CL2021003146A1 - Vectores víricos y uso de los mismos en terapias celulares adoptivas - Google Patents

Vectores víricos y uso de los mismos en terapias celulares adoptivas

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Publication number
CL2021003146A1
CL2021003146A1 CL2021003146A CL2021003146A CL2021003146A1 CL 2021003146 A1 CL2021003146 A1 CL 2021003146A1 CL 2021003146 A CL2021003146 A CL 2021003146A CL 2021003146 A CL2021003146 A CL 2021003146A CL 2021003146 A1 CL2021003146 A1 CL 2021003146A1
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CL
Chile
Prior art keywords
viral vectors
adoptive cell
cell therapies
dimer
encoding
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Application number
CL2021003146A
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English (en)
Inventor
Melinda Mata
Yannick Bulliard
Mamta Kalra
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Immatics Us Inc
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Publication date
Application filed by Immatics Us Inc filed Critical Immatics Us Inc
Publication of CL2021003146A1 publication Critical patent/CL2021003146A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/34—Antigenic peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/0636—T lymphocytes
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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Abstract

Un vector que contiene una primera secuencia nucleotídica S1, que codifica una proteína Z, una segunda secuencia nucleotídica S2, que codifica una proteína Z2, una tercera secuencia nucleotídica S3, que codifica una proteína Y1, y una cuarta secuencia nucleotídica S4, que codifica una proteína Y2, en que Z1 y Z2 forman un primer dímero e Y1 y Y2 forman un segundo dímero, en que el primer dímero Z1Z2 es diferente del segundo dímero Y1Y2.
CL2021003146A 2019-05-27 2021-11-26 Vectores víricos y uso de los mismos en terapias celulares adoptivas CL2021003146A1 (es)

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US201962853123P 2019-05-27 2019-05-27

Publications (1)

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CL2021003146A1 true CL2021003146A1 (es) 2022-09-09

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US (2) US11975025B2 (es)
EP (1) EP3976805A1 (es)
JP (2) JP7621979B2 (es)
KR (1) KR20220029584A (es)
CN (1) CN113874516A (es)
AU (1) AU2020283500B2 (es)
BR (1) BR112021023782A2 (es)
CA (1) CA3141505A1 (es)
CL (1) CL2021003146A1 (es)
CO (1) CO2021017650A2 (es)
CR (1) CR20210669A (es)
EA (1) EA202193139A1 (es)
IL (1) IL288403A (es)
MA (1) MA56036A (es)
MX (1) MX2021014552A (es)
PE (1) PE20220164A1 (es)
PH (1) PH12021552979A1 (es)
SG (1) SG11202112860PA (es)
TW (2) TW202536185A (es)
WO (1) WO2020243134A1 (es)

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