CN104014811A - Method for manufacturing coralline nanometer cobalt by using octreotide acetate as a template - Google Patents
Method for manufacturing coralline nanometer cobalt by using octreotide acetate as a template Download PDFInfo
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- CN104014811A CN104014811A CN201410234741.6A CN201410234741A CN104014811A CN 104014811 A CN104014811 A CN 104014811A CN 201410234741 A CN201410234741 A CN 201410234741A CN 104014811 A CN104014811 A CN 104014811A
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- Prior art keywords
- octreotide acetate
- cobalt
- solution
- template
- octreotide
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- 108010016076 Octreotide Proteins 0.000 title claims abstract description 42
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 title claims abstract description 40
- 229910017052 cobalt Inorganic materials 0.000 title claims abstract description 34
- 239000010941 cobalt Substances 0.000 title claims abstract description 34
- 229960001494 octreotide acetate Drugs 0.000 title claims abstract description 31
- 238000000034 method Methods 0.000 title claims abstract description 12
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 title claims description 32
- 238000004519 manufacturing process Methods 0.000 title description 5
- 239000002245 particle Substances 0.000 claims abstract description 26
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 12
- GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical compound [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 claims abstract description 12
- 229960002700 octreotide Drugs 0.000 claims abstract description 11
- 239000003638 chemical reducing agent Substances 0.000 claims abstract description 7
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 claims description 10
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 5
- 229910000085 borane Inorganic materials 0.000 claims description 5
- 229910000104 sodium hydride Inorganic materials 0.000 claims description 5
- 239000012312 sodium hydride Substances 0.000 claims description 5
- -1 octreotide acetates Chemical class 0.000 claims description 3
- 230000012447 hatching Effects 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 8
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 239000000243 solution Substances 0.000 abstract 2
- 239000003929 acidic solution Substances 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 6
- 230000005540 biological transmission Effects 0.000 description 3
- 238000012512 characterization method Methods 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- 239000002105 nanoparticle Substances 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000005979 thermal decomposition reaction Methods 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000011553 magnetic fluid Substances 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000000593 microemulsion method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Manufacture Of Metal Powder And Suspensions Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
一种利用醋酸奥曲肽为模板制备珊瑚状纳米钴的方法，其主要是用pH2～3盐酸溶解醋酸奥曲肽，将醋酸奥曲肽调节成酸性溶液，再按摩尔比1:10～20比例向上述调解好的溶液中加入氯化钴溶液，并将其放入水浴恒温振荡器中，于100～200rpm.，13～25℃下孵育20～26h；然后一次性向上述孵育好的溶液中加入与氯化钴摩尔比为1:25～35的还原剂硼氢化钠，使其从淡粉色变为深黑色，该深黑色产物即为醋酸奥曲肽-纳米钴粒子。本发明具有制备工艺简单、条件温和，廉价易得，反应易于控制，产率高等优点。A method for preparing coral-like nano-cobalt using octreotide acetate as a template, which mainly dissolves octreotide acetate with hydrochloric acid with pH 2 to 3, adjusts octreotide acetate into an acidic solution, and then transfers the octreotide acetate to the above-mentioned mediation in a molar ratio of 1:10 to 20. Add cobalt chloride solution to the solution, put it into a constant temperature shaker in a water bath, incubate at 100-200rpm, 13-25°C for 20-26h; then add cobalt chloride mole Sodium borohydride, a reducing agent with a ratio of 1:25-35, makes it change from light pink to dark black, and the dark black product is octreotide acetate-nano-cobalt particles. The invention has the advantages of simple preparation process, mild conditions, cheap and easy to obtain, easy to control reaction, high yield and the like.
Description
Technical field
The invention belongs to nano metal material technical field, particularly a kind of preparation method of nano material.
Background technology
Nanometer cobalt particle has many purposes at industrial circles such as electronics industry, magnetic, carbide alloy, surface spraying, chemical catalysis as high-performance magnetism recording materials, magnetic fluid, absorbing material, activated sintering additive etc.
