CN103053530B - Bactericidal composition of propamidine and fluazinam - Google Patents

Abstract

The invention discloses a bactericidal composition of propamidine and fluazinam. The bactericidal composition comprises commonly used auxiliary agents, propamidine and fluazinam. Mass part ratio of propamidine and fluazinam in the composition is 5:1-1:45, and preferably 3:1-1:25. When propamidine and fluazinam are compounded, a substantial synergetic effect is provided. Effective component dose of the compounded agent is substantially reduced than that of separate use. The composition provided by the invention is suitable to be used against crop gray mold caused by botrytis pathogen and crop stalk break casued by sclerotinia pathogen.

Description

Fungicidal composition of propaneamidine and fluazinam

technical field

The fungicidal composition of the present invention uses propaneamidine and fluazinam as active ingredients, and is suitable for preventing and treating botrytis cinerea caused by botrytis and crop sclerotinia caused by sclerotinia.

Background technique

Propanamidine, English common name propamidine, 1,3-bis(4-amidinophenoxy) propane. Propanamidine is a broad-spectrum fungicide with protective and therapeutic effects, and has outstanding control effects on crop gray mold caused by botrytis and sclerotinia caused by sclerotinia.

Fluazinam, English common name fluazinam, chemical name 3-chloro-N-(3-chloro-5-trifluoromethyl-2-pyridyl)-α,α,α-trifluoro-2,6-dinitrate base-p-toluidine. Fluazinam is a protective fungicide. The current commercial dosage form is suspension concentrate, and the main method of use is to spray stems, leaves and soil.

Sclerotinia sclerotiorum mainly causes sclerotinia of various crops; Botrytis cinerea mainly causes botrytis cinerea of various crops.

So far, there is no report on the combination of propamidine and fluazinam.

Contents of the invention

The object of the present invention is to provide a bactericidal composition with high efficiency, low toxicity, low residue, good environmental compatibility and low cost, whose active ingredients are propaneamidine and fluazinam.

The present invention is achieved through the following technical solutions: a bactericidal composition, the active ingredients are propaneamidine and fluazinam, the mass ratio of propaneamidine and fluazinam in the composition is 5:1-1:45, preferably 3 :1～1:25, the total mass percentage of propaneamidine and fluazinam in the composition is 3%～90%.

Add auxiliary agents and excipients to the bactericidal composition to prepare suspension concentrate, water dispersible granule and wettable powder according to the production process well known to those skilled in the art.

The fungicidal composition of the invention is used for preventing and treating botrytis cinerea and crop sclerotinia caused by pathogens of the genus Botrytis.

Advantages of the present invention: the bactericidal composition containing propaneamidine and fluazinam of the present invention, compared with a single product, has the characteristics of a binary bactericidal composition, expands the range of effective activity, and is effective against various types of bacteria caused by Sclerotinia sclerotiorum Plant sclerotinia; all kinds of crop gray mold caused by Botrytis cinerea have good control effect, and delay the emergence of drug resistance, long-lasting effect, reduce the dosage and frequency of use, save cost, easy to use, Save time and labor, and reduce environmental pollution.

Detailed ways

The present invention is illustrated by the following specific examples, but the present invention is not limited to the following specific examples. In these examples, all percentages are by weight unless otherwise indicated.

Formulation Example 1 : 30% propaneamidine·fluazinam suspension concentrate.

Propanamidine 2%, fluazinam 28%, emulsifier 1601# 10%, wetting agent LS 5%, dispersant SOPA-270 3%, thickener bentonite 2%, stabilizer xanthan gum 0.5%, disinfectant Foam agent silicone 0.4%, antifreeze agent glycerin 5%, deionized water to make up to 100%. The above formula is pre-crushed according to the proportion, then added to a sand mill for grinding, and then prepared after high-shear mixing to prepare a 30% propaneamidine·fluazinam suspension concentrate.

Formulation Example 2 : 20% propaneamidine·fluazinam suspension concentrate.

Propanamidine 6%, fluazinam 14%, emulsifier tristyrylphenol polyoxyethylene polyoxypropylene ether 12%, wetting agent calcium dodecylbenzenesulfonate 5%, dispersant alkylphenol polyoxyethylene Ether formaldehyde condensate sulfate 3%, stabilizer gum arabic 0.1%, antifreeze agent glycerin 5%, deionized water to make up to 100%. The above formula is pre-crushed according to the proportion, then added to a sand mill for grinding, and then prepared after high-shear mixing to prepare a 20% propaneamidine·fluazinam suspension concentrate.

Formulation Example 3 : 60% propaneamidine·fluazinam water-dispersible granules.

Propanamidine 5%, fluazinam 55%, wetting agent sodium lauryl sulfate 6%, dispersant lignosulfonate 4%, disintegrant urea 2%, binder polyethylene glycol 3%, Stabilizer soluble starch 3%, kaolin supplemented to 100%. The above formula is dry crushed, granulated, dried and sieved according to the proportion to prepare 60% propaneamidine·fluazinam water dispersible granules.

