BR112012016982B8 - bactéria de ácido lático recombinante de grau alimentício e composição terapêutica - Google Patents

bactéria de ácido lático recombinante de grau alimentício e composição terapêutica

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Publication number
BR112012016982B8
BR112012016982B8 BR112012016982A BR112012016982A BR112012016982B8 BR 112012016982 B8 BR112012016982 B8 BR 112012016982B8 BR 112012016982 A BR112012016982 A BR 112012016982A BR 112012016982 A BR112012016982 A BR 112012016982A BR 112012016982 B8 BR112012016982 B8 BR 112012016982B8
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BR
Brazil
Prior art keywords
proteins
active fraction
trappin
protein
family
Prior art date
Application number
BR112012016982A
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English (en)
Other versions
BR112012016982A2 (pt
BR112012016982B1 (pt
Inventor
Vergnolle Nathalie
Sallenave Jean-Michel
Langella Philippe
Bermudez-Humaran Luis
Original Assignee
Institut National De Rech Pour Lagriculture Lalimentation Et Lenvironnement
Inst Nat De La Rech Agronomique Inra
Pasteur Institut
Univ Paris Diderot Paris 7
Institut National De La Sante Et De La Rech Medicale I N S E R M
Univ Paris
Univ Paris Cite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Institut National De Rech Pour Lagriculture Lalimentation Et Lenvironnement, Inst Nat De La Rech Agronomique Inra, Pasteur Institut, Univ Paris Diderot Paris 7, Institut National De La Sante Et De La Rech Medicale I N S E R M, Univ Paris, Univ Paris Cite filed Critical Institut National De Rech Pour Lagriculture Lalimentation Et Lenvironnement
Publication of BR112012016982A2 publication Critical patent/BR112012016982A2/pt
Publication of BR112012016982B1 publication Critical patent/BR112012016982B1/pt
Publication of BR112012016982B8 publication Critical patent/BR112012016982B8/pt

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/324—Foods, ingredients or supplements having a functional effect on health having an effect on the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

bactérias probióticas recombinantes para a prevenção e tratamento da doença inflamatória do intestino (ibd) e síndrome do intestino irritável (ibs) a presente invenção refere-se ao campo geral da terapia de doenças inflamatórias intestinais (ibd) e/ou síndrome do intestino irritável (ibs). assim, a invenção refere-se a uma molécula selecionada a partir da proteína trappin-2 ou uma fração ativa da proteína trappin-2, um elemento das proteínas da família wap, ou uma fração ativa do elemento das proteínas da família wap, ou um elemento das proteínas da família serpina, ou uma fração ativa de um elemento das proteínas da família serpina para o tratamento da síndrome do intestino irritável (ibs). a invenção também se refere a uma bactéria recombinante de grau alimentício que inclui um gene selecionado a partir de um gene que codifica para a proteína trappin-2, ou uma fração ativa da proteína trappin-2, um gene que codifica para um elemento das proteínas da família wap, ou uma fração ativa de um elemento das proteínas da família wap, ou um gene que codifica para um elemento das proteínas da família serpina, ou uma fração ativa de um elemento das proteínas da família serpina.
BR112012016982A 2010-01-14 2011-01-14 bactéria de ácido lático recombinante de grau alimentício e composição terapêutica BR112012016982B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10305045 2010-01-14
FR10305045.6 2010-01-14
PCT/EP2011/050489 WO2011086172A1 (en) 2010-01-14 2011-01-14 Recombinant probiotic bacteria for the prevention and treatment of inflammatory bowel disease (ibd) and irritable bowel syndrome (ibs)

Publications (3)

Publication Number Publication Date
BR112012016982A2 BR112012016982A2 (pt) 2016-12-13
BR112012016982B1 BR112012016982B1 (pt) 2021-02-09
BR112012016982B8 true BR112012016982B8 (pt) 2022-12-20

Family

ID=42224980

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012016982A BR112012016982B8 (pt) 2010-01-14 2011-01-14 bactéria de ácido lático recombinante de grau alimentício e composição terapêutica

Country Status (10)

Country Link
US (3) US20120195859A1 (pt)
EP (1) EP2451467B1 (pt)
JP (1) JP6007106B2 (pt)
KR (1) KR101667982B1 (pt)
CN (1) CN102740867A (pt)
AU (1) AU2011206532B8 (pt)
BR (1) BR112012016982B8 (pt)
CA (1) CA2786847C (pt)
ES (1) ES2613755T3 (pt)
WO (1) WO2011086172A1 (pt)