The preparation method of nanometer cobalt particle has thermal decomposition method, precipitation-thermal decomposition method, hydrogen reduction method, microemulsion method etc.Some technical requirement of above-mentioned preparation method is high, apparatus expensive, and some complex process, environmental pollution is larger, and the reaction time that some need to be longer, higher temperature and pressure and special device anyway, cause production cost higher.In recent years, what the method for preparing nanometer cobalt was comparatively active is liquid phase reduction, but the nano cobalt granule particle diameter of existing liquid phase reduction preparation technology gained is larger, particle diameter wider distribution, and products therefrom is easily reunited, and is difficult to extensive use.
Summary of the invention
The octreotide acetate that utilizes that the object of the present invention is to provide that a kind of preparation cost is cheap, pollution-free, technique is simple, controlled is prepared the method for coralloid nano cobalt for template, solves that liquid phase reduction can not make that particle diameter is little, a difficult problem for good dispersion and the single nano cobalt granule of composition.The present invention is mainly that employing octreotide acetate molecule is template, perfect and the strict molecular recognition function of utilizing biomolecule to have, by physico-chemical process according to designing requirement at its surperficial avtive spot located growth nano particle, architectural feature and the space confinement effect thereof of biomolecule self can accurately be controlled the size of nano particle and pattern simultaneously, thereby obtain the coralloid nano cobalt particle of expection.
Technical scheme of the present invention is as follows:
(1) get octreotide acetate, taking every milliliter of pH value as 2～3 hydrochloric acid solutions dissolve 0.4～0.8mg octreotide acetates, be mixed with pH value and be 0.4～0.8mM acidity octreotide acetate solution of 2～3;
(2) in the octreotide acetate solution that 1:10～20 ratio has been reconciled to step (1) in molar ratio, add cobalt chloride solution, preferably add the cobalt chloride solution with octreotide acetate solution phase same volume, and put it in water-bath constant temperature oscillator, in 100～200rpm., hatch 20～26h at 13～25 DEG C;
(3) in the solution of dropwise hatching to step (2), the disposable borane reducing agent sodium hydride that to add with cobalt chloride mol ratio be 1:25～35, makes it become aterrimus from pale pink, and this aterrimus product is octreotide acetate-nanometer cobalt particle.
The present invention compared with prior art tool has the following advantages:
1, to adopt octreotide acetate be template in the present invention, its molecular formula is H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-OL (Cys2-Cys7), its molecular structure is simple, active group is clear, be easy to analysis and control, and pass through electrostatic interaction, object ion is easy to be adsorbed onto the surface-active site of octreotide acetate, by controlling reduction rate and reducing degree, and then the nanometer cobalt particle of generation pattern rule, so octreotide acetate has the characteristic of the good biological template of the nanometer cobalt particle of preparing homogeneous.
2, the good dispersion of prepared coralliform cobalt nanoparticle, pattern typical case, form rule, structure are controlled.
3, preparation technology is simple, mild condition, and preparation cost is cheap, course of reaction is easy to control, and is easy to obtain expected results, to equipment require low.
4, the reducing agent, reaction medium and the reactant price that adopt are low, pollution-free.
Brief description of the drawings
Fig. 1 is the TEM figure of octreotide acetate-nanometer cobalt particle of obtaining of the embodiment of the present invention 1.
Fig. 2 is the TEM figure of octreotide acetate-nanometer cobalt particle of obtaining of the embodiment of the present invention 2.
Fig. 3 is the EDS figure of octreotide acetate-nanometer cobalt particle of obtaining of the embodiment of the present invention 2.
Fig. 4 is the TEM figure of octreotide acetate-nanometer cobalt particle of obtaining of the embodiment of the present invention 3.
Detailed description of the invention
Embodiment 1
The octreotide acetate (the biochemical Shanghai of gill Co., Ltd produces) of getting 0.4mg, is dissolved in the hydrochloric acid solution of 1mLpH2, and the pH value that makes octreotide acetate solution is 2; Get above-mentioned octreotide acetate solution 200 μ L, add the cobalt chloride solution (West Asia, Shanghai reagent Co., Ltd) of 200 μ L4mM; The above-mentioned solution preparing is put into water-bath constant temperature oscillator, in 100rpm., at 13 DEG C, hatch after 26h, the disposable 50mM of adding borane reducing agent sodium hydride (production of Beijing Zhong Sheng Hua Teng Science and Technology Ltd.) 80 μ L reduce, make it become aterrimus from pale pink, obtain octreotide acetate-nanometer cobalt particle.
Application transmission electron microscope carries out morphology characterization to coralloid nano cobalt particle, and as shown in Figure 1, the diameter of coralloid nano cobalt particle is 55nm left and right, and pattern rule, is evenly distributed.
Embodiment 2
The octreotide acetate (the biochemical Shanghai of gill Co., Ltd produces) of getting 0.6mg, is dissolved in the hydrochloric acid solution of 1mLpH2.5, and the pH value that makes octreotide acetate solution is 2.5; Get above-mentioned octreotide acetate solution 200 μ L, add the cobalt chloride solution (West Asia, Shanghai reagent Co., Ltd) of 200 μ L6mM; The above-mentioned solution preparing is put into water-bath constant temperature oscillator, in 150rpm., at 20 DEG C, hatch after 24h, the disposable 40mM of adding borane reducing agent sodium hydride (production of Beijing Zhong Sheng Hua Teng Science and Technology Ltd.) 90 μ L reduce, make it become aterrimus from pale pink, obtain octreotide acetate-nanometer cobalt particle.
Application transmission electron microscope carries out morphology characterization to coralloid nano cobalt particle, and as shown in Figure 2, the diameter of coralloid nano cobalt particle is 60-70nm left and right, and pattern rule, is evenly distributed.
Application energy disperse spectroscopy characterizes coralloid nano cobalt particle, as inscribe as shown in the of 3, in power spectrum, there is Co, C, O, the peak that Cl element is corresponding, description taken in conjunction is cobalt at the metallic element on octreotide acetate surface, and O element is the element in albumen, and C element is the element in copper mesh, in addition in albumen, also can there are some C elements, illustrate that octreotide acetate is combined well with cobalt particle, and purity is very high, Cl element carrys out not cobalt chloride thoroughly of autoreduction.
Embodiment 3
The octreotide acetate (the biochemical Shanghai of gill Co., Ltd produces) of getting 0.8mg, is dissolved in the hydrochloric acid solution of 1mLpH3, and the pH value that makes octreotide acetate solution is 3; Get above-mentioned octreotide acetate solution 200 μ L, add the cobalt chloride solution (West Asia, Shanghai reagent Co., Ltd) of 200 μ L8mM; The above-mentioned solution preparing is put into water-bath constant temperature oscillator, in 200rpm., at 25 DEG C, hatch after 20h, the disposable 32mM of adding borane reducing agent sodium hydride (production of Beijing Zhong Sheng Hua Teng Science and Technology Ltd.) 100 μ L reduce, make it become aterrimus from pale pink, obtain octreotide acetate-nanometer cobalt particle.
Application transmission electron microscope carries out morphology characterization to coralloid nano cobalt particle, and as shown in Figure 4, the diameter of coralloid nano cobalt particle is 40-50nm left and right, and pattern rule, is evenly distributed.
Claims (2)
1. utilize octreotide acetate to prepare the method for coralloid nano cobalt for template, it is characterized in that:
(1) get octreotide acetate, taking every milliliter of pH value as 2～3 hydrochloric acid solutions dissolve 0.4～0.8mg octreotide acetates, be mixed with pH value and be 0.4～0.8mM acidity octreotide acetate solution of 2～3;
(2) in the solution that 1:10～20 ratio has been reconciled to step (1) in molar ratio, add cobalt chloride solution, and put it in water-bath constant temperature oscillator, in 100～200rpm., hatch 20～26h at 13～25 DEG C;
(3) the borane reducing agent sodium hydride that to add with cobalt chloride mol ratio in disposable solution of hatching to step (2) be 1:25～35, makes it become aterrimus from pale pink, can obtain the good coralloid nano cobalt particle of monodispersity.
