AU2002224597A1 - Highly reactive branched polymer and proteins or peptides conjugated with the polymer - Google Patents
Highly reactive branched polymer and proteins or peptides conjugated with the polymerInfo
- Publication number
- AU2002224597A1 AU2002224597A1 AU2002224597A AU2459702A AU2002224597A1 AU 2002224597 A1 AU2002224597 A1 AU 2002224597A1 AU 2002224597 A AU2002224597 A AU 2002224597A AU 2459702 A AU2459702 A AU 2459702A AU 2002224597 A1 AU2002224597 A1 AU 2002224597A1
- Authority
- AU
- Australia
- Prior art keywords
- polymer
- proteins
- highly reactive
- peptides conjugated
- reactive branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229920000642 polymer Polymers 0.000 title 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR0044046 | 2000-07-29 | ||
| KR10-2000-0044046A KR100396983B1 (en) | 2000-07-29 | 2000-07-29 | Highly reactive branched polymer and proteins or peptides conjugated with the polymer |
| PCT/KR2001/001209 WO2002009766A1 (en) | 2000-07-29 | 2001-07-13 | Highly reactive branched polymer and proteins or peptides conjugated with the polymer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002224597A1 true AU2002224597A1 (en) | 2002-02-13 |
Family
ID=19680801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002224597A Abandoned AU2002224597A1 (en) | 2000-07-29 | 2001-07-13 | Highly reactive branched polymer and proteins or peptides conjugated with the polymer |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR100396983B1 (en) |
| AU (1) | AU2002224597A1 (en) |
| WO (1) | WO2002009766A1 (en) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100361933B1 (en) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | Chemically defined nonpolymeric bonds form the platform molecule and its conjugate |
| WO2001093914A2 (en) | 2000-06-08 | 2001-12-13 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
| US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
| EP2423335B1 (en) | 2001-06-21 | 2014-05-14 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same |
| KR100761652B1 (en) * | 2001-08-25 | 2007-10-04 | 동아제약주식회사 | Various polymer derivatives and conjugates that bind to proteins or peptides |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7049285B2 (en) * | 2001-10-31 | 2006-05-23 | Myung-Ok Park | Biocompatible polymers including peptide spacer |
| KR100511749B1 (en) * | 2001-11-06 | 2005-09-02 | 선바이오(주) | Modified interferon-beta, and chemically modified conjugates thereof |
| US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
| DE10209821A1 (en) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Coupling of proteins to a modified polysaccharide |
| KR100550206B1 (en) * | 2002-03-18 | 2006-02-08 | 한국과학기술원 | Conjugate of epidermal growth factor and polyethylene glycol and preparation method thereof |
| WO2003095496A1 (en) * | 2002-05-08 | 2003-11-20 | Medical Enzymes Ag | Active carbohydrate containing protecting reagents for chemical modifications, their production and use |
| HK1053577A2 (en) | 2002-06-20 | 2003-10-10 | Bio-Cancer Treatment International Limited | Pharmaceutical composition and method of treatment of human malignanices with arginine deprivation |
| US7538092B2 (en) | 2002-10-08 | 2009-05-26 | Fresenius Kabi Deutschland Gmbh | Pharmaceutically active oligosaccharide conjugates |
| BRPI0407882B1 (en) | 2003-02-26 | 2021-07-27 | Nektar Therapeutics | COMPOSITION INCLUDING POLYMER CONJUGATES - PORTION OF FACTOR VIII AND THEIR MANUFACTURING METHOD |
| PL1615945T3 (en) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Glycopegylation methods and proteins/peptides produced by the methods |
| US7947261B2 (en) | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
| EP2644206B1 (en) * | 2003-05-23 | 2019-04-03 | Nektar Therapeutics | PEG derivatives containing two PEG chains |
| GB0314472D0 (en) | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
| CN100415801C (en) * | 2003-10-28 | 2008-09-03 | 北京键凯科技有限公司 | Polyethylene glycol amino acid N-internal ring carbonyl anhydride active derivatives, and medicinal bonding compound and gel thereof |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| ZA200609412B (en) | 2004-05-17 | 2008-07-30 | Ares Trading Sa | Hydrogel interferon formulations |
| JP4988562B2 (en) | 2004-06-01 | 2012-08-01 | アレス トレーディング ソシエテ アノニム | Stabilized interferon liquid formulation |
| US8048940B2 (en) | 2004-07-09 | 2011-11-01 | Vanderbilt University | Reactive graphitic carbon nanofiber reinforced polymeric composites showing enhanced flexural strength |
| US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
| KR100612484B1 (en) * | 2004-09-02 | 2006-08-16 | 정용지 | Epithelial growth factor-polyethylene glycol conjugate and method for preparing the same |
| WO2006050247A2 (en) | 2004-10-29 | 2006-05-11 | Neose Technologies, Inc. | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| KR100754667B1 (en) * | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | Immunoglobulin Fc Fragments Modified with Non-Peptide Polymers and Pharmaceutical Compositions Comprising the Same |
| WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| EP2975135A1 (en) | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glycopegylated factor IX |
| KR100694994B1 (en) * | 2005-06-13 | 2007-03-14 | 씨제이 주식회사 | Human granulocyte colony forming factor homologue |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| KR100886783B1 (en) | 2006-06-12 | 2009-03-04 | 성균관대학교산학협력단 | PEG-TRAIL conjugate modified with N-terminus, preparation method thereof and use thereof |
| EP2049144B8 (en) | 2006-07-21 | 2015-02-18 | ratiopharm GmbH | Glycosylation of peptides via o-linked glycosylation sequences |
| EP2054521A4 (en) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | METHODS OF PURIFYING CONJUGATES OF POLYPEPTIDES |
| ES2655734T3 (en) | 2006-10-04 | 2018-02-21 | Novo Nordisk A/S | Glycerol glycopeptides and pegylated sugars |
| HRP20130382T1 (en) | 2007-04-03 | 2013-05-31 | Biogenerix Ag | TREATMENT PROCEDURES FOR HELP IN GLYCOPEGILATED G-CSF |
| US8114630B2 (en) | 2007-05-02 | 2012-02-14 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
| CA2690611C (en) | 2007-06-12 | 2015-12-08 | Novo Nordisk A/S | Improved process for the production of nucleotide sugars |
| MX2010002448A (en) | 2007-08-27 | 2010-10-04 | Biogenerix Ag | Liquid formulation of g-csf conjugate. |
| JP5563475B2 (en) | 2007-12-20 | 2014-07-30 | メルク セローノ ソシエテ アノニム | PEG interferon-beta preparation |
| PL2257311T3 (en) | 2008-02-27 | 2014-09-30 | Novo Nordisk As | Conjugated factor viii molecules |
| US8093352B2 (en) | 2008-08-05 | 2012-01-10 | Alcon Research, Ltd. | Polyalkylene oxide polyquaternary ammonium biocides |
| WO2010024557A2 (en) * | 2008-08-25 | 2010-03-04 | Viromed Co., Ltd. | Biopolymer conjugates comprising an interleukin-11 analog |
| NO2440239T3 (en) | 2009-06-09 | 2018-02-10 | ||
| US11007251B2 (en) | 2015-12-17 | 2021-05-18 | The Johns Hopkins University | Ameliorating systemic sclerosis with death receptor agonists |
| AR107483A1 (en) | 2016-01-29 | 2018-05-02 | Hanmi Pharm Ind Co Ltd | CONJUGATE OF THERAPEUTIC ENZYMES |
| EA201892260A1 (en) | 2016-04-07 | 2019-03-29 | Дзе Джонс Хопкинс Юниверсити | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PANCREATITIS AND PAIN WITH THE APPLICATION OF THE AGONISTS OF THE DEATH RECEPTOR |
| WO2021188869A2 (en) | 2020-03-20 | 2021-09-23 | Amgen Inc. | Determination of free n-terminus of pegfilgrastim using an acid protease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US6210707B1 (en) * | 1996-11-12 | 2001-04-03 | The Regents Of The University Of California | Methods of forming protein-linked lipidic microparticles, and compositions thereof |
| US5854194A (en) * | 1996-12-12 | 1998-12-29 | Colgate-Palmolive Co. | Chemical linker compositions |
| EP1008355A1 (en) * | 1998-12-08 | 2000-06-14 | Debio Recherche Pharmaceutique S.A. | Method for identifying or analyzing polymer linkage sites on macromolecules using amino acid report binding |
| AU1325400A (en) * | 1998-10-26 | 2000-05-15 | University Of Utah Research Foundation | Method for preparation of polyethylene glycol aldehyde derivatives |
-
2000
- 2000-07-29 KR KR10-2000-0044046A patent/KR100396983B1/en not_active Expired - Fee Related
-
2001
- 2001-07-13 WO PCT/KR2001/001209 patent/WO2002009766A1/en not_active Ceased
- 2001-07-13 AU AU2002224597A patent/AU2002224597A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR100396983B1 (en) | 2003-09-02 |
| WO2002009766A1 (en) | 2002-02-07 |
| KR20020010363A (en) | 2002-02-04 |
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