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US8524220B1 (en) 2010-02-09 2013-09-03 David Gordon Bermudes Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
FR2990699B1 (fr) 2012-05-21 2016-02-05 Agronomique Inst Nat Rech Cassettes d'expression procaryotes regulees par le stress
WO2013188529A1 (en) * 2012-06-15 2013-12-19 Temple University Of The Commonwealth System Of Higher Education Use of isolated bacterial amyloids for treatment of inflammatory disorders or diseases of the epithelium
EP2706067A1 (en) * 2012-09-06 2014-03-12 Humboldt-Universität zu Berlin Probiotic bacteria as carrier for a helminth-derived immunomodulator for the treatment of inflammatory disorders
BR112015009975A2 (pt) 2012-11-01 2017-07-11 Academisch Ziekenhuis Groningen métodos e composições para a estimulação das bactérias benéficas no trato gastrointestinal
US9593339B1 (en) 2013-02-14 2017-03-14 David Gordon Bermudes Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
EP2851086A1 (en) 2013-09-20 2015-03-25 Sanofi Serpins: methods of therapeutic ß-cell regeneration and function
EP2769732A1 (en) 2013-02-22 2014-08-27 Sanofi Serpins: methods of therapeutic beta-cell regeneration and function
WO2014128257A1 (en) 2013-02-22 2014-08-28 Sanofi Serpins: methods of therapeutic beta-cell regeneration and function
BR112015020819A2 (pt) 2013-03-05 2017-07-18 Academisch Ziekenhuis Groningen uso de faecalibacterium prausnitzii htf-f (dsm 26943) para supressão de inflamação
US9737592B1 (en) 2014-02-14 2017-08-22 David Gordon Bermudes Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment
WO2015168534A1 (en) * 2014-05-02 2015-11-05 Novogy, Inc. Therapeutic treatment of gastrointestinal microbial imbalances through competitive microbe displacement
KR101787543B1 (ko) 2014-08-22 2017-10-19 샘표식품 주식회사 발효배양 산삼을 포함하는 항염증 조성물
WO2016124239A1 (en) * 2015-02-04 2016-08-11 Aurealis Oy Recombinant probiotic bacteria for use in the treatment of a skin dysfunction
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN105106246A (zh) * 2015-08-20 2015-12-02 江南大学 一种植物乳杆菌zs2058及其用途
WO2017053349A1 (en) * 2015-09-21 2017-03-30 Vithera Pharmaceuticals, Inc. Treatment of disease with lactic acid bacteria having stably integrated trappin-2
ITUA20164188A1 (it) * 2016-06-08 2017-12-08 Sofar Spa Nuovo uso medico di probiotici
US10829563B2 (en) 2016-06-16 2020-11-10 INSERM (Institute National de la Santé et de la Recherche Médicale) Method of screening a candidate compound for activity as an elastase 2A (ELA2A) inhibitor
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN110331148B (zh) * 2019-08-20 2021-05-04 华中农业大学 一种编码IFNα蛋白的基因、重组载体pELSH-IFNα、重组干酪乳杆菌及应用
EP4051379A4 (en) * 2019-10-29 2023-12-13 The Regents of the University of California Therapeutic approach for treating inflammatory bowel disease
US12285437B2 (en) 2019-10-30 2025-04-29 The Research Foundation For The State University Of New York Reversing the undesirable pH-profile of doxorubicin via activation of a disubstituted maleamic acid prodrug at tumor acidity
KR102719035B1 (ko) * 2020-04-20 2024-10-18 주식회사 리비옴 혈관 작동성 장 펩티드를 발현하는 미생물, 및 그의 용도
CN111617099B (zh) * 2020-06-16 2022-12-20 青岛农业大学 一种无抗高细胞亲和性结肠炎修复剂与应用方法
EP4210722A1 (en) * 2020-09-07 2023-07-19 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods of treatment of inflammatory bowel diseases
CN113684162B (zh) * 2021-06-03 2024-02-27 江南大学 一种表达小鼠防御素mBD14基因的重组植物乳杆菌及其应用
CN117562249A (zh) * 2023-11-21 2024-02-20 江南大学 一种改善溃疡性结肠炎的发酵物及其制备方法和应用
WO2025224128A1 (en) * 2024-04-24 2025-10-30 Institut National de la Santé et de la Recherche Médicale Methods of treatment of iron overload associated diseases by administration hepcidin locally in the gut

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Also Published As

Publication number Publication date
KR101667982B1 (ko) 2016-10-20
KR20120116435A (ko) 2012-10-22
JP6007106B2 (ja) 2016-10-12
CA2786847C (en) 2017-08-01
EP2451467A1 (en) 2012-05-16
US20130344033A1 (en) 2013-12-26
AU2011206532B8 (en) 2015-08-06
AU2011206532A8 (en) 2015-08-06
US20150073125A1 (en) 2015-03-12
AU2011206532A1 (en) 2012-07-19
CA2786847A1 (en) 2011-07-21
CN102740867A (zh) 2012-10-17
BR112012016982A2 (pt) 2016-12-13
ES2613755T3 (es) 2017-05-25
JP2013517256A (ja) 2013-05-16
US20120195859A1 (en) 2012-08-02
AU2011206532B2 (en) 2015-07-30
US9688742B2 (en) 2017-06-27
WO2011086172A1 (en) 2011-07-21
BR112012016982B1 (pt) 2021-02-09
EP2451467B1 (en) 2016-12-21

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