2. the octreotide acetate that utilizes according to claim 1 is prepared the method for coralloid nano cobalt for template, it is characterized in that: preferably add the cobalt chloride solution with octreotide acetate solution phase same volume.
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| CN201410234741.6A CN104014811B (en) | 2014-05-29 | 2014-05-29 | A kind of octreotide acetate that utilizes is for the method for Template preparation coralloid nano cobalt |
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Cited By (17)
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| CN105312591A (en) * | 2015-11-13 | 2016-02-10 | 燕山大学 | Method for preparing annular platinum nanoparticles with lanreotide acetate serving as template |
| WO2016049138A1 (en) * | 2014-09-23 | 2016-03-31 | Attostat, Inc. | Fuel additive composition and related method |
| US9434006B2 (en) | 2014-09-23 | 2016-09-06 | Attostat, Inc. | Composition containing spherical and coral-shaped nanoparticles and method of making same |
| US9839652B2 (en) | 2015-04-01 | 2017-12-12 | Attostat, Inc. | Nanoparticle compositions and methods for treating or preventing tissue infections and diseases |
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| US9849512B2 (en) | 2011-07-01 | 2017-12-26 | Attostat, Inc. | Method and apparatus for production of uniformly sized nanoparticles |
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| US9883670B2 (en) | 2014-09-23 | 2018-02-06 | Attostat, Inc. | Compositions and methods for treating plant diseases |
| US9885001B2 (en) | 2014-09-23 | 2018-02-06 | Attostat, Inc. | Fuel additive composition and related methods |
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| US9434006B2 (en) | 2014-09-23 | 2016-09-06 | Attostat, Inc. | Composition containing spherical and coral-shaped nanoparticles and method of making same |
| US9839652B2 (en) | 2015-04-01 | 2017-12-12 | Attostat, Inc. | Nanoparticle compositions and methods for treating or preventing tissue infections and diseases |
| US10953043B2 (en) | 2015-04-01 | 2021-03-23 | Attostat, Inc. | Nanoparticle compositions and methods for treating or preventing tissue infections and diseases |
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| US10774429B2 (en) | 2015-04-13 | 2020-09-15 | Attostat, Inc. | Anti-corrosion nanoparticle compositions |
| CN105312591A (en) * | 2015-11-13 | 2016-02-10 | 燕山大学 | Method for preparing annular platinum nanoparticles with lanreotide acetate serving as template |
| US10201571B2 (en) | 2016-01-25 | 2019-02-12 | Attostat, Inc. | Nanoparticle compositions and methods for treating onychomychosis |
| CN106735289B (en) * | 2016-11-30 | 2018-09-04 | 燕山大学 | A method of preparing cubic silver nanoparticle box by template of octreotide acetate |
| US11018376B2 (en) | 2017-11-28 | 2021-05-25 | Attostat, Inc. | Nanoparticle compositions and methods for enhancing lead-acid batteries |
| US11646453B2 (en) | 2017-11-28 | 2023-05-09 | Attostat, Inc. | Nanoparticle compositions and methods for enhancing lead-acid batteries |
| US12119456B2 (en) | 2017-11-28 | 2024-10-15 | Evoq Nano, Inc. | Nanoparticle compositions and methods for enhancing lead-acid batteries |
| US12115250B2 (en) | 2019-07-12 | 2024-10-15 | Evoq Nano, Inc. | Use of nanoparticles for treating respiratory infections associated with cystic fibrosis |
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| US12610952B2 (en) | 2022-08-01 | 2026-04-28 | Evoq Nano, Inc. | Antimicrobial compositions and methods |
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