ATE278711T1 - Verfahren zur selektiven acetylierung - Google Patents

Verfahren zur selektiven acetylierung

Info

Publication number: ATE278711T1
Authority: AT; Austria
Prior art keywords: amino group; epsilon; selective acetylation; free; insulin
Prior art date: 1996-07-11

Application number

AT97928139T

Other languages

English (en)

Inventor

Louis Brammer Hansen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-11

Filing date

1997-07-04

Publication date

2004-10-15

1997-07-04 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE278711T1 publication Critical patent/ATE278711T1/de

Links

238000000034 method Methods 0.000 title abstract 3
230000021736 acetylation Effects 0.000 title 1
238000006640 acetylation reaction Methods 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 3
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
239000004026 insulin derivative Substances 0.000 abstract 1
239000002798 polar solvent Substances 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Paper (AREA)
Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Water Treatment By Electricity Or Magnetism (AREA)

AT97928139T 1996-07-11 1997-07-04 Verfahren zur selektiven acetylierung ATE278711T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK77896		1996-07-11
PCT/DK1997/000296 WO1998002460A1 (en)	1996-07-11	1997-07-04	Selective acylation method

Publications (1)

Publication Number	Publication Date
ATE278711T1 true ATE278711T1 (de)	2004-10-15

Family

ID=8097454

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97928139T ATE278711T1 (de)	1996-07-11	1997-07-04	Verfahren zur selektiven acetylierung

Country Status (8)

Country	Link
EP (1)	EP0938502B1 (de)
JP (1)	JP3300368B2 (de)
AT (1)	ATE278711T1 (de)
AU (1)	AU3255297A (de)
DE (1)	DE69731105T2 (de)
ES (1)	ES2230607T3 (de)
PT (1)	PT938502E (de)
WO (1)	WO1998002460A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6451974B1 (en)	1999-03-17	2002-09-17	Novo Nordisk A/S	Method of acylating peptides and novel acylating agents
CZ20013018A3 (cs)	1999-03-17	2002-02-13	Novo Nordisk A/S	Způsob pro acylování aminoskupiny peptidu nebo proteinu a sloučenina
US7316999B2 (en)	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
US7312192B2 (en) *	2001-09-07	2007-12-25	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
SI1483251T1 (sl)	2002-03-12	2010-03-31	Bristol Myers Squibb Co	C cian epotilonski derivati
EP1546090B1 (de) *	2002-09-25	2009-06-24	Novo Nordisk A/S	Verfahren zur herstellung acylierter peptide
US7273921B2 (en)	2002-09-25	2007-09-25	Novo Nordisk A/S	Method for producing acylated peptides
DK2275439T3 (da) *	2003-08-05	2014-05-12	Novo Nordisk As	Hidtil ukendte insulinderivater
CA2531988C (en) *	2003-08-05	2016-06-28	Novo Nordisk A/S	Novel insulin derivatives
EP1687428A1 (de) *	2003-11-14	2006-08-09	Novo Nordisk A/S	Verfahren zur herstellung von acyliertem insulin
WO2006008238A1 (en) *	2004-07-16	2006-01-26	Novo Nordisk A/S	Method for selective acylation
TWI376234B (en)	2005-02-01	2012-11-11	Msd Oss Bv	Conjugates of a polypeptide and an oligosaccharide
US20080171695A1 (en) *	2005-02-02	2008-07-17	Novo Nordisk A/S	Insulin Derivatives
EP2256130B1 (de) *	2005-02-02	2013-09-25	Novo Nordisk A/S	Neuartige Insulinderivate
ES2371361T3 (es)	2005-12-28	2011-12-30	Novo Nordisk A/S	Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
EP2015770B1 (de) *	2006-05-09	2012-09-26	Novo Nordisk A/S	Insulinderivate
CN101573133B (zh)	2006-07-31	2014-08-27	诺沃-诺迪斯克有限公司	Peg化延长的胰岛素
RU2524150C2 (ru)	2006-09-22	2014-07-27	Ново Нордиск А/С	Аналоги инсулина, устойчивые к протеазам
JP5496082B2 (ja)	2007-04-30	2014-05-21	ノボ・ノルデイスク・エー／エス	タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
JP5552046B2 (ja)	2007-06-13	2014-07-16	ノボ・ノルデイスク・エー／エス	インスリン誘導体を含有する薬学的製剤
EP2217621B1 (de)	2007-11-08	2015-04-22	Novo Nordisk A/S	Insulinderivat
WO2009112583A2 (en)	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
HUE032284T2 (en)	2008-03-18	2017-09-28	Novo Nordisk As	Protease-stabilized, acylated insulin analogues
JP4959005B2 (ja)	2008-10-30	2012-06-20	ノボ・ノルデイスク・エー／エス	毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
CN104364260B (zh)	2012-04-11	2017-02-22	诺和诺德股份有限公司	胰岛素制剂
EP2991672A1 (de)	2013-04-30	2016-03-09	Novo Nordisk A/S	Neuartiges verabreichungsschema
JP6499184B2 (ja)	2013-10-07	2019-04-10	ノヴォノルディスクアー／エス	インスリン類似体の新規な誘導体
PE20210857A1 (es)	2016-12-16	2021-05-18	Novo Nordisk As	Composiciones farmaceuticas que contienen insulina
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1132404A3 (de) *	1993-09-17	2002-03-27	Novo Nordisk A/S	Acyliertes Insulin
US5646242A (en) *	1994-11-17	1997-07-08	Eli Lilly And Company	Selective acylation of epsilon-amino groups
US5693609A (en) *	1994-11-17	1997-12-02	Eli Lilly And Company	Acylated insulin analogs

1997
- 1997-07-04 AT AT97928139T patent/ATE278711T1/de not_active IP Right Cessation
- 1997-07-04 EP EP97928139A patent/EP0938502B1/de not_active Expired - Lifetime
- 1997-07-04 ES ES97928139T patent/ES2230607T3/es not_active Expired - Lifetime
- 1997-07-04 DE DE69731105T patent/DE69731105T2/de not_active Expired - Lifetime
- 1997-07-04 JP JP50552498A patent/JP3300368B2/ja not_active Expired - Lifetime
- 1997-07-04 WO PCT/DK1997/000296 patent/WO1998002460A1/en not_active Ceased
- 1997-07-04 AU AU32552/97A patent/AU3255297A/en not_active Abandoned
- 1997-07-04 PT PT97928139T patent/PT938502E/pt unknown

Also Published As

Publication number	Publication date
DE69731105D1 (de)	2004-11-11
AU3255297A (en)	1998-02-09
EP0938502A1 (de)	1999-09-01
JP3300368B2 (ja)	2002-07-08
ES2230607T3 (es)	2005-05-01
JP2000501419A (ja)	2000-02-08
PT938502E (pt)	2005-02-28
WO1998002460A1 (en)	1998-01-22
EP0938502B1 (de)	2004-10-06
DE69731105T2 (de)	2005-11-17

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Legal Events

Date	Code	Title	Description
2005-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties