BR112015002390A8 - derivados do ácido 5-aminolevulínico (5-ala), sua composição e seu uso como agentes fotossensibilizantes - Google Patents

derivados do ácido 5-aminolevulínico (5-ala), sua composição e seu uso como agentes fotossensibilizantes Download PDF

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Publication number
BR112015002390A8
BR112015002390A8 BR112015002390A BR112015002390A BR112015002390A8 BR 112015002390 A8 BR112015002390 A8 BR 112015002390A8 BR 112015002390 A BR112015002390 A BR 112015002390A BR 112015002390 A BR112015002390 A BR 112015002390A BR 112015002390 A8 BR112015002390 A8 BR 112015002390A8
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BR
Brazil
Prior art keywords
ala
derivatives
aminolevulinic acid
compounds
composition
Prior art date
Application number
BR112015002390A
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English (en)
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BR112015002390B1 (pt
BR112015002390A2 (pt
Inventor
Godal Aslak
Barry Charnock Colin
Klaveness Jo
Erik Braenden Jon
Olav Nilsen Nils
Original Assignee
Photocure Asa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Photocure Asa filed Critical Photocure Asa
Publication of BR112015002390A2 publication Critical patent/BR112015002390A2/pt
Publication of BR112015002390A8 publication Critical patent/BR112015002390A8/pt
Publication of BR112015002390B1 publication Critical patent/BR112015002390B1/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

compostos a invenção refere-se a novos derivados de ácido 5-aminolevulínico (5-ala) e a seus usos como agentes de fotossensibilização. em particular, refere-se a compostos de fórmula geral i e sais farmaceuticamente aceitáveis do mesmo, a métodos para a preparação desses compostos e a seus usos para fins médicos e cosméticos, por exemplo, em métodos de diagnóstico e terapia fotodinâmica: em que r1 representa um átomo de hidrogênio ou um grupo alquila ou cicloalquila opcionalmente substituído; r2, cada um dos quais pode ser igual ou diferente, representa um átomo de hidrogênio ou um grupo alquila opcionalmente substituído; e x é um grupo de ligação.
BR112015002390-8A 2012-08-03 2013-08-02 Derivados do ácido 5-aminolevulínico (5-ala), sua composição e seu uso como agentes fotossensibilizantes BR112015002390B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12179277.4 2012-08-03
EP12179277 2012-08-03
EP12197305 2012-12-14
EP12197305.1 2012-12-14
PCT/EP2013/066317 WO2014020164A1 (en) 2012-08-03 2013-08-02 Compounds

Publications (3)

Publication Number Publication Date
BR112015002390A2 BR112015002390A2 (pt) 2017-07-04
BR112015002390A8 true BR112015002390A8 (pt) 2019-07-30
BR112015002390B1 BR112015002390B1 (pt) 2020-03-24

Family

ID=48948407

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015002390-8A BR112015002390B1 (pt) 2012-08-03 2013-08-02 Derivados do ácido 5-aminolevulínico (5-ala), sua composição e seu uso como agentes fotossensibilizantes

Country Status (18)

Country Link
US (1) US9249086B2 (pt)
EP (1) EP2880012B1 (pt)
JP (1) JP6280117B2 (pt)
KR (1) KR102180174B1 (pt)
CN (1) CN104661994B (pt)
AU (1) AU2013298525B2 (pt)
BR (1) BR112015002390B1 (pt)
CA (1) CA2880422C (pt)
CL (1) CL2015000233A1 (pt)
ES (1) ES2908080T3 (pt)
IL (1) IL236965B (pt)
IN (1) IN2015DN00837A (pt)
MX (1) MX364940B (pt)
NZ (1) NZ629914A (pt)
RU (1) RU2635563C2 (pt)
SG (1) SG11201500805VA (pt)
WO (1) WO2014020164A1 (pt)
ZA (1) ZA201500778B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6595484B2 (ja) 2013-12-20 2019-10-23 ガルデルマ・リサーチ・アンド・デヴェロップメント 光損傷皮膚のパルス光力学的処置
CA2999367C (en) * 2015-09-23 2023-09-26 Xw Laboratories Inc. Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
SG11201805000RA (en) * 2015-12-17 2018-07-30 Photocure Asa Method of photodynamic therapy (pdt) for bladder cancer
GB201522309D0 (en) * 2015-12-17 2016-02-03 Photocure Asa Use
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
CN112010772A (zh) 2016-01-26 2020-12-01 赵鸣 5-氨基酮戊酸及其衍生物的盐化合物和应用
DK3641882T3 (da) * 2017-06-21 2023-12-18 Photocure Asa Fremgangsmåde til fremstilling af en flydende farmaceutisk sammensætning og indretning til anvendelse i en sådan fremgangsmåde
CA3280998A1 (en) 2019-02-13 2025-10-30 Alpheus Medical, Inc. Non-invasive sonodynamic therapy
WO2020243319A1 (en) 2019-05-29 2020-12-03 Sonalasense, Inc. Sonosensitization
CA3185803A1 (en) 2020-08-07 2022-02-10 Vijay Agarwal Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
KR20250154511A (ko) 2023-03-07 2025-10-28 포토큐어 에이에스에이 방광암 치료

Family Cites Families (24)

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JPH07188133A (ja) 1993-12-27 1995-07-25 Asahi Chem Ind Co Ltd δ−アミノレブリン酸またはその同族体の製造法
HU225148B1 (en) * 1995-03-10 2006-07-28 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy or diagnosis, products and kits comprising thereof and method of in vitro diagnosis by their using
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US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
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JPH1112197A (ja) 1997-06-18 1999-01-19 Cosmo Sogo Kenkyusho:Kk 悪性腫瘍診断剤及び治療剤
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JP5323539B2 (ja) 2009-03-11 2013-10-23 コスモ石油株式会社 農作物の収穫部位の収量向上剤

Also Published As

Publication number Publication date
MX2015001374A (es) 2015-09-07
EP2880012B1 (en) 2021-12-15
BR112015002390B1 (pt) 2020-03-24
ZA201500778B (en) 2016-04-28
KR102180174B1 (ko) 2020-11-19
NZ629914A (en) 2017-02-24
RU2635563C2 (ru) 2017-11-14
JP2015528814A (ja) 2015-10-01
WO2014020164A1 (en) 2014-02-06
US9249086B2 (en) 2016-02-02
CL2015000233A1 (es) 2015-04-24
RU2015104830A (ru) 2016-09-27
KR20150039208A (ko) 2015-04-09
CN104661994B (zh) 2017-08-08
CA2880422C (en) 2021-02-09
IL236965B (en) 2019-03-31
AU2013298525B2 (en) 2017-12-14
HK1211283A1 (en) 2016-05-20
ES2908080T3 (es) 2022-04-27
MX364940B (es) 2019-05-15
SG11201500805VA (en) 2015-02-27
AU2013298525A1 (en) 2015-03-05
EP2880012A1 (en) 2015-06-10
CA2880422A1 (en) 2014-02-06
IN2015DN00837A (pt) 2015-06-12
JP6280117B2 (ja) 2018-02-14
CN104661994A (zh) 2015-05-27
US20150191419A1 (en) 2015-07-09
BR112015002390A2 (pt) 2017-07-04

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/08/2013, OBSERVADAS AS CONDICOES LEGAIS.