AU2003270199A1 - Urea compounds active as vanilloid receptor antagonists for the treatment of pain - Google Patents

Urea compounds active as vanilloid receptor antagonists for the treatment of pain

Info

Publication number
AU2003270199A1
AU2003270199A1 AU2003270199A AU2003270199A AU2003270199A1 AU 2003270199 A1 AU2003270199 A1 AU 2003270199A1 AU 2003270199 A AU2003270199 A AU 2003270199A AU 2003270199 A AU2003270199 A AU 2003270199A AU 2003270199 A1 AU2003270199 A1 AU 2003270199A1
Authority
AU
Australia
Prior art keywords
pain
treatment
receptor antagonists
urea compounds
vanilloid receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003270199A
Inventor
Gregor James Macdonald
Stephen Frederick Moss
Harshad Kantilal Rami
Mervyn Thompson
David Richard Witty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0221317A external-priority patent/GB0221317D0/en
Priority claimed from GB0305293A external-priority patent/GB0305293D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU2003270199A1 publication Critical patent/AU2003270199A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003270199A 2002-09-13 2003-09-11 Urea compounds active as vanilloid receptor antagonists for the treatment of pain Abandoned AU2003270199A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0221317A GB0221317D0 (en) 2002-09-13 2002-09-13 Novel compounds
GB0221317.1 2002-09-13
GB0305293A GB0305293D0 (en) 2003-03-07 2003-03-07 Novel compounds
GB0305293.3 2003-03-07
PCT/EP2003/010262 WO2004024710A1 (en) 2002-09-13 2003-09-11 Urea compounds active as vanilloid receptor antagonists for the treatment of pain

Publications (1)

Publication Number Publication Date
AU2003270199A1 true AU2003270199A1 (en) 2004-04-30

Family

ID=31995703

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003270199A Abandoned AU2003270199A1 (en) 2002-09-13 2003-09-11 Urea compounds active as vanilloid receptor antagonists for the treatment of pain

Country Status (2)

Country Link
AU (1) AU2003270199A1 (en)
WO (1) WO2004024710A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY138086A (en) 2001-09-13 2009-04-30 Smithkline Beecham Plc Novel urea derivative as vanilloid receptor-1 antagonist
ATE440835T1 (en) * 2003-03-06 2009-09-15 Glaxo Group Ltd HETEROCYCLIC UREA DERIVATIVES FOR THE TREATMENT OF PAIN.
EP1601665A2 (en) 2003-03-07 2005-12-07 Glaxo Group Limited Urea derivatives
GB0305426D0 (en) * 2003-03-08 2003-04-16 Glaxo Group Ltd Novel compounds
SE0301446D0 (en) 2003-05-16 2003-05-16 Astrazeneca Ab New Compounds
GB0319150D0 (en) 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
JP4935073B2 (en) 2003-10-14 2012-05-23 味の素株式会社 Ether derivatives
JP4775259B2 (en) * 2004-03-31 2011-09-21 味の素株式会社 Aniline derivative
JP2008506695A (en) * 2004-07-13 2008-03-06 グラクソ　グループ　リミテッド Antibacterial agent
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
DE102005023943A1 (en) 2005-05-20 2006-11-23 Grünenthal GmbH Pentafluorosulfanyl-substituted compound and its use for the preparation of medicaments
TW200736227A (en) 2005-12-23 2007-10-01 Astrazeneca Ab New compounds III
AR059826A1 (en) * 2006-03-13 2008-04-30 Univ California UREA INHIBITORS CONFORMATIONALLY RESTRICTED OF SOLUBLE HYDROLASSE EPOXIDE
TWI433839B (en) 2006-08-11 2014-04-11 Neomed Inst Novel benzimidazole derivatives 290
EP1903037A1 (en) * 2006-09-07 2008-03-26 Bayer Schering Pharma Aktiengesellschaft 1-(hetero)aryl-3-[heteroaryl-piperidin-4yl]-thiourea derivatives as modulators of EP2 receptors
JP5603770B2 (en) 2007-05-31 2014-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング CCR2 receptor antagonist and use thereof
WO2008157575A1 (en) * 2007-06-21 2008-12-24 Irm Llc Protein kinase inhibitors and methods for using thereof
WO2009096701A2 (en) 2008-01-28 2009-08-06 Amorepacific Corporation Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
JP5438103B2 (en) 2008-07-02 2014-03-12 アモーレパシフィック コーポレイション Novel compounds as vanilloid receptor antagonists, isomers or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing the same
CN102256963B (en) 2008-12-19 2014-06-11 贝林格尔.英格海姆国际有限公司 Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD
ES2674275T3 (en) 2009-12-17 2018-06-28 Centrexion Therapeutics Corporation CCR2 receptor antagonists and uses thereof
WO2011141474A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP5646736B2 (en) 2010-05-12 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel CCR2 receptor antagonists, methods for their preparation, and their use as drugs
WO2011144501A1 (en) 2010-05-17 2011-11-24 Boehringer Ingelheim International Gmbh Ccr2 antagonists and uses thereof
WO2011147772A1 (en) 2010-05-25 2011-12-01 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists
US8962656B2 (en) 2010-06-01 2015-02-24 Boehringer Ingelheim International Gmbh CCR2 antagonists
EP2731941B1 (en) 2011-07-15 2019-05-08 Boehringer Ingelheim International GmbH Novel and selective ccr2 antagonists
PT3317270T (en) 2015-07-02 2020-08-24 Centrexion Therapeutics Corp (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
DE102022104759A1 (en) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-crystal screening method, in particular for the production of co-crystals

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3424761A (en) * 1966-03-07 1969-01-28 Robins Co Inc A H 3-ureidopyrrolidines
GB1460389A (en) * 1974-07-25 1977-01-06 Pfizer Ltd 4-substituted quinazoline cardiac stimulants
CA2422013A1 (en) * 2000-09-14 2002-03-21 Schering Corporation Substituted urea neuropeptide y y5 receptor antagonists
GB0110901D0 (en) * 2001-05-02 2001-06-27 Smithkline Beecham Plc Novel Compounds
MY138086A (en) * 2001-09-13 2009-04-30 Smithkline Beecham Plc Novel urea derivative as vanilloid receptor-1 antagonist
MXPA04008797A (en) * 2002-03-13 2004-11-26 Janssen Pharmaceutica Nv Inhibitors of histone deacetylase.

Also Published As

Publication number Publication date
WO2004024710A1 (en) 2004-03-25

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase