CN100522175C - Sustained release tablet of oleanolic acid and its preparation method - Google Patents
Sustained release tablet of oleanolic acid and its preparation method Download PDFInfo
- Publication number
- CN100522175C CN100522175C CN 200410044333 CN200410044333A CN100522175C CN 100522175 C CN100522175 C CN 100522175C CN 200410044333 CN200410044333 CN 200410044333 CN 200410044333 A CN200410044333 A CN 200410044333A CN 100522175 C CN100522175 C CN 100522175C
- Authority
- CN
- China
- Prior art keywords
- oleanolic acid
- slow releasing
- releasing tablet
- preparation
- slow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 title claims abstract description 38
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 title claims abstract description 38
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 title claims abstract description 38
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 title claims abstract description 38
- 229940100243 oleanolic acid Drugs 0.000 title claims abstract description 38
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000007939 sustained release tablet Substances 0.000 title abstract 2
- 239000000314 lubricant Substances 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 10
- 239000004094 surface-active agent Substances 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims description 14
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 8
- 238000007907 direct compression Methods 0.000 claims description 8
- 239000000945 filler Substances 0.000 claims description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 7
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 7
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 7
- 238000005303 weighing Methods 0.000 claims description 7
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 6
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 6
- 229960003943 hypromellose Drugs 0.000 claims description 6
- 239000008101 lactose Substances 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 239000001856 Ethyl cellulose Substances 0.000 claims description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 5
- 229920001249 ethyl cellulose Polymers 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims description 4
- 238000005469 granulation Methods 0.000 claims description 4
- 230000003179 granulation Effects 0.000 claims description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 4
- 229940045902 sodium stearyl fumarate Drugs 0.000 claims description 4
- 239000004925 Acrylic resin Substances 0.000 claims description 2
- 229920000178 Acrylic resin Polymers 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- -1 Stepanol MG Chemical compound 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 238000005550 wet granulation Methods 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000002156 mixing Methods 0.000 abstract description 8
- 239000004067 bulking agent Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 description 5
- 229920003134 Eudragit® polymer Polymers 0.000 description 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 206010008909 Chronic Hepatitis Diseases 0.000 description 2
- 229920003156 Eudragit® RL PO Polymers 0.000 description 2
- 229920003160 Eudragit® RS PO Polymers 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 229960001375 lactose Drugs 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 1
- 108010082126 Alanine transaminase Proteins 0.000 description 1
- 229920003155 Eudragit® RL 100 Polymers 0.000 description 1
- 229920003157 Eudragit® RL 30 D Polymers 0.000 description 1
- 229920003159 Eudragit® RS 100 Polymers 0.000 description 1
- 229920003161 Eudragit® RS 30 D Polymers 0.000 description 1
- 206010019799 Hepatitis viral Diseases 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229960004667 ethyl cellulose Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 150000002966 pentacyclic triterpenoids Chemical class 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to a sustained release tablet of oleanolic acid and its preparation method, wherein the preparation comprises micronized oleanolic acid, slow release material, bulking agent, surface active agent and lubricating agent, the preparing process comprises mixing the micronized oleanolic acid, slow release material, bulking agent, surface active agent, lubricating agent according to a finite proportion, finally employing direct tabletting technique or wet process tabletting method then tabletting.
Description
Technical field
The invention belongs to pharmaceutical preparation, relate to a kind of slow release formulation that is applicable to acute, chronic hepatitis, specifically relate to slow releasing tablet of oleanolic acid and preparation method thereof.
Background technology
(Oleanolic Acid OA) is pentacyclic triterpenoid to oleanolic acid, is distributed widely in plant kingdom, is a kind of natural product chemistry composition.This product has the certain protection effect to hepatic injury, and the serum alanine aminotransferase of rising is descended, and promotes liver cell regeneration, quickens the reparation of slough.It is treatment acute icterohepatitis and the more satisfactory medicine of chronic viral hepatitis, and the low side effect of toxicity is few.
China is at present commercially available has only oleanolic acid ordinary tablet and capsule, and dosage form is single.Because oleanolic acid is fat-soluble by force, the dissolution of its preparation is low, causes the absorption by human body availability poor, and this has influenced giving full play to of its curative effect greatly.On the other hand, oleanolic acid tablet and capsule all needed take medicine in one three times, and this hepatopath to the need long-term prescription has increased a lot of troubles undoubtedly.
