower support part can also be provided with zigzag protrusions to prevent The fuser body moves.
本发明的一种椎间融合器的具体实施例2，与实施例1不同的是：中间支撑部的弧形外侧面上设有沿径向延伸的环形凸缘16，环形凸缘16的弧形外侧面与上支撑部和下支撑部的弧形外侧面半径相等，环形凸缘16将上支撑部11和下支撑部12之间的缓冲槽一分为二，两个缓冲槽沿中间支撑部的轴向间隔分布，每一个缓冲槽内均嵌设有环形的嵌件2。嵌件2的形状与实施例1中的嵌件形状相同。The specific embodiment 2 of an intervertebral fusion device of the present invention is different from embodiment 1 in that: an annular flange 16 extending radially is provided on the arc-shaped outer surface of the intermediate support part, and the arc of the annular flange 16 The outer surface of the shape is equal to the radius of the arc outer surface of the upper support part and the lower support part, and the buffer groove between the upper support part 11 and the lower support part 12 is divided into two by the annular flange 16, and the two buffer grooves are supported along the middle The axial intervals of the parts are distributed, and an annular insert 2 is embedded in each buffer groove. The shape of the insert 2 is the same as the shape of the insert in the first embodiment.
本发明的一种椎间融合器的具体实施例3，与实施例1不同的是：中间支撑部的弧形外侧面上设有沿径向延伸的环形凸缘16，环形凸缘16的弧形外侧面半径小于上支撑部和下支撑部的弧形外侧面的半径，这样环形凸缘16位于缓冲槽的内部。嵌件2为圆环形，嵌件2的内侧壁上开设有与环形凸缘16相匹配的凹槽，嵌件2的横截面呈“凹”字型，环形凸缘嵌入凹槽内。The specific embodiment 3 of an intervertebral fusion device of the present invention is different from embodiment 1 in that: an annular flange 16 extending radially is provided on the arc-shaped outer surface of the intermediate support part, and the arc of the annular flange 16 The radius of the outer surface of the shape is smaller than the radius of the arc outer surfaces of the upper support part and the lower support part, so that the annular flange 16 is located inside the buffer groove. The insert 2 is circular, and the inner side wall of the insert 2 is provided with a groove matching the annular flange 16. The cross section of the insert 2 is "concave", and the annular flange is embedded in the groove.
本发明的一种椎间融合器的具体实施例4，与实施例3不同的是：中间支撑部的弧形外侧面上沿轴向间隔设置有两个环形凸缘16，嵌件2的内侧壁上沿轴向间隔设置有两个凹槽，各环形凸缘分别嵌入到对应的凹槽内。The specific embodiment 4 of an intervertebral fusion device of the present invention is different from embodiment 3 in that: two annular flanges 16 are arranged at intervals along the axial direction on the arc-shaped outer surface of the middle support part, and the inner side of the insert 2 Two grooves are arranged at intervals along the axial direction on the wall, and each annular flange is respectively embedded in the corresponding groove.
在其它实施例中，嵌件还可以由其它柔性的生物医学材料制成。上支撑部和下支撑部可以不是实心板状，还可以为横截面为U型的圆环形板簧结构。上支撑部和下支撑部还可以为椭圆形或者大半圆形或者长方形，中间支撑部还可以为中空的立方柱，或者竖直的板状结构，竖直板内部开设有穿孔，用于植骨。当中间支撑部为竖直板状时，上支撑部和下支撑部之间的缓冲槽不是环形槽，缓冲槽为对称设置在竖直板两侧的直槽，嵌件为块状的嵌件。In other embodiments, the insert can also be made of other flexible biomedical materials. The upper support part and the lower support part may not be solid plates, but may also be circular leaf spring structures with a U-shaped cross section. The upper support part and the lower support part can also be oval or large semicircular or rectangular, and the middle support part can also be a hollow cubic column, or a vertical plate-like structure, and the inside of the vertical plate is provided with perforations for bone grafting . When the middle support part is a vertical plate, the buffer groove between the upper support part and the lower support part is not an annular groove, the buffer groove is a straight groove symmetrically arranged on both sides of the vertical plate, and the insert is a block-shaped insert .
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| CN202069721U (en) * | 2009-03-20 | 2011-12-14 | 姚庆强 | Integrally-woven artificial lumbar intervertebral prothesis of hard end plates and soft nucleus pulposus |
| CN102462562A (en) * | 2010-10-28 | 2012-05-23 | 朴庆佑 | Intervertebral cage having flexibility |
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| BR0215928A (en) * | 2002-10-28 | 2005-08-09 | Mathys Medizinaltechnik Ag | Intervertebral disc prosthesis or artificial vertebra |
| ES2341248T3 (en) * | 2004-04-02 | 2010-06-17 | Synthes Gmbh | INTERESTTEBRAL DISK PROTECTION OR ARTIFICIAL VERTEBRA. |
| ES2373980T3 (en) * | 2007-07-26 | 2012-02-10 | Biedermann Motech Gmbh | INTERVERTEBRAL DISK PROSTHESIS. |
| CN201108513Y (en) * | 2007-10-30 | 2008-09-03 | 冠亚国际科技股份有限公司 | Vertebra filling block |
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| CN102475584B (en) * | 2010-11-30 | 2017-04-12 | 宝亿生技股份有限公司 | Vertebral column filling block structure |
| CN104083235A (en) * | 2014-07-11 | 2014-10-08 | 嘉兴德康医疗器械有限公司 | Moldable individual spine fusion device |
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