AU6381701A - Bisamidino compounds as nhe-3 inhibitors - Google Patents

Bisamidino compounds as nhe-3 inhibitors

Info

Publication number
AU6381701A
AU6381701A AU63817/01A AU6381701A AU6381701A AU 6381701 A AU6381701 A AU 6381701A AU 63817/01 A AU63817/01 A AU 63817/01A AU 6381701 A AU6381701 A AU 6381701A AU 6381701 A AU6381701 A AU 6381701A
Authority
AU
Australia
Prior art keywords
bisamidino
nhe
inhibitors
compounds
bisamidino compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
AU63817/01A
Inventor
Norbert Dr. Beier
Rolf Gericke
Peter Raddatz
Claudia Wilm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU6381701A publication Critical patent/AU6381701A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU63817/01A 2000-03-28 2001-03-27 Bisamidino compounds as nhe-3 inhibitors Withdrawn AU6381701A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10015248A DE10015248A1 (en) 2000-03-28 2000-03-28 Bisamidino compounds as NHE-3 inhibitors
DE10015248 2000-03-28
PCT/EP2001/003474 WO2001072742A1 (en) 2000-03-28 2001-03-27 Bisamidino compounds as nhe-3 inhibitors

Publications (1)

Publication Number Publication Date
AU6381701A true AU6381701A (en) 2001-10-08

Family

ID=7636604

Family Applications (1)

Application Number Title Priority Date Filing Date
AU63817/01A Withdrawn AU6381701A (en) 2000-03-28 2001-03-27 Bisamidino compounds as nhe-3 inhibitors

Country Status (4)

Country Link
AR (1) AR027734A1 (en)
AU (1) AU6381701A (en)
DE (1) DE10015248A1 (en)
WO (1) WO2001072742A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187045A1 (en) 2001-12-21 2003-10-02 Uwe Heinelt Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic
DE10163239A1 (en) * 2001-12-21 2003-07-10 Aventis Pharma Gmbh Substituted imidazolidines, process for their preparation, their use as medicaments or diagnostic agents, and medicaments containing them
US7049333B2 (en) 2002-06-04 2006-05-23 Sanofi-Aventis Deutschland Gmbh Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis
US20050054705A1 (en) 2003-02-04 2005-03-10 Aventis Pharma Deutschland Gmbh N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE10304374A1 (en) 2003-02-04 2004-08-05 Aventis Pharma Deutschland Gmbh Novel substituted 2-aminoimidazoles, process for their preparation, their use as medicament or diagnostic agent and medicament containing them
DE10341240A1 (en) 2003-09-08 2005-04-07 Aventis Pharma Deutschland Gmbh Substituted thienoimidazoles, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them
CA2549736A1 (en) * 2003-12-05 2005-06-23 The University Of North Carolina At Chapel Hill Cationic substituted benzofurans as antimicrobial agents
DE102005001411A1 (en) 2005-01-12 2006-07-27 Sanofi-Aventis Deutschland Gmbh Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as medicament, and medicament containing them
EP2170872B1 (en) 2007-06-28 2010-09-01 Sanofi-Aventis U.S. LLC Process for the preparation of the n-(2-chloro-4-methyl-3-thienyl)-1h- benzimidazol-2-amine hydrochloride and intermediates thereof
JP5745406B2 (en) 2008-09-02 2015-07-08 サノフイ Substituted aminoindanes and analogs thereof, and pharmaceutical uses thereof
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
MX381407B (en) 2008-12-31 2025-03-12 Ardelyx Inc COMPOUNDS AND METHODS FOR INHIBITING SODIUM ION/HYDROGEN ION EXCHANGER (NHE)-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND DISORDERS OF THE GASTROINTESTINAL TRACT.
MX366293B (en) 2012-08-21 2019-07-04 Ardelyx Inc Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders.
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
HRP20191000T1 (en) 2013-04-12 2019-09-20 Ardelyx, Inc. Nhe3-binding compounds and methods for inhibiting phosphate transport
RU2703456C2 (en) 2014-07-25 2019-10-17 Тайсо Фармасьютикал Ко., Лтд. Phenyltetrahydroisoquinoline compound, substituted with heteroaryl
MX395405B (en) 2017-01-09 2025-03-25 Ardelyx Inc COMPOUNDS USEFUL FOR TREATING GASTROINTESTINAL TRACT DISORDERS.
MX2019008171A (en) 2017-01-09 2020-02-05 Ardelyx Inc Inhibitors of nhe-mediated antiport.
MX2020001412A (en) 2017-08-04 2020-08-03 Ardelyx Inc COMPOUNDS AND METHODS TO TREAT HYPERKOLAEMIA.
PH12021551892A1 (en) 2019-02-07 2022-08-01 Ardelyx Inc Glycyrrhetinic acid derivatives for use in treating hyperkalemia
EP4706758A3 (en) 2019-05-21 2026-05-06 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19633966A1 (en) * 1996-08-22 1998-02-26 Hoechst Ag Phenyl-substituted alkenylcarboxylic acid guanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
US6011059A (en) * 1997-12-24 2000-01-04 Bristol-Myers Squibb Company Acyl guanidine sodium/proton exchange inhibitors and method

Also Published As

Publication number Publication date
AR027734A1 (en) 2003-04-09
DE10015248A1 (en) 2001-10-04
WO2001072742A1 (en) 2001-10-04

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Legal Events

Date Code Title Description
MK13 Application withdrawn section 141(2)/reg 8.3(2) - pct appl. non-entering nat. phase, withdrawn by applicant