Formulation Example 4 : 50% propaneamidine·fluazinam water-dispersible granules.

Propanamidine 3%, fluazinam 47%, wetting agent saponin powder 6%, dispersant sodium naphthalenesulfonate formaldehyde condensate 4%, disintegrant bentonite 2%, binder cyclodextrin 2%, stabilizer Soluble starch 3%, kaolin supplemented to 100%. The above formula is dry pulverized, granulated, dried and sieved according to the proportion to prepare 50% propaneamidine·fluazinam water dispersible granules.

Formulation Example 5 : 50% propaneamidine·fluazinam wettable powder.

Propanamidine 1%, fluazinam 49%, wetting agent pull-off powder 3%, dispersant lignosulfonate 6%, filler talc 15%, filler kaolin make up to 100%. The above formula is coarsely pulverized in proportion, put into a mixer and mixed evenly, and then jet pulverized to obtain 50% propaneamidine·fluazinam wettable powder.

Formulation Example 6 : 40% propaneamidine·fluazinam wettable powder.

Propanamidine 2%, fluazinam 38%, wetting agent pull-off powder 3%, dispersant dodecylphenol polyvinyl ether sulfonate 5%, filler white carbon black 3%, kaolin make up to 100%. The above formula is coarsely pulverized in proportion, put into a mixer and mixed evenly, and then jet pulverized to obtain 40% propaneamidine·fluazinam wettable powder.

Biological Assay Example 1: Indoor virulence assay of Sclerotinia sclerotiorum combined with propaneamidine and fluazinam.

Table 1. Indoor toxicity test results of Sclerotinia sclerotiorum combined with propamidine and fluazinam.

As can be seen from Table 1, propaneamidine and fluazinam bactericidal composition of the present invention have higher synergism to sclerotinia, propaneamidine and fluazinam 3:1,1:1,1:3,1: 9. The synergistic effect of 1:25 is obvious, and the co-toxicity coefficient is greater than 140. Other ratios show different degrees of synergistic effect.

Biological Assay Example 2 : Field efficacy test on lettuce sclerotinia.

This test was carried out in Futian Town, Boluo County, Huizhou City, Guangdong Province in March 2012. The spray was uniformly sprayed with 45 kg of water per mu, and the pesticide was applied once. The control effect after 7 days of spraying is shown in Table 2.

Table 2. Results of field efficacy tests on lettuce sclerotinia.

As can be seen from Table 2, the bactericidal composition mixed with propaneamidine and fluazinam has a good control effect on lettuce sclerotinia. It was found in the test that the composition is safe to lettuce, and it can reach 7 days after the medicine. Ideal control effect.

Biological Assay Example 3: Field efficacy test against Botrytis cinerea.

This test was carried out in Liangzhuang Town, Yuedai District, Tai'an City, Shandong Province in April 2012. The spray was uniformly sprayed with 45kg of water per mu, and the pesticide was applied once. The control effect after 7 days of spraying is shown in Table 3.

Table 3. Results of field efficacy tests on tomato gray mold.

As can be seen from Table 3, the fungicidal composition of propaneamidine and fluazinam has a good control effect on tomato gray mold. It was found in the test that the composition is safe to tomatoes, and the ideal control effect can be achieved 7 days after the application. effect.

Biological Assay Example 4: Field efficacy test on Sclerotinia sclerotiorum.

This test was carried out in Fangji Town, Funan County, Anhui Province in April 2012. The spray was uniformly sprayed with 45kg of water per mu, and the pesticide was applied once. The control effect after 7 days of spraying is shown in Table 4.

Table 4. Results of field efficacy tests on Sclerotinia sclerotiorum.

It can be seen from Table 4 that the bactericidal composition compounded by propaneamidine and fluazinam has a good control effect on rape sclerotinia. It was found in the test that the composition is safe to rape, and it can reach 7 days after application. Ideal anti-efficacy.

In summary, the fungicidal composition compounded by propaneamidine and fluazinam has good control effect on crop sclerotinia caused by pathogens of Sclerotinia genus and botrytis cinerea caused by pathogens of Botrytis genus, Safe for crops and friendly to the environment. Compared with a single dose, the frequency of medication is reduced and the cost is saved. Therefore research and development of the present invention and popularization are of great significance.

Claims (4)

1. A bactericidal composition of propaneamidine and fluazinam, characterized in that: the active ingredients are propaneamidine and fluazinam; the mass ratio of propaneamidine and fluazinam in the composition is 3:1～1:25 . 2. The bactericidal composition of propaneamidine and fluazinam according to claim 1, characterized in that: the bactericidal composition also contains auxiliary components of pesticide preparations. 3. The bactericidal composition of propaneamidine and fluazinam according to claim 1, characterized in that: its dosage form is suspension concentrate, water dispersible granule or wettable powder. 4. the application of the bactericidal composition of propaneamidine and fluazinam according to claim 1 in the control of botrytis cinerea caused by botrytis pathogens, crop sclerotinia caused by sclerotinia pathogens .