Summary of the invention
The objective of the invention is provides slow releasing tablet of a kind of oleanolic acid and preparation method thereof in order to overcome above-mentioned the deficiencies in the prior art.Its only needed take medicine once in one, just can continue 24 hours curative effects, can be used as the liver-protective good medicine of efficient, safety, low toxicity, long-acting, taking convenience.
Pharmaceutical formulation of the present invention is composed of the following components by weight percentage:
A, oleanolic acid 10～75%
B, slow-release material 5～50%
C, filler 15～80%
D, surfactant 0～2%
E, lubricant 0.1～5%
Preparation of the present invention uses the direct compression prepared, also can use tablet forming technique preparation behind the wet granulation.Concrete preparation method is as described below:
(1) direct compression technology:
Principal agent, slow-release material, filler, surfactant are taken by weighing respectively according to quantity.Cross 80 mesh sieve mixings, add again behind the lubricant mixing, promptly get the oleanolic acid slow releasing tablet by the standard quantity tabletting.
(2) wet granule compression tablet technology:
Principal agent, slow-release material, filler, the surfactant amount of connecing are taken by weighing respectively.Cross 80 mesh sieve mixings, with 50～70% alcohol granulations, 60 ℃ of dry back granulate are pressed the standard quantity tabletting behind the adding lubricant mixing, promptly get the oleanolic acid slow releasing tablet.
Principal agent is selected oleanolic acid for use in the slow releasing tablet of the present invention, and its particle diameter is 48～150um, preferred 70～120um.
Slow-release material can be selected one of hypromellose (HPMC), ethyl cellulose (EC), Aquacoat (Surelease), acrylic resin (Eudragit RS100, Eudragit RL100, Eudragit RS30D, Eudragit RL30D, Eudragit RS PO, Eudragit RL PO, Eudragit NE30) or their mixture in the slow releasing tablet of the present invention.
Filler can be selected microcrystalline Cellulose (MCC), lactose, starch, calcium hydrogen phosphate or their mixture in the slow releasing tablet of the present invention.
Optional polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, the sucrose stearate selected of surfactant in the slow releasing tablet of the present invention.
Lubricant can be selected micropowder silica gel, Pulvis Talci, magnesium stearate, Stepanol MG, sodium stearyl fumarate, sucrose stearate etc. for use in the slow releasing tablet of the present invention.
Slow releasing tablet of the present invention only needed take medicine once in one as the ideal medicament of treatment acute, chronic hepatitis, with existing that preparation is compared, good effect, safe, toxicity is low, taking convenience.
Specific embodiment
Embodiment 1:
Pharmaceutical formulation of the present invention is made up of following component:
Oleanolic acid 60.0g
Hypromellose 40.0g
Lactose 120.0g
Sodium lauryl sulphate 1.0g
Magnesium stearate 2.0g
Make 1000 altogether
Adopt the direct compression prepared.Concrete preparation method is as described below: oleanolic acid, hypromellose, lactose, sodium lauryl sulphate take by weighing respectively according to quantity, cross 80 mesh sieve mix homogeneously; Mix with magnesium stearate, the mixing that sieves is pressed the standard quantity tabletting, promptly gets slow releasing tablet again.
Embodiment 2:
Pharmaceutical formulation of the present invention is made up of following component:
Oleanolic acid 60.0g
Hypromellose 35.0g
Ethyl cellulose 10.0g
Lactose 80.0g
Starch 40.0g
Sucrose stearate 4.0g
Make 1000 altogether
Adopt the wet granule compression tablet prepared.Concrete preparation method is as described below: oleanolic acid, hypromellose, ethyl cellulose, lactose, starch are taken by weighing respectively according to quantity, cross 80 mesh sieve mix homogeneously; Use 50% alcohol granulation, behind 60 ℃ of dry 4h, granulate adds sucrose stearate again, presses the standard quantity direct compression behind the mixing, promptly gets the oleanolic acid slow releasing tablet.
Embodiment 3:
Pharmaceutical formulation of the present invention is made up of following component:
Oleanolic acid 180.0g
Eudragit?RS?PO 15.0g
Eudragit?RL?PO 15.0g
Microcrystalline Cellulose 50.0g
Starch 40.0g
Sodium stearyl fumarate 3.0g
Make 1000 altogether
This dosage form adopts direct compression technology, uses the preparation of conventional tablet pharmaceutical equipment.Concrete preparation method is as described below: oleanolic acid, Eudragit RS PO, Eudragit RL PO, microcrystalline Cellulose, starch are taken by weighing respectively according to quantity, cross 80 mesh sieve mix homogeneously, use 50% alcohol granulation, behind 60 ℃ of dry 4h, granulate, add sodium stearyl fumarate, press the standard quantity direct compression behind the mixing, promptly get the oleanolic acid slow releasing tablet.
