BR112013026397A2 - Compostos cromenona como inibidores de pi 3-cinase para o tratamento de câncer - Google Patents

Compostos cromenona como inibidores de pi 3-cinase para o tratamento de câncer

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Publication number
BR112013026397A2
BR112013026397A2 BR112013026397A BR112013026397A BR112013026397A2 BR 112013026397 A2 BR112013026397 A2 BR 112013026397A2 BR 112013026397 A BR112013026397 A BR 112013026397A BR 112013026397 A BR112013026397 A BR 112013026397A BR 112013026397 A2 BR112013026397 A2 BR 112013026397A2
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Brazil
Prior art keywords
treatment
cancer
kinase inhibitors
chromenone compounds
chromenone
Prior art date
Application number
BR112013026397A
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English (en)
Inventor
Christophe Barlaam Bernard
Louis Degorce Sebastian
Marie Paul Lambert-Van Der Brempt Christine
Marcel Lohmann Jean-Jacques
Ple Patrick
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR112013026397A2 publication Critical patent/BR112013026397A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSTOS CROMENONA COMO INIBIDORES DE PI 3-CINASE PARA O TRATAMENTO DE CÂNCER. A invenção refere-se a compostos cromenona de Fórmula I; ou sais farmaceuticamente aceitáveis dos mesmos, em que cada um de R1, R2, R3, R4, R5, n e R6 têm qualquer um dos significados definidos aqui anteriormente no relatório; processos para sua preparação, composições farmacêuticas contendo-os e seu uso na fabricação de um medicamento para uso no tratamento de distúrbios proliferativos celulares.
BR112013026397A 2011-04-13 2012-04-12 Compostos cromenona como inibidores de pi 3-cinase para o tratamento de câncer BR112013026397A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11290187 2011-04-13
PCT/GB2012/050793 WO2012140419A1 (en) 2011-04-13 2012-04-12 Chromenone compounds as pi 3 -kinase inhibitors for the treatment of cancer

Publications (1)

Publication Number Publication Date
BR112013026397A2 true BR112013026397A2 (pt) 2017-09-12

Family

ID=46017999

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013026397A BR112013026397A2 (pt) 2011-04-13 2012-04-12 Compostos cromenona como inibidores de pi 3-cinase para o tratamento de câncer

Country Status (14)

Country Link
US (2) US8530470B2 (pt)
EP (1) EP2697220B1 (pt)
JP (1) JP5937674B2 (pt)
KR (1) KR101854950B1 (pt)
CN (1) CN103596948B (pt)
AR (1) AR086100A1 (pt)
AU (1) AU2012241594B2 (pt)
BR (1) BR112013026397A2 (pt)
CA (1) CA2832787A1 (pt)
ES (1) ES2565384T3 (pt)
MX (1) MX340300B (pt)
RU (1) RU2598028C2 (pt)
UY (1) UY34013A (pt)
WO (1) WO2012140419A1 (pt)

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WO2014072937A1 (en) 2012-11-08 2014-05-15 Rhizen Pharmaceuticals Sa Pharmaceutical compositions containing a pde4 inhibitor and a pi3 delta or dual pi3 delta-gamma kinase inhibitor
JPWO2015146561A1 (ja) * 2014-03-26 2017-04-13 住友精化株式会社 臭化芳香族エステル化合物の製造方法
CN104744376A (zh) * 2015-03-14 2015-07-01 长沙深橙生物科技有限公司 一种2-异丙基嘧啶衍生物的制备方法
CN104803921A (zh) * 2015-03-14 2015-07-29 长沙深橙生物科技有限公司 一种苯取代嘧啶衍生物的制备方法
BR112018007068B1 (pt) * 2015-10-09 2024-01-02 Janssen Pharmaceutica N.V. Derivados de quinoxalina e piridopirazina como inibidores de pi3kbeta, seu uso e composição farmacêutica que os compreende
WO2017090002A2 (en) * 2015-11-27 2017-06-01 Gvk Biosciences Private Limited Inhibitors of pi3 kinases
RU2612875C1 (ru) * 2015-12-14 2017-03-13 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) Средство для ингибирования фермента тирозил-днк-фосфодиэстеразы 1 человека
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
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RU2764522C1 (ru) * 2021-05-25 2022-01-18 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) 3,3'[(гексано-1,6-диилбис(азанедиил)]бис-(7-гидрокси-6-метоксикарбонил-2-оксо-2H-хромен), обладающий антибактериальной активностью
CN113717138B (zh) * 2021-10-21 2023-02-24 沈阳药科大学 一类氮芥类色原酮衍生物与应用
WO2024125644A1 (zh) * 2022-12-16 2024-06-20 西藏海思科制药有限公司 一种含羧基的杂环衍生物及其在医药上的应用

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Also Published As

Publication number Publication date
MX2013011931A (es) 2014-03-27
WO2012140419A1 (en) 2012-10-18
AU2012241594B2 (en) 2016-03-10
CN103596948B (zh) 2016-04-27
US8530470B2 (en) 2013-09-10
RU2013147736A (ru) 2015-05-20
CN103596948A (zh) 2014-02-19
UY34013A (es) 2012-11-30
ES2565384T3 (es) 2016-04-04
JP2014510779A (ja) 2014-05-01
US20120264731A1 (en) 2012-10-18
AU2012241594A1 (en) 2013-10-17
RU2598028C2 (ru) 2016-09-20
EP2697220B1 (en) 2016-01-13
AR086100A1 (es) 2013-11-20
HK1193823A1 (zh) 2014-10-03
CA2832787A1 (en) 2012-10-18
EP2697220A1 (en) 2014-02-19
JP5937674B2 (ja) 2016-06-22
KR101854950B1 (ko) 2018-05-04
KR20140027985A (ko) 2014-03-07
US20140038937A1 (en) 2014-02-06
MX340300B (es) 2016-07-05

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