Through investigating, the release in vitro degree of the oleanolic acid slow releasing tablet that the foregoing description is made is: 1h:10～30%:6h:40～70%; 12h: 〉=75%.
At this preamble, the specific embodiment of preferred embodiment has been described the present invention.Yet should be understood that those skilled in the art can not make various changes or modifications the present invention departing from spirit of the present invention, but these equivalent form of values fall within equally in the application's appended claims institute restricted portion.
Claims (6)
1, a kind of oleanolic acid slow releasing tablet is characterized in that: it is principal agent that medicament active composition adopts micronized oleanolic acid, and other composition is an adjuvant, and pharmaceutical formulation of the present invention is made up of following component by weight percentage:
A, oleanolic acid 10～75%, micronized oleanolic acid particle diameter is 48～150um;
B, slow-release material 5～50%, slow-release material are one or several the combination in hypromellose, ethyl cellulose, Aquacoat and the acrylic resin;
C, filler 15～80%;
D, surfactant 0～2%;
E, lubricant 0.1～5%.
2, oleanolic acid slow releasing tablet as claimed in claim 1 is characterized in that: described filler is one or more the combination in microcrystalline Cellulose, lactose and the starch.
3, oleanolic acid slow releasing tablet as claimed in claim 1 is characterized in that: described surfactant is sodium lauryl sulphate or sucrose stearate.
4, oleanolic acid slow releasing tablet as claimed in claim 1 is characterized in that: described lubricant is micropowder silica gel, magnesium stearate, Stepanol MG, sodium stearyl fumarate or sucrose stearate.
5, a kind of method for preparing oleanolic acid slow releasing tablet as claimed in claim 1; it is characterized in that: said preparation adopts direct compression technology; concrete preparation method is as described below: micronized oleanolic acid, slow-release material, filler, surfactant are taken by weighing according to quantity; mix homogeneously; again with mix lubricant after direct compression, promptly get the oleanolic acid slow releasing tablet.
6, a kind of method for preparing oleanolic acid slow releasing tablet as claimed in claim 1; it is characterized in that: tablet forming technique prepared after said preparation adopted wet granulation; concrete preparation method is as described below: micronized oleanolic acid, slow-release material, filler, surfactant are taken by weighing according to quantity; behind the mix homogeneously with 50～75% alcohol granulations; 60 ℃ of dry back granulate; tabletting after the adding mix lubricant promptly gets the oleanolic acid slow releasing tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410044333 CN100522175C (en) | 2004-05-26 | 2004-05-26 | Sustained release tablet of oleanolic acid and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410044333 CN100522175C (en) | 2004-05-26 | 2004-05-26 | Sustained release tablet of oleanolic acid and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1704062A CN1704062A (en) | 2005-12-07 |
| CN100522175C true CN100522175C (en) | 2009-08-05 |
Family
ID=35575783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410044333 Expired - Fee Related CN100522175C (en) | 2004-05-26 | 2004-05-26 | Sustained release tablet of oleanolic acid and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100522175C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102114023A (en) * | 2010-09-27 | 2011-07-06 | 林秀坤 | Oleanolic acid with anti-oophoroma action and pharmaceutical preparations thereof |
| CN102114022A (en) * | 2010-09-27 | 2011-07-06 | 林秀坤 | Application of oleanolic acid in resisting colon cancer and pharmaceutical preparations thereof |
| CN102106860A (en) * | 2010-09-27 | 2011-06-29 | 林秀坤 | Anti-liver-cancer effect of Oleanolic acid and pharmaceutic preparation |
| CN102114021A (en) * | 2010-09-27 | 2011-07-06 | 林秀坤 | Application of oleanolic acid in resisting breast cancer and pharmaceutical preparations thereof |
| CN102133219A (en) * | 2010-09-27 | 2011-07-27 | 林秀坤 | Anti-cervical cancer effect of oleanolic acid and pharmaceutical preparation thereof |
| CN102151275A (en) * | 2010-11-07 | 2011-08-17 | 林秀坤 | Pancreatic cancer-resisting effect of oleanolic acid and pharmaceutical preparation of oleanolic acid |
-
2004
- 2004-05-26 CN CN 200410044333 patent/CN100522175C/en not_active Expired - Fee Related
Non-Patent Citations (6)
| Title |
|---|
| 抗肝炎中药研究开发的现状与展望. 肖小河等.传染病药学，第11卷第2期. 2001 |
| 抗肝炎中药研究开发的现状与展望. 肖小河等.传染病药学，第11卷第2期. 2001 * |
| 用固体分散法提高齐墩果酸片溶出速率. 徐晓阳等.黑龙江医药，第10卷第6期. 1997 |
| 用固体分散法提高齐墩果酸片溶出速率. 徐晓阳等.黑龙江医药，第10卷第6期. 1997 * |
| 药剂学. 屠锡德，694，719，1113，1114，人民卫生出版社. 2004 |
| 药剂学. 屠锡德，694，719，1113，1114，人民卫生出版社. 2004 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1704062A (en) | 2005-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101099729B (en) | Oral solid preparation containing ambroxol hydrochloride and salbutamol active components | |
| CN110037994B (en) | A kind of ibuprofen immediate-release sustained-release double-layer tablet and preparation method thereof | |
| CN103070864B (en) | Repaglinide and metformin hydrochloride medicinal composition and its preparation method | |
| CN100522175C (en) | Sustained release tablet of oleanolic acid and its preparation method | |
| CN103239719A (en) | Metformin compound pharmaceutical composition and preparation method thereof | |
| CN101284011B (en) | Oleanolic acid orally disintegrating tablet and preparation method thereof | |
| CN106822907B (en) | Two-phase release preparation containing racecadotril and preparation method thereof | |
| CN101502517A (en) | Glipizide enteric sustained-release preparation composition and method for preparing the same | |
| CA2492156C (en) | Tablet composition containing kampo medicinal extract and its manufacturing process | |
| CN102846573A (en) | Silibinin double-layer slow-release tablets and preparation method thereof | |
| CN102327266A (en) | Pharmaceutical composition containing Iloperidone and preparation method thereof | |
| CN102451171B (en) | Tindazole vaginal effervescent tablet and preparation method thereof | |
| CN103110601B (en) | Gliclazide gastric floating tablet and preparation method thereof | |
| CN101244068B (en) | Hemsleyadin sustained release preparation | |
| CN101152155A (en) | Hydrochloric acid Ivabradine solid pharmaceutical composition and method for preparing the same | |
| CN108078936A (en) | Trimebutine maleate dispersion tablet and preparation method thereof | |
| CN102258493A (en) | Salidroside slow release tablets and preparation method thereof | |
| CN114010632A (en) | Enalapril maleate and furosemide compound tablet and preparation method and application thereof | |
| JP2022112698A (en) | Pharmaceutical composition containing apixaban | |
| CN100386086C (en) | Dispersed compound tablet of glycyrrhizic acid and glycyrrhizinate and its preparing process | |
| CN102988322B (en) | Arginine ibuprofen tablet and preparation method thereof | |
| CN101804040A (en) | Ketoprofen slow-release orally disintegrating tablets | |
| CN103494816B (en) | A pharmaceutical composition for treating diabetes | |
| CN102349882A (en) | Medicinal composition containing trandolapril and preparation process thereof | |
| CN103656609A (en) | Trandolapril dispersion pharmaceutical composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: HANGZHOU MINSHENG MEDCINE CO., LTD. Free format text: FORMER NAME: HANGZHOU MINSHENG PHARMACEUTICAL GROUP CO. |
|
| CP03 | Change of name, title or address |
Address after: No. 108 Tong Road, Hangzhou, Zhejiang, Yuhang Patentee after: Hangzhou Minsheng Pharmaceutical Co., Ltd. Address before: No. 108 Tong Road, Hangzhou, Zhejiang, Yuhang Patentee before: Hangzhou Minsheng Pharmaceutical Group Co., Ltd. |
|
| ASS | Succession or assignment of patent right |
Owner name: GUANGZHOU RENHENG PHARMACEUTICAL TECHNOLOGY CO., L Free format text: FORMER OWNER: HANGZHOU MINSHENG PHARMACEUTICAL CO., LTD. Effective date: 20150528 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 310011 HANGZHOU, ZHEJIANG PROVINCE TO: 510305 GUANGZHOU, GUANGDONG PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20150528 Address after: 510305 west side of the third floor of A4 building, 171 Haizhuqu District Road, Guangdong, Guangzhou Patentee after: Guangzhou Ren Heng Pharmaceutical Technology Co., Ltd Address before: 310011 No. 108 Tong Road, Hangzhou, Zhejiang, Yuhang Patentee before: Hangzhou Minsheng Pharmaceutical Co., Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090805 Termination date: 20160526 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |